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Exploring novel anticancer pyrazole benzenesulfonamides featuring tail approach strategy as carbonic anhydrase inhibitors
Exploring novel anticancer pyrazole benzenesulfonamides featuring tail approach strategy as carbonic anhydrase inhibitors
Carbonic anhydrases (CAs) are essential metalloenzymes, present in both prokaryotes and eukaryotes, that catalyse the reve...
Synthesis and evaluation of aromatic BDSF bioisosteres on biofilm formation and colistin sensitivity in pathogenic bacteria
Synthesis and evaluation of aromatic BDSF bioisosteres on biofilm formation and colistin sensitivity in pathogenic bacteria
KeywordsDiffusible signal factorQuorum sensingBiofilmsResistanceAcinetobacter baumanniiEscherichia coliBurkholderia multiv...
Schools and Society During the COVID-19 Pandemic
Schools and Society During the COVID-19 Pandemic
This Open Access volume provides an analysis of the effects of the COVID-19 Pandemic on the education systems.
Management for Digital Transformation
Management for Digital Transformation
This book communicates the latest developments and thinking on the digital transformation subject worldwide
Techno-societal 2022
Techno-societal 2022
This book focuses on technologies that help develop and improve society and originates from Techno-Societal 2022
History of Romanian Technology and Industry
History of Romanian Technology and Industry
This volume showcases the valuable achievements of the Romanian technology and industry worldwide, from electrical enginee...
Synthesis of novel furan-based chalcone derivatives as anti-tuberculosis agents: in vitro, cytotoxicity assessment and in silico
Synthesis of novel furan-based chalcone derivatives as anti-tuberculosis agents: in vitro, cytotoxicity assessment and in silico
Background: The aim of the study is to identify a novel furan-based chalcone derivative as potent inhibitor against the H3...
Development of a NIR fluorescent probe for fluorescence-assisted EGFR-TKI applicable patients screening and drug resistance monitoring
Development of a NIR fluorescent probe for fluorescence-assisted EGFR-TKI applicable patients screening and drug resistance monitoring
Lung cancer reminds one of the most lethal and highest morbidity cancer worldwide, and non-small cell lung cancer (NSCLC) ...
Withaferin A: A Dietary Supplement with Promising Potential as an Anti-Tumor Therapeutic for Cancer Treatment - Pharmacology and Mechanisms
Withaferin A: A Dietary Supplement with Promising Potential as an Anti-Tumor Therapeutic for Cancer Treatment - Pharmacology and Mechanisms
Aiming to comprehensively summarize the pharmacological characteristics of Withaferin A as a potential anti-tumor drug can...
Efficacy of Super-Bioavailable Itraconazole and Conventional Itraconazole at Different Dosing Regimens in Glabrous Tinea Infection - A Randomized Clinical Trial
Efficacy of Super-Bioavailable Itraconazole and Conventional Itraconazole at Different Dosing Regimens in Glabrous Tinea Infection - A Randomized Clinical Trial
Evaluating the efficacy and safety of SB-itraconazole-130mg and CITZ-200 mg once daily compared with CITZ-100 mg twice dai...
Neuroprotective Effects of Melatonin and Celecoxib against Ethanol-Induced Neurodegeneration: A Computational and Pharmacological Approach [Corrigendum]
Neuroprotective Effects of Melatonin and Celecoxib against Ethanol-Induced Neurodegeneration: A Computational and Pharmacological Approach [Corrigendum]
Corrigendum for the article Neuroprotective effects of melatonin and celecoxib against ethanol-induced neurodegeneration: ...
Effect of Intraoperative Dexmedetomidine Use on Postoperative Delirium in the Elderly After Laryngectomy: A Randomized Controlled Clinical Trial
Effect of Intraoperative Dexmedetomidine Use on Postoperative Delirium in the Elderly After Laryngectomy: A Randomized Controlled Clinical Trial
Dexmedetomidine assoc. with decreased postop CRP & IL-6 levels; intraoperative dexmedetomidine resulted in higher occu...
Genetic diversity of Panax ginseng cultivated in Japan and its relation with some plant characteristics
Genetic diversity of Panax ginseng cultivated in Japan and its relation with some plant characteristics
In East Asia, Panax ginseng is one of the most important medicinal plants and has been used in traditional medicines from ...
Daphnepedunins G and H, anti-HIV macrocyclic 3,4-seco-daphnane orthoesters from Daphne pedunculata
Daphnepedunins G and H, anti-HIV macrocyclic 3,4-seco-daphnane orthoesters from Daphne pedunculata
Daphnepedunins G (1) and H (2) with unusual macrocyclic 3,4-seco-daphnane orthoester structure were isolated from Daphne p...
Cheminformatics-driven discovery of hit compounds against Paracoccidioides spp.
Cheminformatics-driven discovery of hit compounds against Paracoccidioides spp.
Aims: The development of safe and effective therapies for treating paracoccidioidomycosis using computational strategies w...
An overview of imidazole and its analogues as potent anticancer agents
An overview of imidazole and its analogues as potent anticancer agents
The quest for novel, physiologically active imidazoles remains an exciting topic of research among medicinal chemists. The...
