SCI时时刷

search
+
Novel benzenesulfonamide bearing 1,2,4-triazoles as potent anti-microbial and anti-oxidant agents
Novel benzenesulfonamide bearing 1,2,4-triazoles as potent anti-microbial and anti-oxidant agents
A series comprising 30 novel benzenesulfonamide bearing 1,2,4-triazoles 1a–1h, 2a–2h, 3a–3h, 4b–4f...
Discovery of novel 2-hydroxyl-4-benzyloxybenzyl aniline derivatives as potential multifunctional agents for the treatment of Parkinson's disease
To discover novel multifunctional agents for the treatment of Parkinson's disease, a series of 2-hydroxyl-4-benzyloxybenzy...
Novel S1R agonists counteracting NMDA excitotoxicity and oxidative stress: A step forward in the discovery of neuroprotective agents
Sigma-1 receptor (S1R) has been considered a promising therapeutic target for several neurodegenerative diseases and S1R a...
Memantine derived compounds as potent in vitro inhibitors of urease: Repurposing of memantine, sonication assisted derivatization and in vitro enzyme inhibition, kinetics and molecular docking studies
Memantine derived compounds as potent in vitro inhibitors of urease: Repurposing of memantine, sonication assisted derivatization and in vitro enzyme inhibition, kinetics and molecular docking studies
The phenyl-substituted thiourea derivatives (2-21) of memantine (1) were synthesized through a sonication-assisted single-...
Insight into non-nucleoside triazole-based systems as viral polymerases inhibitors
Viruses have been recognized as the etiological agents responsible for many pathological conditions ranging from asymptoma...
Design, synthesis and biological activity of hybrid antifungals derived from fluconazole and mebendazole
A novel series of triazole alcohol antifungals bearing a 5-benzoylbenzimidazol-2-ylthio side chain have been designed and ...
1,2,4-Amino-triazine derivatives as pyruvate dehydrogenase kinase inhibitors: Synthesis and pharmacological evaluation
Among the different hallmarks of cancer, deregulation of cellular metabolism turned out to be an essential mechanism in pr...
Synthesis and evaluation of N-sulfonylpiperidine-3-carboxamide derivatives as capsid assembly modulators inhibiting HBV in vitro and in HBV-transgenic mice
The hepatitis B virus (HBV) capsid assembly modulators (CAMs) have been developed as effective anti-HBV agents in the trea...
Design and synthesis of benzochromene derivatives as AcrB inhibitors for the reversal of bacterial multidrug resistance
A series of novel benzo[h]chromene compounds were designed, synthesized and evaluated for their biological activity as Acr...
Nonsteroidal anti-inflammatory drugs (NSAIDs) and nucleotide analog GS-441524 conjugates with potent in vivo efficacy against coronaviruses
Coronaviruses (CoVs) infect a broad range of hosts, including humans and various animals, with a tendency to cross the spe...
Discovery of multi-target directed 3-OH pyrrolidine derivatives through a semisynthetic approach from alkaloid vasicine for the treatment of Alzheimer's disease
Vasicine is a pyrroloquinazoline alkaloid, which has been isolated from the plant Adhatoda vasica. Naturally inspired semi...
Elevated labile iron in castration–resistant prostate cancer is targetable with ferrous iron–activatable antiandrogen therapy
Clinical responses to second generation androgen signaling inhibitors (e.g., enzalutamide) in metastatic castration-resist...
Discovery of 4-oxo-N-phenyl-1,4-dihydroquinoline-3-carboxamide derivatives as novel anti-inflammatory agents for the treatment of acute lung injury and sepsis
Acute lung injury (ALI) and sepsis, characterized by systemic inflammatory response syndrome, remain the major causes of d...
Design, synthesis, and evaluation of substituted alkylindoles that activate G protein-coupled receptors distinct from the cannabinoid CB1 and CB2 receptors
The alkylindole (AI), WIN55212-2, modulates the activity of several proteins, including cannabinoid receptors 1 and 2 (CB1...
Design and evaluation of dibenzoazepine-tetrahydroisoquinoline hybrids as potential P-glycoprotein inhibitors against multidrug resistant K562/A02 cells
Multidrug resistance (MDR) caused by P-glycoprotein (P-gp) is a main barrier to the success of cancer chemotherapies. In t...
Development and Evaluation of Self-Emulsifying Drug-Delivery System–Based Tablets for Simvastatin, a BCS Class II Drug
Development and Evaluation of Self-Emulsifying Drug-Delivery System–Based Tablets for Simvastatin, a BCS Class II Drug
This study aimed at formulating and characterization of SEDDS-based tablets for simvastatin using castor and olive oils as...
