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Cucurbitacin IIa Alleviates Colitis via Promoting the Release of Host-Derived Extracellular Vesicles Encapsulating microRNA-30b-5p
Cucurbitacin IIa Alleviates Colitis via Promoting the Release of Host-Derived Extracellular Vesicles Encapsulating microRNA-30b-5p
In this study, we first investigated the effects of cucurbitacin IIa on colitis symptoms and inflammation using a DSS-indu...
Identification and Validation of Pivotal Genes in Osteoarthritis Combined with WGCNA Analysis
Identification and Validation of Pivotal Genes in Osteoarthritis Combined with WGCNA Analysis
The four key genes (GADD45B, CLDN5, HILPDA and CDKN1B) hold potential as biomarkers for OA diagnosis and treatment. Precis...
Baricitinib Successfully Treated a Teenager with Refractory Livedoid Vasculopathy: A Case Report and Literature Review
Baricitinib Successfully Treated a Teenager with Refractory Livedoid Vasculopathy: A Case Report and Literature Review
Presenting a case that provides new evidence regarding the efficacy of JAK inhibitors in the treatment of refractory lived...
Integrative Bioinformatics Analysis to Identify Key Ferroptosis-Related Genes and Immune Infiltration in Aortic Aneurysm and Dissection: Implication of PTGS2
Integrative Bioinformatics Analysis to Identify Key Ferroptosis-Related Genes and Immune Infiltration in Aortic Aneurysm and Dissection: Implication of PTGS2
Immune cell populations were analyzed and the Spearman's correlations were calculated between immune cell populations and ...
CLEC11A-Driven Molecular Mechanisms in Intervertebral Disc Degeneration: A Comprehensive Multi-Omics Study
CLEC11A-Driven Molecular Mechanisms in Intervertebral Disc Degeneration: A Comprehensive Multi-Omics Study
Identifying potential risk genes that may induce IVDD and exploring inflammatory proteins and metabolites mediating the ca...
A Novel Nomogram for Predicting the Risk of Pneumonia After Intracerebral Hemorrhage
A Novel Nomogram for Predicting the Risk of Pneumonia After Intracerebral Hemorrhage
Creating a novel nomogram for pneumonia after intracerebral hemorrhage. Read more
Rhein Mitigates Lung Injury in Severe Acute Pancreatitis Through the Inhibition of MARK4-Mediated Microtubule Destabilization
Rhein Mitigates Lung Injury in Severe Acute Pancreatitis Through the Inhibition of MARK4-Mediated Microtubule Destabilization
Exploring the therapeutic effect and molecular mechanism of rhein on severe acute pancreatitis associated acute lung injur...
Dynamic Complement Protein Changes in Aqueous Humor and Plasma of Patients With Retinal Vein Occlusion During Ranibizumab Treatment
Dynamic Complement Protein Changes in Aqueous Humor and Plasma of Patients With Retinal Vein Occlusion During Ranibizumab Treatment
To assess the dynamic changes in complement protein levels in aqueous humor & plasma of RVO patients undergoing intrav...
Significance of the Lesion–Pleura Relationship in Differentiating Peripheral Inflammatory Lesions and Lung Cancers
Significance of the Lesion–Pleura Relationship in Differentiating Peripheral Inflammatory Lesions and Lung Cancers
The aim of this study is to determine the potential diagnostic significance of the relationship between pulmonary lesions ...
Development and Validation of the Systemic Inflammatory Response Index-Based Nomogram for Predicting Short-Term Adverse Events in Patients With Acute Uncomplicated Type B Aortic Intramural Hematoma
Development and Validation of the Systemic Inflammatory Response Index-Based Nomogram for Predicting Short-Term Adverse Events in Patients With Acute Uncomplicated Type B Aortic Intramural Hematoma
SIRI-based nomogram is a valuable prognostic tool for predicting short-term ARAEs in patients with acute uncomplicated Typ...
