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Development of potent indole-3-carboxamide autotaxin inhibitors with preferred lipophilicity for in vivo treatment of pulmonary fibrosis
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Discovery of novel sitolactone derivative leading to PANoptosis and differentiation of acute myeloid leukemia cells
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RET Inhibitor SPP86 Is a Potential Candidate for the Clinical Treatment of Cutaneous Melanoma [Letter]
RET Inhibitor SPP86 Is a Potential Candidate for the Clinical Treatment of Cutaneous Melanoma [Letter]
Letter for the article RET Inhibitor SPP86 Triggers Apoptosis and Activates the DNA Damage Response Through the Suppressio...
SIRT5: a potential target for discovering bioactive natural products
SIRT5: a potential target for discovering bioactive natural products
Silent information regulator 5 (SIRT5) is the fifth member of the sirtuin family, which is mainly expressed in mi...
Corrigendum to “Structure and biological properties of mixed-ligand Cu(II) Schiff base complexes as potential anticancer agents”[Eur. J. Med. Chem. 134 (2017) 207–217]>
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Corrigendum to “A chemical modification of a peroxisome proliferator-activated receptor pan agonist produced a shift to a new dual alpha/gamma partial agonist endowed with mitochondrial pyruvate carrier inhibition and antidiabetic properties” [Eur. J. Med. Chem. 275 (2024) 116567]
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Identification of constrained peptidomimetics carrying a Michael acceptor warhead as antitrypanosomal agents
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The assembled decoders to prepare for “bioactive X″ against progressive deterioration of liver disease: From NAFLD to HCC
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Natural pyrrolo[1,2-a]quinazolinone derivatives: Design, synthesis, characterization, and bio-evaluation as novel antiviral agents
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Discovery of a novel Wnt inhibitor DK419: Reversing temozolomide resistance in glioblastoma by switching off Wnt/β-catenin signaling pathway to inhibit MGMT expression
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Discovery of a first-in-class PROTAC degrader of histone lysine demethylase KDM4
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Substitutions at the C-8 position of quinazolin-4-ones improve the potency of nicotinamide site binding tankyrase inhibitors
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Health Technology Assessment: Evaluation of 8 CGRP-Targeted Therapy Drugs for the Treatment of Migraine
Health Technology Assessment: Evaluation of 8 CGRP-Targeted Therapy Drugs for the Treatment of Migraine
To scientifically evaluate the clinical value of the comprehensive attributes of Calcitonin gene-related peptide (CGRP) in...
Meroterpenes and prenylated acylphloroglucinol from the aerial parts of Hypericum erectum
Meroterpenes and prenylated acylphloroglucinol from the aerial parts of Hypericum erectum
Two previously undescribed specialized metabolites, erecricins F (1) and G (2), along with two known metabolites, erectumi...
Fungal protein D1 inhibits the proliferation of A549 cells via activating the p53/miR-34a signaling pathway
Fungal protein D1 inhibits the proliferation of A549 cells via activating the p53/miR-34a signaling pathway
Boletus bicolor is a kind of wild edible boletus, which is widely distributed in China. We have isolated the protein D1 fr...
Exploring macroinvertebrate community assembly rules: unraveling the effects of flow intermittency and poor ecological potential on environmental filtering and limiting similarity through functional traits
Exploring macroinvertebrate community assembly rules: unraveling the effects of flow intermittency and poor ecological potential on environmental filtering and limiting similarity through functional traits
Flow intermittency and poor environmental conditions can occur separately or simultaneously, affecting the occurrence of t...
Design, synthesis, and biological evaluation of β-carboline derivatives as ABCB1 inhibitors for reversing multidrug resistance
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Discovery of β-amino acid substituted naphthalene sulfonamide derivatives as potent Kelch-like ECH-associated protein 1−nuclear factor erythroid 2-related factor 2 (Keap1−Nrf2) protein−protein interaction inhibitors for ulcerative colitis management
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Population Pharmacokinetics of Prolonged Infusion for Meropenem: Tailoring Dosing Recommendations for Chinese Critically Ill Patients on Continuous Renal Replacement Therapy with Consideration for Renal Function
Population Pharmacokinetics of Prolonged Infusion for Meropenem: Tailoring Dosing Recommendations for Chinese Critically Ill Patients on Continuous Renal Replacement Therapy with Consideration for Renal Function
Performing a population pharmacokinetic (PK) analysis of prolonged meropenem infusion in critically ill CRRT patients to i...
