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CXCR4-targeted nitric oxide nanoparticles deliver PD-L1 siRNA for immunotherapy against glioblastoma
Glioblastoma multiforme (GBM) is one of the most aggressive malignant cancers of the central nervous system (CNS), represe...
Size optimization of carfilzomib nanocrystals for systemic delivery to solid tumors
The ubiquitin-proteasome system (UPS) has emerged as a promising therapeutic target for cancer chemotherapy in the past tw...
Nano-assemblies enhance chaperone activity, stability, and delivery of alpha B-crystallin-D3 (αB-D3)
Crystallin proteins are the major structural constituents of the eye lens that control lens transparency and refractivity ...
Perspective on a chemistry classification system for AI-assisted formulation development
First, I want to thank Professor Vincent H.L. Lee for the invitation to write this perspective on the impact of modeling a...
The past, present, and future of chemotherapy with a focus on individualization of drug dosing
While there have been rapid advances in developing new and more targeted drugs to treat cancer, much less progress has bee...
Application of machine learning techniques to the analysis and prediction of drug pharmacokinetics
Model-driven analysis has a long history in the pharmacokinetic/pharmacodynamics (PK/PD) field [1]. Mathematical models co...
Nano drug delivery systems for antisense oligonucleotides (ASO) therapeutics
Recent advances in pharmacology and a better understanding of underlying diseases have established a strong correlation be...
Extracellular matrix degrading enzyme with stroma-targeting peptides enhance the penetration of liposomes into tumors
Blood vessels in solid tumors possess larger intra-endothelial gaps, and they are leakier than normal blood vessels [1,2]....
Perimeter and carvacrol-loading regulate angiogenesis and biofilm growth in 3D printed PLA scaffolds
Carvacrol is a natural low-cost compound derived from oregano which presents anti-bacterial properties against both Gram-p...
Metal-organic frameworks: A promising option for the diagnosis and treatment of Alzheimer's disease
Metal-organic frameworks (MOFs) have emerged as highly porous/crystalline materials prepared from metal ions/clusters and ...
Liquid–liquid phase separation drug aggregate: Merit for oral delivery of amorphous solid dispersions
More than 75% of the drug candidates are considered insoluble, limiting their oral absorption [[1], [2], [3]]. As a promis...
Insulin-loaded liposomes packaged in alginate hydrogels promote the oral bioavailability of insulin
Diabetes is a severe disease impacting nearly 10% of the whole population, which is still increasing in the predictable fu...
Size-switchable polymer-based nanomedicines in the advanced therapy of rheumatoid arthritis
Chronic inflammatory diseases (CIDs), such as rheumatoid arthritis (RA), osteoarthritis (OA) and asthma, have a substantia...
Airway epithelial cell-specific delivery of lipid nanoparticles loading siRNA for asthma treatment
With specific and inherent mRNA cleaving activity, small interfering RNA (siRNA) has been deemed promising therapeutics to...
Mapping in vivo microclimate pH distribution in exenatide-encapsulated PLGA microspheres
Volume 352, December 2022, Pages 438-449AbstractThe pH inside the aqueous pores of poly(lactic-co-glycolic acid) (PLGA) mi...
pH-labile artificial natural killer cells for overcoming tumor drug resistance
Natural killer (NK) cells exert cytotoxic effects against infected or stressed cells, such as tumor cells, without the lim...
Distinguishing nanoparticle drug release mechanisms by asymmetric flow field–flow fractionation
This research demonstrates the development, application, and mechanistic value of a multi-detector asymmetric flow field-f...
Nanoadjuvants Actively targeting lymph node conduits and blocking tumor invasion in lymphatic vessels
Great efforts have been made to manipulate nanoparticles (NPs) with a diameter of 10–100 nm to passively target lymph node...
Glucose-responsive nanoparticles designed via a molecular-docking-driven method for insulin delivery
KeywordsDiabetesInsulin deliveryGlucose-responsive nanoparticlesAnti-hypoglycemia propertiesMolecular dockingAbbreviation ...
Core-shell nanosystems designed for effective oral delivery of polypeptide drugs
The stomach acid degradation, mucus clearance and intestinal epithelial impermeability severely limit the oral delivery of...
Six-month sustained delivery of anti-VEGF from in-situ forming hydrogel in the suprachoroidal space
Volume 352, December 2022, Pages 472-484Highlights•Anti-VEGF released for 6 months from in-situ forming hydrogel in the su...
Proton-mediated burst of dual-drug loaded liposomes for biofilm dispersal and bacterial killing
Exposure of infectious biofilms to dispersants induces high bacterial concentrations in blood that may cause sepsis. Preve...
Glioma diagnosis and therapy: Current challenges and nanomaterial-based solutions
Glioma is often referred to as one of the most dreadful central nervous system (CNS)-specific tumors with rapidly-prolifer...
Precise oral delivery systems for probiotics: A review
Probiotics have several health benefits to the host. However, low pH in the stomach, various digestive enzymes and bile sa...
Active and passive drug release by self-assembled lubricin (PRG4) anti-fouling coatings
Electroactive polymers (EAPs) have been investigated as materials for use in a range of biomedical applications, ranging f...
Combining drug salt formation with amorphous solid dispersions – a double edged sword
Glass transition temperature (Tg) is important for amorphous compounds because it can have implications on their physical ...
High-definition electroporation: Precise and efficient transfection on a microelectrode array
Intracellular delivery is critical for a plethora of biomedical applications, including mRNA transfection and gene editing...
Intracellular infection-responsive release of NO and peptides for synergistic bacterial eradication
Bacteria have the ability to invade and survive in host cells to form intracellular bacteria (ICBs), and challenges remain...