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Tumor budding is a prognostic factor in head and neck squamous cell carcinoma: A comprehensive meta-analysis and trial sequential analysis
Tumor budding is a prognostic factor in head and neck squamous cell carcinoma: A comprehensive meta-analysis and trial sequential analysis
Fábio França Vieira e Silva, DDS, Pathology Expert, M.Sc. in Molecular Oncology, Ph.D. Dentist expert in Pathology and Mol...
Treatment of acral and mucosal melanoma: Current and emerging targeted therapies
Treatment of acral and mucosal melanoma: Current and emerging targeted therapies
Melanomas, skin tumors that develop from melanocytes, (Linares et al., 2015) comprise only ∼2% of skin cancer cases, (Lina...
Natriuretic peptides: Another tool for the management of cancer?
Natriuretic peptides: Another tool for the management of cancer?
José Tuñón, MD, PhD Head of the Department of Cardiology in Fundación Jiménez Díaz, Full-Professor and Chairman of the Dep...
The relation between excess adiposity and breast cancer in women: Clinical implications and management
The relation between excess adiposity and breast cancer in women: Clinical implications and management
Volume 193, January 2024, 104213Author links open overlay panel, , , Highlights•There is complex and bidirectional relatio...
Antibody drug conjugates in older patients: State of the art
Antibody drug conjugates in older patients: State of the art
Antibody Drug Conjugates (ADCs) are one of the most recent growing anticancer drugs, with approvals in both hematologic ma...
Primary neuroendocrine neoplasms of the vulva: A review of the MITO rare cancer group
Primary neuroendocrine neoplasms of the vulva: A review of the MITO rare cancer group
Robert Fruscio, Associate Professor of Obstetrics and Gynecology at the University of Milan-Bicocca, in Monza, Italy and s...
Potential applications of ferroptosis inducers and regulatory molecules in hematological malignancy therapy
Potential applications of ferroptosis inducers and regulatory molecules in hematological malignancy therapy
Ferroptosis is a type of cell death characterized by the accumulation of excess iron and lipid peroxide (LPO). In recent y...
Interleukin-1 receptor accessory protein (IL-1RAP): A magic bullet candidate for immunotherapy of human malignancies
Interleukin-1 receptor accessory protein (IL-1RAP): A magic bullet candidate for immunotherapy of human malignancies
Cancer is one of the leading causes of death in the global health system (Bray et al., 2021). In this regard, more than 19...
CpG-biomarkers in tumor tissue and prediction models for the survival of colorectal cancer: A systematic review and external validation study
CpG-biomarkers in tumor tissue and prediction models for the survival of colorectal cancer: A systematic review and external validation study
Colorectal cancer (CRC) is the third most common cancer and a leading cause of cancer-related death worldwide (Dekker et a...
Advances, opportunities and challenges in developing therapeutic cancer vaccines
Advances, opportunities and challenges in developing therapeutic cancer vaccines
Vaccines have been instrumental in saving countless lives. They are cost-effective and efficient in protecting against pat...
Preoperative therapy in melanoma: Evolving perspectives in clinical trials
Preoperative therapy in melanoma: Evolving perspectives in clinical trials
Advances in melanoma treatment have followed since the introduction of immune and targeted therapies since 2011 (Kakish et...
Clonal hematopoiesis and inflammation: A review of mechanisms and clinical implications
Clonal hematopoiesis and inflammation: A review of mechanisms and clinical implications
Clonal hematopoiesis (CH) is defined by the acquisition of somatic mutations in hematopoietic stem and progenitor cells (H...
Plasmacytoid dendritic cell expansion in myeloid neoplasms: A novel distinct subset of myeloid neoplasm?
Plasmacytoid dendritic cell expansion in myeloid neoplasms: A novel distinct subset of myeloid neoplasm?
Dendritic cells (DCs) are a class of antigen-presenting cells originating from bone marrow(BM)-derived pluripotent hematop...
Surgical and survival outcomes with perioperative or neoadjuvant immune-checkpoint inhibitors combined with platinum-based chemotherapy in resectable NSCLC: A systematic review and meta-analysis of randomised clinical trials
Surgical and survival outcomes with perioperative or neoadjuvant immune-checkpoint inhibitors combined with platinum-based chemotherapy in resectable NSCLC: A systematic review and meta-analysis of randomised clinical trials
The use of neoadjuvant or perioperative anti-PD(L)1 was recently tested in multiple clinical trials. We performed a system...
Insights into the molecular roles of FOXR2 in the pathology of primary pediatric brain tumors
Insights into the molecular roles of FOXR2 in the pathology of primary pediatric brain tumors
The forkhead box genes code for a family of transcription factors (TFs) that contain a conserved winged-helix DNA-binding ...
