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Active Ingredients and Potential Mechanism of Additive Sishen Decoction in Treating Rheumatoid Arthritis with Network Pharmacology and Molecular Dynamics Simulation and Experimental Verification
Active Ingredients and Potential Mechanism of Additive Sishen Decoction in Treating Rheumatoid Arthritis with Network Pharmacology and Molecular Dynamics Simulation and Experimental Verification
Investigating the Active ingredients and potential mechanism of additive Sishen decoction (ASSD) in treating rheumatoid ar...
Effect of Esketamine on Cognitive Recovery After Propofol Sedation for Outpatient Colonoscopy: A Randomized Clinical Trial
Effect of Esketamine on Cognitive Recovery After Propofol Sedation for Outpatient Colonoscopy: A Randomized Clinical Trial
Investigating effects of esketamine on multiple dimensions of recovery, particularly cognition, in patients undergoing col...
Integrated Microbiome and Metabolome Analysis Reveals Correlations Between Gut Microbiota Components and Metabolic Profiles in Mice With Mitoxantrone-Induced Cardiotoxicity
Integrated Microbiome and Metabolome Analysis Reveals Correlations Between Gut Microbiota Components and Metabolic Profiles in Mice With Mitoxantrone-Induced Cardiotoxicity
Accordingly, we elucidate the understanding of MTX-provoked cardiotoxicity and establish a foundation for innovative appro...
Exosomes in Oral Diseases: Mechanisms and Therapeutic Applications
Exosomes in Oral Diseases: Mechanisms and Therapeutic Applications
Exosomes in Oral Diseases: Mechanisms and Therapeutic Applications
Effects of Lupeol on Intestinal Anastomosis After Experimental Intestinal Ischemia-Reperfusion Injury in Rats
Effects of Lupeol on Intestinal Anastomosis After Experimental Intestinal Ischemia-Reperfusion Injury in Rats
The effects of lupeol on intestinal ischemia-reperfusion injury, not only biochemically and histopathologically, but also ...
Clinical Efficacy Between Intravenous Paracetamol and Intravenous Fentanyl for Propofol Deep Sedation in Colonoscopy: A Randomized Controlled Trial
Clinical Efficacy Between Intravenous Paracetamol and Intravenous Fentanyl for Propofol Deep Sedation in Colonoscopy: A Randomized Controlled Trial
Investigating the clinical efficacy of intravenous paracetamol compared to intravenous fentanyl under propofol deep sedati...
Design, synthesis and insecticidal activities of novel m-diamide compounds containing n-propyl group
Design, synthesis and insecticidal activities of novel m-diamide compounds containing n-propyl group
To develop a structurally novel and efficient insecticide, a series of meta-diamide compounds incorporating n-propyl group...
Design, synthesis and antifungal study of novel 2-aryl-3,4-dihydroisoquinolin-2-ium salts containing benzoate moieties
Design, synthesis and antifungal study of novel 2-aryl-3,4-dihydroisoquinolin-2-ium salts containing benzoate moieties
To discover natural-derived fungicides, three series of 2-aryl-3,4-dihydroisoquinolinium salts (6–8) containing benz...
Structural, Electrical, and Optical Responses in Hybrid Perovskite Semiconductors: The Influence of Symmetry in Central Molecule Interactions
Structural, Electrical, and Optical Responses in Hybrid Perovskite Semiconductors: The Influence of Symmetry in Central Molecule Interactions
Hybrid organic–inorganic lead halide perovskites (HOIPs) have recently attracted ever-increasing attention due to th...
Computation-Based Development of Carrier Materials and Catalysts for Liquid Organic Hydrogen Carrier Systems
Computation-Based Development of Carrier Materials and Catalysts for Liquid Organic Hydrogen Carrier Systems
Liquid Organic Hydrogen Carriers (LOHCs) have emerged as a promising solution for hydrogen storage, offering high hydrogen...
