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Oncogenic potential of truncated-Gli3 via the Gsk3β/Gli3/AR-V7 axis in castration-resistant prostate cancer
Oncogenic potential of truncated-Gli3 via the Gsk3β/Gli3/AR-V7 axis in castration-resistant prostate cancer
The functional activation of the androgen receptor (AR) and its interplay with the aberrant Hh/Gli cascade are pivotal in ...
Evidence of DNA methylation heterogeneity and epipolymorphism in kidney cancer tissue samples
Evidence of DNA methylation heterogeneity and epipolymorphism in kidney cancer tissue samples
Clear cell renal cell carcinoma (ccRCC) is characterised by significant genetic heterogeneity, which has diagnostic and pr...
Pyrithione zinc alters mismatch repair to trigger tumor immunogenicity
Pyrithione zinc alters mismatch repair to trigger tumor immunogenicity
Mismatch repair deficiency (dMMR) cancers are highly sensitive to immunotherapy, but only account for a small fraction of ...
m6A-modified circSTX6 as a key regulator of cervical cancer malignancy via SPI1 and IL6/JAK2/STAT3 pathways
m6A-modified circSTX6 as a key regulator of cervical cancer malignancy via SPI1 and IL6/JAK2/STAT3 pathways
In recent years, circRNAs have garnered increasing attention for their role in cervical cancer. However, the functions of ...
Retraction Note: Exosomal miR-4466 from nicotine-activated neutrophils promotes tumor cell stemness and metabolism in lung cancer metastasis
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Global profiling of alternative splicing in non-small cell lung cancer reveals novel histological and population differences
Global profiling of alternative splicing in non-small cell lung cancer reveals novel histological and population differences
Lung cancer is one of the most frequently diagnosed cancers in the US. African-American (AA) men are more likely to develo...
Mevalonate kinase inhibits anti-tumor immunity by impairing the tumor cell-intrinsic interferon response in microsatellite instability colorectal cancer
Mevalonate kinase inhibits anti-tumor immunity by impairing the tumor cell-intrinsic interferon response in microsatellite instability colorectal cancer
Insufficient tumor cell-intrinsic interferon response represents a major obstacle in immune checkpoint blockade (ICB) ther...
A TBX2-driven signaling switch from androgen receptor to glucocorticoid receptor confers therapeutic resistance in prostate cancer
A TBX2-driven signaling switch from androgen receptor to glucocorticoid receptor confers therapeutic resistance in prostate cancer
Recent studies suggest that glucocorticoid receptor (GR) activation can cause enzalutamide resistance in advanced prostate...
CBL0137 and NKG2A blockade: a novel immuno-oncology combination therapy for Myc-overexpressing triple-negative breast cancers
CBL0137 and NKG2A blockade: a novel immuno-oncology combination therapy for Myc-overexpressing triple-negative breast cancers
The MYC proto-oncogene is upregulated in >60% of triple-negative breast cancers (TNBCs), it can directly promote tu...
PRMT5-regulated splicing of DNA repair genes drives chemoresistance in breast cancer stem cells
PRMT5-regulated splicing of DNA repair genes drives chemoresistance in breast cancer stem cells
Breast cancer stem cells (BCSCs) are a rare cell population that is responsible for tumour initiation, metastasis and chem...
Identification of novel germline mutations in FUT7 and EXT1 linked with hereditary multiple exostoses
Identification of novel germline mutations in FUT7 and EXT1 linked with hereditary multiple exostoses
Hereditary multiple exostoses (HME) is an autosomal dominant skeletal disorder primarily linked with mutations in Exostosi...
Mitochondrial unfolded protein response-dependent β-catenin signaling promotes neuroendocrine prostate cancer
Mitochondrial unfolded protein response-dependent β-catenin signaling promotes neuroendocrine prostate cancer
The mitochondrial unfolded protein response (UPRmt) maintains mitochondrial quality control and proteostasis under stress ...
Editorial Expression of Concern: DCAF12 promotes apoptosis and inhibits NF-κB activation by acting as an endogenous antagonist of IAPs
The Editors-in-Chief are issuing this Editorial Expression of Concern to alert readers that concerns have been raised abou...
Lack of dominant-negative activity for tumor-related ZNRF3 missense mutations at endogenous levels
Lack of dominant-negative activity for tumor-related ZNRF3 missense mutations at endogenous levels
ZNRF3, a negative regulator of β-catenin signaling, removes Wnt receptors from the membrane. Currently, it is unknown...
Pseudokinase TRIB3 stabilizes SSRP1 via USP10-mediated deubiquitination to promote multiple myeloma progression
Pseudokinase TRIB3 stabilizes SSRP1 via USP10-mediated deubiquitination to promote multiple myeloma progression
Multiple myeloma (MM), the world’s second most common hematologic malignancy, poses considerable clinical challenges...
