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Unveiling RACK1: a key regulator of the PI3K/AKT pathway in prostate cancer development
Unveiling RACK1: a key regulator of the PI3K/AKT pathway in prostate cancer development
The dysregulated PI3K/AKT pathway is pivotal in the onset and progression of various cancers, including prostate cancer. H...
Editorial Expression of Concern: Activation of NF-κB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications
Editorial Expression of Concern to: Oncogene https://doi.org/10.1038/sj.onc.1205664, published online...
Correction: Regucalcin promotes dormancy of prostate cancer
Correction: Regucalcin promotes dormancy of prostate cancer
Authors and AffiliationsDepartment of Cancer Biology, Wake Forest Baptist Medical Center, Winston-Salem, NC, USASambad Sha...
RBM15 facilitates osimertinib resistance of lung adenocarcinoma through m6A-dependent epigenetic silencing of SPOCK1
RBM15 facilitates osimertinib resistance of lung adenocarcinoma through m6A-dependent epigenetic silencing of SPOCK1
Lung cancer is the leading cause of cancer-related mortality globally. N6-methyladenosine (m6A) is the most abundant modif...
Nuclear EGFR in breast cancer suppresses NK cell recruitment and cytotoxicity
Nuclear EGFR in breast cancer suppresses NK cell recruitment and cytotoxicity
Natural Killer (NK) cells can target and destroy cancer cells, yet tumor microenvironments typically suppress NK cell recr...
Spermine oxidase promotes Helicobacter pylori-mediated gastric carcinogenesis through acrolein production
Spermine oxidase promotes Helicobacter pylori-mediated gastric carcinogenesis through acrolein production
Helicobacter pylori is the primary cause of gastric cancer, and there is a need to discover new molecular targets for ther...
Targeting DDX3X eliminates leukemia stem cells in chronic myeloid leukemia by blocking NT5DC2 mRNA translation
Targeting DDX3X eliminates leukemia stem cells in chronic myeloid leukemia by blocking NT5DC2 mRNA translation
Tyrosine kinase inhibitors (TKIs) are highly effective in the treatment of patients with chronic myeloid leukemia (CML), b...
Super-enhancer MYCNOS-SE promotes chemoresistance in small cell lung cancer by recruiting transcription factors CTCF and KLF15
Super-enhancer MYCNOS-SE promotes chemoresistance in small cell lung cancer by recruiting transcription factors CTCF and KLF15
Small cell lung cancer (SCLC) is an aggressive form of lung cancer that often becomes resistant to chemotherapy. Understan...
Enhancing low-dose radiotherapy efficacy with PARP inhibitors via FBL-mediated oxidative stress response in colorectal cancer
Enhancing low-dose radiotherapy efficacy with PARP inhibitors via FBL-mediated oxidative stress response in colorectal cancer
The effectiveness of radiotherapy in colorectal cancer (CRC) relies on its ability to induce cell death via the generation...
The Ku70-SIX1-GPT2 axis regulates alpha-ketoglutarate metabolism to drive progression of prostate cancer
The Ku70-SIX1-GPT2 axis regulates alpha-ketoglutarate metabolism to drive progression of prostate cancer
Sine oculis homeobox homolog 1 (SIX1) is a new identified cancer driver in the development of prostate cancer (PC). Howeve...
Manipulating the EphB4-ephrinB2 axis to reduce metastasis in HNSCC
Manipulating the EphB4-ephrinB2 axis to reduce metastasis in HNSCC
The EphB4-ephrinB2 signaling axis has been heavily implicated in metastasis across numerous cancer types. Our emerging und...
Hypoxia induced cellular and exosomal RPPH1 promotes breast cancer angiogenesis and metastasis through stabilizing the IGF2BP2/FGFR2 axis
Hypoxia induced cellular and exosomal RPPH1 promotes breast cancer angiogenesis and metastasis through stabilizing the IGF2BP2/FGFR2 axis
Metastasis is the major cause of breast cancer mortality, with angiogenesis and tumor-released exosomes playing key roles....
Editorial Expression of Concern: 5-Aza-2′-deoxycytidine and IFN-γ cooperate to sensitize for TRAIL-induced apoptosis by upregulating caspase-8
The Editors-in-Chief would like to alert the readers that concerns have been raised regarding highly ...
Correction: AR loss in prostate cancer stroma mediated by NF-κB and p38-MAPK signaling disrupts stromal morphogen production
Authors and AffiliationsCancer Biology Graduate Interdisciplinary Program, University of Arizona, Tucson, AZ, USAShekha Ta...
Nuclear versus cytoplasmic IKKα signaling in keratinocytes leads to opposite skin phenotypes and inflammatory responses, and a different predisposition to cancer
Nuclear versus cytoplasmic IKKα signaling in keratinocytes leads to opposite skin phenotypes and inflammatory responses, and a different predisposition to cancer
IKKα is known as an essential protein for skin homeostasis. However, the lack of suitable models to investigate its f...
