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Graphdiyne nanoplatforms for photothermal-ferroptosis combination therapy against glioblastoma
Glioblastoma (GBM) is the most common primary malignant tumor of the central nervous system, with a median survival of les...
Lipidation of a bioactive cyclotide-based CXCR4 antagonist greatly improves its pharmacokinetic profile in vivo
The G-protein coupled chemokine receptor 4 (CXCR4) plays an important role in several human diseases, including cancer, au...
Plant-derived single domain COVID-19 antibodies
Data show a decrease in the risk of hospitalization and death from COVID-19. To date, global vaccinations for SARS-CoV-2 p...
Targeting lactate metabolism and immune interaction in breast tumor via protease-triggered delivery
Breast cancer has been the world's mostly commonly-diagnosed cancer since 2020 [1]. In China alone, it accounts for approx...
Reducing off-target drug accumulation by exploiting a type-III interferon response
The field of therapeutic nanomedicines is still attempting to fully characterize and understand the immune responses trigg...
Ammonium trifluoroborate-modified poly(β-aminoesters): A case study for PET-guided in vivo pharmacokinetic studies of a non-viral gene delivery system
The recent breakthrough advances on nucleic acid-based therapies serve as a glimpse into the tremendous potential of this ...
Programmed antigen capture-harnessed dendritic cells by margination-hitchhiking lung delivery
Cancer immunotherapy boosts the immune system and primes T cells to recognize and fight cancer cells, potentially suppress...
Osteoimmunomodulatory GelMA/liposome coatings to promote bone regeneration of orthopedic implants
Despite being the most widely used biomaterials in orthopedic surgery, metallic implants do not induce new bone growth bec...
Core-shell tecto dendrimer-mediated cooperative chemoimmunotherapy of breast cancer
The host immune system always identifies and eliminates tumor cells through multiple pathways [1,2]. To form effective ant...
Employing single valency polyphenol to prepare metal-phenolic network antitumor reagents through FeOOH assistance
Natural bioactive polyphenols contain many phenolic hydroxyl groups, possessing anti-inflammation, antibacterial, anti-tum...
Investigating structural attributes of drug encapsulated microspheres with quantitative X-ray imaging
The intra-sphere and inter-sphere structural attributes of controlled release microsphere drug products can greatly impact...
Drug induced mitochondria dysfunction to enhance photodynamic therapy of hypoxic tumors
Fast proliferation of malignant cells and insufficient neovascularization induce a hypoxic microenvironment during tumor o...
Unleashing the potential of cell biomimetic nanoparticles: Strategies and challenges in their design and fabrication for therapeutic applications
Dr. Assaf Zinger is a researcher and educator in the field of nanomedicine and engineering. He currently serves as an Assi...
Therapeutic applications of nanoparticles targeting neutrophil and extracellular traps
Neutrophils are the most abundant circulating leukocytes (up to 70%) and act as the first line of defense, being the first...
Cascade-amplified self-immolative polymeric prodrug for cancer therapy by disrupting redox homeostasis
Prodrugs are a branch of medications that are pharmacologically inactive but can be readily converted to their active meta...
Smart hydrothermally responsive microneedle for topical tumor treatment
Unreachable subcutaneous solid tumors, especially relatively deep-seated breast cancer and melanoma, have become one of th...
Redox modulation with a perfluorocarbon nanoparticle to reverse Treg-mediated immunosuppression and enhance anti-tumor immunity
Immunotherapy evokes body's own immune system to discover and destroy cancer cells, which provides effective ways in treat...
A starch-based implant as a controlled drug release system: Non-invasive in vivo characterization using multispectral fluorescence imaging.
Solid implants are parenteral depot systems that can provide a controlled release of drugs in the desired body area over a...
Kidney targeting peptide-modified biomimetic nanoplatforms for treatment of acute kidney injury
Acute kidney injury (AKI) is a clinical syndrome characterized by a sudden decrease in glomerular filtration rate, followe...
Efficient colonic drug delivery in domestic pigs employing a tablet formulation with dual control concept
KeywordsColonic drug deliveryPhysiologically based pharmacokinetic modelingPharmacokinetic deconvolutionDomestic pigTeleme...
Mannose 6-phosphate receptor-targeting antibodies preserve Fc receptor-mediated recycling
Identified as the key receptor for lysosomal delivery, the ubiquitous cation-independent mannose 6-phosphate membrane rece...
Focused ultrasound enhances transgene expression of intranasal hGDNF DNA nanoparticles in the sonicated brain regions
The therapeutic potential of many gene therapies is limited by their inability to cross the blood brain barrier (BBB). Whi...
Succinate based polymers drive immunometabolism in dendritic cells to generate cancer immunotherapy
Therapeutics that modulate immune cell metabolism have achieved major success in cancer research. [[1], [2], [3], [4]] Not...
A chemiluminescent reporter assisted by in-situ neutrophils for imaging O2− at inflammatory sites
Inflammation [1], which is the biological response of an organism's immune system to the endogenous or exogenous insult to...
Delivery of hydroxycamptothecin via sonoporation: An effective therapy for liver fibrosis
Hepatic fibrosis is the common pathway for most chronic liver diseases characterized by excessive accumulation of extracel...
Fluid flow influences ultrasound-assisted endothelial membrane permeabilization and calcium flux
Ultrasound contrast agent consists of a suspension of encapsulated gas-filled microbubbles, typically polydisperse and ran...
Tumor lysates-constructed hydrogel to potentiate tumor immunotherapy
T cell-based immunotherapy (TCBI) pioneers a new stage of tumor treatment in recent years [1,2]. However, the clinical res...
Intranasal nanotherapeutics for brain targeting and clinical studies in Parkinson's disease
Parkinson's disease (PD) is a neurodegenerative disorder, which is the most common age-related disorder after Alzheimer's ...
Design of experiments in the optimization of nanoparticle-based drug delivery systems
The development of robust protocols and the establishment of a products are the essential building blocks upon which scien...
Emerging nanoparticle platforms to improve the administration of glucocorticoids
Glucocorticoids (GC) are highly efficient drugs widely used to treat inflammatory and autoimmune diseases. Routes of admin...
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