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Retraction Note: Genetic alterations of the NRP/B gene are associated with human brain tumors
Authors and AffiliationsDivision of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Institutes of Med...
Correction: Differential effects of JNK1 and JNK2 on signal specific induction of apoptosis
Correction: Differential effects of JNK1 and JNK2 on signal specific induction of apoptosis
Author notesKonrad HochedlingerPresent address: Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge...
Correction to: OSR1 phosphorylates the Smad2/3 linker region and induces TGF-β1 autocrine to promote EMT and metastasis in breast cancer
Authors and AffiliationsDepartment of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of ...
SOX9 drives KRAS-induced lung adenocarcinoma progression and suppresses anti-tumor immunity
SOX9 drives KRAS-induced lung adenocarcinoma progression and suppresses anti-tumor immunity
The SOX9 transcription factor ensures proper tissue development and homeostasis and has been implicated in promoting tumor...
Editorial Expression of Concern: SIRPa1 receptors interfere with the EGFRvIII signalosome to inhibit glioblastoma cell transformation and migration
Authors and AffiliationsDepartment of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, PA, USAG....
A bi-steric mTORC1-selective inhibitor overcomes drug resistance in breast cancer
A bi-steric mTORC1-selective inhibitor overcomes drug resistance in breast cancer
Activation of the PI3K-mTOR pathway is central to breast cancer pathogenesis including resistance to many targeted therapi...
Retraction Note: Mesenchymal stem cells-derived exosomal microRNA-139-5p restrains tumorigenesis in bladder cancer by targeting PRC1
Authors and AffiliationsDepartment of Urology, The Affiliated Hospital of Qingdao University, Qingdao, 266003, PR ChinaYue...
Retraction Note: HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs
Vascular Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, USAH. Zh...
ZNF133 is a potent suppressor in breast carcinogenesis through dampening L1CAM, a driver for tumor progression
ZNF133 is a potent suppressor in breast carcinogenesis through dampening L1CAM, a driver for tumor progression
Due to the complexity and heterogeneity of breast cancer, the therapeutic effects of breast cancer treatment vary between ...
Palmitoyl acyltransferase ZDHHC7 inhibits androgen receptor and suppresses prostate cancer
Palmitoyl acyltransferase ZDHHC7 inhibits androgen receptor and suppresses prostate cancer
The hormonal transcription factor androgen receptor (AR) is a master regulator of prostate cancer (PCa). Protein palmitoyl...
Brg1 controls stemness and metastasis of pancreatic cancer through regulating hypoxia pathway
Brg1 controls stemness and metastasis of pancreatic cancer through regulating hypoxia pathway
Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease. We previously reported that chromatin remodeler Brg1 is ...
A DNA-PK phosphorylation site on MET regulates its signaling interface with the DNA damage response
A DNA-PK phosphorylation site on MET regulates its signaling interface with the DNA damage response
The DNA damage response (DDR) is intertwined with signaling pathways downstream of oncogenic receptor tyrosine kinases (RT...
TRIM25 promotes temozolomide resistance in glioma by regulating oxidative stress and ferroptotic cell death via the ubiquitination of keap1
TRIM25 promotes temozolomide resistance in glioma by regulating oxidative stress and ferroptotic cell death via the ubiquitination of keap1
Resistance to temozolomide (TMZ) remains an important cause of treatment failure in patients with glioblastoma multiforme ...
Correction: Restoring PUMA induction overcomes KRAS-mediated resistance to anti-EGFR antibodies in colorectal cancer
Correction: Restoring PUMA induction overcomes KRAS-mediated resistance to anti-EGFR antibodies in colorectal cancer
UPMC Hillman Cancer Center, Pittsburgh, PA, 15213, USAKyle Knickelbein, Jingshan Tong, Dongshi Chen, Yi-Jun Wang, Jian Yu ...
Protein glycosylation alterations in hepatocellular carcinoma: function and clinical implications
Protein glycosylation alterations in hepatocellular carcinoma: function and clinical implications
Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide. Understanding the cancer mechanisms p...
Vimentin is required for tumor progression and metastasis in a mouse model of non–small cell lung cancer
Vimentin is required for tumor progression and metastasis in a mouse model of non–small cell lung cancer
Vimentin is highly expressed in metastatic cancers, and its expression correlates with poor patient prognoses. However, no...
