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Paul Hunter Plotz (1937-2024): renaissance rheumatologist, human rights advocate and mensch
Paul Hunter Plotz (1937-2024): renaissance rheumatologist, human rights advocate and mensch
Paul Hunter Plotz, MD, a Scientist Emeritus in the National Institute of Arthritis and Musculoskeletal and Skin Diseases (...
Helicobacter pylori upregulates PAD4 expression via stabilising HIF-1{alpha} to exacerbate rheumatoid arthritis
Helicobacter pylori upregulates PAD4 expression via stabilising HIF-1{alpha} to exacerbate rheumatoid arthritis
WHAT IS ALREADY KNOWN ON THIS TOPICWHAT THIS STUDY ADDS H. pylori infection promotes synovial cell proliferation and infla...
Association of rheumatoid factor, anti-citrullinated protein antibodies and shared epitope with clinical response to initial treatment in patients with early rheumatoid arthritis: data from a randomised controlled trial
Association of rheumatoid factor, anti-citrullinated protein antibodies and shared epitope with clinical response to initial treatment in patients with early rheumatoid arthritis: data from a randomised controlled trial
WHAT IS ALREADY KNOWN ON THIS TOPICRheumatoid factor (RF) and anti-citrullinated protein antibody (ACPA) serology are impo...
Guselkumab in Behcets disease
Guselkumab in Behcets disease
The mucocutaneous and articular clinical phenotype is the most common presentation of Behçet’s disease (BD).1 Current trea...
Mystery of hidden pearls: bursitis in the shoulder
Mystery of hidden pearls: bursitis in the shoulder
A woman aged 52 years, known to have rheumatoid arthritis for 12 years, presented with worsening of joint pain for 2 weeks...
Journey through discovery of 75 years glucocorticoids: evolution of our knowledge of glucocorticoid receptor mechanisms in rheumatic diseases
Journey through discovery of 75 years glucocorticoids: evolution of our knowledge of glucocorticoid receptor mechanisms in rheumatic diseases
StarterRaoul Dufy received corticosteroid therapy in 1950 as one of the first patients to be treated with cortisone to rel...
Ruxolitinib as a salvage therapy in adult-onset macrophage activation syndrome: insights from eight cases
Ruxolitinib as a salvage therapy in adult-onset macrophage activation syndrome: insights from eight cases
Macrophage activation syndrome (MAS) is a life-threatening complication of rheumatic disorder characteristic by excessive ...
Systemic juvenile idiopathic arthritis and adult-onset Stills disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Stills disease
Systemic juvenile idiopathic arthritis and adult-onset Stills disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Stills disease
IntroductionStill’s disease was described in children in 1897 by Sir George Frederick Still and is today called systemic j...
Efficacy and safety of therapies for Stills disease and macrophage activation syndrome (MAS): a systematic review informing the EULAR/PReS guidelines for the management of Stills disease
Efficacy and safety of therapies for Stills disease and macrophage activation syndrome (MAS): a systematic review informing the EULAR/PReS guidelines for the management of Stills disease
IntroductionAdult-onset Still’s disease (AOSD) and systemic juvenile idiopathic arthritis (sJIA) are the adult and child c...
Plasma proteome profiling in giant cell arteritis
Plasma proteome profiling in giant cell arteritis
IntroductionEarly in its disease course, giant cell arteritis (GCA) can cause irreversible vision loss and cerebrovascular...
Remission and low disease activity are associated with lower healthcare costs: results from the Systemic Lupus International Collaborating Clinics (SLICC) inception cohort
Remission and low disease activity are associated with lower healthcare costs: results from the Systemic Lupus International Collaborating Clinics (SLICC) inception cohort
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Identifying the association between serum urate levels and gout flares in patients taking urate-lowering therapy: a post hoc cohort analysis of the CARES trial with consideration of dropout
Identifying the association between serum urate levels and gout flares in patients taking urate-lowering therapy: a post hoc cohort analysis of the CARES trial with consideration of dropout
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Exploring the effect on primary endpoints in trials testing targeted therapy interventions for rheumatoid arthritis: a meta-epidemiological study on the appropriate use of a core outcome set
Exploring the effect on primary endpoints in trials testing targeted therapy interventions for rheumatoid arthritis: a meta-epidemiological study on the appropriate use of a core outcome set
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Efficacy and safety of targeted therapies in VEXAS syndrome: retrospective study from the FRENVEX
Efficacy and safety of targeted therapies in VEXAS syndrome: retrospective study from the FRENVEX
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Efficacy and safety of first-line biological DMARDs in rheumatoid arthritis patients with chronic kidney disease
Efficacy and safety of first-line biological DMARDs in rheumatoid arthritis patients with chronic kidney disease
IntroductionChronic kidney disease (CKD) is notably more prevalent in patients with rheumatoid arthritis (RA) than in the ...