Extracellular Vesicles in Periodontitis: Pathogenic Mechanisms and Therapeutic Potential
Extracellular Vesicles in Periodontitis: Pathogenic Mechanisms and Therapeutic Potential
This study was aimed to fully explore the potential of EVs in periodontitis treatment by revealing the nuances of the dual...
Dose-Weighted Network Pharmacology: Evaluating Traditional Chinese Medicine Formulations for Lumbar Disc Herniation
Dose-Weighted Network Pharmacology: Evaluating Traditional Chinese Medicine Formulations for Lumbar Disc Herniation
Introducing dose-weighted network pharmacology, a novel approach that incorporates drug dosage as a quantitative factor in...
IRF3 Promotes Production of IL-6 and Nitric Oxide but Represses CCL22 in RAW264.7 Macrophage Cells Exposed to Lipopolysaccharides in Culture
IRF3 Promotes Production of IL-6 and Nitric Oxide but Represses CCL22 in RAW264.7 Macrophage Cells Exposed to Lipopolysaccharides in Culture
IRF3 is critical to expression of pro- & anti-inflammatory factors produced by macrophages responding to LPS & cou...
Altered CD73-Adenosine Signaling Linked to Infection in Patients undergoing hemodialysis
Altered CD73-Adenosine Signaling Linked to Infection in Patients undergoing hemodialysis
Lower CD73+T cell levels are strongly associated with infection complications in patients undergoing HD. Altered CD73-aden...
Enhancing the Predictive Value of SII and NLR in LAA Stroke: Addressing Unexplored Limitations and Future Directions [Letter]
Enhancing the Predictive Value of SII and NLR in LAA Stroke: Addressing Unexplored Limitations and Future Directions [Letter]
Letter for the article
Lactate Ameliorates Kainic Acid-Induced Neuroinflammation and Cognitive Impairment via the Chemokine Signaling Pathway in Mice
Lactate Ameliorates Kainic Acid-Induced Neuroinflammation and Cognitive Impairment via the Chemokine Signaling Pathway in Mice
This study aims to investigate the impact of lactate intervention and its underlying mechanisms on epilepsy.
The Upregulation of IL-1β Induced by Cisplatin Triggers PI3K/AKT/MMP9 Pathway in Pericytes Mediating the Leakage of the Blood Labyrinth Barrier
The Upregulation of IL-1β Induced by Cisplatin Triggers PI3K/AKT/MMP9 Pathway in Pericytes Mediating the Leakage of the Blood Labyrinth Barrier
We meticulously established a CDDP-induced ototoxicity mice model and a primary cultured in vitro BLB model to validate ou...
Interleukin-1 Receptor-Associated Kinase-3 Aggravates Neuroinflammatory Injury After Intracerebral Hemorrhage via Activation NF-κB/IL-17A Pathway in Mice
Interleukin-1 Receptor-Associated Kinase-3 Aggravates Neuroinflammatory Injury After Intracerebral Hemorrhage via Activation NF-κB/IL-17A Pathway in Mice
IRAK3 aggravates neuroinflammation by activating the NF-κB/IL-17A signaling pathway, thereby exacerbating neurologic...
The Potential Proallergenic Activity of Tranzschelia pruni-spinosae and Phragmidium rubi-idaei in vitro Studies
The Potential Proallergenic Activity of Tranzschelia pruni-spinosae and Phragmidium rubi-idaei in vitro Studies
Parasitic microfungi exhibit pro-inflammatory solid properties which is the basis of allergenic reactions in in vitro uppe...
Metabolism-Related Adipokines and Metabolic Diseases: Their Role in Osteoarthritis
Metabolism-Related Adipokines and Metabolic Diseases: Their Role in Osteoarthritis
Focusing on the impact and mechanisms of metabolic diseases and adipokines on Osteoarthritis onset and progression. Read more
Decrease of NAD+ Inhibits the Apoptosis of OLP T Cells via Inducing Mitochondrial Fission
Decrease of NAD+ Inhibits the Apoptosis of OLP T Cells via Inducing Mitochondrial Fission
Exploring the role of NAD+ in modulating mitochondrial fission and apoptosis in T cells under the Oral lichen planus (OLP)...
