SCI时时刷

search
+
Promotion of neurite outgrowth by 3,5,7,3ʹ,4ʹ-pentamethoxyflavone is mediated through ERK signaling pathway in Neuro2a cells
Promotion of neurite outgrowth by 3,5,7,3ʹ,4ʹ-pentamethoxyflavone is mediated through ERK signaling pathway in Neuro2a cells
In this study, the effects of 3,5,7,3ʹ,4ʹ-pentamethoxyflavone (KP1), a major bioactive ingredient isolated from ...
Ameliorative effect of bofutsushosan (Fangfengtongshengsan) extract on the progression of aging-induced obesity
Ameliorative effect of bofutsushosan (Fangfengtongshengsan) extract on the progression of aging-induced obesity
This study aimed to compare fat accumulation in young and aged mice raised on a high-fat diet and to characterize the obes...
Promotion of neurite outgrowth by 3,5,7,3ʹ,4ʹ-pentamethoxyflavone is mediated through ERK signaling pathway in Neuro2a cells
Promotion of neurite outgrowth by 3,5,7,3ʹ,4ʹ-pentamethoxyflavone is mediated through ERK signaling pathway in Neuro2a cells
In this study, the effects of 3,5,7,3ʹ,4ʹ-pentamethoxyflavone (KP1), a major bioactive ingredient isolated from ...
Two new sesterterpenoids from Atractylodes japonica Koidz. ex Kitam
Two new sesterterpenoids from Atractylodes japonica Koidz. ex Kitam
Two new sesterterpenoids, atractylodes japonica terpenoid acid I (1) and atractylodes japonica terpenoid aldehyde I (2), w...
Two new sesterterpenoids from Atractylodes japonica Koidz. ex Kitam
Two new sesterterpenoids from Atractylodes japonica Koidz. ex Kitam
Two new sesterterpenoids, atractylodes japonica terpenoid acid I (1) and atractylodes japonica terpenoid aldehyde I (2), w...
Evaluation of Rhododendri Mollis Flos and its representative component as a potential analgesic
Evaluation of Rhododendri Mollis Flos and its representative component as a potential analgesic
Rhododendri Mollis Flos (R. mole Flos), the dried flowers of Rhododendron mole G. Don, have the ability to relieve pain, d...
Polyphyllin I induces rapid ferroptosis in acute myeloid leukemia through simultaneous targeting PI3K/SREBP-1/SCD1 axis and triggering of lipid peroxidation
Polyphyllin I induces rapid ferroptosis in acute myeloid leukemia through simultaneous targeting PI3K/SREBP-1/SCD1 axis and triggering of lipid peroxidation
Acute myeloid leukemia (AML) is a malignant disease that is difficult to completely cure. Polyphyllin I (PPI), a steroidal...
Quinazoline sulfonamide derivatives targeting MicroRNA-34a/MDM4/p53 apoptotic axis with radiosensitizing activity
Quinazoline sulfonamide derivatives targeting MicroRNA-34a/MDM4/p53 apoptotic axis with radiosensitizing activity
Aim: New quinazoline benzenesulfonamide hybrids 4a–n were synthesized to determine their cytotoxicity and effect on the mi...
A C-PCM Outlook of Structural and Spectroscopic (IR, 1H NMR) Properties of [Cp2Mo(6-mercaptopurine)]Cl Complex
A C-PCM Outlook of Structural and Spectroscopic (IR, 1H NMR) Properties of [Cp2Mo(6-mercaptopurine)]Cl Complex
In the present research, solvent effect on the structure and spectroscopic properties of two isomers of Cp2Mo(6-mercaptopu...
Effect of Al-Doping on Structural and Adsorption Properties of NiFe2O4 via Modified Sol–Gel Approach for CO2 Adsorption
Effect of Al-Doping on Structural and Adsorption Properties of NiFe2O4 via Modified Sol–Gel Approach for CO2 Adsorption
Aluminium doped nickel ferrite (NiFe2−xAlxO4) with different Al content ranging from 0.3 ≤ x ...
Design, synthesis, and biological evaluation of some 2-(3-oxo-5,6-diphenyl-1,2,4-triazin-2(3H)-yl)-N-phenylacetamide hybrids as MTDLs for Alzheimer's disease therapy
Design, synthesis, and biological evaluation of some 2-(3-oxo-5,6-diphenyl-1,2,4-triazin-2(3H)-yl)-N-phenylacetamide hybrids as MTDLs for Alzheimer's disease therapy
The incidence of AD, a leading cause of disability and death, is expected to grow rapidly over the next decade [1]. The fi...
Exploring the modulatory influence on the antimalarial activity of amodiaquine using scaffold hybridisation with ferrocene integration
Exploring the modulatory influence on the antimalarial activity of amodiaquine using scaffold hybridisation with ferrocene integration
Amodiaquine (AQ) is a potent antimalarial drug used in combination with artesunate as part of artemisinin-based combinatio...
Scutellarin ameliorates diabetic nephropathy via TGF-β1 signaling pathway
Scutellarin ameliorates diabetic nephropathy via TGF-β1 signaling pathway
Breviscapine, a natural flavonoid mixture derived from the traditional Chinese herb Erigeron breviscapus (Vant.) Hand-Mazz...
Research strategies of small molecules as chemotherapeutics to overcome multiple myeloma resistance
Research strategies of small molecules as chemotherapeutics to overcome multiple myeloma resistance
Multiple myeloma (MM), also known as plasma cell myeloma, is the second most common hematological malignancy [1]. The main...
