SCI时时刷

search
+
CAB39 promotes cisplatin resistance in bladder cancer via the LKB1-AMPK-LC3 pathway
CAB39 promotes cisplatin resistance in bladder cancer via the LKB1-AMPK-LC3 pathway
Bladder cancer (BC) is a prevalent malignant tumor that accounts for nearly 170,000 deaths worldwide [1]. Over the past de...
Exhaustive exercise alters native and site-specific H2O2 emission in red and white skeletal muscle mitochondria
Exhaustive exercise alters native and site-specific H2O2 emission in red and white skeletal muscle mitochondria
The metabolic rate of skeletal muscle increases by more than an order of magnitude during contraction [1,2] and therefore ...
Extracellular pyruvate kinase M2 induces cell migration through p-Tyr42 RhoA-mediated superoxide generation and epithelial-mesenchymal transition
Extracellular pyruvate kinase M2 induces cell migration through p-Tyr42 RhoA-mediated superoxide generation and epithelial-mesenchymal transition
Cancer is the leading cause of mortality worldwide [1], and its metastasis is a more critical factor for mortality than th...
Kaempferol stimulation of autophagy regulates the ferroptosis under the oxidative stress as mediated with AMP-activated protein kinase
Kaempferol stimulation of autophagy regulates the ferroptosis under the oxidative stress as mediated with AMP-activated protein kinase
The liver is an indispensable organ in the human body that helps with metabolism, nutrient storage, and detoxification in ...
NECAB2 is an endosomal protein important for striatal function
NECAB2 is an endosomal protein important for striatal function
The striatum is an important brain structure involved in motor and action planning, decision-making, motivation and reward...
Mitochondria pleiotropism in stem cell senescence: Mechanisms and therapeutic approaches
Mitochondria pleiotropism in stem cell senescence: Mechanisms and therapeutic approaches
Aging is a complex and inevitable process that affects all multicellular organisms. It is characterized by the progressive...
Pre-harvest supplemental LED treatments led to improved postharvest quality of sweet basil leaves
Pre-harvest supplemental LED treatments led to improved postharvest quality of sweet basil leaves
Plants with a high content of secondary metabolites are a focus of study due to their ability to prevent multiple diseases...
Sodium Tanshinone IIA Sulfonate Ameliorates Oxygen-glucose Deprivation/Reoxygenation-induced Neuronal Injury via Protection of Mitochondria and Promotion of Autophagy
Sodium Tanshinone IIA Sulfonate Ameliorates Oxygen-glucose Deprivation/Reoxygenation-induced Neuronal Injury via Protection of Mitochondria and Promotion of Autophagy
Sodium tanshinone IIA sulfonate (STS) has shown significant clinical therapeutic effects in cerebral ischemic stroke (CIS)...
The Dopaminergic System Modulates the Electrophysiological Activity of the Suprachiasmatic Nucleus Dependent on the Circadian Cycle
The Dopaminergic System Modulates the Electrophysiological Activity of the Suprachiasmatic Nucleus Dependent on the Circadian Cycle
The suprachiasmatic nucleus of the hypothalamus (SCN) controls mammalian circadian rhythms. Circadian rhythms influence th...
Capsaicin, The Vanilloid Receptor TRPV1 Agonist in Neuroprotection: Mechanisms Involved and Significance
Capsaicin, The Vanilloid Receptor TRPV1 Agonist in Neuroprotection: Mechanisms Involved and Significance
Hot peppers, also called chilli, chilli pepper, or paprika of the plant genus Capsicum (family Solanaceae), are one of the...
Flavonoids in Combination with Stem Cells for the Treatment of Neurological Disorders
Flavonoids in Combination with Stem Cells for the Treatment of Neurological Disorders
Neurological disorders are the leading cause of disability and the world's second leading cause of death. Despite the ...
LncRNA MALAT1 Promoted Neuronal Necroptosis in Cerebral Ischemia-reperfusion Mice by Stabilizing HSP90
LncRNA MALAT1 Promoted Neuronal Necroptosis in Cerebral Ischemia-reperfusion Mice by Stabilizing HSP90
The objective of this research was to investigate the role of lncRNA MALAT1 and HSP90 in the regulation of neuronal necrop...
Characterization of a (p)ppApp synthetase belonging to a new family of polymorphic toxin associated with temperate phages
Characterization of a (p)ppApp synthetase belonging to a new family of polymorphic toxin associated with temperate phages
Polygonum Cuspidate (P. cuspidatum) is a traditional topical preparation of Chinese medicine. The aim of this study was to...
An Innate Host Defense Protein; β2-Microglobulin Keeps a Check on α-Synuclein Amyloid Assembly: Implications in Parkinson's disease
An Innate Host Defense Protein; β2-Microglobulin Keeps a Check on α-Synuclein Amyloid Assembly: Implications in Parkinson's disease
Most proteins fold into well-defined 3D structures through a controlled mechanism of protein homeostasis governed by an ex...
Metal-ruthenium complex based on dipyridylamine group as membrane-active antibacterial agent effectively decrease the development of drug-resistance on Staphylococcus aureus
Metal-ruthenium complex based on dipyridylamine group as membrane-active antibacterial agent effectively decrease the development of drug-resistance on Staphylococcus aureus
Bacterial resistance is a major problem caused by the overuse of antibiotics. The main causes of antimicrobial resistance ...
