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ULK1-dependent phosphorylation of PKM2 antagonizes O-GlcNAcylation and regulates the Warburg effect in breast cancer
ULK1-dependent phosphorylation of PKM2 antagonizes O-GlcNAcylation and regulates the Warburg effect in breast cancer
Pyruvate kinase M2 (PKM2) is a central metabolic enzyme driving the Warburg effect in tumor growth. Previous investigation...
Correction: A novel oncogenic BTK isoform is overexpressed in colon cancers and required for RAS-mediated transformation
Correction: A novel oncogenic BTK isoform is overexpressed in colon cancers and required for RAS-mediated transformation
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Correction: In vivo genome-wide CRISPR screening identifies CITED2 as a driver of prostate cancer bone metastasis
Juan M. ArriagaPresent address: Department of Oncological Sciences, Department of Urology, Icahn School of Medicine at Mou...
COL5A1 promotes triple-negative breast cancer progression by activating tumor cell-macrophage crosstalk
COL5A1 promotes triple-negative breast cancer progression by activating tumor cell-macrophage crosstalk
Triple-negative breast cancer (TNBC) is an exceptionally aggressive subtype of breast cancer. Despite the recognized inter...
Inherited KDM6AA649T facilitates tumor-immune escape and exacerbates colorectal signet-ring cell carcinoma outcomes
Inherited KDM6AA649T facilitates tumor-immune escape and exacerbates colorectal signet-ring cell carcinoma outcomes
Childhood onset of colorectal signet-ring cell carcinoma (CR-SRCC) is extremely rare and featured as highly malignant with...
LPCAT2 inhibits colorectal cancer progression via the PRMT1/SLC7A11 axis
LPCAT2 inhibits colorectal cancer progression via the PRMT1/SLC7A11 axis
Colorectal cancer (CRC) has a high degree of heterogeneity and identifying the genetic information of individual tumor cel...
Transcription factor ZIC2 regulates the tumorigenic phenotypes associated with both bulk and cancer stem cells in epithelial ovarian cancer
Transcription factor ZIC2 regulates the tumorigenic phenotypes associated with both bulk and cancer stem cells in epithelial ovarian cancer
Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy in North America. Current therapeutic regimens a...
FAK-LINC01089 negative regulatory loop controls chemoresistance and progression of small cell lung cancer
FAK-LINC01089 negative regulatory loop controls chemoresistance and progression of small cell lung cancer
The focal adhesion kinase (FAK) tyrosine kinase is activated and upregulated in multiple cancer types including small cell...
Bone marrow stromal cells dictate lanosterol biosynthesis and ferroptosis of multiple myeloma
Bone marrow stromal cells dictate lanosterol biosynthesis and ferroptosis of multiple myeloma
Ferroptosis has been demonstrated a promising way to counteract chemoresistance of multiple myeloma (MM), however, roles a...
NRF2 activation by cysteine as a survival mechanism for triple-negative breast cancer cells
NRF2 activation by cysteine as a survival mechanism for triple-negative breast cancer cells
Triple-negative breast cancer (TNBC) is a very aggressive and heterogeneous group of tumors. In order to develop effective...
PDIA2 has a dual function in promoting androgen deprivation therapy induced venous thrombosis events and castrate resistant prostate cancer progression
PDIA2 has a dual function in promoting androgen deprivation therapy induced venous thrombosis events and castrate resistant prostate cancer progression
Androgen deprivation therapy (ADT) is the first line of treatment for metastatic prostate cancer (PCa) that effectively de...
Correction: Evolutionarily conserved dual lysine motif determines the non-chaperone function of secreted Hsp90alpha in tumour progression
Correction: Evolutionarily conserved dual lysine motif determines the non-chaperone function of secreted Hsp90alpha in tumour progression
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Correction: E-cadherin interacts with EGFR resulting in hyper-activation of ERK in multiple models of breast cancer
Department of Chemical and Biomolecular Engineering, Johns Hopkins University, 3400 N Charles St, Baltimore, MD, 21218, US...
Correction: Robustness of cancer microbiome signals over a broad range of methodological variation
Serena Fraraccio & Stephen WandroPresent address: Center for Microbiome Innovation, University of California San Diego...
Inactivation of kindlin-3 increases human melanoma aggressiveness through the collagen-activated tyrosine kinase receptor DDR1
Inactivation of kindlin-3 increases human melanoma aggressiveness through the collagen-activated tyrosine kinase receptor DDR1
The role of the focal adhesion protein kindlin-3 as a tumor suppressor and its interaction mechanisms with extracellular m...
The role of human 5-Lipoxygenase (5-LO) in carcinogenesis - a question of canonical and non-canonical functions
The role of human 5-Lipoxygenase (5-LO) in carcinogenesis - a question of canonical and non-canonical functions
5-Lipoxygenase (5-LO), a fatty acid oxygenase, is the central enzyme in leukotriene (LT) biosynthesis, potent arachidonic ...