Tissue factor promotes TREX1 protein stability to evade cGAS-STING innate immune response in pancreatic ductal adenocarcinoma
Tissue factor promotes TREX1 protein stability to evade cGAS-STING innate immune response in pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) remains the most challenging human malignancy that urgently needs effective therap...
TFF3 drives Hippo dependent EGFR-TKI resistance in lung adenocarcinoma
TFF3 drives Hippo dependent EGFR-TKI resistance in lung adenocarcinoma
Intrinsic and acquired resistance represent major obstacles to optimize outcomes in epidermal growth factor receptor (EGFR...
Senescent lung fibroblasts in idiopathic pulmonary fibrosis facilitate non-small cell lung cancer progression by secreting exosomal MMP1
Senescent lung fibroblasts in idiopathic pulmonary fibrosis facilitate non-small cell lung cancer progression by secreting exosomal MMP1
Lung cancer is a fatal complication of idiopathic pulmonary fibrosis (IPF) with a poor prognosis. Current treatments are i...
Delactylase effects of SIRT1 on a positive feedback loop involving the H19-glycolysis-histone lactylation in gastric cancer
Delactylase effects of SIRT1 on a positive feedback loop involving the H19-glycolysis-histone lactylation in gastric cancer
Histone lactylation, a novel epigenetic modification, is regulated by the lactate produced by glycolysis. Glycolysis is ac...
Frequent copy number gain of MCL1 is a therapeutic target for osteosarcoma
Frequent copy number gain of MCL1 is a therapeutic target for osteosarcoma
Osteosarcoma (OS) is a primary malignant bone tumor primarily affecting children and adolescents. The lack of progress in ...
Editorial Expression of Concern: Role of hypoxia inducible factor-1 alpha in modulation of apoptosis resistance
Cite this articleKilic, M., Kasperczyk, H., Fulda, S. et al. Editorial Expression of Concern: Role of hypoxia inducible fa...
SPTLC2 drives an EGFR-FAK-HBEGF signaling axis to promote ovarian cancer progression
SPTLC2 drives an EGFR-FAK-HBEGF signaling axis to promote ovarian cancer progression
The epidermal growth factor receptor (EGFR) signaling pathway is frequently associated with ovarian cancer (OC) progressio...
LGALS9B stabilizes EEF1D protein and activates the PI3K/AKT signaling pathway to promote gastric cancer occurrence and metastasis
LGALS9B stabilizes EEF1D protein and activates the PI3K/AKT signaling pathway to promote gastric cancer occurrence and metastasis
Gastric cancer ranks among the most prevalent malignancies globally, characterized by limited treatment efficacy and high ...
BEX4 inhibits the progression of clear cell renal cell carcinoma by stabilizing SH2D4A, which is achieved by blocking SIRT2 activity
BEX4 inhibits the progression of clear cell renal cell carcinoma by stabilizing SH2D4A, which is achieved by blocking SIRT2 activity
Clear cell renal cell carcinoma (ccRCC) is one of the most common malignancies. Recently, the role of brain-expressed X-li...
Metabolic imaging distinguishes ovarian cancer subtypes and detects their early and variable responses to treatment
Metabolic imaging distinguishes ovarian cancer subtypes and detects their early and variable responses to treatment
High grade serous ovarian cancer displays two metabolic subtypes; a high OXPHOS subtype that shows increased expression of...
JAK2/ULK1 axis promotes cervical cancer progression by autophagy induction and SRPK1 phosphorylation
JAK2/ULK1 axis promotes cervical cancer progression by autophagy induction and SRPK1 phosphorylation
Cervical cancer is the most common gynecologic cancer. Autophagy is involved in the progression of CCa. ULK1 is a crucial ...
Breast cancer stem cell-derived exosomal lnc-PDGFD induces fibroblast-niche formation and promotes lung metastasis
Breast cancer stem cell-derived exosomal lnc-PDGFD induces fibroblast-niche formation and promotes lung metastasis
Triple-negative breast cancer (TNBC) is the most aggressive subtype with high metastatic potential and lack of therapeutic...
Targeting RBM39 suppresses tumor growth and sensitizes osteosarcoma cells to cisplatin
Targeting RBM39 suppresses tumor growth and sensitizes osteosarcoma cells to cisplatin
Osteosarcoma is one of the most common malignant primary bone tumors and lacks effective therapeutic targets. Recent studi...
Reversal of endocrine resistance via N6AMT1-NEDD4L pathway-mediated p110α degradation
Reversal of endocrine resistance via N6AMT1-NEDD4L pathway-mediated p110α degradation
Approximately 70% of breast cancer (BC) cases are luminal-type (estrogen receptor-positive, ER+), suitable for endocrine t...
A novel micropeptide miPEP205 suppresses the growth and metastasis of TNBC
A novel micropeptide miPEP205 suppresses the growth and metastasis of TNBC
Triple negative breast cancer (TNBC) is the most aggressive subtype of breast cancer and poses a treatment challenge due t...
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