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Repression of the major immediate early promoter of human cytomegalovirus allows transcription from an alternate promoter
Repression of the major immediate early promoter of human cytomegalovirus allows transcription from an alternate promoter
Following infection, the human cytomegalovirus (HCMV) genome becomes rapidly associated with host histones which can contr...
ICTV Virus Taxonomy Profile: Phenuiviridae 2023
ICTV Virus Taxonomy Profile: Phenuiviridae 2023
The family Phenuiviridae comprises viruses with 2–8 segments of negative-sense or ambisense RNA, comprising 8.1–25.1 kb in...
ICTV Virus Taxonomy Profile: Arenaviridae 2023
ICTV Virus Taxonomy Profile: Arenaviridae 2023
Arenaviridae is a family for ambisense RNA viruses with genomes of about 10.5 kb that infect mammals, snakes, and fish. Th...
RNase L-activating 2′–5′ oligoadenylates bind ABCF1, ABCF3 and Decr-1
RNase L-activating 2′–5′ oligoadenylates bind ABCF1, ABCF3 and Decr-1
A notable signalling mechanism employed by mammalian innate immune signalling pathways uses nucleotide-based second messen...
Mutational analysis reveals a novel role for hepatitis C virus NS5A domain I in cyclophilin-dependent genome replication
Mutational analysis reveals a novel role for hepatitis C virus NS5A domain I in cyclophilin-dependent genome replication
The hepatitis C virus (HCV) NS5A protein is comprised of three domains (D1–3). Previously, we observed that two alanine su...
The CD46 ectodomain participates in human cytomegalovirus infection of epithelial cells
The CD46 ectodomain participates in human cytomegalovirus infection of epithelial cells
Human cytomegalovirus (HCMV) primary infections are typically asymptomatic in healthy individuals yet can cause increased ...
A Coxsackievirus B1-mediated nonlytic Extracellular Vesicle-to-cell mechanism of virus transmission and its possible control through modulation of EV release
A Coxsackievirus B1-mediated nonlytic Extracellular Vesicle-to-cell mechanism of virus transmission and its possible control through modulation of EV release
Like most non-enveloped viruses, CVB1 mainly uses cell lysis to spread. Details of a nonlytic virus transmission remain un...
A novel chimeric vaccine candidate for porcine reproductive and respiratory syndrome virus (PRRSV) I and II elicits neutralizing antibodies against both types
A novel chimeric vaccine candidate for porcine reproductive and respiratory syndrome virus (PRRSV) I and II elicits neutralizing antibodies against both types
Porcine reproductive and respiratory syndrome virus (PRRSV) is an economically important virus within the swine industry. ...
Continued adaptation of A/H2N2 viruses during pandemic circulation in humans
Continued adaptation of A/H2N2 viruses during pandemic circulation in humans
Influenza A viruses of the H2N2 subtype sparked a pandemic in 1957 and circulated in humans until 1968. Because A/H2N2 vir...
VP24 matrix proteins of eight filoviruses downregulate innate immune response by inhibiting the interferon-induced pathway
VP24 matrix proteins of eight filoviruses downregulate innate immune response by inhibiting the interferon-induced pathway
Filoviruses encode viral protein 24 (VP24) which effectively inhibit the innate immune responses in infected cells. Here w...
Bourbon virus, a newly discovered zoonotic thogotovirus
Bourbon virus, a newly discovered zoonotic thogotovirus
The recent discovery of Bourbon virus (BRBV) put a new focus on the genus of thogotoviruses as zoonotic, tick-transmitted ...
Isolation and genome sequencing of cytomegaloviruses from Natal multimammate mice (Mastomys natalensis)
Isolation and genome sequencing of cytomegaloviruses from Natal multimammate mice (Mastomys natalensis)
Distinct cytomegaloviruses (CMVs) are widely distributed across their mammalian hosts in a highly host species-restricted ...
Annual (2023) taxonomic update of RNA-directed RNA polymerase-encoding negative-sense RNA viruses (realm Riboviria: kingdom Orthornavirae: phylum Negarnaviricota)
Annual (2023) taxonomic update of RNA-directed RNA polymerase-encoding negative-sense RNA viruses (realm Riboviria: kingdom Orthornavirae: phylum Negarnaviricota)
In April 2023, following the annual International Committee on Taxonomy of Viruses (ICTV) ratification vote on newly propo...
Genetic diversity, recombination and cross-species transmission of a waterbird gammacoronavirus in the wild
Genetic diversity, recombination and cross-species transmission of a waterbird gammacoronavirus in the wild
Viruses emerging from wildlife can cause outbreaks in humans and domesticated animals. Predicting the emergence of future ...
Hepatobiliary organoids derived from leporids support the replication of hepatotropic lagoviruses
Hepatobiliary organoids derived from leporids support the replication of hepatotropic lagoviruses
The genus Lagovirus of the family Caliciviridae contains some of the most virulent vertebrate viruses known. Lagoviruses i...