The splicing factor WBP11 mediates MCM7 intron retention to promote the malignant progression of ovarian cancer
The splicing factor WBP11 mediates MCM7 intron retention to promote the malignant progression of ovarian cancer
Accumulating studies suggest that splicing factors play important roles in many diseases including human cancers. Our stud...
The lincRNA JUNI regulates the stress-dependent induction of c-Jun, cellular migration and survival through the modulation of the DUSP14-JNK axis
The lincRNA JUNI regulates the stress-dependent induction of c-Jun, cellular migration and survival through the modulation of the DUSP14-JNK axis
Cancer cells employ adaptive mechanisms to survive various stressors, including genotoxic drugs. Understanding the factors...
USP26 promotes colorectal cancer tumorigenesis by restraining PRKN-mediated mitophagy
USP26 promotes colorectal cancer tumorigenesis by restraining PRKN-mediated mitophagy
Deubiquitinating enzymes (DUBs) are promising targets for cancer therapy because of their pivotal roles in various physiol...
An integrated ceRNA network identifies miR-375 as an upregulated miRNA playing a tumor suppressive role in aggressive prostate cancer
An integrated ceRNA network identifies miR-375 as an upregulated miRNA playing a tumor suppressive role in aggressive prostate cancer
Prostate cancer (PCa) remains a significant cause of morbidity and mortality among men worldwide. A number of genes have b...
ScRNA-seq of gastric cancer tissues reveals differences in the immune microenvironment of primary tumors and metastases
ScRNA-seq of gastric cancer tissues reveals differences in the immune microenvironment of primary tumors and metastases
Gastric carcinoma (GC) is regarded as one of the deadliest cancer characterized by diversity and haste metastasis and suff...
Targeting STING elicits GSDMD-dependent pyroptosis and boosts anti-tumor immunity in renal cell carcinoma
Targeting STING elicits GSDMD-dependent pyroptosis and boosts anti-tumor immunity in renal cell carcinoma
While Stimulator-of-interferon genes (STING) is an innate immune adapter cruicial for sensing cytosolic DNA and modulating...
SC912 inhibits AR-V7 activity in castration-resistant prostate cancer by targeting the androgen receptor N-terminal domain
SC912 inhibits AR-V7 activity in castration-resistant prostate cancer by targeting the androgen receptor N-terminal domain
Androgen deprivation therapies (ADT) are the mainstay treatments for castration-resistant prostate cancer (CRPC). ADT supp...
Loss of RNA-binding protein CELF2 promotes acute leukemia development via FAT10-mTORC1
Loss of RNA-binding protein CELF2 promotes acute leukemia development via FAT10-mTORC1
RNA-binding proteins (RBPs) are critical regulators for RNA transcription and translation. As a key member of RBPs, ELAV-l...
Colorectal cancer cells secreting DKK4 transform fibroblasts to promote tumour metastasis
Colorectal cancer cells secreting DKK4 transform fibroblasts to promote tumour metastasis
Wnt/β-catenin signalling is aberrantly activated in most colorectal cancer (CRC) and is one key driver involved in th...
ZEB1 controls a lineage-specific transcriptional program essential for melanoma cell state transitions
ZEB1 controls a lineage-specific transcriptional program essential for melanoma cell state transitions
Cell plasticity sustains intra-tumor heterogeneity and treatment resistance in melanoma. Deciphering the transcriptional m...
RNF126-mediated ubiquitination of FSP1 affects its subcellular localization and ferroptosis
RNF126-mediated ubiquitination of FSP1 affects its subcellular localization and ferroptosis
Medulloblastoma (MB) is a prevalent malignant brain tumor among children, which can be classified into four primary molecu...
E-cadherin interacts with EGFR resulting in hyper-activation of ERK in multiple models of breast cancer
E-cadherin interacts with EGFR resulting in hyper-activation of ERK in multiple models of breast cancer
The loss of intercellular adhesion molecule E-cadherin is a hallmark of the epithelial-mesenchymal transition (EMT), durin...
DHODH inhibition represents a therapeutic strategy and improves abiraterone treatment in castration-resistant prostate cancer
DHODH inhibition represents a therapeutic strategy and improves abiraterone treatment in castration-resistant prostate cancer
Castration-resistant prostate cancer (CRPC) is an aggressive disease with poor prognosis, and there is an urgent need for ...
p53 modulates kinase inhibitor resistance and lineage plasticity in NF1-related MPNSTs
p53 modulates kinase inhibitor resistance and lineage plasticity in NF1-related MPNSTs
Malignant peripheral nerve sheath tumors (MPNSTs) are chemotherapy resistant sarcomas that are a leading cause of death in...
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