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4-vinylcyclohexene diepoxide induces apoptosis by excessive reactive oxygen species and DNA damage in human ovarian granulosa cells
4-Vinylcyclohexene diepoxide (VCD) is a hazardous industrial material which is widely used in the production of fragrances...
A novel co-culture model of human prostate epithelial and stromal cells for androgenic and antiandrogenic screening
KeywordsEndocrine-disrupter screeningIn vitro modelProstate3D cell cultureEpithelial and stromal cocultureAndrogenImage pr...
A cell culture system to model pharmacokinetics using adjustable-volume perfused mixing chambers
KeywordsPharmacokineticsPerfusion cell cultureIn vitro modelResidence time distributionsLymphomaAbbreviationsRTDResidence ...
Cadmium exposure impairs oocyte meiotic maturation by inducing endoplasmic reticulum stress in vitro maturation of porcine oocytes
Cadmium (Cd) is toxic metal that can induce various diseases, such as cardiovascular, nervous, and reproductive systems. T...
Lysosomal trapping of 4-dimethylamino-1-{3-(1-methyl-1H-imidazole-2-yl)propanoyl}piperidine, a hydrophilic and weakly basic amine, in human aortic vascular smooth muscle cells
Some weakly basic compounds lead to cell death accompanied by cellular vacuolation. The novel analgesic agent, 4-dimethyla...
GSK461364A suppresses proliferation of gastric cancer cells and induces apoptosis
Polo-like kinase 1 (PLK1) is crucial in regulating cell division and has been shown to have an oncogenic function in sever...
Telomere loss is accompanied by decreased pool of shelterin proteins TRF2 and RAP1, elevated levels of TERRA and enhanced glycolysis in imatinib-resistant CML cells
Telomere length may be maintained by telomerase nucleoprotein complex and shelterin complex, namely TRF1, TRF2, TIN2, TPP1...
Inhibition of aflatoxins on UDP-glucuronosyltransferases (UGTs)
Aflatoxins have been recognized as the most harmful mycotoxins leading to various toxic effects. The present study aims to...
Blocking Autophagy by the Two-Pore Channels Antagonist Tetrandrine Improves Sorafenib-Induced Death of Hepatocellular Carcinoma Cells
Sorafenib, an oral multi-kinase inhibitor, used to treat hepatocellular carcinoma (HCC). However, drug resistance is still...
BuOH fraction of Salix Babylonica L. extract increases pancreatic beta-cell tumor death at lower doses without harming their function
Salix babylonica L. is a species of the willow tree. Insulinoma is a tumor originating from pancreatic beta cells. This st...
Characterization of elements, PAHs, AhR-activity and pro-inflammatory responses of road tunnel-derived particulate matter in human hepatocyte-like and bronchial epithelial cells
KeywordsAir pollutionDiesel exhaust particlesInflammationMetalsPolyaromatic compoundsAryl hydrocarbon receptor (AhR)Airway...
Mechanism of non-steroidal anti-androgen-induced liver injury: Reactive metabolites of flutamide and bicalutamide activate inflammasomes
Flutamide is a non-steroidal anti-androgen agent, which is mainly used for the treatment of prostate cancer. Flutamide is ...
Biological effects triggered by chemical respiratory sensitizers on THP-1 monocytic cells
KeywordsRespiratory sensitizationNew approach methodologiesChemical respiratory allergyDendritic cell activationLow molecu...
Evaluation of the cytotoxic activity of triphenyl phosphate on mouse spermatocytes cells
Triphenyl phosphate (TPhP) is one of the most commonly found organophosphorus flame retardants (OPFRs) in the environment ...
Antigenotoxic effect of hyperoside against Mitomycin C and hydrogen peroxide-induced genotoxic damage on human lymphocytes
KeywordsHyperosideGenotoxicityAntigenotoxicityChromosomal abnormalitySister chromatid exchangeMicronucleusAbbreviationsCAs...
The essential role of GSTP1 I105V polymorphism in the prediction of CDNB metabolism and toxicity: In silico and in vitro insights
Humans are continuously exposed to toxic chemicals such as nitro-chlorobenzene (CDNB) through occupation, water, and even ...
Drug transporter expression and activity in cryopreserved human hepatocytes isolated from chimeric TK-NOG mice with humanized livers
Chimeric mice with humanized liver are thought to represent a sustainable source of isolated human hepatocytes for in vitr...
Development of a peptide reactivity assay for screening botanicals and natural substances: Proof of concept studies
Consumer products containing botanicals or natural substances (BNS) are often preferred because there is a perception that...
Fluid shear stress affects the metabolic and toxicological response of the rainbow trout gill cell line RTgill-W1
The Rainbow trout gill cell-line (RTgill-W1) has been accepted by the Organisation for Economic Co-operation and Developme...
Human vasculature-on-a-chip with macrophage-mediated endothelial activation: The biological effect of aerosol from heated tobacco products on monocyte adhesion
Heated tobacco products (HTPs) are expected to have the potential to reduce risks of smoking-associated cardiovascular dis...
PBTK modeled perfluoroalkyl acid kinetics in zebrafish eleutheroembryos suggests impacts on bioconcentrations by chorion porosity dynamics
The zebrafish eleutheroembryo (zfe) is widely used as a model to characterize the toxicity of chemicals. However, analytic...
High-content analysis of testicular toxicity of BPA and its selected analogs in mouse spermatogonial, Sertoli cells, and Leydig cells revealed BPAF induced unique multinucleation phenotype associated with the increased DNA synthesis
Bisphenol A is an endocrine disruptor that has been shown to have testicular toxicity in animal models. Its structural ana...
The effect of airborne Palladium nanoparticles on human lung cells, endothelium and blood – A combinatory approach using three in vitro models
A better understanding of the mechanisms behind adverse health effects caused by airborne fine particles and nanoparticles...
Curcumin from Curcuma longa Linn. (Family: Zingiberaceae) attenuates hypochlorous acid-induced cytotoxicity and oxidative damage to human red blood cells
ABTS2,2′-azino-bis-(3- ethylbenzothiozoline-6-sulfonic acid)AFRAscorbate free radicalAMPadenosine 5′-monophosphateATPadeno...
In vitro toxicity of naringin and berberine alone, and encapsulated within PMMA nanoparticles
Phytochemical compounds, such as naringin and berberine, have been used for many years due to their antioxidant activities...
Oxidative stress-mediated mitochondrial apoptosis induced by the acaricide, fenpyroximate, on cultured human colon cancer HCT 116 cells
Fenpyroximate (FEN) is an acaricide that inhibits mitochondrial electron transport at the NADH-coenzyme Q oxidoreductase (...
At low levels, inorganic mercury interference with antigen signaling is associated with modifications to a panel of novel phosphoserine sites in B cell receptor pathway proteins
The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium via the PRIDE (Perez-Riverol e...
Mettl3-mediated transcriptome-wide m6A methylation induced by cigarette smoking in human bronchial epithelial cells
Cigarette smoke exposure is a well-recognized causative factor for Chronic obstructive pulmonary disease (COPD), but the m...
Establishment of a human induced pluripotent stem cell derived alveolar organoid for toxicity assessment
Alveolar epithelial cells (AECs) are vulnerable to injury, which can result in epithelial hyperplasia, apoptosis, and chro...
Lipoxin A4 methyl ester attenuated ketamine-induced neurotoxicity in SH-SY5Y cells via regulating leptin pathway
Ketamine, the widely used intravenous anesthetic, has been reported to cause neurotoxicity and disturbs normal neurogenesi...
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