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Exploring novel anticancer pyrazole benzenesulfonamides featuring tail approach strategy as carbonic anhydrase inhibitors
Exploring novel anticancer pyrazole benzenesulfonamides featuring tail approach strategy as carbonic anhydrase inhibitors
Carbonic anhydrases (CAs) are essential metalloenzymes, present in both prokaryotes and eukaryotes, that catalyse the reve...
Schools and Society During the COVID-19 Pandemic
Schools and Society During the COVID-19 Pandemic
This Open Access volume provides an analysis of the effects of the COVID-19 Pandemic on the education systems.
Management for Digital Transformation
Management for Digital Transformation
This book communicates the latest developments and thinking on the digital transformation subject worldwide
Techno-societal 2022
Techno-societal 2022
This book focuses on technologies that help develop and improve society and originates from Techno-Societal 2022
History of Romanian Technology and Industry
History of Romanian Technology and Industry
This volume showcases the valuable achievements of the Romanian technology and industry worldwide, from electrical enginee...
Synthesis of novel furan-based chalcone derivatives as anti-tuberculosis agents: in vitro, cytotoxicity assessment and in silico
Synthesis of novel furan-based chalcone derivatives as anti-tuberculosis agents: in vitro, cytotoxicity assessment and in silico
Background: The aim of the study is to identify a novel furan-based chalcone derivative as potent inhibitor against the H3...
Genetic diversity of Panax ginseng cultivated in Japan and its relation with some plant characteristics
Genetic diversity of Panax ginseng cultivated in Japan and its relation with some plant characteristics
In East Asia, Panax ginseng is one of the most important medicinal plants and has been used in traditional medicines from ...
Daphnepedunins G and H, anti-HIV macrocyclic 3,4-seco-daphnane orthoesters from Daphne pedunculata
Daphnepedunins G and H, anti-HIV macrocyclic 3,4-seco-daphnane orthoesters from Daphne pedunculata
Daphnepedunins G (1) and H (2) with unusual macrocyclic 3,4-seco-daphnane orthoester structure were isolated from Daphne p...
Cheminformatics-driven discovery of hit compounds against Paracoccidioides spp.
Cheminformatics-driven discovery of hit compounds against Paracoccidioides spp.
Aims: The development of safe and effective therapies for treating paracoccidioidomycosis using computational strategies w...
An overview of imidazole and its analogues as potent anticancer agents
An overview of imidazole and its analogues as potent anticancer agents
The quest for novel, physiologically active imidazoles remains an exciting topic of research among medicinal chemists. The...
Diphenyl-substituted triazine derivatives: synthesis, α-glucosidase inhibitory activity, kinetics and in silico studies
Diphenyl-substituted triazine derivatives: synthesis, α-glucosidase inhibitory activity, kinetics and in silico studies
Background: Diabetes mellitus (DM) is a chronic disorder considered a major global health challenge in the 21st century. α...
Novel 4-aminoquinoline analogs targeting the HIF-1α signaling pathway
Novel 4-aminoquinoline analogs targeting the HIF-1α signaling pathway
Background: The aminoquinoline core exhibits versatile pharmacological properties, particularly in the area of anticancer ...
Synthesis and HDAC1 inhibitory activity of a novel series of coumarin-based amide derivatives for treatment of cancer
Synthesis and HDAC1 inhibitory activity of a novel series of coumarin-based amide derivatives for treatment of cancer
Background: Histone deacetylases (HDACs) play a vital role in the epigenetic regulation of transcription and expression. H...
Synthesis, cytotoxic activity evaluation and mechanistic investigation of novel 3,7-diarylsubstituted 6-azaindoles
Synthesis, cytotoxic activity evaluation and mechanistic investigation of novel 3,7-diarylsubstituted 6-azaindoles
All four positional isomers of the azaindole (1H-pyrrolopyridine) fused ring system can be considered as isosteric structu...
Synthesis and biological evaluation of fluoroquinolones containing a pyridoxine derivatives moiety
Synthesis and biological evaluation of fluoroquinolones containing a pyridoxine derivatives moiety
Nowadays, the increasing emergence of antibiotic resistance in pathogenic bacteria is one of the biggest problems of the h...
Design, synthesis and antiproliferative activity of ACY-1215 analogs as potent selective histone deacetylases 6 inhibitors
Design, synthesis and antiproliferative activity of ACY-1215 analogs as potent selective histone deacetylases 6 inhibitors
Histone deacetylase 6 (HDAC6) plays an important role in cancer treatment, and the development of selective HDAC6 inhibito...
Bio-Inspired Information Pathways
Bio-Inspired Information Pathways
This contributed OA book reports on fundamental findings in information processing in the nervous systems and applications...
Faricimab: Transforming the Future of Macular Diseases Treatment - A Comprehensive Review of Clinical Studies
Faricimab: Transforming the Future of Macular Diseases Treatment - A Comprehensive Review of Clinical Studies
Pharmacological characteristics of faricimab & clinical trials/real-world studies that assess its effectiveness/safety...