Hypoxia dampens innate immune signalling at early time points and increases Zika virus RNA levels in iPSC-derived macrophages
Hypoxia dampens innate immune signalling at early time points and increases Zika virus RNA levels in iPSC-derived macrophages
Type I interferons (IFNs) are the major host defence against viral infection and are induced following activation of cell ...
Epidermal growth factor receptor promotes infectious spleen and kidney necrosis virus invasion via PI3K-Akt signaling pathway
Epidermal growth factor receptor promotes infectious spleen and kidney necrosis virus invasion via PI3K-Akt signaling pathway
Infectious spleen and kidney necrosis virus disease (ISKNVD) caused significant economic losses to the fishery industry. E...
New viruses of Cladosporium sp. expand considerably the taxonomic structure of Gammapartitivirus genus
New viruses of Cladosporium sp. expand considerably the taxonomic structure of Gammapartitivirus genus
Despite the fact that Cladosporium sp. are ubiquitous fungi, their viromes have been little studied. By analysing a collec...
Open reading frames M12/M13 jointly contribute to MHV-68 latency
Open reading frames M12/M13 jointly contribute to MHV-68 latency
Murine gammaherpesvirus 68 (MHV-68), a widely used small-animal model for the analysis of gammaherpesvirus pathogenesis, e...
Abolishment of spawner-isolated mortality virus and where the remaining science leads
Abolishment of spawner-isolated mortality virus and where the remaining science leads
In the late 1980s, there was histological and electron microscopy evidence for a parvovirus-like virus in Australian prawn...
Inhibition of salt inducible kinases reduces rhythmic HIV-1 replication and reactivation from latency
Inhibition of salt inducible kinases reduces rhythmic HIV-1 replication and reactivation from latency
Human immunodeficiency virus type 1 (HIV-1) causes a major burden on global health, and eradication of latent virus infect...
Pathogenicity, genomic analysis and structure of abalone asfa-like virus: evidence for classification in the family Asfarviridae
Pathogenicity, genomic analysis and structure of abalone asfa-like virus: evidence for classification in the family Asfarviridae
This paper presents the rationale for classifying abalone asfa-like virus (AbALV) in the family Asfarviridae based on anal...
Corrigendum: Inhibition of phosphodiesterase 12 results in antiviral activity against several RNA viruses including SARS-CoV-2
Corrigendum: Inhibition of phosphodiesterase 12 results in antiviral activity against several RNA viruses including SARS-CoV-2
Microbiology Society journals contain high-quality research papers and topical review articles. We are a not-for-profit pu...
Phylogenetic and antigenic analysis of infectious bronchitis virus isolated from commercial and backyard chickens in Pakistan, 2015–2018
Phylogenetic and antigenic analysis of infectious bronchitis virus isolated from commercial and backyard chickens in Pakistan, 2015–2018
Infectious bronchitis virus (IBV) is a rapidly evolving virus affecting both vaccinated and unvaccinated poultry flocks an...
Inhibition of phosphodiesterase 12 results in antiviral activity against several RNA viruses including SARS-CoV-2
Inhibition of phosphodiesterase 12 results in antiviral activity against several RNA viruses including SARS-CoV-2
The 2',5'- oligoadenylate synthetase (OAS) – ribonuclease L (RNAseL) - phosphodiesterase 12 (PDE12) path...
ICTV Virus Taxonomy Profile: Lispiviridae 2023
ICTV Virus Taxonomy Profile: Lispiviridae 2023
Members of the family Lispiviridae are viruses with negative-sense RNA genomes of 6.5–15.5 kb that have mainly been found ...
A highly discriminatory RNA strand-specific assay to facilitate analysis of the role of cis-acting elements in foot-and-mouth disease virus replication
A highly discriminatory RNA strand-specific assay to facilitate analysis of the role of cis-acting elements in foot-and-mouth disease virus replication
Foot-and-mouth-disease virus (FMDV), the aetiological agent responsible for foot-and-mouth disease (FMD), is a member of t...
Dengue virus M and E proteins belonging to genotype II (Cosmopolitan) of serotype 2 are influenced by the nature of M residue 36
Dengue virus M and E proteins belonging to genotype II (Cosmopolitan) of serotype 2 are influenced by the nature of M residue 36
Mosquito-borne dengue disease is caused by the dengue virus serotype-1 to serotype-4. The contemporary dengue outbreaks in...
Production of antigenically stable enterovirus A71 virus-like particles in Pichia pastoris as a vaccine candidate
Production of antigenically stable enterovirus A71 virus-like particles in Pichia pastoris as a vaccine candidate
Enterovirus A71 (EVA71) causes widespread disease in young children with occasional fatal consequences. In common with oth...
ARF6 is a host factor for SARS-CoV-2 infection in vitro
ARF6 is a host factor for SARS-CoV-2 infection in vitro
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly emerged beta-coronavirus that enter cells via two ...
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