Synthesis, cytotoxicity, Pan-HDAC inhibitory activity and docking study of new N-(2-aminophenyl)-2-methylquinoline-4-carboxamide and (E)-N-(2-aminophenyl)-2-styrylquinoline-4-carboxamide derivatives as anticancer agents
Synthesis, cytotoxicity, Pan-HDAC inhibitory activity and docking study of new N-(2-aminophenyl)-2-methylquinoline-4-carboxamide and (E)-N-(2-aminophenyl)-2-styrylquinoline-4-carboxamide derivatives as anticancer agents
In this study, new cytotoxic agents based on 2-aminobenzamide scaffold were designed, synthesized and evaluated against A5...
Medicinal uses, phytochemistry, pharmacology, and taxonomy of Poygonum aviculare L.: a comprehensive review
Medicinal uses, phytochemistry, pharmacology, and taxonomy of Poygonum aviculare L.: a comprehensive review
Polygonum aviculare is a plant widely distributed in all continents and very common in temperate regions of the world. The...
Effect of fluoride ions on coordination structure of titanium in molten NaCl-KCl
Effect of fluoride ions on coordination structure of titanium in molten NaCl-KCl
The effects of fluoride ions (F−) on the electrochemical behavior and coordination properties of titanium ions (Tin+...
Combined “Gateway” and “Spillover” effects originated from a CeNi5 alloy catalyst for hydrogen storage of MgH2
Combined “Gateway” and “Spillover” effects originated from a CeNi5 alloy catalyst for hydrogen storage of MgH2
Efficient catalysts enable MgH2 with superior hydrogen storage performance. Herein, we successfully synthesized a catalyst...
Solvent extraction and separation of cobalt from leachate of spent lithium-ion battery cathodes with N263 in nitrite media
Solvent extraction and separation of cobalt from leachate of spent lithium-ion battery cathodes with N263 in nitrite media
To effectively separate and recover Co(II) from the leachate of spent lithium-ion battery cathodes, we investigated solven...
Reaction behavior and non-isothermal kinetics of suspension magnetization roasting of limonite and siderite
Reaction behavior and non-isothermal kinetics of suspension magnetization roasting of limonite and siderite
In order to develop limonite and decrease CO2 emissions, siderite is proposed as a clean reductant for suspension magnetiz...
First-principles calculations of Ni-(Co)-Mn-Cu-Ti all-d-metal Heusler alloy on martensitic transformation, mechanical and magnetic properties
First-principles calculations of Ni-(Co)-Mn-Cu-Ti all-d-metal Heusler alloy on martensitic transformation, mechanical and magnetic properties
The martensitic transformation, mechanical, and magnetic properties of the Ni2Mn1.5−xCuxTi0.5 (x = 0.125, 0.25, 0.37...
Metallurgical properties of CaO-SiO2-Al2O3-4.6wt%MgO-Fe2O3 slag system pertaining to spent automotive catalyst smelting
Metallurgical properties of CaO-SiO2-Al2O3-4.6wt%MgO-Fe2O3 slag system pertaining to spent automotive catalyst smelting
The metallurgical properties of the CaO-SiO2-Al2O3-4.6wt%MgO-Fe2O3 slag system, formed by the co-treatment process of spen...
Optimization on microstructure, mechanical properties and damping capacities of duplex structured Mg-8Li-4Zn-1Mn alloys
Optimization on microstructure, mechanical properties and damping capacities of duplex structured Mg-8Li-4Zn-1Mn alloys
Optimizing the mechanical properties and damping capacity of the duplex-structured Mg-Li-Zn-Mn alloy by tailoring the micr...
Effect of ball milling time on the microstructure and compressive properties of the Fe-Mn-Al porous steel
Effect of ball milling time on the microstructure and compressive properties of the Fe-Mn-Al porous steel
In the present work, Fe-Mn-Al-C powder mixtures were manufactured by elemental powders with different ball milling time, a...
Microstructure, segregation and precipitate evolution in directionally solidified GH4742 superalloy
Microstructure, segregation and precipitate evolution in directionally solidified GH4742 superalloy
The evolution of microstructure, elemental segregation, and precipitation in GH4742 superalloy under a wide range of cooli...
Influence of complicated faults on the differentiation and accumulation of in-situ stress in deep rock mass
Influence of complicated faults on the differentiation and accumulation of in-situ stress in deep rock mass
High geostress will become a normality in the deep because in-situ stress rises linearly with depth. The geological struct...
Preparation and property of self-sealed plasma electrolytic oxide coating on magnesium alloy
Preparation and property of self-sealed plasma electrolytic oxide coating on magnesium alloy
Plasma electrochemical oxidation (PEO) is a surface modification technology to form ceramic coatings on magnesium alloys. ...
Numerical investigation of the mechanical behavior of the backfill—rock composite structure under triaxial compression
Numerical investigation of the mechanical behavior of the backfill—rock composite structure under triaxial compression
To ensure safe and economical backfill mining, the mechanical response of the backfill—rock interaction system needs...
阅读更多
format_indent_increase