CD8+ tissue-resident memory T cells are expanded in primary Sjögrens disease and can be therapeutically targeted by CD103 blockade
CD8+ tissue-resident memory T cells are expanded in primary Sjögrens disease and can be therapeutically targeted by CD103 blockade
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Correspondence on 'EULAR recommendations for the management of ANCA-associated vasculitis: 2022 update by Hellmich et al
Correspondence on 'EULAR recommendations for the management of ANCA-associated vasculitis: 2022 update by Hellmich et al
Shared decision-making (SDM) is a collaborative approach to disease management whereby patients and clinicians discuss the...
Response to: Correspondence on 'EULAR recommendations for the management of ANCA-associated vasculitis: 2022 update by Hellmich et al
Response to: Correspondence on 'EULAR recommendations for the management of ANCA-associated vasculitis: 2022 update by Hellmich et al
We wish to thank Robson et al for emphasising the role of shared decision-making between healthcare providers and patients...
Inflammatory tissue priming: novel insights and therapeutic opportunities for inflammatory rheumatic diseases
Inflammatory tissue priming: novel insights and therapeutic opportunities for inflammatory rheumatic diseases
Due to optimised treatment strategies and the availability of new therapies during the last decades, formerly devastating ...
Predictors for severe persisting pain in rheumatoid arthritis are associated with pain origin and appraisal of pain
Predictors for severe persisting pain in rheumatoid arthritis are associated with pain origin and appraisal of pain
WHAT IS ALREADY KNOWN ON THIS TOPICPain is a cardinal symptom of inflammatory arthritis and represents a critical paramete...
Vascular disease persistence in giant cell arteritis: are stromal cells neglected?
Vascular disease persistence in giant cell arteritis: are stromal cells neglected?
IntroductionGiant cell arteritis (GCA), an age-related inflammatory disease of large and medium-sized arteries, predilects...
Integrated safety analysis of filgotinib in patients with moderate-to-severe rheumatoid arthritis over a treatment duration of up to 8.3 years
Integrated safety analysis of filgotinib in patients with moderate-to-severe rheumatoid arthritis over a treatment duration of up to 8.3 years
IntroductionRheumatoid arthritis (RA) is a persistent inflammatory condition with no cure; patients rely on long-term trea...
NAT10 promotes synovial aggression by increasing the stability and translation of N4-acetylated PTX3 mRNA in rheumatoid arthritis
NAT10 promotes synovial aggression by increasing the stability and translation of N4-acetylated PTX3 mRNA in rheumatoid arthritis
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Disentangling the riddle of systemic lupus erythematosus with antiphospholipid syndrome: blood transcriptome analysis reveals a less-pronounced IFN-signature and distinct molecular profiles in venous versus arterial events
Disentangling the riddle of systemic lupus erythematosus with antiphospholipid syndrome: blood transcriptome analysis reveals a less-pronounced IFN-signature and distinct molecular profiles in venous versus arterial events
IntroductionApproximately 30% of patients with systemic lupus erythematosus (SLE) harbour antiphospholipid antibodies (aPL...
Combined inhibition of IL-1, IL-33 and IL-36 signalling by targeting IL1RAP ameliorates skin and lung fibrosis in preclinical models of systemic sclerosis
Combined inhibition of IL-1, IL-33 and IL-36 signalling by targeting IL1RAP ameliorates skin and lung fibrosis in preclinical models of systemic sclerosis
IntroductionFibrosis describes the accumulation of extracellular matrix in tissues and organs. Although short-term fibroge...
Correspondence on 'Long COVID: a new word for naming fibromyalgia? by Mariette
Correspondence on 'Long COVID: a new word for naming fibromyalgia? by Mariette
I read the Viewpoint on long-COVID by Mariette with interest and consent.1 Mariette, skilled experimental and clinical imm...
Acute rheumatic fever in the province of Manitoba, Canada, before and after the coronavirus (COVID-19) pandemic
Acute rheumatic fever in the province of Manitoba, Canada, before and after the coronavirus (COVID-19) pandemic
The COVID-19 pandemic came with strict public health guidelines for social distancing and infection control measures. Scho...
Disease activity drives divergent epigenetic and transcriptomic reprogramming of monocyte subpopulations in systemic lupus erythematosus
Disease activity drives divergent epigenetic and transcriptomic reprogramming of monocyte subpopulations in systemic lupus erythematosus
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Nasal tophi
Nasal tophi
A 39-year-old man presented at our hospital due to recurrent swelling, redness and pain in his nasal area over the past 2 ...
Sacroiliac radiographic progression over 10 years in axSpA: data from the DESIR inception cohort
Sacroiliac radiographic progression over 10 years in axSpA: data from the DESIR inception cohort
WHAT IS ALREADY KNOWN ON THIS TOPICInformation about the likelihood of radiographic sacroiliitis over time in patients wit...
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