The Role of Dectin-1-Akt-RNF146 Pathway in β-Glucan Induced Immune Trained State of Monocyte in Sepsis
The Role of Dectin-1-Akt-RNF146 Pathway in β-Glucan Induced Immune Trained State of Monocyte in Sepsis
The Role of Dectin-1-Akt-RNF146 Pathway in β-Glucan Induced Immune Trained State of Monocyte in Sepsis
α-Methyl-Tryptophan Inhibits SLC6A14 Expression and Exhibits Immunomodulatory Effects in Crohn’s Disease
α-Methyl-Tryptophan Inhibits SLC6A14 Expression and Exhibits Immunomodulatory Effects in Crohn’s Disease
Controlling SLC6A14 expression inhibits the intestinal immune activity of DSS-induced CD in mice to an appreciable extent,...
Immune Profile Differences between IgG4-Related Diseases and Primary Sjögren’s Syndrome
Immune Profile Differences between IgG4-Related Diseases and Primary Sjögren’s Syndrome
identifying altered serological parameters and potential biomarkers of Immunoglobulin G4-related disease and primary Sj&ou...
Identification of Anoikis-Related Genes in Chronic Kidney Disease Based on Bioinformatics Analysis Combined with Experimental Validation
Identification of Anoikis-Related Genes in Chronic Kidney Disease Based on Bioinformatics Analysis Combined with Experimental Validation
Establishing the Anoikis-related gene signature in Chronic Kidney Disease by bioinformatics analysis.
Single-Cell RNA-Seq Uncovers Cellular Heterogeneity from Deep Fascia in Necrotizing Fasciitis Patients
Single-Cell RNA-Seq Uncovers Cellular Heterogeneity from Deep Fascia in Necrotizing Fasciitis Patients
We aim to investigate the change of cells from deep fascia in response to necrotizing fasciitis by single-cell RNA-seq.
Neutrophils: From Inflammatory Bowel Disease to Colitis-Associated Colorectal Cancer
Neutrophils: From Inflammatory Bowel Disease to Colitis-Associated Colorectal Cancer
The functional roles of neutrophils in IBD & CAC is essential for advancing our understanding of IBD pathogenesis and ...
Identifying Key Biomarkers Related to Immune Response in the Progression of Diabetic Kidney Disease: Mendelian Randomization Combined With Comprehensive Transcriptomics and Single-Cell Sequencing Analysis
Identifying Key Biomarkers Related to Immune Response in the Progression of Diabetic Kidney Disease: Mendelian Randomization Combined With Comprehensive Transcriptomics and Single-Cell Sequencing Analysis
AKT2, IL2RB, NRXN3, SLIT3, and TBPL1 genes are closely related to DKD, which may be useful in the diagnosis and therapy of...
Circ_0001084/miR-181c-5p/PTPN4 Axis Mitigates Cardiomyocyte Injury by Modulating the TLR4/NF-κB Pathway: Insights into Therapeutic Potential for Myocardial Reperfusion Injury
Circ_0001084/miR-181c-5p/PTPN4 Axis Mitigates Cardiomyocyte Injury by Modulating the TLR4/NF-κB Pathway: Insights into Therapeutic Potential for Myocardial Reperfusion Injury
This study combined bioinformatic and experimental techniques to investigate myocardial injury.
Fu Tu Sheng Jin Rehabilitation Formula Mitigate Airway Inflammation, Mucus Secretion and Immune Dysfunction Induced by SARS-CoV-2 Spike Protein
Fu Tu Sheng Jin Rehabilitation Formula Mitigate Airway Inflammation, Mucus Secretion and Immune Dysfunction Induced by SARS-CoV-2 Spike Protein
We observed that FTSJRF reduced lung damage, improved mucus secretion, promoted the maturation of DCs, and maintained Th17...
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