Multidisciplinary management of HER2-positive breast cancer with brain metastases: An evidence-based pragmatic approach moving from pathophysiology to clinical data
Multidisciplinary management of HER2-positive breast cancer with brain metastases: An evidence-based pragmatic approach moving from pathophysiology to clinical data
Icro Meattini, MD, is an Italian radiation oncologist. Born on January 8, 1980, in Florence, Italy, Meattini has dedicated...
Personalized medicine for metastatic prostate cancer: The paradigm of PARP inhibitors
Personalized medicine for metastatic prostate cancer: The paradigm of PARP inhibitors
Vincenza Conteduca is Associate Professor at the Department of Medical and Surgical Sciences, Unit of Medical Oncology and...
The ever-expanding landscape of antibody-drug conjugates (ADCs) in solid tumors: A systematic review
The ever-expanding landscape of antibody-drug conjugates (ADCs) in solid tumors: A systematic review
Theodoros Foukakis, MD PhD, is a medical oncologist, associate professor of oncology and research group leader at Karolins...
Adaptive therapy: a tumor therapy strategy based on Darwinian evolution theory
Adaptive therapy: a tumor therapy strategy based on Darwinian evolution theory
Shouping Xu, Chief physician, Professor, Researcher, Doctoral supervisor. Currently, he is the director of the first Ward ...
Total neoadjuvant therapy in rectal cancer: the evidence and expectations
Total neoadjuvant therapy in rectal cancer: the evidence and expectations
Radka Lohynska, Assoc. Prof., MD, PhD, is a radiation oncologist with deep expertise in radiotherapy of a wide range of ma...
Cost-effectiveness of first-line immunotherapy for advanced non-small cell lung cancer with different PD-L1 expression levels: A comprehensive overview
Cost-effectiveness of first-line immunotherapy for advanced non-small cell lung cancer with different PD-L1 expression levels: A comprehensive overview
Despite the constantly changing spectrum of cancer worldwide, lung cancer remains the leading cause of mortality, accounti...
cGAS-STING at the crossroads in cancer therapy
cGAS-STING at the crossroads in cancer therapy
Organisms survive with the ability to accurately recognize and eliminate harmful microbes. The innate immune system of mam...
Targeting breast cancer stem cells through retinoids: A new hope for treatment
Targeting breast cancer stem cells through retinoids: A new hope for treatment
Cancer being one of the major health concerns refers to many various malignancies sharing identical paramount properties (...
Salvage radiotherapy after initial cryotherapy for localized prostate cancer: A systematic review of the literature
Salvage radiotherapy after initial cryotherapy for localized prostate cancer: A systematic review of the literature
Cryotherapy is a minimally invasive procedure that destroys tumor cells by exposure to extremely low temperatures (lower t...
THE EDUCATIONAL CONTRIBUTION OF THE COLLEGE OF THE EUROPEAN SCHOOL OF ONCOLOGY (ESCO): A SURVEY ANALYSIS OF THE FIRST THREE YEARS
THE EDUCATIONAL CONTRIBUTION OF THE COLLEGE OF THE EUROPEAN SCHOOL OF ONCOLOGY (ESCO): A SURVEY ANALYSIS OF THE FIRST THREE YEARS
Christian Rolfo - is Professor of Medicine (Oncology and Hematology) in the Center of Excellence for Thoracic Oncology, Th...
The CDK4/6 Inhibitors Biomarker Landscape: the most Relevant Biomarkers of Response or Resistance for Further Research and Potential Clinical Utility
The CDK4/6 Inhibitors Biomarker Landscape: the most Relevant Biomarkers of Response or Resistance for Further Research and Potential Clinical Utility
Giuseppe Curigliano, MD, PhD. Medical oncologist and researcher with experience in clinical trials, patient care, and publ...
Immune checkpoint inhibitors for the treatment of non-small cell lung cancer: the regulatory journey in Brazil
Immune checkpoint inhibitors for the treatment of non-small cell lung cancer: the regulatory journey in Brazil
The burden of disease and mortality from cancer has grown rapidly across the world. Lung cancer was the second most freque...
Infections in haematology patients treated with CAR-T therapies: A systematic review and meta-analysis
Infections in haematology patients treated with CAR-T therapies: A systematic review and meta-analysis
Dr Tim Spelman is a PhD biostatistician and clinician with over 20 years of experience in statistics and epidemiology. He ...
Adjuvant Therapy for Renal Cell Carcinoma: A Systematic Review of Current Landscape and Future Directions
Adjuvant Therapy for Renal Cell Carcinoma: A Systematic Review of Current Landscape and Future Directions
Renal cell carcinoma (RCC) with sarcomatoid and/or rhabdoid (S/R) dedifferentiation is a highly aggressive tumor with a po...
Diagnosis and treatment of cholangiocarcinoma in Italy: a Delphi consensus statement
Diagnosis and treatment of cholangiocarcinoma in Italy: a Delphi consensus statement
Cholangiocarcinoma (CCA) is a cancer that arises from the biliary tree, whereas biliary tract cancers that arise from the ...
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