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TGF-β2-induced alterations of m6A methylation in hTERT RPE-1 cells
TGF-β2-induced alterations of m6A methylation in hTERT RPE-1 cells
N6-methyladenosine (m6A) is a methylation modification of the nitrogen atom at position 6 of adenine, which is widely foun...
The response of retinal ganglion cells to optical defocused visual stimuli in mouse retinas
The response of retinal ganglion cells to optical defocused visual stimuli in mouse retinas
Myopia and astigmatism are two primary types of refractive errors characterized by inaccurate focusing images on the retin...
Revisiting rabbit models for keratoconus: A long-term study on collagenase-induced disease progression
Revisiting rabbit models for keratoconus: A long-term study on collagenase-induced disease progression
Keratoconus (KC) is a commonly occurring corneal disorder characterised by progressive ectasia with thinning of cornea res...
Human lens epithelial-secreted exosomes attenuate ocular angiogenesis via inhibiting microglial activation
Human lens epithelial-secreted exosomes attenuate ocular angiogenesis via inhibiting microglial activation
Neovascular ocular diseases, a group of eye diseases characterized by pathological neovascularization (NV), include diabet...
MiR-181a-5p may regulate cell proliferation and autophagy in myopia and the associated retinopathy
MiR-181a-5p may regulate cell proliferation and autophagy in myopia and the associated retinopathy
The mechanism of myopia and the associated retinopathy remains unclear, and dysregulated microRNAs (miRNAs) are implicated...
CircRNA expression profiles and regulatory networks in the vitreous humor of people with high myopia
CircRNA expression profiles and regulatory networks in the vitreous humor of people with high myopia
Myopia is a growing global public health problem. This condition is particularly serious in Southeast Asia, where the prev...
Long noncoding RNA ZFAS1: A novel anti-apoptotic target in Fuchs endothelial corneal dystrophy
Long noncoding RNA ZFAS1: A novel anti-apoptotic target in Fuchs endothelial corneal dystrophy
Fuchs endothelial corneal dystrophy (FECD) is the leading indication for endothelial keratoplasty, characterized by cornea...
Influence of the calcium voltage-gated channel auxiliary subunit (CACNA2D1) absence on intraocular pressure in mice
Influence of the calcium voltage-gated channel auxiliary subunit (CACNA2D1) absence on intraocular pressure in mice
The etiology of elevated intraocular pressure (IOP), a major risk factor for glaucoma (optic nerve atrophy), is poorly und...
Oxymatrine mitigates Aspergillus fumigatus keratitis by suppressing fungal activity and restricting pyroptosis
Oxymatrine mitigates Aspergillus fumigatus keratitis by suppressing fungal activity and restricting pyroptosis
Fungal keratitis (FK) is an intractable keratopathy that often causes permanent blindness. The history of previous plant t...
Verification of the gene and protein expression of the aquaglyceroporin AQP3 in the mammalian lens
Verification of the gene and protein expression of the aquaglyceroporin AQP3 in the mammalian lens
Transport of water is critical for maintaining the transparency of the avascular lens, and the lens is known to express at...
Gut microbiota compositional profile in patients with posner-schlossman syndrome
Gut microbiota compositional profile in patients with posner-schlossman syndrome
The cause of Posner-Schlossman syndrome (PSS) remains unknown and its frequent recurrence may eventually lead to irreversi...
Identification of dysregulation of sphingolipids in retinoblastoma using liquid chromatography-mass spectrometry
Identification of dysregulation of sphingolipids in retinoblastoma using liquid chromatography-mass spectrometry
Retinoblastoma (RB) is an ocular cancer mostly prevalent in children below 5 years of age. It is estimated that, 8000 new ...
GSDMD mediated pyroptosis induced inflammation of Graves’ orbitopathy via the NF-κB/ AIM2/ Caspase-1 pathway
GSDMD mediated pyroptosis induced inflammation of Graves’ orbitopathy via the NF-κB/ AIM2/ Caspase-1 pathway
Graves’ orbitopathy (GO) is a common autoimmune disease that occurs in about 50% of patients with Graves' disease (GD) (Ba...
