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Cardioprotective effects of alantolactone on isoproterenol-induced cardiac injury and cobalt chloride-induced cardiomyocyte injury
Cardioprotective effects of alantolactone on isoproterenol-induced cardiac injury and cobalt chloride-induced cardiomyocyte injury
ObjectivesAlantolactone (AL) is a compound extracted from the roots of Inula Racemosa that has shown beneficial effects in...
Linear IGA bullous dermatosis potentially triggered by vaccination
Linear IGA bullous dermatosis potentially triggered by vaccination
Linear IgA bullous dermatosis (LABD) is a mucocutaneous autoimmune blistering disease affecting both adults and children. ...
Elevated number of IL-21+ TFH and CD86+CD38+ B cells in blood of renal transplant recipients with AMR under conventional immuno-suppression
Elevated number of IL-21+ TFH and CD86+CD38+ B cells in blood of renal transplant recipients with AMR under conventional immuno-suppression
The objective of this study is to detect the number of different subsets of TFH and B cells in renal transplant recipients...
Enriched CD45RA−CD62L+ central memory T and decreased CD3+CD56+ natural killer T lymphocyte subsets in the rectum of ulcerative colitis patients
Enriched CD45RA−CD62L+ central memory T and decreased CD3+CD56+ natural killer T lymphocyte subsets in the rectum of ulcerative colitis patients
ObjectivesTo investigate the distinctive features of lymphocytes promoting inflammation in ulcerative colitis.MethodsWe pe...
Rapamycin as a potent and selective inhibitor of vascular endothelial growth factor receptor in breast carcinoma
Rapamycin as a potent and selective inhibitor of vascular endothelial growth factor receptor in breast carcinoma
Angiogenesis is the process of new vascular formation, which is derived from various factors. For suppressing cancer cell ...
Garcinia kola treatment exhibits immunomodulatory properties while not affecting type 1 diabetes development in an experimental mouse model
Garcinia kola treatment exhibits immunomodulatory properties while not affecting type 1 diabetes development in an experimental mouse model
ObjectiveT cells orchestrate an inflammatory response that destroys pancreatic insulin-producing β cells during the develo...
Research on the mechanisms of taraxerol for the treatment of gastric cancer effect based on network pharmacology
Research on the mechanisms of taraxerol for the treatment of gastric cancer effect based on network pharmacology
Background: Modern pharmacological studies have shown that traditional Chinese medicine (TCM) Taraxacum mongolicum possess...
Abnormal sperm morphology is associated with sensitization to inhaled allergens
Abnormal sperm morphology is associated with sensitization to inhaled allergens
Background: Allergy is associated with the loss of tolerance of environmental antigens, combined with a pathological immun...
MicroRNA-30 inhibits the growth of human ovarian cancer cells by suppressing RAB32 expression
MicroRNA-30 inhibits the growth of human ovarian cancer cells by suppressing RAB32 expression
IntroductionMicroRNAs (miRs) exhibit the potential to act as therapeutic targets for the management of human cancers inclu...
Liquiritigenin enhances cyclic adenosine monophosphate production to mitigate inflammation in dendritic cells
Liquiritigenin enhances cyclic adenosine monophosphate production to mitigate inflammation in dendritic cells
Objective: This study aims to dissect the mechanism of traditional Chinese medicinal herbs against asthma; we chose to fir...
Splenic CD4+ and CD8+ T-cells highly expressed PD-1 and Tim-3 in cirrhotic patients with HCV infection and portal hypertension
Splenic CD4+ and CD8+ T-cells highly expressed PD-1 and Tim-3 in cirrhotic patients with HCV infection and portal hypertension
Introduction: The spleen plays an important role in regulating the immune response to infectious pathogens. T-cells dysfun...
Natural killer cell deficiency experiences higher risk of sepsis after critical intracerebral hemorrhage
Natural killer cell deficiency experiences higher risk of sepsis after critical intracerebral hemorrhage
Background: Lymphopenia is common in intracerebral hemorrhage (ICH) and may predispose to severe infections such as sepsis...
SARS-CoV-2 tropism across the upper aerodigestive tract
SARS-CoV-2 tropism across the upper aerodigestive tract
Access to society journal content varies across our titles. If you have access to a journal via a society or association ...
Early use of canakinumab to prevent mechanical ventilation in select COVID-19 patients: A retrospective, observational analysis
Early use of canakinumab to prevent mechanical ventilation in select COVID-19 patients: A retrospective, observational analysis
IntroductionThe fully-human monoclonal anti-interleukin (IL)-1β antibody canakinumab may inhibit the production of inflamm...
