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ftr82 is necessary for hair cell morphogenesis and auditory function during zebrafish development
Sensory hair cell (HC) damages are usually responsible for sensorineural hearing loss (Wagner and Shin, 2019; Guo et al., ...
Landscape of the intratumroal microenvironment in bladder cancer: Implications for prognosis and immunotherapy
Available online 1 December 2022Author links open overlay panelHighlights:•Our study presents the landscape of intratumora...
Evaluating GPCR modeling and docking strategies in the era of deep learning-based protein structure prediction
Available online 1 December 2022Author links open overlay panelAbstractWhile deep learning (DL) has brought a revolution i...
CapsNh-Kcr: capsule network-based prediction of lysine crotonylation sites in human non-histone proteins
Lysine crotonylation (Kcr) is one of the most important post-translational modifications (PTMs) that is widely detected in...
ChEAP: ChIP-exo Analysis Pipeline and the investigation of Escherichia coli RpoN protein-DNA interactions
Available online 2 December 2022Author links open overlay panelAbstractGenome-scale studies of the bacterial regulatory ne...
A new nano hyperbranched β-pinene polymer: Controlled synthesis and nonviral gene delivery
Recently, an extensive research effort has been directed toward the improvement of nonviral transfection vectors, such as ...
Porous silicon surface modification via a microwave-induced in situ cyclic disulfide (S-S) cleavage and Si-S bond formation
Porous silicon (pSi) materials have gained a great deal of attention from various research fields, and their surface-funct...
Computational investigation of functional water molecules in GPCRs bound to G protein or arrestin
Computational investigation of functional water molecules in GPCRs bound to G protein or arrestin
G protein-coupled receptors (GPCRs) are membrane proteins constituting the largest family of drug targets. The activated G...
Active-site cysteine 215 sulfonation targets protein tyrosine phosphatase PTP1B for Cullin1 E3 ligase-mediated degradation
Living organisms utilize oxygen to maintain the cellular homeostasis throughout their lifespan. A unique feature of oxygen...
PGCLCs of human 45,XO reveal pathogenetic pathways of neurocognitive and psychosocial disorders
PGCLCs of human 45,XO reveal pathogenetic pathways of neurocognitive and psychosocial disorders
Neurocognitive disorders and psychosocial difficulties are common in patients with Turner syndrome and multiple neurodegen...
Mechanosensitive piezo1 calcium channel activates connexin 43 hemichannels through PI3K signaling pathway in bone
Mechanosensitive piezo1 calcium channel activates connexin 43 hemichannels through PI3K signaling pathway in bone
Mechanical loading promotes bone formation and osteocytes are a major mechanosensory cell in the bone. Both Piezo1 channel...
MicroRNA-378a-3p prevents initiation and growth of colorectal cancer by fine tuning polyamine synthesis
MicroRNA-378a-3p prevents initiation and growth of colorectal cancer by fine tuning polyamine synthesis
Inhibitors of ornithine decarboxylase (ODC) are effective at preventing colorectal cancer (CRC). However, their high toxic...
A synthetic pregnenolone analog promotes microtubule dynamics and neural development
A synthetic pregnenolone analog promotes microtubule dynamics and neural development
Pregnenolone (P5) is a neurosteroid that promotes microtubule polymerization. It also reduces stress and negative symptoms...
Proteomic signatures of schizophrenia-sourced iPSC-derived neural cells and brain organoids are similar to patients' postmortem brains
Proteomic signatures of schizophrenia-sourced iPSC-derived neural cells and brain organoids are similar to patients' postmortem brains
Schizophrenia is a complex and severe neuropsychiatric disorder, with a wide range of debilitating symptoms. Several aspec...