CircSTRBP contributes to H2O2-induced lens epithelium cell dysfunction through increasing NOX4 mRNA stability by recruiting IGF2BP1
CircSTRBP contributes to H2O2-induced lens epithelium cell dysfunction through increasing NOX4 mRNA stability by recruiting IGF2BP1
Age-related cataract (ARC) is one of the leading causes of blindness and distance vision impairment (Liu et al., 2017; Asb...
Heterogenous thinning of peripapillary tissues occurs early during high myopia development in juvenile tree shrews
Heterogenous thinning of peripapillary tissues occurs early during high myopia development in juvenile tree shrews
Myopia, or nearsightedness, has been increasing dramatically (Dolgin, 2015; Holden et al., 2016; Lin et al., 2004; Matsumu...
Compensation of inner retina to early-stage photoreceptor degeneration in a RhoP23H/+ mouse model of retinitis pigmentosa
Compensation of inner retina to early-stage photoreceptor degeneration in a RhoP23H/+ mouse model of retinitis pigmentosa
Retinitis pigmentosa (RP) is the most common inherited retinal degenerative disease and affects 1 in 3000–7000 people worl...
Impact of culture media on primary human corneal endothelial cells derived from old donors
Impact of culture media on primary human corneal endothelial cells derived from old donors
Corneal endothelial dysfunction is a major indication for corneal transplantation. However, a global shortage of donor cor...
Establishment of mouse model of neurotrophic keratopathy through TRPV1 neuronal ablation
Establishment of mouse model of neurotrophic keratopathy through TRPV1 neuronal ablation
Neurotrophic keratopathy (NK) is a degenerative corneal disease characterized by decreased or absent corneal sensation and...
In vivo quasi-elastic light scattering detects molecular changes in the lenses of adolescents with down syndrome
In vivo quasi-elastic light scattering detects molecular changes in the lenses of adolescents with down syndrome
Down syndrome (DS, Trisomy 21) is the most common chromosomal disorder in humans, affecting 1 in 700 newborns in the Unite...
A method for generating zonular tension in the murine eye by embedding and compressing the globe in a hydrogel
A method for generating zonular tension in the murine eye by embedding and compressing the globe in a hydrogel
The ocular lens is the primary organ within the eye responsible for accommodation. During accommodation, the lens is subje...
Transcriptome alterations in sf3b4-depleted zebrafish: Insights into cataract formation in retinitis pigmentosa model
Transcriptome alterations in sf3b4-depleted zebrafish: Insights into cataract formation in retinitis pigmentosa model
Posterior subcapsular cataract (PSC) frequently develops as a complication in patients with retinitis pigmentosa (RP). Des...
Investigating the therapeutic potential of Allium cepa extract in combating pesticide exposure induced ocular damage
Investigating the therapeutic potential of Allium cepa extract in combating pesticide exposure induced ocular damage
The benefit of pesticides that protect crops against pests and help in increasing agricultural yield comes at a significan...
Expression of Nephronectin in the Descemet's membrane of mouse corneas during development and adult homeostasis
Expression of Nephronectin in the Descemet's membrane of mouse corneas during development and adult homeostasis
The extracellular matrix (ECM) plays an important role in regulating cell behavior and fate in response to environmental c...
Shotgun lipidomics of human subretinal fluids under rod-dominant retina reveals cone-dominated lipids
Shotgun lipidomics of human subretinal fluids under rod-dominant retina reveals cone-dominated lipids
Eye diseases resulting in blindness can be caused by a dyshomeostasis of biomolecules such as lipids and proteins in the r...
Genistein stimulates the viability and prevents myofibroblastic transformation in human trabecular meshwork cells stimulated by TGF-β
Genistein stimulates the viability and prevents myofibroblastic transformation in human trabecular meshwork cells stimulated by TGF-β
The ageing of population leading to rise in glaucoma cases and becoming an epidemiological problem. Since the turn of the ...