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Antileishmania and immunomodulatory potential of cashew nut shell liquid and cardanol
Conventional treatments for leishmaniasis have caused serious adverse effects, poor tolerance, development of resistant st...
Development of an oral mucosal irritation test using a three-dimensional human buccal oral mucosal model
The oral mucosa can become irritated by oral care products and lip cosmetics. Therefore, it is important to determine the ...
In vitro neurotoxic potential of emerging flame retardants on neuroblastoma cells in an acute exposure scenario
KeywordsFlame retardant (FR)In vitro neurotoxicityTris(13-dichloro-2-propyl)phosphate (TDCPP)Triphenyl phosphate (TPhP)Bis...
Acetylshikonin induces apoptosis of human osteosarcoma U2OS cells by triggering ROS-dependent multiple signal pathways
Acetylshikonin a natural compound isolated from the root of Lithospermum erythrorhizon and one of the shikonin derivatives...
Expansion of the application domain of a macromolecular ocular irritation test (OptiSafe™)
The OptiSafe (OS) test is shelf-stable, macromolecular eye irritation test that does not include any animal ingredient or ...
Molecular mechanism of di-n-butyl phthalate promotion of bladder cancer development
PurposeTo determine whether di-n-butyl phthalate (DBP) promotes the occurrence of bladder cancer (BCa) and explore the act...
In vitro genotoxic and antigenotoxic effects of an exopolysaccharide isolated from Lactobacillus salivarius KC27L
Exopolysaccharide isolated from Lactobacillus salivarius (new genus name Ligilactobacillus) KC27L strain (EPSKC27L) exhibi...
Rubus rosifolius (Rosaceae) stem extract induces cell injury and apoptosis in human hepatoma cell line
KeywordsRubus rosifolius toxicityMicronucleus testComet assayCell cycle analysisApoptosis analysisGene expressionAbbreviat...
The morphology, functionality, and longevity of a novel all human hepatic cell-based tri-culture system
There remains a significant need for a convenient, phenotypically stable long-term culture platform for primary human hepa...
Autophagy induces mTOR-dependent glucose uptake and mTOR-independent lactate utilization in cadmium-treated A549 cells
Cadmium (Cd) is a non-essential heavy metal with many harmful effects, especially tumorigenesis. Previously we established...
Organic ultraviolet filters regulate hyaluronan metabolism in human epidermal keratinocytes through the phosphatidylinositol 3-kinase pathway
Chronic exposure of skin to ultraviolet (UV) radiation is responsible for skin ageing, which includes degradation of the e...
Plumbagin downregulates UHRF1, p-Akt, MMP-2 and suppresses survival, growth and migration of cervical cancer CaSki cells
Plumbagin is a natural compound known to impede growth of cancerous cells. However, anti-cervical cancer effects of plumba...
Exosome proteomics study of the effects of traditional cigarettes and electronic cigarettes on human bronchial epithelial cells
Electronic cigarette (e-Cig) has been promoted as a safer alternative to traditional cigarette (t-Cig) recently. However, ...
High content analysis of in vitro alveolar macrophage responses can provide mechanistic insight for inhaled product safety assessment
Assessing the safety of inhaled substances in the alveolar region of the lung requires an understanding of how the respire...
Transcriptome sequencing reveals neurotoxicity in embryonic neural stem/progenitor cells under heat stress
Neural tube malformation is a common kind of human birth defect. High temperature is one of the most common physical terat...
Sinapic and ferulic acid phenethyl esters increase the expression of steroidogenic genes in MA-10 tumor Leydig cells
During aging, the production of androgens by the testis Leydig cells gradually decreases. Phenolic compounds can improve t...
Glucose starvation impairs NER and γ-H2AX after UVB irradiation
Glucose is the major source for energy production. As tumor cells have higher glucose requirement, combination of glucose ...
MitoQ alleviates triptolide-induced cardiotoxicity via activation of p62/Nrf2 axis in H9c2 cells
Triptolide (TP) is one of the major components of Tripterygium wilfordii, which is a traditional Chinese medicine widely u...
Suppression of lncRNA Snhg1 inhibits high glucose-induced inflammation and proliferation in mouse mesangial cells
Volume 86, February 2023, 105482Highlights•Levels of Snhg1 were Increased in DN renal tissues and HG-treated MCs.•Snhg1 en...
Aqua-(2-formylbenzoato)triphenyltin(IV) induces cell cycle arrest and apoptosis in hypoxic triple negative breast cancer cells
Hypoxia plays a vital role in tumor microenvironment by allowing development and maintenance of cancer cells thereby led t...
Chlorpyrifos induces neuronal cell death via both oxidative stress and Akt activation downstream-regulated CHOP-triggered apoptotic pathways
Chlorpyrifos (CPF) is one of the most abundant and widely used organophosphate pesticides for agricultural, industrial, an...
PFOS disrupts key developmental pathways during hiPSC-derived cardiomyocyte differentiation in vitro
Volume 85, December 2022, 105475Highlights•PFOS disrupts cardiac differentiation in hiPSCs from two different donors.•Tran...