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Selectivity, efficacy and safety of JAKinibs: new evidence for a still evolving story
Selectivity, efficacy and safety of JAKinibs: new evidence for a still evolving story
IntroductionOver the past decades, important insight were gained of the molecular components of the Janus kinase (JAK)-sig...
Long-term mortality in treated-to-target RA and UA: results of the BeSt and IMPROVED cohort
Long-term mortality in treated-to-target RA and UA: results of the BeSt and IMPROVED cohort
MethodsPatientsWe performed this analysis in two Dutch trial cohorts. In BeSt (BehandelStrategieen, that is, treatment str...
Definition of rheumatoid arthritis flare based on SDAI and CDAI
Definition of rheumatoid arthritis flare based on SDAI and CDAI
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Abatacept and non-melanoma skin cancer in patients with rheumatoid arthritis: a comprehensive evaluation of randomised controlled trials and observational studies
Abatacept and non-melanoma skin cancer in patients with rheumatoid arthritis: a comprehensive evaluation of randomised controlled trials and observational studies
WHAT IS ALREADY KNOWN ON THIS TOPICPatients with rheumatoid arthritis (RA) may be at increased risk of non-melanoma skin c...
Rheuma-VOR study: optimising healthcare of rheumatic diseases by multiprofessional coordinating centres
Rheuma-VOR study: optimising healthcare of rheumatic diseases by multiprofessional coordinating centres
IntroductionThe time to diagnosis and thus the start of therapy has an impact on the progression of chronic inflammatory r...
Rheumatology and Long COVID: lessons from the study of fibromyalgia
Rheumatology and Long COVID: lessons from the study of fibromyalgia
Long COVID at a glanceAs the pandemic has evolved, a growing number of patients infected with SARS-CoV-2 have reported lon...
Annals of the Rheumatic Diseases collection on osteoarthritis (2018-2023): hopes and disappointments
Annals of the Rheumatic Diseases collection on osteoarthritis (2018-2023): hopes and disappointments
Over the past 5 years, we have witnessed significant advances in the field of osteoarthritis (OA) in terms of epidemiology...
Bimekizumab treatment in patients with active axial spondyloarthritis: 52-week efficacy and safety from the randomised parallel phase 3 BE MOBILE 1 and BE MOBILE 2 studies
Bimekizumab treatment in patients with active axial spondyloarthritis: 52-week efficacy and safety from the randomised parallel phase 3 BE MOBILE 1 and BE MOBILE 2 studies
Video Abstract Disclaimer: this video summarises a scientific article published by BMJ Publishing Group Limited (BMJ). The...
Efficacy and safety of avacopan in patients with ANCA-associated vasculitis receiving rituximab in a randomised trial
Efficacy and safety of avacopan in patients with ANCA-associated vasculitis receiving rituximab in a randomised trial
MethodsStudy designThis analysis of patients treated with RTX was a prespecified subgroup of the ADVOCATE study, a multice...
Specific descriptions of axial involvement are associated with radiographic damage development after 2 years in psoriatic arthritis patients
Specific descriptions of axial involvement are associated with radiographic damage development after 2 years in psoriatic arthritis patients
WHAT IS ALREADY KNOWN ON THIS TOPICWHAT THIS STUDY ADDSSpinal radiographic progression is associated with baseline axial i...
Extracting immunological and clinical heterogeneity across autoimmune rheumatic diseases by cohort-wide immunophenotyping
Extracting immunological and clinical heterogeneity across autoimmune rheumatic diseases by cohort-wide immunophenotyping
IntroductionAutoimmune rheumatic diseases (AIRDs) are systemic diseases characterised by orchestration of disrupted self-t...
Rituximab as maintenance therapy for ANCA-associated vasculitides: pooled analysis and long-term outcome of 277 patients included in the MAINRITSAN trials
Rituximab as maintenance therapy for ANCA-associated vasculitides: pooled analysis and long-term outcome of 277 patients included in the MAINRITSAN trials
MethodsDesignThe present study is a nationwide, prospective cohort study conducted in 39 centres in France between October...
Frosted branch angiitis in systemic lupus erythematosus
Frosted branch angiitis in systemic lupus erythematosus
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IL-17A inhibitor-induced leucocytoclastic vasculitis is responsive to IL-23 blockade in a psoriatic arthritis patient
IL-17A inhibitor-induced leucocytoclastic vasculitis is responsive to IL-23 blockade in a psoriatic arthritis patient
IntroductionSecukinumab is a fully humanised monoclonal antibody directed at interleukin 17A (IL-17A) which has been widel...
HLA-DRB1 and HLA-DQA1 associated with immunogenicity to adalimumab therapy in patients with rheumatoid arthritis
HLA-DRB1 and HLA-DQA1 associated with immunogenicity to adalimumab therapy in patients with rheumatoid arthritis
Advanced targeted therapies including tumour necrosis factor inhibitors (TNFis) have transformed the clinical management o...
