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Ad-hoc modifications of cyclic mimetics of SOCS1 protein: Structural and functional insights
Suppressors of cytokine signaling 1 (SOCS1) protein, a negative regulator of the Janus kinase (JAK)-signal transducer and ...
Design, synthesis, and biological evaluation of low-toxic lappaconitine derivatives as potential analgesics
The C18-diterpenoid alkaloid lappaconitine (LA) is a non-addictive analgesic used in China. The toxicity (LD50 = 11.7 mg/k...
Design, synthesis, and biological evaluation of Wee1 kinase degraders
Proteolysis targeting chimera (PROTAC) technology has received widespread attention in recent years as a promising strateg...
Synthesis and Bioactivity Evaluation of a Novel 1,2,4-Oxadiazole Derivative in vitro and in 3×Tg Mice
Synthesis and Bioactivity Evaluation of a Novel 1,2,4-Oxadiazole Derivative in vitro and in 3×Tg Mice
We found a novel 1,2,4-oxadiazole derivative (wyc-7-20) with low toxicity on SH-SY5Y and HepG2 cells and improvement of th...
Endocannabinoid Signaling
Endocannabinoid Signaling
​This second edition provides new and updated chapters detailing all major elements of the eCB system and identification o...
Advances on Mechanics, Design Engineering and Manufacturing IV
Advances on Mechanics, Design Engineering and Manufacturing IV
The proceedings of JCM 2022 discusses methods, technologies and applications of engineering design in additive manufacturi...
Medicina, Vol. 58, Pages 1344: Crohn’s Disease and Jejunal Artery Aneurysms: A Report of the First Case and a Review of the Literature
Medicina, Vol. 58, Pages 1344: Crohn’s Disease and Jejunal Artery Aneurysms: A Report of the First Case and a Review of the Literature
Background and Objectives: Jejunal artery (JA) and ileal artery (IA) aneurysms constitute less than 3% of all visceral art...
Medicina, Vol. 58, Pages 1346: Potential Association between Subclinical Hypothyroidism and Childhood Migraine
Medicina, Vol. 58, Pages 1346: Potential Association between Subclinical Hypothyroidism and Childhood Migraine
Background and Objectives: Migraine is caused by genetic susceptibility that is triggered by environmental as well as biol...
JPM, Vol. 12, Pages 1574: Bibliometric Analysis of the Scientific Production on Compassion Fatigue
JPM, Vol. 12, Pages 1574: Bibliometric Analysis of the Scientific Production on Compassion Fatigue
Background: Compassion fatigue is a common phenomenon among healthcare professionals and includes several concepts that sh...
Medicina, Vol. 58, Pages 1323: Impact of Anticoagulants in Reducing Mortality and Disability in Cardioembolic Stroke Patients
Medicina, Vol. 58, Pages 1323: Impact of Anticoagulants in Reducing Mortality and Disability in Cardioembolic Stroke Patients
Background and Objectives: Stroke is currently the second most common cause of death and disability-adjusted life years wo...
Medicina, Vol. 58, Pages 1325: Sleep Disorders and Their Associated Factors during the COVID-19 Pandemic: Data from Peruvian Medical Students
Medicina, Vol. 58, Pages 1325: Sleep Disorders and Their Associated Factors during the COVID-19 Pandemic: Data from Peruvian Medical Students
Background and objectives: Sleep disorders are a common public health problem among college students. The objective of thi...
Medicina, Vol. 58, Pages 1328: The Impact of Revascularization in a Patient with Atypical Manifestations of Hypoperfusion
Medicina, Vol. 58, Pages 1328: The Impact of Revascularization in a Patient with Atypical Manifestations of Hypoperfusion
Background and Objectives: Carotid revascularization is one of the most effective treatment options in patients with sever...
Medicina, Vol. 58, Pages 1327: Integrating Radiosensitivity Gene Signature Improves Glioma Outcome and Radiotherapy Response Prediction
Medicina, Vol. 58, Pages 1327: Integrating Radiosensitivity Gene Signature Improves Glioma Outcome and Radiotherapy Response Prediction
Response to radiotherapy (RT) in gliomas varies widely between patients. It is necessary to identify glioma-associated rad...
Medicina, Vol. 58, Pages 1329: Clear Cell Renal Cell Carcinoma, Diagnostic and Therapeutic Difficulties, Case Report and Literature Review
Medicina, Vol. 58, Pages 1329: Clear Cell Renal Cell Carcinoma, Diagnostic and Therapeutic Difficulties, Case Report and Literature Review
Nephroblastoma is the most common kidney tumour in children, constitutes about 85% of cases. Although renal cell carcinoma...
Medicina, Vol. 58, Pages 1339: Effect of β-Blocker Therapy on the Level of Soluble ST2 Protein in Pediatric Dilated Cardiomyopathy
Medicina, Vol. 58, Pages 1339: Effect of β-Blocker Therapy on the Level of Soluble ST2 Protein in Pediatric Dilated Cardiomyopathy
Background and Objectives: A prognosis for kids with pediatric dilated cardiomyopathy (PDCM) is urgently needed to identif...