Pyrimidine-based dual-target inhibitors targeting epidermal growth factor receptor for overcoming drug resistance in cancer therapy(2006-present)
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A novel pyridine-2-one AMPK inhibitor: Discovery, mechanism, and in vivo evaluation in a hypoxic pulmonary arterial hypertension rat model
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Discovery of noncovalent diaminopyrimidine-based Inhibitors for glioblastoma via a dual FAK/DNA targeting strategy
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New cerebrosides and ceramide with other constituents from the aerial parts of Raphidiocystis mannii Hook. f. and their cytotoxic activities
New cerebrosides and ceramide with other constituents from the aerial parts of Raphidiocystis mannii Hook. f. and their cytotoxic activities
Two new cerebrosides, raphimanosides A (1) and B (2), and a new ceramide, raphimanide (3), were isolated from the aerial p...
Esketamine at a Clinical Dose Attenuates Cerebral Ischemia/Reperfusion Injury by Inhibiting AKT Signaling Pathway to Facilitate Microglia M2 Polarization and Autophagy
Esketamine at a Clinical Dose Attenuates Cerebral Ischemia/Reperfusion Injury by Inhibiting AKT Signaling Pathway to Facilitate Microglia M2 Polarization and Autophagy
This study provides new insights into the neuroprotective mechanisms of esketamine and the potential therapeutic strategie...
Comprehensive Analysis of Metabolic Changes in Mice Exposed to Corilagin Based on GC-MS Analysis
Comprehensive Analysis of Metabolic Changes in Mice Exposed to Corilagin Based on GC-MS Analysis
Exploring the pharmacological mechanism of Corilagin. Read more
Kidney volume and function of low-birth-weight children at 5 years: impact of singleton and twin birth
Kidney volume and function of low-birth-weight children at 5 years: impact of singleton and twin birth
Many studies have demonstrated the association between low birth weight (LBW) and chronic kidney disease, estimated glomer...
The need for smart microalgal bioprospecting
The need for smart microalgal bioprospecting
Microalgae’s adaptability and resilience to Earth’s diverse environments have evolved these photosynthetic mic...
A review of click chemistry in the synthesis of organophosphorus triazoles and their biological activities
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Insights into NEK2 inhibitors as antitumor agents: From mechanisms to potential therapeutics
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Discovery of novel JQ1 derivatives as dual ferroptosis and apoptosis inducers for the treatment of triple-negative breast cancer
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Novel technetium-99m-labelled ribociclib isocyanide derivatives for imaging cyclin-dependent kinase 4/6 (CDK4/6) expression in cancer
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Design, synthesis, and biological evaluation of imidazolidinone derivatives as potent PPARα/δ agonists for the treatment of cholestatic liver diseases
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Design, synthesis, and anti-liver fibrosis activity of novel non-steroidal vitamin D receptor agonists based on open-ring steroid scaffold
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Synthesis and antibacterial activity of environmentally friendly sulfonium compounds
Synthesis and antibacterial activity of environmentally friendly sulfonium compounds
The abuse and overuse of antibacterial drugs have caused the increasing drug resistance of pathogenic bacteria, which thre...
Pancreatic lipase inhibitors as anti-obesity agents: a review of recent chemical scaffolds and their pancreatic lipase inhibitory potential
Pancreatic lipase inhibitors as anti-obesity agents: a review of recent chemical scaffolds and their pancreatic lipase inhibitory potential
Obesity is an excessive accumulation of fat in the body. The disease of obesity is increasing all over the world. At prese...
Design and synthesis of isatin derivative payloaded peptide-drug conjugate as tubulin inhibitor against colorectal cancer
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Discovery of CZY43 as a new small-molecule degrader of pseudokinase HER3
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Synthesis and biological assessment of BUB1B inhibitors for the treatment of clear cell renal cell carcinoma
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Design, synthesis, and antitumor evaluation of triazolopyridine derivatives as novel inhibitors for BRD4
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