SCI时时刷

search
+
Phosphorylation of USP27X by PIM2 promotes glycolysis and breast cancer progression via deubiquitylation of MYC
Phosphorylation of USP27X by PIM2 promotes glycolysis and breast cancer progression via deubiquitylation of MYC
Aberrant cell proliferation is a hallmark of cancer, including breast cancer. Here, we show that USP27X is required for ce...
GSTO1 aggravates EGFR-TKIs resistance and tumor metastasis via deglutathionylation of NPM1 in lung adenocarcinoma
GSTO1 aggravates EGFR-TKIs resistance and tumor metastasis via deglutathionylation of NPM1 in lung adenocarcinoma
Despite significantly improved clinical outcomes in EGFR-mutant lung adenocarcinoma, all patients develop acquired resista...
PIM1/NF-κB/CCL2 blockade enhances anti-PD-1 therapy response by modulating macrophage infiltration and polarization in tumor microenvironment of NSCLC
PIM1/NF-κB/CCL2 blockade enhances anti-PD-1 therapy response by modulating macrophage infiltration and polarization in tumor microenvironment of NSCLC
Elevated infiltration of tumor-associated macrophages (TAMs) drives tumor progression and correlates with poor prognosis f...
Correction: Colorectal cancer cells secreting DKK4 transform fibroblasts to promote tumour metastasis
Correction: Colorectal cancer cells secreting DKK4 transform fibroblasts to promote tumour metastasis
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Editorial Expression of Concern: Deacetylation of cortactin by SIRT1 promotes cell migration
Editorial Expression of Concern to: OncogeneThe Editors-in-Chief would like to alert readers that after publication of thi...
Correction: Regulation of cancer stem cell activity by thyroid hormone receptor β
Authors and AffiliationsLaboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National I...
N6-methyladenosine modified circPAK2 promotes lymph node metastasis via targeting IGF2BPs/VEGFA signaling in gastric cancer
N6-methyladenosine modified circPAK2 promotes lymph node metastasis via targeting IGF2BPs/VEGFA signaling in gastric cancer
Circular RNAs (circRNAs) have emerged as key regulators of cancer occurrence and progression, as well as promising biomark...
GDNF-induced phosphorylation of MUC21 promotes pancreatic cancer perineural invasion and metastasis by activating RAC2 GTPase
GDNF-induced phosphorylation of MUC21 promotes pancreatic cancer perineural invasion and metastasis by activating RAC2 GTPase
Perineural invasion (PNI) is an adverse prognostic feature of pancreatic ductal adenocarcinoma (PDAC). However, the unders...
Editorial Expression of Concern: Cytotoxic drug-induced, p53-mediated upregulation of caspase-8 in tumor cells
Authors and AffiliationsDepartment of Oncology/Hematology, Dr von Haunersches Kinderspital, München, GermanyH. Ehrhardt, S...
Differential transcriptional invasion signatures from patient derived organoid models define a functional prognostic tool for head and neck cancer
Differential transcriptional invasion signatures from patient derived organoid models define a functional prognostic tool for head and neck cancer
Clinical outcome for patients suffering from HPV-negative head and neck squamous cell carcinoma (HNSCC) remains poor. This...
Retraction Note: The molecular mechanism of microRNA-145 to suppress invasion-metastasis cascade in gastric cancer
Author notesThese authors contributed equally: P. Gao, A.-Y. Xing.Authors and AffiliationsDepartment of Pathology, Qilu Ho...
Estrogen-related receptor alpha promotes thyroid tumor cell survival via a tumor subtype-specific regulation of target gene networks
Estrogen-related receptor alpha promotes thyroid tumor cell survival via a tumor subtype-specific regulation of target gene networks
Mortalin (encoded by HSPA9) is a mitochondrial chaperone often overexpressed in cancer through as-yet-unknown mechanisms. ...
Evaluation of the gene fusion landscape in early onset sporadic rectal cancer reveals association with chromatin architecture and genome stability
Evaluation of the gene fusion landscape in early onset sporadic rectal cancer reveals association with chromatin architecture and genome stability
Gene fusions represent a distinct class of structural variants identified frequently in cancer genomes across cancer types...
N6-methyladenosine modified TGFB2 triggers lipid metabolism reprogramming to confer pancreatic ductal adenocarcinoma gemcitabine resistance
N6-methyladenosine modified TGFB2 triggers lipid metabolism reprogramming to confer pancreatic ductal adenocarcinoma gemcitabine resistance
Gemcitabine resistance is a major obstacle to the effectiveness of chemotherapy in pancreatic ductal adenocarcinoma (PDAC)...
TP53 somatic evolution in cervical liquid-based cytology and blood from individuals with and without ovarian cancer and BRCA1 or BRCA2 germline mutations
TP53 somatic evolution in cervical liquid-based cytology and blood from individuals with and without ovarian cancer and BRCA1 or BRCA2 germline mutations
Somatic TP53 mutations are prevalent in normal tissue but little is known about their association with cancer risk. Cervic...