Combining Network Pharmacology, Molecular Docking and Experimental Validation to Explore the Effects and Mechanisms of Indirubin on Acute Lymphoblastic Leukemia
Combining Network Pharmacology, Molecular Docking and Experimental Validation to Explore the Effects and Mechanisms of Indirubin on Acute Lymphoblastic Leukemia
Action and mechanism of indirubin in acute lymphoblastic leukemia through network pharmacology and potential therapeutic a...
Low-Dose Dexmedetomidine Attenuates the Dose Requirement of Propofol for Suppression of Body Movement in Patients Undergoing Operative Hysteroscopy
Low-Dose Dexmedetomidine Attenuates the Dose Requirement of Propofol for Suppression of Body Movement in Patients Undergoing Operative Hysteroscopy
The effect of low dose dexmedetomidine on the dose-response relationship of propofol for sedation in patients undergoing o...
Medication Safety in Intravenous Therapy: Compatibility of Etoposide with Frequently Drugs Used in Tumour Critical Care During Simulated Y-Site Administration
Medication Safety in Intravenous Therapy: Compatibility of Etoposide with Frequently Drugs Used in Tumour Critical Care During Simulated Y-Site Administration
Compatibility of etoposide during simulated Y-site administration with 45 continuous-infusion drugs that are commonly admi...
Recent Advances in Propranolol Hydrochloride Formulations for the Treatment of Infantile Hemangiomas
Recent Advances in Propranolol Hydrochloride Formulations for the Treatment of Infantile Hemangiomas
Infantile hemangiomas (IHs) are a kind of skin soft tissue benign tumors in infants, with a high incidence rate and signif...
Comprehensive Bioactive Compound Profiling of Artocarpus heterophyllus Leaves: LC-MS/MS Analysis, Antioxidant Potential, and Molecular Insights
Comprehensive Bioactive Compound Profiling of Artocarpus heterophyllus Leaves: LC-MS/MS Analysis, Antioxidant Potential, and Molecular Insights
By integrating traditional knowledge with scientific research, we establish the significance of Artocarpus heterophyllus l...
Lenvatinib Monotherapy Versus Lenvatinib in Combination with PD-1 Blockades as Re-Challenging Treatment for Patients with Metastatic Osteosarcoma: A Real-World Study
Lenvatinib Monotherapy Versus Lenvatinib in Combination with PD-1 Blockades as Re-Challenging Treatment for Patients with Metastatic Osteosarcoma: A Real-World Study
This retrospective study aims to summarize the real-world experiences of rechallenging patients with metastatic osteosarco...
The Clinical Research Landscape of Intracranial Nicardipine for Aneurysmal Subarachnoid Hemorrhage: Insights From Bibliometric Analysis
The Clinical Research Landscape of Intracranial Nicardipine for Aneurysmal Subarachnoid Hemorrhage: Insights From Bibliometric Analysis
Identifying the publication trends and research hotspots intracranial nicardipine for aneurysmal subarachnoid hemorrhage t...
Metabolomic Analysis, Antiproliferative, Anti-Migratory, and Anti-Invasive Potential of Amlodipine in Lung Cancer Cells
Metabolomic Analysis, Antiproliferative, Anti-Migratory, and Anti-Invasive Potential of Amlodipine in Lung Cancer Cells
Examining the metabolomics changes that may occur due to amlodipine's anticancer effects on non-small cell lung cancer cel...
Exploring the potential of isatin hybrids as anticancer agents: recent advances and future prospective
Exploring the potential of isatin hybrids as anticancer agents: recent advances and future prospective
Synthesis of hybrid molecules via molecular hybridization technique has been known to be a promising strategy which involv...
Structural and optical properties of Cu:CdS thin films on soft polymer substrate
Structural and optical properties of Cu:CdS thin films on soft polymer substrate
The structural and optical properties of copper doped cadmium sulfide (Cu:CdS) thin films on flexible polyethylene terepth...
Design, synthesis, and biological evaluation of quinazolinone-dihydropyrimidinone as a potential anti-diabetic agent via GLUT4 translocation stimulation
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