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ERK hyperactivation serves as a unified mechanism of escape in intrinsic and acquired CDK4/6 inhibitor resistance in acral lentiginous melanoma
ERK hyperactivation serves as a unified mechanism of escape in intrinsic and acquired CDK4/6 inhibitor resistance in acral lentiginous melanoma
Patients with metastatic acral lentiginous melanoma (ALM) suffer worse outcomes relative to patients with other forms of c...
FOXO3a-regulated arginine metabolic plasticity adaptively promotes esophageal cancer proliferation and metastasis
FOXO3a-regulated arginine metabolic plasticity adaptively promotes esophageal cancer proliferation and metastasis
Esophageal squamous cell carcinoma (ESCC) is a common malignant tumor with a poor prognosis due to a lack of early detecti...
MYCN and SNRPD3 cooperate to maintain a balance of alternative splicing events that drives neuroblastoma progression
MYCN and SNRPD3 cooperate to maintain a balance of alternative splicing events that drives neuroblastoma progression
Many of the pro-tumorigenic functions of the oncogene MYCN are attributed to its regulation of global gene expression prog...
RBM45 reprograms lipid metabolism promoting hepatocellular carcinoma via Rictor and ACSL1/ACSL4
RBM45 reprograms lipid metabolism promoting hepatocellular carcinoma via Rictor and ACSL1/ACSL4
Reprogramming of lipid metabolism during hepatocarcinogenesis is not well elucidated. Here, we aimed to explore pivotal RN...
M7G modification of FTH1 and pri-miR-26a regulates ferroptosis and chemotherapy resistance in osteosarcoma
M7G modification of FTH1 and pri-miR-26a regulates ferroptosis and chemotherapy resistance in osteosarcoma
Doxorubicin and platinum are widely used in the frontline treatment of osteosarcoma, but resistance to chemotherapy limits...
Revealing the tumor suppressive sequence within KL1 domain of the hormone Klotho
Revealing the tumor suppressive sequence within KL1 domain of the hormone Klotho
Klotho, a 1012 amino acid transmembrane protein, is a potent tumor suppressor in different cancer types. Klotho is compose...
UBE2J1 is the E2 ubiquitin-conjugating enzyme regulating androgen receptor degradation and antiandrogen resistance
UBE2J1 is the E2 ubiquitin-conjugating enzyme regulating androgen receptor degradation and antiandrogen resistance
Prostate cancer (PCa) is primarily driven by aberrant Androgen Receptor (AR) signaling. Although there has been substantia...
Functional evaluation of dendritic cells and extracellular vesicles as immunotherapy for breast cancer
Functional evaluation of dendritic cells and extracellular vesicles as immunotherapy for breast cancer
Dendritic cells (DCs) play critical roles in recognizing and presenting antigens to T cells. They secrete dendritic cell-d...
PSMD14 stabilizes estrogen signaling and facilitates breast cancer progression via deubiquitinating ERα
PSMD14 stabilizes estrogen signaling and facilitates breast cancer progression via deubiquitinating ERα
The over-activation of ERα signaling is regarded as the major driver for luminal breast cancers, which could be effec...
The RORɣ/SREBP2 pathway is a master regulator of cholesterol metabolism and serves as potential therapeutic target in t(4;11) leukemia
The RORɣ/SREBP2 pathway is a master regulator of cholesterol metabolism and serves as potential therapeutic target in t(4;11) leukemia
Dysregulated cholesterol homeostasis promotes tumorigenesis and progression. Therefore, metabolic reprogramming constitute...
PRAME induces genomic instability in uveal melanoma
PRAME induces genomic instability in uveal melanoma
PRAME is a CUL2 ubiquitin ligase subunit that is normally expressed in the testis but becomes aberrantly overexpressed in ...
Glucocorticoid treatment influences prostate cancer cell growth and the tumor microenvironment via altered glucocorticoid receptor signaling in prostate fibroblasts
Glucocorticoid treatment influences prostate cancer cell growth and the tumor microenvironment via altered glucocorticoid receptor signaling in prostate fibroblasts
Despite significant therapeutic advances in recent years, treatment of metastatic prostate cancer (PCa) remains palliative...
Correction: DNA polymerase beta modulates cancer progression via enhancing CDH13 expression by promoter demethylation
Correction: DNA polymerase beta modulates cancer progression via enhancing CDH13 expression by promoter demethylation
A Pol β was knocked down in MCF-7 and A549 cells. Western blot analysis of protein levels of Pol β. B, D Representative im...
The DNA/RNA helicase DHX9 orchestrates the KDM2B-mediated transcriptional regulation of YAP1 in Ewing sarcoma
The DNA/RNA helicase DHX9 orchestrates the KDM2B-mediated transcriptional regulation of YAP1 in Ewing sarcoma
Ewing sarcomas (ES) are aggressive paediatric tumours of bone and soft tissues. Resistance to chemotherapy and high propen...
Tumor-mesothelium HOXA11-PDGF BB/TGF β1-miR-181a-5p-Egr1 feedforward amplifier circuity propels mesothelial fibrosis and peritoneal metastasis of gastric cancer
Tumor-mesothelium HOXA11-PDGF BB/TGF β1-miR-181a-5p-Egr1 feedforward amplifier circuity propels mesothelial fibrosis and peritoneal metastasis of gastric cancer
A proportion of gastric cancer (GC) patients suffer from peritoneal metastasis (PM) in the late stage of tumor and these p...
