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Repurposing promethazine hydrochloride to inhibit biofilm formation against Burkholderia thailandensis
Repurposing promethazine hydrochloride to inhibit biofilm formation against Burkholderia thailandensis
Melioidosis is a severe infectious disease caused by Burkholderia pseudomallei, an intracellular pathogen with a high mort...
Serotype distribution, antibiotic resistance, multilocus sequence typing, and virulence factors of invasive and non-invasive Streptococcus pneumoniae in Northeast China from 2000 to 2021
Serotype distribution, antibiotic resistance, multilocus sequence typing, and virulence factors of invasive and non-invasive Streptococcus pneumoniae in Northeast China from 2000 to 2021
Streptococcus pneumoniae infection is a major public health concern with high morbidity and mortality rates. This study ai...
Alteration of β-glucan in the emerging fungal pathogen Candida auris leads to immune evasion and increased virulence
Alteration of β-glucan in the emerging fungal pathogen Candida auris leads to immune evasion and increased virulence
Candida auris is an emerging pathogenic yeast that has been categorized as a global public health threat and a critical pr...
Exploring the potential of Lactocaseibacillus rhamnosus PMC203 in inducing autophagy to reduce the burden of Mycobacterium tuberculosis
Exploring the potential of Lactocaseibacillus rhamnosus PMC203 in inducing autophagy to reduce the burden of Mycobacterium tuberculosis
Mycobacterium tuberculosis, a lethal pathogen in human history, causes millions of deaths annually, which demands the deve...
Identification of homologs of the Chlamydia trachomatis effector CteG reveals a family of Chlamydiaceae type III secreted proteins that can be delivered into host cells
Identification of homologs of the Chlamydia trachomatis effector CteG reveals a family of Chlamydiaceae type III secreted proteins that can be delivered into host cells
Chlamydiae are a large group of obligate endosymbionts of eukaryotes that includes the Chlamydiaceae family, comprising se...
Effects of acetate-producing Blautia wexlerae on oxidative stress and NLRP3 inflammasome in obesity-associated male infertility
Effects of acetate-producing Blautia wexlerae on oxidative stress and NLRP3 inflammasome in obesity-associated male infertility
Background: Obesity-associated male infertility is a common complication of obesity and has been increasing in prevalence....
Lysozyme: an endogenous antimicrobial protein with potent activity against extracellular, but not intracellular Mycobacterium tuberculosis
Lysozyme: an endogenous antimicrobial protein with potent activity against extracellular, but not intracellular Mycobacterium tuberculosis
Endogenous antimicrobial peptides (AMPs) play a key role in the host defense against pathogens. AMPs attack pathogens pref...
Lipopolysaccharide with long O-antigen is crucial for Salmonella Enteritidis to evade complement activity and to facilitate bacterial survival in vivo in the Galleria mellonella infection model
Lipopolysaccharide with long O-antigen is crucial for Salmonella Enteritidis to evade complement activity and to facilitate bacterial survival in vivo in the Galleria mellonella infection model
Bacterial resistance to serum is a key virulence factor for the development of systemic infections. The amount of lipopoly...
One-dose intradermal rabies booster enhances rabies antibody production and avidity maturation
One-dose intradermal rabies booster enhances rabies antibody production and avidity maturation
The incidence of rabies in Thailand reached its peak in 2018 with 18 human deaths. Preexposure prophylaxis (PrEP) vaccinat...
Quantitative assay to analyze neutralization and inhibition of authentic Middle East respiratory syndrome coronavirus
Quantitative assay to analyze neutralization and inhibition of authentic Middle East respiratory syndrome coronavirus
To date, there is no licensed vaccine for Middle East respiratory syndrome coronavirus (MERS-CoV). Therefore, MERS-CoV is ...
Understanding host–pathogen interaction: paving the path for individualized anti-infective therapy
Understanding host–pathogen interaction: paving the path for individualized anti-infective therapy
In the COVID-19 pandemic, we were challenged by the spread of SARS-CoV2, a virus not ...
Topical application of ozonated sunflower oil accelerates the healing of lesions of cutaneous leishmaniasis in mice under meglumine antimoniate treatment
Topical application of ozonated sunflower oil accelerates the healing of lesions of cutaneous leishmaniasis in mice under meglumine antimoniate treatment
Besides being scarce, the drugs available for treating cutaneous leishmaniasis have many adverse effects. Ozone is an opti...
The Moraxella catarrhalis AdhC–FghA system is important for formaldehyde detoxification and protection against pulmonary clearance
The Moraxella catarrhalis AdhC–FghA system is important for formaldehyde detoxification and protection against pulmonary clearance
Multidrug-resistant clinical isolates of Moraxella catarrhalis have emerged, increasing the demand for the identification ...
Inflammation, the kynurenines, and mucosal injury during human experimental enterotoxigenic Escherichia coli infection
Inflammation, the kynurenines, and mucosal injury during human experimental enterotoxigenic Escherichia coli infection
Enterotoxigenic Escherichia coli (ETEC) is an important cause of diarrhea in children and travelers, especially in low- an...