Probing benzenesulfonamide–thiazolidinone hybrids as multitarget directed ligands for efficient control of type 2 diabetes mellitus through targeting the enzymes: α-glucosidase and carbonic anhydrase II
Probing benzenesulfonamide–thiazolidinone hybrids as multitarget directed ligands for efficient control of type 2 diabetes mellitus through targeting the enzymes: α-glucosidase and carbonic anhydrase II
In recent years, there has been an increasing focus on the design of multi-target-directed ligands for the purpose of crea...
Discovery of novel ocotillol derivatives modulating glucocorticoid receptor/NF-κB signaling for the treatment of sepsis
Discovery of novel ocotillol derivatives modulating glucocorticoid receptor/NF-κB signaling for the treatment of sepsis
Sepsis results from a dysregulated immune response to infection and leads to multiple organ failure [1], and it is respons...
RNA-Based Antipsoriatic Gene Therapy: An Updated Review Focusing on Evidence from Animal Models
RNA-Based Antipsoriatic Gene Therapy: An Updated Review Focusing on Evidence from Animal Models
Investigating RNA-based gene therapy exploration in different types of psoriasis-like animal models to improve the treatme...
Validation of Core Ingredients and Molecular Mechanism of Cinobufotalin Injection Against Liver Cancer
Validation of Core Ingredients and Molecular Mechanism of Cinobufotalin Injection Against Liver Cancer
Validation of core ingredients and molecular mechanism of cinobufotalin injection against liver cancer. Read more
Dynasore Alleviates LPS-Induced Acute Lung Injury by Inhibiting NLRP3 Inflammasome-Mediated Pyroptosis
Dynasore Alleviates LPS-Induced Acute Lung Injury by Inhibiting NLRP3 Inflammasome-Mediated Pyroptosis
Investigation of the effect of dynasore on macrophage activation and its potential mechanisms in LPS-induced ALI in vitro ...
Propofol and Dexmedetomidine Ameliorate Endotoxemia-Associated Encephalopathy via Inhibiting Ferroptosis
Propofol and Dexmedetomidine Ameliorate Endotoxemia-Associated Encephalopathy via Inhibiting Ferroptosis
Exploring and compaing the effects of propofol and dexmedetomidine on the encephalopathy induced by endotoxemia. Read more
Medicinal plants used in traditional medicine to enhance immunity: A survey in the southeastern area of Morocco and a literature review
Objective: The threat of immune escape and the discovery of antibiotic-resistant pathogens, as well as the failure of cert...
Evaluating the efficacy of Terminalia chebula Retz. 5% cream compared to hydroquinone 2% cream in the treatment of melasma
Objective: Melasma is a multifactorial, chronic, acquired skin disorder of hyperpigmentation. Terminalia chebula Retz. (T....
Roselle (Hibiscus sabdariffa L.) extract as an adjunct to valsartan in patients with mild chronic kidney disease: A double-blind randomized controlled clinical trial
Objective: The objective of this study was to evaluate the effectiveness of Hibiscus sabdariffa L. extract (HS) as an adju...
Experimental and clinical studies on pharmacological actions of the genus Achillea: A comprehensive and updated review
Objective: Species of the genus Achillea (from the family Compositae or Asteraceae) are widely used for their numerous pha...
Health risk of human exposure to microplastics: a review
Health risk of human exposure to microplastics: a review
Microplastics are emerging contaminants that have been detected recently in most environmental and biological systems, yet...
Synthesis of LAVR-289, a new [(Z)-3-(acetoxymethyl)-4-(2,4-diaminopyrimidin-6-yl)oxy-but-2-enyl]phosphonic acid prodrug with pronounced antiviral activity against DNA viruses
Synthesis of LAVR-289, a new [(Z)-3-(acetoxymethyl)-4-(2,4-diaminopyrimidin-6-yl)oxy-but-2-enyl]phosphonic acid prodrug with pronounced antiviral activity against DNA viruses
KeywordsAcyclic nucleoside phosphonateO-(2,4-diaminopyrimidin-6-yl)Olefin cross-metathesisDNA virusesVaricella-zoster viru...
Discovery of N-(4-((6-(3,5- Dimethoxyphenyl)-9H-purine derivatives as irreversible covalent FGFR inhibitors
Discovery of N-(4-((6-(3,5- Dimethoxyphenyl)-9H-purine derivatives as irreversible covalent FGFR inhibitors
Consisting of an extracellular ligand-binding domain, a transmembrane domain, and a cytosolic tyrosine kinase domain, fibr...
Natural and Synthetic Drugs Approached for the Treatment of Recurrent Aphthous Stomatitis Over the Last Decade
Natural and Synthetic Drugs Approached for the Treatment of Recurrent Aphthous Stomatitis Over the Last Decade
Natural and Synthetic Drugs Approached for the Treatment of Recurrent Aphthous Stomatitis Over the Last Decade
The Median Effective Dose of Intrathecal Hyperbaric Bupivacaine for Cesarean Section at Moderately High-Altitude
The Median Effective Dose of Intrathecal Hyperbaric Bupivacaine for Cesarean Section at Moderately High-Altitude
To ascertain the ED90 or ED95 dose of local anesthetics for cesarean section at moderately high altitudes.
Effect of Fluid Therapy in Early Morning on the Incidence of Post-Induction Hypotension During Non-Cardiac Surgery After Noon: A Single-Center Retrospective Study
Effect of Fluid Therapy in Early Morning on the Incidence of Post-Induction Hypotension During Non-Cardiac Surgery After Noon: A Single-Center Retrospective Study
The influence of prophylactic high-volume fluid in the early morning of the operation day on the incidence of PIH during n...
阅读更多
format_indent_increase