Profiling the cancer-prone microenvironment in a zebrafish model for MPNST
Profiling the cancer-prone microenvironment in a zebrafish model for MPNST
Microenvironmental contributions to soft tissue sarcoma progression are relatively undefined, particularly during sarcoma ...
EphA2 regulates vascular permeability and prostate cancer metastasis via modulation of cell junction protein phosphorylation
EphA2 regulates vascular permeability and prostate cancer metastasis via modulation of cell junction protein phosphorylation
Prostate cancer morbidity and mortality demonstrate a need for more effective targeted therapies. One potential target is ...
Chimeric protein EWS::FLI1 drives cell proliferation in Ewing Sarcoma via aberrant expression of KCNN1/SK1 and dysregulation of calcium signaling
Chimeric protein EWS::FLI1 drives cell proliferation in Ewing Sarcoma via aberrant expression of KCNN1/SK1 and dysregulation of calcium signaling
Ewing sarcoma (ES) is characterized by EWS::FLI1 or EWS::ERG fusion proteins. Knowing that ion channels are involved in tu...
Sex-dependent differences in hematopoietic stem cell aging and leukemogenic potential
Sex-dependent differences in hematopoietic stem cell aging and leukemogenic potential
Sex influences many biological outcomes, but how sex affects hematopoietic stem cell (HSC) aging and hematological disorde...
GPA33 expression in colorectal cancer can be induced by WNT inhibition and targeted by cellular therapy
GPA33 expression in colorectal cancer can be induced by WNT inhibition and targeted by cellular therapy
GPA33 is a promising surface antigen for targeted therapy in colorectal cancer (CRC). It is expressed almost exclusively i...
Methylmalonic acid induces metabolic abnormalities and exhaustion in CD8+ T cells to suppress anti-tumor immunity
Methylmalonic acid induces metabolic abnormalities and exhaustion in CD8+ T cells to suppress anti-tumor immunity
Systemic levels of methylmalonic acid (MMA), a byproduct of propionate metabolism, increase with age and MMA promotes tumo...
Hypoxia-dependent recruitment of error-prone DNA polymerases to genome replication
Hypoxia-dependent recruitment of error-prone DNA polymerases to genome replication
Hypoxia is common in tumors and is associated with cancer progression and drug resistance, driven, at least in part, by ge...
Transcriptional regulation by MYC: an emerging new model
Transcriptional regulation by MYC: an emerging new model
The transcription factor MYC has long been recognized for its pivotal role in transcriptional regulation of genes fundamen...
KRAS-mediated upregulation of CIP2A promotes suppression of PP2A-B56α to initiate pancreatic cancer development
KRAS-mediated upregulation of CIP2A promotes suppression of PP2A-B56α to initiate pancreatic cancer development
Oncogenic mutations in KRAS are present in ~95% of patients diagnosed with pancreatic ductal adenocarcinoma (PDAC) and are...
Zinc ions activate AKT and promote prostate cancer cell proliferation via disrupting AKT intramolecular interaction
Zinc ions activate AKT and promote prostate cancer cell proliferation via disrupting AKT intramolecular interaction
Prostate is a zinc rich organ and the physiological function of the abundant zinc ions is relatively less understood. AKT ...
Dependence of PAX3-FOXO1 chromatin occupancy on ETS1 at important disease-promoting genes exposes new targetable vulnerability in Fusion-Positive Rhabdomyosarcoma
Dependence of PAX3-FOXO1 chromatin occupancy on ETS1 at important disease-promoting genes exposes new targetable vulnerability in Fusion-Positive Rhabdomyosarcoma
Rhabdomyosarcoma (RMS), a malignancy of impaired myogenic differentiation, is the most common soft tissue pediatric cancer...
MAZ promotes tumor proliferation and immune evasion in lung adenocarcinoma
MAZ promotes tumor proliferation and immune evasion in lung adenocarcinoma
Lung adenocarcinoma (LUAD) is the most dominant histological subtype of lung cancer and one of the most lethal malignancie...
IL-17RA/CTSK axis mediates H. pylori-induced castration-resistant prostate cancer growth
IL-17RA/CTSK axis mediates H. pylori-induced castration-resistant prostate cancer growth
In this investigation, we explored the molecular dynamics guiding the progression of castration-resistant prostate cancer ...
Correction: Editorial Expression of Concern: Sensitization for death receptor- or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer
Authors and AffiliationsUniversity Children’s Hospital, Prittwitzstr. 43, D-89075, Ulm, GermanySimone Fulda, Martin U. Kuü...
USP10 drives cancer stemness and enables super-competitor signalling in colorectal cancer
USP10 drives cancer stemness and enables super-competitor signalling in colorectal cancer
The contribution of deubiquitylating enzymes (DUBs) to β-Catenin stabilization in intestinal stem cells and colorecta...
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