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Chemotherapeutic effect of baicalein/epirubicin combination against liver cell carcinoma in-vitro: Inducing apoptosis and autophagy
Chemotherapeutic effect of baicalein/epirubicin combination against liver cell carcinoma in-vitro: Inducing apoptosis and autophagy
Hepatocellular carcinoma (HCC) is considered a major problem worldwide. It is the fifth most common cancer and the second ...
Electromagnetic field (50 Hz) enhance metabolic potential and induce adaptive/reprogramming response mediated by the increase of N6-methyladenosine RNA methylation in adipose-derived mesenchymal stem cells in vitro
Electromagnetic field (50 Hz) enhance metabolic potential and induce adaptive/reprogramming response mediated by the increase of N6-methyladenosine RNA methylation in adipose-derived mesenchymal stem cells in vitro
Mesenchymal stem cells (MSCs) are multipotent cells that play an important role in tissue homeostasis and regeneration by ...
Inhibitory effects of the main metabolites of Apatinib on CYP450 isozymes in human and rat liver microsomes
Inhibitory effects of the main metabolites of Apatinib on CYP450 isozymes in human and rat liver microsomes
PurposeThe inhibitory effect of Apatinib on cytochrome P450 (CYP450) enzymes has been studied. However, it is unknown whet...
A multiparametric and orthogonal approach indicates low toxicity for zein nanoparticles in a repellent formulation
A multiparametric and orthogonal approach indicates low toxicity for zein nanoparticles in a repellent formulation
Arthropods can transmit pathogens and infect other organisms, contributing to endemics worldwide (Benelli, 2015; Benelli a...
Pyruvate dehydrogenase is a potential mitochondrial off-target for gentamicin based on in silico predictions and in vitro inhibition studies
Pyruvate dehydrogenase is a potential mitochondrial off-target for gentamicin based on in silico predictions and in vitro inhibition studies
KeywordsIn silico predictionsDrug-induced kidney injuryPyruvate dehydrogenaseMitochondriaOff-targetData availabilityThe ra...
Phototoxic action of meloxicam contributes to dysregulation of redox homeostasis in normal human skin cells – Molecular and biochemical analysis of antioxidant enzymes in melanocytes and fibroblasts
Phototoxic action of meloxicam contributes to dysregulation of redox homeostasis in normal human skin cells – Molecular and biochemical analysis of antioxidant enzymes in melanocytes and fibroblasts
The World Health Organization defines an adverse drug reaction (ADR) as “a response to a drug that is harmful and unintend...
Evaluation of the acute toxicity of ellagic acid and gallic acid incorporated in Poloxamer407® gel, in Zophobas morio larvae
Evaluation of the acute toxicity of ellagic acid and gallic acid incorporated in Poloxamer407® gel, in Zophobas morio larvae
Gallic acid (GA) and ellagic acid (EA) are natural compounds known for their antioxidant properties and potential health b...
DEHP and DINP accelerate aging effects in male and female of Drosophila melanogaster depend on AKT/FOXO pathway
DEHP and DINP accelerate aging effects in male and female of Drosophila melanogaster depend on AKT/FOXO pathway
Phthalates are commonly used as plasticizers to improve the durability, resistance, and flexibility of polyvinyl chloride ...
Newly synthesized derivatives with a thiosemicarbazide group reduce the viability of cancer cell lines. Acute toxicity assessment in Zebrafish (Danio rerio) early life stages
Newly synthesized derivatives with a thiosemicarbazide group reduce the viability of cancer cell lines. Acute toxicity assessment in Zebrafish (Danio rerio) early life stages
Cancers are the most common cause of death worldwide, and the number is still increasing in developing countries (Wild et ...
Cytotoxic and genotoxic effects of triphenyl phosphate on root tip cells of Allium cepa L.
Cytotoxic and genotoxic effects of triphenyl phosphate on root tip cells of Allium cepa L.
Currently, different polymer types are used for producing various consumer products ranging from electric and electronic d...
In vitro anticancer effects of recombinant anisoplin through activation of SAPK/JNK and downregulation of NFκB
In vitro anticancer effects of recombinant anisoplin through activation of SAPK/JNK and downregulation of NFκB
Fungal ribotoxins are extracellular ribonucleases produced by a wide range of endophytic fungi, including entomopathogenic...
Life cell imaging of amiodarone sequestration into lamellar bodies of alveolar type II cells
Life cell imaging of amiodarone sequestration into lamellar bodies of alveolar type II cells
Amiodarone is widely used to treat cardiac arrhythmias and is very effective in preventing these disorders. However, its u...
Applications of Premature Chromosome Condensation technique for genetic analysis
Applications of Premature Chromosome Condensation technique for genetic analysis
Premature chromosomal condensation (PCC) is a rapid cytogenetic technique that is useful for the assessment of genetic dam...
Skin barrier function for regulatory skin absorption tests and effects on testosterone and sucrose absorption
Skin barrier function for regulatory skin absorption tests and effects on testosterone and sucrose absorption
Regulatory in vitro skin absorption (also known as skin penetration) studies are routinely performed for different regulat...
Predictive toxicological effects of Artemisia absinthium essential oil on hepatic stellate cells
Predictive toxicological effects of Artemisia absinthium essential oil on hepatic stellate cells
Over the last decades, using medicinal plants to treat diseases has been considered a relevant strategy, especially in dev...
