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Chemotherapeutic effect of baicalein/epirubicin combination against liver cell carcinoma in-vitro: Inducing apoptosis and autophagy
Chemotherapeutic effect of baicalein/epirubicin combination against liver cell carcinoma in-vitro: Inducing apoptosis and autophagy
Hepatocellular carcinoma (HCC) is considered a major problem worldwide. It is the fifth most common cancer and the second ...
Inhibitory effects of the main metabolites of Apatinib on CYP450 isozymes in human and rat liver microsomes
Inhibitory effects of the main metabolites of Apatinib on CYP450 isozymes in human and rat liver microsomes
PurposeThe inhibitory effect of Apatinib on cytochrome P450 (CYP450) enzymes has been studied. However, it is unknown whet...
A multiparametric and orthogonal approach indicates low toxicity for zein nanoparticles in a repellent formulation
A multiparametric and orthogonal approach indicates low toxicity for zein nanoparticles in a repellent formulation
Arthropods can transmit pathogens and infect other organisms, contributing to endemics worldwide (Benelli, 2015; Benelli a...
Pyruvate dehydrogenase is a potential mitochondrial off-target for gentamicin based on in silico predictions and in vitro inhibition studies
Pyruvate dehydrogenase is a potential mitochondrial off-target for gentamicin based on in silico predictions and in vitro inhibition studies
KeywordsIn silico predictionsDrug-induced kidney injuryPyruvate dehydrogenaseMitochondriaOff-targetData availabilityThe ra...
Evaluation of the acute toxicity of ellagic acid and gallic acid incorporated in Poloxamer407® gel, in Zophobas morio larvae
Evaluation of the acute toxicity of ellagic acid and gallic acid incorporated in Poloxamer407® gel, in Zophobas morio larvae
Gallic acid (GA) and ellagic acid (EA) are natural compounds known for their antioxidant properties and potential health b...
DEHP and DINP accelerate aging effects in male and female of Drosophila melanogaster depend on AKT/FOXO pathway
DEHP and DINP accelerate aging effects in male and female of Drosophila melanogaster depend on AKT/FOXO pathway
Phthalates are commonly used as plasticizers to improve the durability, resistance, and flexibility of polyvinyl chloride ...
Cytotoxic and genotoxic effects of triphenyl phosphate on root tip cells of Allium cepa L.
Cytotoxic and genotoxic effects of triphenyl phosphate on root tip cells of Allium cepa L.
Currently, different polymer types are used for producing various consumer products ranging from electric and electronic d...
In vitro anticancer effects of recombinant anisoplin through activation of SAPK/JNK and downregulation of NFκB
In vitro anticancer effects of recombinant anisoplin through activation of SAPK/JNK and downregulation of NFκB
Fungal ribotoxins are extracellular ribonucleases produced by a wide range of endophytic fungi, including entomopathogenic...
Life cell imaging of amiodarone sequestration into lamellar bodies of alveolar type II cells
Life cell imaging of amiodarone sequestration into lamellar bodies of alveolar type II cells
Amiodarone is widely used to treat cardiac arrhythmias and is very effective in preventing these disorders. However, its u...
Applications of Premature Chromosome Condensation technique for genetic analysis
Applications of Premature Chromosome Condensation technique for genetic analysis
Premature chromosomal condensation (PCC) is a rapid cytogenetic technique that is useful for the assessment of genetic dam...
Skin barrier function for regulatory skin absorption tests and effects on testosterone and sucrose absorption
Skin barrier function for regulatory skin absorption tests and effects on testosterone and sucrose absorption
Regulatory in vitro skin absorption (also known as skin penetration) studies are routinely performed for different regulat...
Predictive toxicological effects of Artemisia absinthium essential oil on hepatic stellate cells
Predictive toxicological effects of Artemisia absinthium essential oil on hepatic stellate cells
Over the last decades, using medicinal plants to treat diseases has been considered a relevant strategy, especially in dev...
Knockdown of JMJD3 ameliorates cigarette smoke extract-triggered bronchial epithelial cell injury via ACSL4-dependent ferroptosis
Knockdown of JMJD3 ameliorates cigarette smoke extract-triggered bronchial epithelial cell injury via ACSL4-dependent ferroptosis
Chronic obstructive pulmonary disease (COPD) is a highly prevalent and curable airway disorder featured by airway limitati...
The SNHG10-miR-495-3p-PTEN axis is involved in sevoflurane-mediated protective effects in cardiomyocytes against hypoxia/reoxygenation injury
The SNHG10-miR-495-3p-PTEN axis is involved in sevoflurane-mediated protective effects in cardiomyocytes against hypoxia/reoxygenation injury
Ischemic heart disease (IHD) has caused a large burden on individuals and health care resources worldwide, since it underp...
How to use an in vitro approach to characterize the toxicity of airborne compounds
How to use an in vitro approach to characterize the toxicity of airborne compounds
Humans are exposed to a wide range of toxic compounds in their daily lives via three major routes of exposure: inhalation,...
Utilizing primary human airway mucociliary tissue cultures to model ramifications of chronic E-cigarette usage
Utilizing primary human airway mucociliary tissue cultures to model ramifications of chronic E-cigarette usage
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3D multi-cell-type liver organoids: A new model of non-alcoholic fatty liver disease for drug safety assessments
3D multi-cell-type liver organoids: A new model of non-alcoholic fatty liver disease for drug safety assessments
The administration of drugs sometimes leads to the occurrence of serious adverse events, which are associated with signifi...
MLtox, online phototoxicity prediction webpage
MLtox, online phototoxicity prediction webpage
Phototoxicity, sometimes in the literature referred to as photo-irritation, is a chemically induced reaction requiring lig...
Apparent limitations of OECD TG 431 for classification of acrylic- and methacrylic-based adhesives
Apparent limitations of OECD TG 431 for classification of acrylic- and methacrylic-based adhesives
KeywordsOpen-source skin modelReconstructed human epidermisSkin corrosionAdhesivesOECD TG 431Phenion® OS-REpAbbreviationsA...