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Doubling Down on a Medical Medium
Doubling Down on a Medical Medium
Doubling Down on a Medical Medium The editors announce a new series, Double Take videos, which offer brief but more in-dep...
Treatment and Prevention of Heat-Related Illness
Treatment and Prevention of Heat-Related Illness
Key Clinical Points Treatment and Prevention of Heat-Related Illness Climate change is causing increasingly frequent and s...
Quality Improvement and Children’s Hospitals
Quality Improvement and Children’s Hospitals
To the Editor: It has often seemed that U.S. children’s hospitals were being left out of the value-based care movement. Ch...
Seeking Simpler Solutions with Diabetes Technology
Seeking Simpler Solutions with Diabetes Technology
In January 1922, the management of type 1 diabetes was forever altered when Leonard Thompson became the first person to re...
Adagrasib in Non–Small-Cell Lung Cancer
Adagrasib in Non–Small-Cell Lung Cancer
To the Editor: Jänne et al. (July 14 issue)1 report the results of a phase 2 study of adagrasib involving patients with KR...
Case 30-2022: A Newborn Girl with Hypoglycemia
Case 30-2022: A Newborn Girl with Hypoglycemia
A Newborn Girl with Hypoglycemia A newborn girl was admitted to the neonatal ICU with prolonged hypoglycemia. At 34 weeks ...
GPRC5D-Targeted CAR T Cells for Myeloma
GPRC5D-Targeted CAR T Cells for Myeloma
Abstract Background B-cell maturation antigen (BCMA)–directed chimeric antigen receptor (CAR) T-cell therapies have genera...
Multicenter, Randomized Trial of a Bionic Pancreas in Type 1 Diabetes
Multicenter, Randomized Trial of a Bionic Pancreas in Type 1 Diabetes
Abstract Background Currently available semiautomated insulin-delivery systems require individualized insulin regimens for...
Audio Interview: Assessing Bivalent Vaccines against Covid-19
Audio Interview: Assessing Bivalent Vaccines against Covid-19
Assessing Bivalent Vaccines against Covid-19 In this audio interview conducted on September 23, 2022, the editors discuss ...
Sickle Cell Disease and Gene Therapy — Patient and Physician Perspectives
Sickle Cell Disease and Gene Therapy — Patient and Physician Perspectives
Perspectives on Gene Therapy for Sickle Cell Disease Rooted in the patient experience, this Double Take video breaks down ...
Lepromatous Leprosy
Lepromatous Leprosy
Images in Clinical Medicine from The New England Journal of Medicine — Lepromatous Leprosy
A Novel Circulating MicroRNA for the Detection of Acute Myocarditis
A Novel Circulating MicroRNA for the Detection of Acute Myocarditis
To the Editor: Blanco-Domínguez et al. (May 27, 2021, issue)1 describe a potential microRNA blood-based assay for the dete...
Gastroesophageal Reflux Disease
Gastroesophageal Reflux Disease
Key Clinical Points Gastroesophageal Reflux Disease Patients with heartburn and symptoms such as dysphagia, odynophagia, w...
IL-1RA Antibodies in Myocarditis after SARS-CoV-2 Vaccination
IL-1RA Antibodies in Myocarditis after SARS-CoV-2 Vaccination
IL-1RA and Myocarditis after SARS-CoV-2 Vaccination Neutralizing autoantibodies to interleukin-1 receptor antagonist were ...
Transforming Management of Opioid Use Disorder with Universal Treatment
Transforming Management of Opioid Use Disorder with Universal Treatment
Management of OUD with Universal Treatment Barriers at multiple levels impede the use of evidence-based medication for opi...
Glycemia Reduction in Type 2 Diabetes — Glycemic Outcomes
Glycemia Reduction in Type 2 Diabetes — Glycemic Outcomes
Abstract Background The comparative effectiveness of glucose-lowering medications for use with metformin to maintain targe...
Glycemia Reduction in Type 2 Diabetes — Microvascular and Cardiovascular Outcomes
Glycemia Reduction in Type 2 Diabetes — Microvascular and Cardiovascular Outcomes
Abstract Background Data are lacking on the comparative effectiveness of commonly used glucose-lowering medications, when ...
Treatment of Mantle-Cell Lymphoma
Treatment of Mantle-Cell Lymphoma
To the Editor: In the report by Wang et al. (June 30 issue)1 on the randomized, controlled SHINE trial of first-line ibrut...
Burkitt’s Lymphoma
Burkitt’s Lymphoma
Burkitt’s Lymphoma Burkitt’s lymphoma is a rapidly proliferating lymphoma of germinal-center B cells. Most patients are cu...
Audio Interview: Can Vaccines Prevent Transmission of Covid-19?
Audio Interview: Can Vaccines Prevent Transmission of Covid-19?
Can Vaccines Prevent Transmission of Covid-19? In this audio interview conducted on September 20, 2022, the editors discus...
After Metformin — Next Steps for Type 2 Diabetes with Low Cardiovascular Risk
After Metformin — Next Steps for Type 2 Diabetes with Low Cardiovascular Risk
In two articles in this issue of the Journal, the members of the GRADE Study Research Group1,2 report the findings of the ...
Trastuzumab Deruxtecan in HER2-Low Breast Cancer
Trastuzumab Deruxtecan in HER2-Low Breast Cancer
To the Editor: In the DESTINY-Breast04 trial, involving patients with metastatic breast cancer expressing low levels of hu...
Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS
Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS
Abstract Background The intrathecally administered antisense oligonucleotide tofersen reduces synthesis of the superoxide ...
Case 29-2022: A 33-Year-Old Man with Chronic Diarrhea and Autoimmune Enteropathy
Case 29-2022: A 33-Year-Old Man with Chronic Diarrhea and Autoimmune Enteropathy
A Man with Chronic Diarrhea and Autoimmune Enteropathy A 33-year-old man was evaluated for relapsing diarrhea, which had i...
Product Hopping in the Drug Industry — Lessons from Albuterol
Product Hopping in the Drug Industry — Lessons from Albuterol
Product Hopping in the Drug Industry Product hops to albuterol inhalers containing hydrofluoroalkane rather than chloroflu...
Autosomal Dominant Osteopetrosis
Autosomal Dominant Osteopetrosis
Images in Clinical Medicine from The New England Journal of Medicine — Autosomal Dominant Osteopetrosis
The War-Zone Mentality — Mental Health Effects of Gun Violence in U.S. Children and Adolescents
The War-Zone Mentality — Mental Health Effects of Gun Violence in U.S. Children and Adolescents
The War-Zone Mentality Gun violence in the United States causes traumatic responses in those who are directly exposed and ...
Cerebral Embolic Protection during Transcatheter Aortic-Valve Replacement
Cerebral Embolic Protection during Transcatheter Aortic-Valve Replacement
Original Article from The New England Journal of Medicine — Cerebral Embolic Protection during Transcatheter Aortic-...
Does Capturing Debris during TAVR Prevent Strokes?
Does Capturing Debris during TAVR Prevent Strokes?
Transcatheter aortic-valve replacement (TAVR) has become the predominant intervention for the treatment of aortic stenosis...
The Law of Licensure and Quality Regulation
The Law of Licensure and Quality Regulation
The Law of Licensure and Quality Regulation U.S. federal and state laws, licensing requirements, payers’ conditions of par...