Knockdown of JMJD3 ameliorates cigarette smoke extract-triggered bronchial epithelial cell injury via ACSL4-dependent ferroptosis
Knockdown of JMJD3 ameliorates cigarette smoke extract-triggered bronchial epithelial cell injury via ACSL4-dependent ferroptosis
Chronic obstructive pulmonary disease (COPD) is a highly prevalent and curable airway disorder featured by airway limitati...
The SNHG10-miR-495-3p-PTEN axis is involved in sevoflurane-mediated protective effects in cardiomyocytes against hypoxia/reoxygenation injury
The SNHG10-miR-495-3p-PTEN axis is involved in sevoflurane-mediated protective effects in cardiomyocytes against hypoxia/reoxygenation injury
Ischemic heart disease (IHD) has caused a large burden on individuals and health care resources worldwide, since it underp...
Cucurbitacin B and erastin co-treatment synergistically induced ferroptosis in breast cancer cells via altered iron-regulating proteins and lipid peroxidation
Cucurbitacin B and erastin co-treatment synergistically induced ferroptosis in breast cancer cells via altered iron-regulating proteins and lipid peroxidation
Cucurbitacin B (CuB) is a derivative of cucurbitacins, a class of triterpenoid compounds extracted from Cucurbitaceae fami...
Assessment of the utility of the novel Phenion® full thickness human skin model for detecting the skin irritation potential of antimicrobial cleaning products
Assessment of the utility of the novel Phenion® full thickness human skin model for detecting the skin irritation potential of antimicrobial cleaning products
KeywordsSkin irritationIn vitroFormulationsAntimicrobial cleaning productsDisinfectantsPhenion® FTAbbreviationsACPAntimicr...
m-Cresol,a pesticide intermediate, induces hepatotoxicity and behavioral abnormalities in zebrafish larvae through oxidative stress, apoptosis
m-Cresol,a pesticide intermediate, induces hepatotoxicity and behavioral abnormalities in zebrafish larvae through oxidative stress, apoptosis
In recent years, increasing attention is being paid to the environmental damage caused by pesticide residues. Pollution of...
Knockdown of angiopoietin-like 4 suppresses sepsis-induced acute lung injury by blocking the NF-κB pathway activation and hindering macrophage M1 polarization and pyroptosis
Knockdown of angiopoietin-like 4 suppresses sepsis-induced acute lung injury by blocking the NF-κB pathway activation and hindering macrophage M1 polarization and pyroptosis
Sepsis was redefined as fatal organ dysfunction resulting from disordered host response against infection, with a hospital...
Puerarin alleviates hyperosmotic stress-induced oxidative stress, inflammation, apoptosis and barrier damage of human corneal epithelial cells by targeting SIRT1/NLRP3 signaling
Puerarin alleviates hyperosmotic stress-induced oxidative stress, inflammation, apoptosis and barrier damage of human corneal epithelial cells by targeting SIRT1/NLRP3 signaling
Dry eye disease (DED) is a common eye disease caused by a lack of tear production or excessive evaporation of tears, resul...
How to use an in vitro approach to characterize the toxicity of airborne compounds
How to use an in vitro approach to characterize the toxicity of airborne compounds
Humans are exposed to a wide range of toxic compounds in their daily lives via three major routes of exposure: inhalation,...
Utilizing primary human airway mucociliary tissue cultures to model ramifications of chronic E-cigarette usage
Utilizing primary human airway mucociliary tissue cultures to model ramifications of chronic E-cigarette usage
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The use of in silico molecular modelling to screen potential estrogen mimics as part of medicines and agrochemicals development and product license applications.
The use of in silico molecular modelling to screen potential estrogen mimics as part of medicines and agrochemicals development and product license applications.
Estrogen mimics are a diverse group of synthetic and naturally occurring compounds that can interact with estrogen recepto...
Overdose with the anesthetic propofol causes hematological cytotoxicity and immune cell alteration in an experimental ex vivo whole blood culture model
Overdose with the anesthetic propofol causes hematological cytotoxicity and immune cell alteration in an experimental ex vivo whole blood culture model
The anesthetic propofol (CAS 2078-54-8; 2,6-diisopropylphenol) is commonly used for a short period of sedation in surgical...
3D multi-cell-type liver organoids: A new model of non-alcoholic fatty liver disease for drug safety assessments
3D multi-cell-type liver organoids: A new model of non-alcoholic fatty liver disease for drug safety assessments
The administration of drugs sometimes leads to the occurrence of serious adverse events, which are associated with signifi...
Impacts of high-dose riboflavin on cytotoxicity, antioxidant, growth, reproductive gene expressions, and genotoxicity in the rainbow trout gonadal cells
Impacts of high-dose riboflavin on cytotoxicity, antioxidant, growth, reproductive gene expressions, and genotoxicity in the rainbow trout gonadal cells
Riboflavin is a bright yellow, heat resistant, sensitive to UV, water-soluble vitamin (B2) and exists widely in dairy prod...
MLtox, online phototoxicity prediction webpage
MLtox, online phototoxicity prediction webpage
Phototoxicity, sometimes in the literature referred to as photo-irritation, is a chemically induced reaction requiring lig...
Apparent limitations of OECD TG 431 for classification of acrylic- and methacrylic-based adhesives
Apparent limitations of OECD TG 431 for classification of acrylic- and methacrylic-based adhesives
KeywordsOpen-source skin modelReconstructed human epidermisSkin corrosionAdhesivesOECD TG 431Phenion® OS-REpAbbreviationsA...
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