Diphenyl-substituted triazine derivatives: synthesis, α-glucosidase inhibitory activity, kinetics and in silico studies
Diphenyl-substituted triazine derivatives: synthesis, α-glucosidase inhibitory activity, kinetics and in silico studies
Background: Diabetes mellitus (DM) is a chronic disorder considered a major global health challenge in the 21st century. α...
Novel 4-aminoquinoline analogs targeting the HIF-1α signaling pathway
Novel 4-aminoquinoline analogs targeting the HIF-1α signaling pathway
Background: The aminoquinoline core exhibits versatile pharmacological properties, particularly in the area of anticancer ...
Current in silico methods for multi-target drug discovery in early anticancer research: the rise of the perturbation-theory machine learning approach
Current in silico methods for multi-target drug discovery in early anticancer research: the rise of the perturbation-theory machine learning approach
This work was financially supported by the Foundation for Science and Technology/the Ministry of Science, Technology and H...
Synthesis and HDAC1 inhibitory activity of a novel series of coumarin-based amide derivatives for treatment of cancer
Synthesis and HDAC1 inhibitory activity of a novel series of coumarin-based amide derivatives for treatment of cancer
Background: Histone deacetylases (HDACs) play a vital role in the epigenetic regulation of transcription and expression. H...
Synthesis, cytotoxic activity evaluation and mechanistic investigation of novel 3,7-diarylsubstituted 6-azaindoles
Synthesis, cytotoxic activity evaluation and mechanistic investigation of novel 3,7-diarylsubstituted 6-azaindoles
All four positional isomers of the azaindole (1H-pyrrolopyridine) fused ring system can be considered as isosteric structu...
Synthesis and biological evaluation of fluoroquinolones containing a pyridoxine derivatives moiety
Synthesis and biological evaluation of fluoroquinolones containing a pyridoxine derivatives moiety
Nowadays, the increasing emergence of antibiotic resistance in pathogenic bacteria is one of the biggest problems of the h...
Galantamine-memantine hybrids for Alzheimer's disease: The influence of linker rigidity in biological activity and pharmacokinetic properties
Galantamine-memantine hybrids for Alzheimer's disease: The influence of linker rigidity in biological activity and pharmacokinetic properties
Neurodegenerative processes characterizing Alzheimer's disease (AD) are strictly related to the impairment of cholinergic ...
Design, synthesis and antiproliferative activity of ACY-1215 analogs as potent selective histone deacetylases 6 inhibitors
Design, synthesis and antiproliferative activity of ACY-1215 analogs as potent selective histone deacetylases 6 inhibitors
Histone deacetylase 6 (HDAC6) plays an important role in cancer treatment, and the development of selective HDAC6 inhibito...
Impact of Postoperative Dexmedetomidine Infusion on Incidence of Delirium in Elderly Patients Undergoing Major Elective Noncardiac Surgery: a Randomized Clinical Trial [Retraction]
Impact of Postoperative Dexmedetomidine Infusion on Incidence of Delirium in Elderly Patients Undergoing Major Elective Noncardiac Surgery: a Randomized Clinical Trial [Retraction]
Retraction for the article Impact of postoperative dexmedetomidine infusion on incidence of delirium in elderly patients u...
Efficacy and Safety of Different Doses of Remimazolam Tosilate Applied in Upper Gastrointestinal Endoscopy: A Prospective Randomized Controlled Double-Blind Trial
Efficacy and Safety of Different Doses of Remimazolam Tosilate Applied in Upper Gastrointestinal Endoscopy: A Prospective Randomized Controlled Double-Blind Trial
A randomized controlled clinical trial to investigate the efficacy and safety of different doses of remimazolam applied in...
Bio-Inspired Information Pathways
Bio-Inspired Information Pathways
This contributed OA book reports on fundamental findings in information processing in the nervous systems and applications...
The Effect of Low-Dose Esketamine on Postoperative Neurocognitive Dysfunction in Elderly Patients Undergoing General Anesthesia for Gastrointestinal Tumors: A Randomized Controlled Trial [Letter]
The Effect of Low-Dose Esketamine on Postoperative Neurocognitive Dysfunction in Elderly Patients Undergoing General Anesthesia for Gastrointestinal Tumors: A Randomized Controlled Trial [Letter]
Letter for the article The Effect of Low-Dose Esketamine on Postoperative Neurocognitive Dysfunction in Elderly Patients U...
Faricimab: Transforming the Future of Macular Diseases Treatment - A Comprehensive Review of Clinical Studies
Faricimab: Transforming the Future of Macular Diseases Treatment - A Comprehensive Review of Clinical Studies
Pharmacological characteristics of faricimab & clinical trials/real-world studies that assess its effectiveness/safety...
The Efficacy and Safety of Remimazolam Besylate Combined with Esketamine for Outpatient Colonoscopy: A Prospective, Randomized, Controlled Clinical Trial
The Efficacy and Safety of Remimazolam Besylate Combined with Esketamine for Outpatient Colonoscopy: A Prospective, Randomized, Controlled Clinical Trial
Evaluating the efficacy and safety of remimazolam besylate combined with esketamine for outpatient colonoscopy
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