Advances in the understanding of circRNAs that influence viral replication in host cells
Advances in the understanding of circRNAs that influence viral replication in host cells
Circular RNAs (circRNAs) are non-coding RNAs discovered in recent years, which are produced by back-splicing involving the...
Echinacoside, a promising sortase A inhibitor, combined with vancomycin against murine models of MRSA-induced pneumonia
Echinacoside, a promising sortase A inhibitor, combined with vancomycin against murine models of MRSA-induced pneumonia
Methicillin-resistant Staphylococcus aureus (MRSA) is a pathogenic bacterium responsible for a range of severe infections,...
Expression of mammalian cell entry genes in clinical isolates of M. tuberculosis and the cell entry potential and immunological reactivity of the Rv0590A protein
Expression of mammalian cell entry genes in clinical isolates of M. tuberculosis and the cell entry potential and immunological reactivity of the Rv0590A protein
Mammalian cell entry (mce) operons play a vital role in cell invasion and survival of M. tuberculosis. Of the mce genes, t...
Comparative genotyping of SARS-CoV-2 among Egyptian patients: near-full length genomic sequences versus selected spike and nucleocapsid regions
Comparative genotyping of SARS-CoV-2 among Egyptian patients: near-full length genomic sequences versus selected spike and nucleocapsid regions
Several tools have been developed for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) genotyping based on eit...
Prediction of outcome using CD14++CD16−, CD14++CD16+ and CD14+CD16++ monocyte subpopulations in patients with complicated intra-abdominal infections
Prediction of outcome using CD14++CD16−, CD14++CD16+ and CD14+CD16++ monocyte subpopulations in patients with complicated intra-abdominal infections
There is still no study investigating the prognostic performance of CD14++CD16−, CD14++CD16+ and CD14+CD16++ monocyt...
Eicosapentaenoic acid influences the pathogenesis of Candida albicans in Caenorhabditis elegans via inhibition of hyphal formation and stimulation of the host immune response
Eicosapentaenoic acid influences the pathogenesis of Candida albicans in Caenorhabditis elegans via inhibition of hyphal formation and stimulation of the host immune response
The intake of omega-3 polyunsaturated fatty acids, including eicosapentaenoic acid (EPA), is associated with health benefi...
Histone methyltransferase SETD2 inhibits M1 macrophage polarization and glycolysis by suppressing HIF-1α in sepsis-induced acute lung injury
Histone methyltransferase SETD2 inhibits M1 macrophage polarization and glycolysis by suppressing HIF-1α in sepsis-induced acute lung injury
Sepsis is a severe syndrome caused by the imbalance of the host response to infection, accompanied by multiple organ damag...
CD146 deficiency promotes inflammatory type 2 responses in pulmonary cryptococcosis
CD146 deficiency promotes inflammatory type 2 responses in pulmonary cryptococcosis
Cryptococcus neoformans (C. neoformans) is an important opportunistic fungal pathogen for pulmonary cryptococcosis. Previo...
Automated antigen assays display a high heterogeneity for the detection of SARS-CoV-2 variants of concern, including several Omicron sublineages
Automated antigen assays display a high heterogeneity for the detection of SARS-CoV-2 variants of concern, including several Omicron sublineages
Diagnostic tests for direct pathogen detection have been instrumental to contain the severe acute respiratory syndrome cor...
Ten rapid antigen tests for SARS-CoV-2 widely differ in their ability to detect Omicron-BA.4 and -BA.5
Ten rapid antigen tests for SARS-CoV-2 widely differ in their ability to detect Omicron-BA.4 and -BA.5
Since late 2021, the variant landscape of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been domina...
COVID-19 recurrence is related to disease-early profile T cells while detection of anti-S1 IgG is related to multifunctional T cells
COVID-19 recurrence is related to disease-early profile T cells while detection of anti-S1 IgG is related to multifunctional T cells
COVID-19 is caused by SARS-CoV-2 infection and leads from asymptomatic to severe outcomes. The recurrence of the COVID-19 ...
Antibody Fc-binding profiles and ACE2 affinity to SARS-CoV-2 RBD variants
Antibody Fc-binding profiles and ACE2 affinity to SARS-CoV-2 RBD variants
Emerging SARS-CoV-2 variants, notably Omicron, continue to remain a formidable challenge to worldwide public health. The S...
Correction to: Picking up speed: cell cycle regulation during effector CD8+ T cell differentiation
Correction to: Picking up speed: cell cycle regulation during effector CD8+ T cell differentiation
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Association of IFIH1 and DDX58 genes polymorphism with susceptibility to COVID-19
Association of IFIH1 and DDX58 genes polymorphism with susceptibility to COVID-19
Pattern recognition receptors of the innate immune system, such as RIG-I and MDA5, are responsible for recognizing viruses...
Innate immune response in patients with acute Chikungunya disease
Innate immune response in patients with acute Chikungunya disease
Chikungunya disease (CHIKD) is an arbovirose that presents with high morbidity, mainly due to arthralgia. Inflammatory med...
Picking up speed: cell cycle regulation during effector CD8+ T cell differentiation
Picking up speed: cell cycle regulation during effector CD8+ T cell differentiation
Clonal expansion and development of immunological memory are two hallmarks of adaptive immune responses. Resolving the int...
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