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In vitro safety assessment of alkyl lactate esters in human umbilical vein endothelial cells (HUVECs)
Safety assessment requires information on both the chronic and acute effects of chemicals. Chemical materials such as food...
Adjuvants in fungicide formulations can be skin sensitizers and cause different types of cell stress responses
New approaches based on -omics technologies can identify biomarkers and processes regulated in response to xenobiotics, an...
Oxidative stress and apoptotic index modifications in the hippocampus of rat pups born to mothers exposed to buprenorphine during lactation
BackgroundThe effect of opioids administration during lactation on nervous system has not fully understood.ObjectiveThe ai...
Aggregation-prone A53T mutant of α-synuclein exaggerates methamphetamine neurotoxicity in SH-SY5Y cells: protective role of cellular cholesterol
The aim of this study is to examine the effects of wild type as well as a mutant (A53T) form of α-synuclein (α-syn) on neu...
Acute and Sub-chronic Toxicity Study of Rang Chuet (Thunbergia laurifolia Lindl.) Extracts and its Antioxidant Activities
Rang Chuet (Thunbergia laurifolia Lindl.) is a Thai medicinal plant with pharmacological properties: it can be used as an ...
Envenomation by the Green Bush Viper Atheris squamigera
The Green Bush Viper, Atheris squamigera, is native to West and Central Africa and has few well reported envenomations. Bi...
Recreational drug use among young, hospitalized patients with acute coronary syndrome: A retrospective study
BackgroundCocaine use is a well-established risk factor for acute coronary syndrome (ACS) although other recreational drug...
Toxicity of polystyrene microplastics in freshwater algae Scenedesmus obliquus: Effects of particle size and surface charge
Microplastics (MPs) are perpetual contaminants that are mostly generated by human activity and are deposited in aquatic ec...
Determination of heavy metals contamination in thyme products by inductively coupled plasma mass spectrometry
Thyme herbs constitute a major part of the Mediterranean diet and are gaining worldwide popularity. However, their chemica...
Acute oral toxicity of damnacanthal and its anticancer activity against colorectal tumorigenesis
MTT3-(4,5-Dimethythiazol-2-yl)− 2,5-diphenyltetrazolium bromideDPBSDulbecco’s phosphate buffered salinePMSFPhenylmethanesu...
Silver nanoparticle-induced alteration of mitochondrial and ER homeostasis affects human breast cancer cell fate
Breast cancer is one of the most frequent forms of cancer. Although different treatment modalities are available, none has...
In vitro and in vivo hepatotoxicity study of Afriplex™ GRT through an inflammatory response
BackgroundThe focus on traditional and complementary medicine for supplementation and treatment of diseases is high. Aspal...
In vitro and in vivo hepatotoxicity study of AfriplexTM GRT through an inflammatory response
BackgroundThe focus on traditional and complementary medicine for supplementation and treatment of diseases is high. Aspal...
Carpet Industry Irrigational Sources Risk Assessment: Heavy Metal Contaminated Vegetables and Cereal Crops in Northern India
Wastewater is often discharged to natural water bodies through an open channel as well as used by marginal farmers to irri...
Gallic acid reverses ovarian disturbances in mice with Letrozole-Induced PCOS via modulating Adipo R1 expression.
Research questionWomen are increasingly suffering from polycystic ovary syndrome (PCOS). Its pathophysiology is still unkn...
Ziziphus abyssinica root bark extract ameliorates paracetamol-induced liver toxicity in rats possibly via the attenuation of oxidative stress
Ziziphus abyssinica root bark is widely used in folk medicine to manage liver diseases, particularly, jaundice but its eff...
Reversible cefazolin-induced status epilepticus in a peritoneal dialysis patient
Cefazolin-induced neurotoxicity with the documented toxic concentration has not been reported in uremic patients on contin...
Inhibitory effects of Thai herbal extracts on the cytochrome P450 3A-mediated the metabolism of gefitinib, lapatinib and sorafenib
Herbal products are widely used in cancer patients via co−administration with chemotherapy. Previous studies have demonstr...
Prenatal developmental toxicity study of herbal tea of Moringa stenopetala and Mentha spicata leaves formulation in Wistar rats
BackgroundMoringa stenopetala and Mentha spicata have long been used to treat diabetes, hypertension, asthma, and other ai...
Histopathological responses and recovery in gills and liver of Nile tilapia (Oreochromis niloticus) exposed to diesel oil
Water pollution due to crude oil has become one of the major means of pollution lately. We experimented to study to what e...
Kolaviron alleviates haematological abnormalities and hepato-renal damage in Naja nigricollis nigricollis venom-treated rats
MethodsTwenty-four male rats were grouped into four (n = 6). A single intravenous dose of NNN venom (≈½LD50) was given to ...
Characterization and quantification of endocrine disruptors in female menstrual blood samples
Selected endocrine disrupting chemicals (EDCs) were measured in adult female menstrual blood for the first time in Ghana, ...
Phosphatase inhibition by sodium orthovanadate displays anti-inflammatory action by suppressing AKT-IKKβ signaling in RAW264.7 cells
Sodium orthovanadate (Na3VO4) is an inhibitor of phosphatases that acts as a phosphate analog and is being developed as an...
Concentrations of urinary parabens and reproductive hormones in Iranian women: Exposure and risk assessment
Parabens are antimicrobial preservatives in a variety of processed foods and beverages, cosmetics, pharmaceuticals, and pe...
Mitigating properties of vitamin E and olive oil on the teratomorphogenic impacts of lambda-cyhalothrin in developing chick embryos
Embryonic toxicity of lambda-cyhalothrin (LCH) and the mitigating properties of extra virgin olive oil (EVO) and vitamin E...