DDR2-regulated arginase activity in ovarian cancer-associated fibroblasts promotes collagen production and tumor progression
DDR2-regulated arginase activity in ovarian cancer-associated fibroblasts promotes collagen production and tumor progression
Ovarian cancer has poor survival outcomes particularly for advanced stage, metastatic disease. Metastasis is promoted by i...
The urothelial gene regulatory network: understanding biology to improve bladder cancer management
The urothelial gene regulatory network: understanding biology to improve bladder cancer management
The urothelium is a stratified epithelium composed of basal cells, one or more layers of intermediate cells, and an upper ...
Selective inhibition of CDK9 in triple negative breast cancer
Selective inhibition of CDK9 in triple negative breast cancer
Targeted therapy for triple-negative breast cancers (TNBC) remains a clinical challenge due to tumour heterogeneity. Since...
Targeting DDX11 promotes PARP inhibitor sensitivity in hepatocellular carcinoma by attenuating BRCA2-RAD51 mediated homologous recombination
Targeting DDX11 promotes PARP inhibitor sensitivity in hepatocellular carcinoma by attenuating BRCA2-RAD51 mediated homologous recombination
Homologous recombination (HR) is a major DNA double-strand break (DSB) repair pathway of clinical interest because of trea...
Dual targeting of MAPK and PI3K pathways unlocks redifferentiation of Braf-mutated thyroid cancer organoids
Dual targeting of MAPK and PI3K pathways unlocks redifferentiation of Braf-mutated thyroid cancer organoids
Thyroid cancer is the most common endocrine malignancy and several genetic events have been described to promote the devel...
Targeting DGAT1 inhibits prostate cancer cells growth by inducing autophagy flux blockage via oxidative stress
Targeting DGAT1 inhibits prostate cancer cells growth by inducing autophagy flux blockage via oxidative stress
Impaired macroautophagy/autophagy flux has been implicated in the treatment of prostate cancer (PCa). However, the mechani...
USP11 potentiates HGF/AKT signaling and drives metastasis in hepatocellular carcinoma
USP11 potentiates HGF/AKT signaling and drives metastasis in hepatocellular carcinoma
USP11 is a member of the ubiquitin-specific protease family and plays a crucial role in tumor progression in various cance...
Correction: MiR-16 mediates trastuzumab and lapatinib response in ErbB-2-positive breast and gastric cancer via its novel targets CCNJ and FUBP1
Correction: MiR-16 mediates trastuzumab and lapatinib response in ErbB-2-positive breast and gastric cancer via its novel targets CCNJ and FUBP1
Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental, CONICET, Buenos Aires...
Correction: RET signalling provides tumorigenic mechanism and tissue specificity for AIP-related somatotrophinomas
Correction: RET signalling provides tumorigenic mechanism and tissue specificity for AIP-related somatotrophinomas
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Low expression of ZFP36L1 in osteosarcoma promotes lung metastasis by inhibiting the SDC4-TGF-β signaling feedback loop
Low expression of ZFP36L1 in osteosarcoma promotes lung metastasis by inhibiting the SDC4-TGF-β signaling feedback loop
ZFP36L1, which is a negative regulator of gene transcripts, has been proven to regulate the progression of several carcino...
Shallow whole genome re-sequencing to precisely predict benefit from PARP inhibitor
DiSilvestro P, Banerjee S, Colombo N, Scambia G, Kim BG, Oaknin A, et al. Overall Survival With Maintenance Olaparib at a ...
Shallow whole genome sequencing approach to detect Homologous Recombination Deficiency in the PAOLA-1/ENGOT-OV25 phase-III trial
Shallow whole genome sequencing approach to detect Homologous Recombination Deficiency in the PAOLA-1/ENGOT-OV25 phase-III trial
The bevacizumab (bev)/olaparib (ola) maintenance regimen was approved for BRCA1/2-mutated (BRCAmut) and Homologous Recombi...
LncRNA MIR31HG fosters stemness malignant features of non-small cell lung cancer via H3K4me1- and H3K27Ace-mediated GLI2 expression
LncRNA MIR31HG fosters stemness malignant features of non-small cell lung cancer via H3K4me1- and H3K27Ace-mediated GLI2 expression
Non-coding RNAs are responsible for oncogenesis and the development of stemness features, including multidrug resistance a...
O-GlcNAcylation of melanophilin enhances radiation resistance in glioblastoma via suppressing TRIM21 mediated ubiquitination
O-GlcNAcylation of melanophilin enhances radiation resistance in glioblastoma via suppressing TRIM21 mediated ubiquitination
The molecular mechanism of glioblastoma (GBM) radiation resistance remains poorly understood. The aim of this study was to...
Regulated secretion of mutant p53 negatively affects T lymphocytes in the tumor microenvironment
Regulated secretion of mutant p53 negatively affects T lymphocytes in the tumor microenvironment
Several studies have demonstrated the role of the oncogenic mutant p53 in promoting tumor progression; however, there is l...
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