IgM antibodies against acetylated proteins as a possible starting point of the anti-modified protein antibody response in rheumatoid arthritis
IgM antibodies against acetylated proteins as a possible starting point of the anti-modified protein antibody response in rheumatoid arthritis
Rheumatoid arthritis (RA) is characterised by the presence of anti-modified protein antibodies (AMPA): anti-citrullinated ...
Card9/neutrophil signalling axis promotes IL-17A-mediated ankylosing spondylitis
Card9/neutrophil signalling axis promotes IL-17A-mediated ankylosing spondylitis
WHAT IS ALREADY KNOWN ON THIS TOPICCARD9 is a fundamental signalling-molecule in Th17-responses and antifungal immunity; t...
Directed differentiation of human pluripotent stem cells into articular cartilage reveals effects caused by absence of WISP3, the gene responsible for progressive pseudorheumatoid arthropathy of childhood
Directed differentiation of human pluripotent stem cells into articular cartilage reveals effects caused by absence of WISP3, the gene responsible for progressive pseudorheumatoid arthropathy of childhood
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Is colchicine prophylaxis required with start-low go-slow allopurinol dose escalation in gout? A non-inferiority randomised double-blind placebo-controlled trial
Is colchicine prophylaxis required with start-low go-slow allopurinol dose escalation in gout? A non-inferiority randomised double-blind placebo-controlled trial
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Disease activity drives transcriptomic heterogeneity in early untreated rheumatoid synovitis
Disease activity drives transcriptomic heterogeneity in early untreated rheumatoid synovitis
IntroductionSynovitis is the clinical hallmark of rheumatoid arthritis (RA), and the analysis of synovial tissue from affe...
Evaluating the causal effect of circulating proteome on the risk of osteoarthritis-related traits
Evaluating the causal effect of circulating proteome on the risk of osteoarthritis-related traits
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Anti-GM-CSF otilimab versus sarilumab or placebo in patients with rheumatoid arthritis and inadequate response to targeted therapies: a phase III randomised trial (contRAst 3)
Anti-GM-CSF otilimab versus sarilumab or placebo in patients with rheumatoid arthritis and inadequate response to targeted therapies: a phase III randomised trial (contRAst 3)
IntroductionDespite the range of disease-modifying anti-rheumatic drugs (DMARDs) that have transformed the therapeutic lan...
Spanish cohort of VEXAS syndrome: clinical manifestations, outcome of treatments and novel evidences about UBA1 mosaicism
Spanish cohort of VEXAS syndrome: clinical manifestations, outcome of treatments and novel evidences about UBA1 mosaicism
IntroductionAutoinflammatory diseases (AIDs) are genetically determined conditions characterised by recurrent sterile infl...
Correspondence on 'The 2019 American College of Rheumatology/European League Against Rheumatism classification criteria for IgG4-related disease by Wallace et al
Correspondence on 'The 2019 American College of Rheumatology/European League Against Rheumatism classification criteria for IgG4-related disease by Wallace et al
IgG4-related disease (IgG4-RD) was initially discovered as a clearly different entity in patients with sclerosing cholangi...
Correspondence on 'NCF1-339 polymorphism is associated with altered formation of neutrophil extracellular traps, high serum interferon activity and antiphospholipid syndrome in systemic lupus erythematosus by Linge et al
Correspondence on 'NCF1-339 polymorphism is associated with altered formation of neutrophil extracellular traps, high serum interferon activity and antiphospholipid syndrome in systemic lupus erythematosus by Linge et al
We read with great interest the article by Linge et al 1 on ‘NCF1- 339 polymorphism is associated with altered formation o...
Lessons from negative phase 3 trials in rheumatoid arthritis anno 2023
Lessons from negative phase 3 trials in rheumatoid arthritis anno 2023
A recent phase 3 trial (contRAst 3) with otilimab, a drug targeting granulocyte-macrophage colony-stimulating factor (GM-C...
Potential for biosimilars in rheumatology in Africa
Potential for biosimilars in rheumatology in Africa
Biosimilars are products which are highly similar to a reference biologic product (RBP). In Africa, regulatory frameworks ...
Anti-GM-CSF otilimab versus tofacitinib or placebo in patients with active rheumatoid arthritis and an inadequate response to conventional or biologic DMARDs: two phase 3 randomised trials (contRAst 1 and contRAst 2)
Anti-GM-CSF otilimab versus tofacitinib or placebo in patients with active rheumatoid arthritis and an inadequate response to conventional or biologic DMARDs: two phase 3 randomised trials (contRAst 1 and contRAst 2)
WHAT IS ALREADY KNOWN ON THIS TOPICNot all patients with rheumatoid arthritis (RA) achieve effective disease control with ...
Contributions of joint damage-related events to gout pathogenesis: new insights from laboratory research
Contributions of joint damage-related events to gout pathogenesis: new insights from laboratory research
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Finger ischaemia, enlarged spleen and lung nodules
Finger ischaemia, enlarged spleen and lung nodules
A 48-year-old man presented with a 10 kg weight loss and fever. On examination, there was digital ischaemia (figure 1), oe...
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