Empowering peptidomics: utilizing computational tools and approaches
Empowering peptidomics: utilizing computational tools and approaches
Bioinformatics plays a critical role in the advancement of peptidomics by providing powerful tools for data analysis, inte...
13C NMR-based dereplication using MixONat software to decipher potent anti-cholinesterase compounds in Mesua lepidota bark
13C NMR-based dereplication using MixONat software to decipher potent anti-cholinesterase compounds in Mesua lepidota bark
Alzheimer’s disease (AD) is a devastating neurodegenerative disorder that accounts for more than 80% of age-related dement...
Analysis of the Glycoprotein Properties and Glycan Structures of Chicken Angiotensin Converting Enzyme 2
Analysis of the Glycoprotein Properties and Glycan Structures of Chicken Angiotensin Converting Enzyme 2
Glycosylation of angiotensin converting enzyme 2 (ACE2), the principal receptor protein of severe scute respiratory syndro...
LncRNA LINC01123 promotes malignancy of ovarian cancer by targeting hsa-miR-516b-5p/VEGFA
LncRNA LINC01123 promotes malignancy of ovarian cancer by targeting hsa-miR-516b-5p/VEGFA
Long non-coding RNAs (lncRNAs) play a critical role in the development of ovarian cancer (OC). The study aimed to determin...
Proline provides a nitrogen source in the retinal pigment epithelium to synthesize and export amino acids for the neural retina
Proline provides a nitrogen source in the retinal pigment epithelium to synthesize and export amino acids for the neural retina
Keywordsretinaretinal pigment epitheliumnitrogenammoniumglutamineaspartatealanineleucinetransaminaseAbbreviationRPEretinal...
A Real-Time Analysis of Protein Transport via the Twin Arginine Translocation Pathway in Response to Different Components of the Protonmotive Force
A Real-Time Analysis of Protein Transport via the Twin Arginine Translocation Pathway in Response to Different Components of the Protonmotive Force
Research Article Collection: BioenergeticsA Real-Time Analysis of Protein Transport via the Twin Arginine Translocation Pa...
A novel phosphorylation site involved in dissociating RAF kinase from the scaffolding protein 14-3-3 and disrupting RAF dimerization
A novel phosphorylation site involved in dissociating RAF kinase from the scaffolding protein 14-3-3 and disrupting RAF dimerization
KeywordsphosphorylationRAF kinase14-3-3scaffolding proteincancerdimerizationATP-competitive inhibitorparadoxical activatio...
Caffeine causes cell cycle arrest at G0/G1 and increases of ubiquitinated proteins, ATP and mitochondrial membrane potential in renal cells
Caffeine causes cell cycle arrest at G0/G1 and increases of ubiquitinated proteins, ATP and mitochondrial membrane potential in renal cells
Available online 21 September 2023Author links open overlay panel, , , Highlights•From 936 proteins identified, caffeine i...
Biological informed graph neural network for tumor mutation burden prediction and immunotherapy-related pathway analysis in gastric cancer
Biological informed graph neural network for tumor mutation burden prediction and immunotherapy-related pathway analysis in gastric cancer
Interpretable biologically informed deep semi-graph neural network. The PGLCN consists three core modules: biological grap...
Biological and physico-chemical characterization of human norovirus-like particles under various environmental conditions
Biological and physico-chemical characterization of human norovirus-like particles under various environmental conditions
Human norovirus (HuNoV) is the main etiological agent of gastroenteritis, causing up to 80% of nonbacterial gastroenteriti...
Design, optimization, in vitro and in vivo evaluation of triamcinolone acetonide nanocrystals loaded in situ gel for topical ocular delivery
Design, optimization, in vitro and in vivo evaluation of triamcinolone acetonide nanocrystals loaded in situ gel for topical ocular delivery
One of the most challenging yet exciting research areas in the field of pharmaceutical drug development is ocular drug del...
The application of capability indices in the validation of ELISA methodology
The application of capability indices in the validation of ELISA methodology
Aim: To investigate the impact of sample replication number (duplicate vs triplicate) on the validation of ELISA methodolo...
Good clinical practices in the bioanalytical laboratory
Good clinical practices in the bioanalytical laboratory
Despite the existence of good clinical practice guidelines, the way in which they are applied to the bioanalytical laborat...
Melatonin alleviates early brain injury by inhibiting the NRF2-mediated ferroptosis pathway after subarachnoid hemorrhage
Melatonin alleviates early brain injury by inhibiting the NRF2-mediated ferroptosis pathway after subarachnoid hemorrhage
Subarachnoid hemorrhage (SAH) is a common type of stroke, and the ruptured cerebral aneurysm is the most common cause of s...
Canagliflozin reduces chemoresistance in hepatocellular carcinoma through PKM2-c-Myc complex-mediated glutamine starvation
Canagliflozin reduces chemoresistance in hepatocellular carcinoma through PKM2-c-Myc complex-mediated glutamine starvation
Hepatocellular carcinoma (HCC) remains a global health challenge with a high incidence and poor prognosis [1,2]. The 5-yea...
阅读更多
format_indent_increase