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A natural IgM hitchhiking strategy for delivery of cancer nanovaccines to splenic marginal zone B cells
A natural IgM hitchhiking strategy for delivery of cancer nanovaccines to splenic marginal zone B cells
Cancer remains one of the most prevalent and challenging diseases in the world, making the development of effective treatm...
Engineered liposomes targeting hepatic stellate cells overcome pathological barriers and reverse liver fibrosis
Engineered liposomes targeting hepatic stellate cells overcome pathological barriers and reverse liver fibrosis
Liver fibrosis, characterized by the activated hepatic stellate cells (HSCs) and abnormal accumulation of extracellular ma...
Enhancing photodynamic immunotherapy by reprograming the immunosuppressive tumor microenvironment with hypoxia relief
Enhancing photodynamic immunotherapy by reprograming the immunosuppressive tumor microenvironment with hypoxia relief
Cancer immunotherapy is a treatment that eliminates the tumors by generating or boosting the host immune responses against...
A redox-responsive prodrug for tumor-targeted glutamine restriction
A redox-responsive prodrug for tumor-targeted glutamine restriction
KeywordsGlutamine inhibitorDON (6-Diazo-5-oxo-L-norleucine)cancer metabolismImmune modulationDrug deliverySafetyToxicityDa...
Substrate-free dissolving microneedles with barbed shape to increase adhesion and drug-delivery efficiency to skin
Substrate-free dissolving microneedles with barbed shape to increase adhesion and drug-delivery efficiency to skin
Psoriasis is a chronic, multi-system inflammatory skin disease with a long disease cycle, risking recurrence or almost lif...
Liposome-based dry powder vaccine immunization targeting the lungs induces broad protection against pneumococcus
Liposome-based dry powder vaccine immunization targeting the lungs induces broad protection against pneumococcus
Streptococcus pneumoniae is an important human pathogen. Currently used conjugate vaccines are effective against invasive ...
Decellularized brain extracellular matrix based NGF-releasing cryogel for brain tissue engineering in traumatic brain injury
Decellularized brain extracellular matrix based NGF-releasing cryogel for brain tissue engineering in traumatic brain injury
Traumatic brain injury (TBI) is a disruption in normal brain function caused by sudden traumatic damage resulting in tissu...
Engineered exosomes with enhanced stability and delivery efficiency for glioblastoma therapy
Engineered exosomes with enhanced stability and delivery efficiency for glioblastoma therapy
Due to tumor location and often locally invasive growth, glioblastoma is associated with high mortality and poor prognosis...
Efficient gene delivery by multifunctional star poly (β-amino ester)s into difficult-to-transfect macrophages for M1 polarization
Efficient gene delivery by multifunctional star poly (β-amino ester)s into difficult-to-transfect macrophages for M1 polarization
Tumor-associated macrophages (TAMs) play a critical role as immunoregulatory cells and constitute a significant proportion...
CD44-targeted melanin-based nanoplatform for alleviation of ischemia/reperfusion-induced acute kidney injury
CD44-targeted melanin-based nanoplatform for alleviation of ischemia/reperfusion-induced acute kidney injury
Ischemia/reperfusion (I/R)-induced acute kidney injury (AKI) is a severe kidney disease characterized by an abrupt reducti...
Controlling the function of bioactive worm micelles by enzyme-cleavable non-covalent inter-assembly cross-linking
Controlling the function of bioactive worm micelles by enzyme-cleavable non-covalent inter-assembly cross-linking
Drugs that form self-assembled supramolecular structures to be most-active is a promising way of creating new highly speci...
Lipid-mediated protein corona regulation with increased apolipoprotein A-I recruitment for glioma targeting
Lipid-mediated protein corona regulation with increased apolipoprotein A-I recruitment for glioma targeting
Targeted drug delivery systems have emerged as appealing strategies for disease treatment [[1], [2], [3]] due to their hug...
Lipid core-shell nanoparticles co-deliver FOLFOX regimen and siPD-L1 for synergistic targeted cancer treatment
Lipid core-shell nanoparticles co-deliver FOLFOX regimen and siPD-L1 for synergistic targeted cancer treatment
The combination of folinic acid (FOL), 5-FU (F) and OXP (OX), noted as FOLFOX regimen, has been used as standard treatment...
Multi-material 3D printed eutectogel microneedle patches integrated with fast customization and tunable drug delivery
Multi-material 3D printed eutectogel microneedle patches integrated with fast customization and tunable drug delivery
Microneedle (MN) patches have emerged as an effective smart monitor and transdermal drug delivery system that can surmount...
Dual stimuli-responsive and sustained drug delivery NanoSensoGel formulation for prevention of cisplatin-induced ototoxicity
Dual stimuli-responsive and sustained drug delivery NanoSensoGel formulation for prevention of cisplatin-induced ototoxicity
Cisplatin (CisPt) is a highly effective antitumor drug generally used in the treatment of solid malignant tumors and, is c...
Enhancing gene transfection of poly(β-amino ester)s through modulation of amphiphilicity and chain sequence
Enhancing gene transfection of poly(β-amino ester)s through modulation of amphiphilicity and chain sequence
With the completion of the Human Genome Project, more and more disease-related genes have been identified. As a result, ge...
Biomimetic nano-chelate diethyldithiocarbamate Cu/Fe for enhanced metalloimmunity and ferroptosis activation in glioma therapy
Biomimetic nano-chelate diethyldithiocarbamate Cu/Fe for enhanced metalloimmunity and ferroptosis activation in glioma therapy
Common treatments for glioma typically involve a combination of surgery, radiation therapy, and drugs [1]. However, the ef...
E3MPH16: An efficient endosomolytic peptide for intracellular protein delivery
E3MPH16: An efficient endosomolytic peptide for intracellular protein delivery
The efficient introduction of proteins, including antibodies, into the cytosol of target cells, poses a significant challe...
Determining topical product bioequivalence with stimulated Raman scattering microscopy
Determining topical product bioequivalence with stimulated Raman scattering microscopy
Low-cost drugs, an essential part of affordable healthcare, are associated with broader accessibility to treatments, bette...
Rhamnose-PEG-induced supramolecular helices: Addressing challenges of drug solubility and release efficiency in transdermal patch
Rhamnose-PEG-induced supramolecular helices: Addressing challenges of drug solubility and release efficiency in transdermal patch
Transdermal drug delivery systems (TDDS) have risen to prominence as an effective and patient-friendly drug administration...
Nano-chemical priming strategy to enhance TGF-β resistance and anti-tumor activity of natural killer cells
Nano-chemical priming strategy to enhance TGF-β resistance and anti-tumor activity of natural killer cells
In recent years, adoptive immune cell therapies (AICT) involving lymphocytes have emerged as a promising approach within t...
Next generation therapeutics for retinal neurodegenerative diseases
Next generation therapeutics for retinal neurodegenerative diseases
Retinal neurodegenerative diseases are a leading cause of irreversible vision loss worldwide [1]. In glaucoma, prolonged e...
Modular design of cyclic peptide – polymer conjugate nanotubes for delivery and tunable release of anti-cancer drug compounds
Modular design of cyclic peptide – polymer conjugate nanotubes for delivery and tunable release of anti-cancer drug compounds
High aspect-ratio nanomaterials have recently emerged as promising drug delivery vehicles due to evidence of strong cellul...