Glioma immunotherapy enhancement and CD8-specific sialic acid cleavage by isocitrate dehydrogenase (IDH)-1
Glioma immunotherapy enhancement and CD8-specific sialic acid cleavage by isocitrate dehydrogenase (IDH)-1
The promise of adaptive cancer immunotherapy in treating highly malignant tumors such as glioblastoma multiforme (GBM) can...
Targeting MFAP5 in cancer-associated fibroblasts sensitizes pancreatic cancer to PD-L1-based immunochemotherapy via remodeling the matrix
Targeting MFAP5 in cancer-associated fibroblasts sensitizes pancreatic cancer to PD-L1-based immunochemotherapy via remodeling the matrix
Highly desmoplastic and immunosuppressive tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDAC) contribu...
EZH2-Myc driven glioblastoma elicited by cytomegalovirus infection of human astrocytes
EZH2-Myc driven glioblastoma elicited by cytomegalovirus infection of human astrocytes
Mounting evidence is identifying human cytomegalovirus (HCMV) as a potential oncogenic virus. HCMV has been detected in ma...
m6A methylation regulates hypoxia-induced pancreatic cancer glycolytic metabolism through ALKBH5-HDAC4-HIF1α positive feedback loop
m6A methylation regulates hypoxia-induced pancreatic cancer glycolytic metabolism through ALKBH5-HDAC4-HIF1α positive feedback loop
Pancreatic cancer (PC) is the most hypoxic cancer type among solid tumors. The dynamic changes of RNA N6-methyl-adenosine ...
New perspectives for targeting therapy in ALK-positive human cancers
New perspectives for targeting therapy in ALK-positive human cancers
Anaplastic lymphoma kinase (ALK) is a member of the insulin receptor protein-tyrosine kinase superfamily and was first dis...
RNF125 attenuates hepatocellular carcinoma progression by downregulating SRSF1-ERK pathway
RNF125 attenuates hepatocellular carcinoma progression by downregulating SRSF1-ERK pathway
Hepatocellular carcinoma (HCC) is one of the most deadly malignant cancers worldwide. Research into the crucial genes resp...
Peritoneal high-fat environment promotes peritoneal metastasis of gastric cancer cells through activation of NSUN2-mediated ORAI2 m5C modification
Peritoneal high-fat environment promotes peritoneal metastasis of gastric cancer cells through activation of NSUN2-mediated ORAI2 m5C modification
Peritoneal metastasis (PM) is an important metastatic modality of gastric cancer (GC).It is associated with poor prognosis...
Biological and clinical implications of FGFR aberrations in paediatric and young adult cancers
Biological and clinical implications of FGFR aberrations in paediatric and young adult cancers
Rare but recurrent mutations in the fibroblast growth factor receptor (FGFR) pathways, most commonly in one of the four FG...
Glutathione peroxidase 2 knockdown suppresses gastric cancer progression and metastasis via regulation of kynurenine metabolism
Glutathione peroxidase 2 knockdown suppresses gastric cancer progression and metastasis via regulation of kynurenine metabolism
Gastric cancer (GC) is among the most lethal malignancies due to its poor early diagnosis and high metastasis rate, and ne...
mTOR inhibition suppresses Myc-driven polyposis by inducing immunogenic cell death
mTOR inhibition suppresses Myc-driven polyposis by inducing immunogenic cell death
Myc is a key driver of colorectal cancer initiation and progression, but remains a difficult drug target. In this study, w...
DNMT3AR882H accelerates angioimmunoblastic T-cell lymphoma in mice
DNMT3AR882H accelerates angioimmunoblastic T-cell lymphoma in mice
DNA methylation-related genes, including TET2, IDH2, and DNMT3A are highly frequently mutated in angioimmunoblastic T-cell...
A novel integrated approach to predicting cancer immunotherapy efficacy
A novel integrated approach to predicting cancer immunotherapy efficacy
Immunotherapies have revolutionized cancer treatment modalities; however, predicting clinical response accurately and reli...
TYMS promotes genomic instability and tumor progression in Ink4a/Arf null background
TYMS promotes genomic instability and tumor progression in Ink4a/Arf null background
We previously showed that elevated TYMS exhibits oncogenic properties and promotes tumorigenesis after a long latency, sug...
Correction: The ELF3-regulated lncRNA UBE2CP3 is over-stabilized by RNA–RNA interactions and drives gastric cancer metastasis via miR-138-5p/ITGA2 axis
Correction: The ELF3-regulated lncRNA UBE2CP3 is over-stabilized by RNA–RNA interactions and drives gastric cancer metastasis via miR-138-5p/ITGA2 axis
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
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