Analysis of human glioma-associated co-inhibitory immune checkpoints in glioma microenvironment and peripheral blood
Analysis of human glioma-associated co-inhibitory immune checkpoints in glioma microenvironment and peripheral blood
One biomarker for a better therapeutic effect of immune checkpoint inhibitors is high expression of checkpoint in tumor mi...
Acute kidney injury in a mouse model of meningococcal disease
Acute kidney injury in a mouse model of meningococcal disease
IntroductionMeningococcal disease is associated with high mortality. When acute kidney injury (AKI) occurs in patients wit...
Systemic corticosteroids for management of COVID-19: Saving lives or causing harm?
Systemic corticosteroids for management of COVID-19: Saving lives or causing harm?
The underlying cause of many complications associated with severe COVID-19 is attributed to the inflammatory cytokine stor...
A nano based approach to alleviate cisplatin induced nephrotoxicity
A nano based approach to alleviate cisplatin induced nephrotoxicity
Background and objectiveCisplatin, an effective drug against cancer, commonly induces nephrotoxicity; limiting its therape...
Overexpression of NEK2 is correlated with poor prognosis in human clear cell renal cell carcinoma
Overexpression of NEK2 is correlated with poor prognosis in human clear cell renal cell carcinoma
Objectives: Never in mitosis gene A-related kinase 2 (NEK2) has been implicated in tumorigenesis in various tissues, but i...
The COVID-19 vaccination experience in Bangladesh: Findings from a cross-sectional study
The COVID-19 vaccination experience in Bangladesh: Findings from a cross-sectional study
ObjectivesVaccination rollout against COVID-19 has started in developed countries in early December 2020. Mass immunizatio...
Mannose-binding lectin serum levels and (Gly54asp) gene polymorphism in recurrent aphthous stomatitis: A case-control study
Mannose-binding lectin serum levels and (Gly54asp) gene polymorphism in recurrent aphthous stomatitis: A case-control study
Objectives: Dysregulation of the immune response appears to play a significant role in recurrent aphthous stomatitis (RAS)...
Entecavir-associated thrombocytopenia
Entecavir-associated thrombocytopenia
Entecavir (ETV) is widely used in the treatment of hepatitis B, but there are only a few reports about entecavir-associate...
Oral booster probiotic bifidobacteria in SARS-COV-2 patients
Oral booster probiotic bifidobacteria in SARS-COV-2 patients
Oral booster-single strain probiotic bifidobacteria could be a potential strategy for SARS-CoV-2. This study aims to evalu...
The correlation between lipoprotein associated phospholipase A2 and central overweight status
The correlation between lipoprotein associated phospholipase A2 and central overweight status
Objective: Being overweight is associated with an increased risk of diabetes mellitus, hypertension, and cardiovascular di...
The role of the sphingosine axis in immune regulation: A dichotomy in the anti-inflammatory effects between sphingosine kinase 1 and sphingosine kinase 2-dependent pathways
The role of the sphingosine axis in immune regulation: A dichotomy in the anti-inflammatory effects between sphingosine kinase 1 and sphingosine kinase 2-dependent pathways
Background: Sphingosine kinase has been identified as playing a central role in the immune cascade, being a common mediato...
Benefits of prescribing low-dose digoxin in atrial fibrillation
Benefits of prescribing low-dose digoxin in atrial fibrillation
IntroductionThe role of digoxin (cardiac glycoside) in controlling the heart rate (HR) for the treatment of atrial fibrill...
Curative role of mesenchymal stromal cells in chronic pancreatitis: Modulation of MAPK and TGF-β1/SMAD factors
Curative role of mesenchymal stromal cells in chronic pancreatitis: Modulation of MAPK and TGF-β1/SMAD factors
Background and objective: Living organisms respond to physical, chemical, and biological threats with a potent inflammator...
The bioinformatics analysis of quercetin in octagonal lotus for the screening of breast cancer MYC, CXCL10, CXCL11, and E2F1
The bioinformatics analysis of quercetin in octagonal lotus for the screening of breast cancer MYC, CXCL10, CXCL11, and E2F1
BackgroundComprehensive bioinformatics analysis of the effective molecular screening of Podophyllum octagonal in breast ca...
The 30th birthday of chronic ulcerative stomatitis: A systematic review
The 30th birthday of chronic ulcerative stomatitis: A systematic review
ObjectivesChronic ulcerative stomatitis (CUS) is a chronic, ulcerative condition of the oral cavity, clinically and histol...
Thrombo-inflammatory biomarkers to predict sepsis outcome
Thrombo-inflammatory biomarkers to predict sepsis outcome
Background: Sepsis has been redefined recently as life-threatening organ dysfunction caused by dysregulated host responses...
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