Notch3-regulated microRNAs impair CXCR4-dependent maturation of thymocytes allowing maintenance and progression of T-ALL
Notch3-regulated microRNAs impair CXCR4-dependent maturation of thymocytes allowing maintenance and progression of T-ALL
Malignant transformation of T-cell progenitors causes T-cell acute lymphoblastic leukemia (T-ALL), an aggressive childhood...
Retraction Note: Mechanism of leptin expression in breast cancer cells: role of hypoxia-inducible factor-1α
Author notesThese two authors contributed equally to this work S. Cascio, V. Bartella.Authors and AffiliationsSbarro Insti...
Correction: Transactivation of human endogenous retrovirus K (HERV-K) by KSHV promotes Kaposi’s sarcoma development
Correction: Transactivation of human endogenous retrovirus K (HERV-K) by KSHV promotes Kaposi’s sarcoma development
Department of Genetics, Louisiana State University Health Sciences Center, Louisiana Cancer Research Center, 1700 Tulane A...
Tumor-resident microbiota contributes to colorectal cancer liver metastasis by lactylation and immune modulation
Tumor-resident microbiota contributes to colorectal cancer liver metastasis by lactylation and immune modulation
The role of tumor-resident microbiota in modulating tumor immunity remains unclear. Here, we discovered an abundance of in...
Role of gut microbiota in the pathogenesis of castration-resistant prostate cancer: a comprehensive study using sequencing and animal models
Role of gut microbiota in the pathogenesis of castration-resistant prostate cancer: a comprehensive study using sequencing and animal models
CRPC remains a significant challenge in prostate cancer research. We aimed to elucidate the role of gut microbiota and its...
Impact of structural biology and the protein data bank on us fda new drug approvals of low molecular weight antineoplastic agents 2019–2023
Impact of structural biology and the protein data bank on us fda new drug approvals of low molecular weight antineoplastic agents 2019–2023
Open access to three-dimensional atomic-level biostructure information from the Protein Data Bank (PDB) facilitated discov...
Plexin D1 emerges as a novel target in the development of neural lineage plasticity in treatment-resistant prostate cancer
Plexin D1 emerges as a novel target in the development of neural lineage plasticity in treatment-resistant prostate cancer
Treatment-induced neuroendocrine prostate cancer (t-NEPC) often arises from adenocarcinoma via lineage plasticity in respo...
METTL3-mediated N6-methyladenosine modification of STAT5A promotes gastric cancer progression by regulating KLF4
METTL3-mediated N6-methyladenosine modification of STAT5A promotes gastric cancer progression by regulating KLF4
N6-methyladenosine (m6A) is the predominant post-transcriptional RNA modification in eukaryotes and plays a pivotal regula...
Environmental monobutyl phthalate exposure promotes liver cancer via reprogrammed cholesterol metabolism and activation of the IRE1α-XBP1s pathway
Environmental monobutyl phthalate exposure promotes liver cancer via reprogrammed cholesterol metabolism and activation of the IRE1α-XBP1s pathway
Humans are widely exposed to phthalates, a major chemical plasticizer that accumulates in the liver. However, little is kn...
MLK3 promotes prooncogenic signaling in hepatocellular carcinoma via TGFβ pathway
MLK3 promotes prooncogenic signaling in hepatocellular carcinoma via TGFβ pathway
Advanced hepatocellular carcinoma (HCC) is a lethal disease, with limited therapeutic options. Mixed Lineage Kinase 3 (MLK...
Distinguishing high-metastasis-potential circulating tumor cells through fluidic shear stress in a bloodstream-like microfluidic circulatory system
Distinguishing high-metastasis-potential circulating tumor cells through fluidic shear stress in a bloodstream-like microfluidic circulatory system
Circulating tumor cells (CTCs) play a critical role as initiators in tumor metastasis, which unlocks an irreversible proce...
Editorial Expression of Concern: Biologic sequelae of interleukin-6 induced PI3-K/Akt signaling in multiple myeloma
Authors and AffiliationsJerome Lipper Multiple Myeloma Center, Department of Adult Oncology, Dana-Farber Cancer Institute,...
Correction: Interaction between STAT3 and GLI1/tGLI1 oncogenic transcription factors promotes the aggressiveness of triple-negative breast cancers and HER2-enriched breast cancer
Correction: Interaction between STAT3 and GLI1/tGLI1 oncogenic transcription factors promotes the aggressiveness of triple-negative breast cancers and HER2-enriched breast cancer
Authors and AffiliationsDepartment of Cancer Biology, Winston-Salem, NC, USASherona R. Sirkisoon, Richard L. Carpenter, Ta...
Clustering single-cell RNA sequencing data via iterative smoothing and self-supervised discriminative embedding
Clustering single-cell RNA sequencing data via iterative smoothing and self-supervised discriminative embedding
Single-cell transcriptome sequencing (scRNA-seq) is a high-throughput technique used to study gene expression at the singl...
Correction: Targeting STAT3 by a small molecule suppresses pancreatic cancer progression
Correction: Targeting STAT3 by a small molecule suppresses pancreatic cancer progression
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
阅读更多
format_indent_increase