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Possible Retinotoxicity of Long-term Vardenafil Treatment
Possible Retinotoxicity of Long-term Vardenafil Treatment
Diabetes mellitus (DM) and its complications pose an ever-increasing economic and social burden on modern societies. Today...
Examining the Correlation of Lymphangiogenesis Biomarkers with Clinical Condition in Age-Related Macular Degeneration (AMD)
Examining the Correlation of Lymphangiogenesis Biomarkers with Clinical Condition in Age-Related Macular Degeneration (AMD)
Drusen are considered a characteristic feature of AMD and are one of its earliest findings. The contents of the deposits c...
Aqueous humour protein dysregulation in Asian eyes with primary open angle glaucoma
Aqueous humour protein dysregulation in Asian eyes with primary open angle glaucoma
Glaucoma is the most common cause of irreversible blindness worldwide (Cedrone et al., 2008). Characterized by retinal gan...
Autophagy in dry AMD: a promising therapeutic strategy for retinal pigment epithelial cell damage
Autophagy in dry AMD: a promising therapeutic strategy for retinal pigment epithelial cell damage
Age-related macular degeneration (AMD) is the primary cause of central vision loss in individuals over the age of 55, sign...
Increased molar ratio of free fatty acids to albumin in blood as cause and early biomarker for the development of cataracts and Alzheimer's disease
Increased molar ratio of free fatty acids to albumin in blood as cause and early biomarker for the development of cataracts and Alzheimer's disease
The aging eye lens has been characterised “as an aging paradigm par excellence” (Quinlan and Giblin, 2022). There is a clo...
Tamoxifen protects photoreceptors in the sodium iodate model
Tamoxifen protects photoreceptors in the sodium iodate model
Selective estrogen receptor modulators (SERM) can act as either agonists or antagonists depending on the cell-type and rec...
INOS ablation promotes corneal wound healing via activation of Akt signaling
INOS ablation promotes corneal wound healing via activation of Akt signaling
The cornea is the anterior physical barrier that protects against pathogen invasion. Various causes, such as trauma, infla...
Nicotinamide promotes the differentiation of functional corneal endothelial cells from human embryonic stem cells
Nicotinamide promotes the differentiation of functional corneal endothelial cells from human embryonic stem cells
The corneal endothelium is a cell monolayer on the posterior surface of the cornea that maintains the normal hydration of ...
Optimizing retinal ganglion cell nuclear staining for automated cell counting
Optimizing retinal ganglion cell nuclear staining for automated cell counting
The retinal ganglion cells (RGCs) serve as the critical pathway for transmitting visual information from the retina to the...
Retinal microcirculation: A window into systemic circulation and metabolic disease
Retinal microcirculation: A window into systemic circulation and metabolic disease
The recent COVID-19 pandemic has significantly increased the workload on medical practitioners due to the treatment of sev...
Validation of retinal oximetry vessel selection using fluorescein angiography in patients with optic disc drusen
Validation of retinal oximetry vessel selection using fluorescein angiography in patients with optic disc drusen
Fluorescein angiography (FA) has been used to visualize the retinal blood vessels and perfusion thereby enhancing the know...
Two-phase mechanism in the treatment of corneal stromal fibrosis with topical losartan
Two-phase mechanism in the treatment of corneal stromal fibrosis with topical losartan
Several studies in rabbits and case reports in humans have demonstrated the efficacy and safety of topical losartan (2-but...
Photoreceptor deficits appear at eye opening in Rs1 mutant mouse models of X-linked retinoschisis
Photoreceptor deficits appear at eye opening in Rs1 mutant mouse models of X-linked retinoschisis
X-linked retinoschisis (XLRS) is an early onset degenerative retinal disease characterized by cystic lesions in the middle...
PEDF-derived peptide protects against Amyloid-β toxicity in vitro and prevents retinal dysfunction in rats
PEDF-derived peptide protects against Amyloid-β toxicity in vitro and prevents retinal dysfunction in rats
Drusen, the defining features of age-related macular degeneration (AMD), are a risk factor for progression into advanced d...
Fibronectin binds integrin α5β1 to regulate macular neovascularization through the Wnt/β-catenin signaling pathway
Fibronectin binds integrin α5β1 to regulate macular neovascularization through the Wnt/β-catenin signaling pathway
Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss in the industrialized world. Accordi...
Analysis aqueous humor lipid profile of neovascular glaucoma secondary to diabetic retinopathy and lipidomic alteration response to anti-VEGF treatment
Analysis aqueous humor lipid profile of neovascular glaucoma secondary to diabetic retinopathy and lipidomic alteration response to anti-VEGF treatment
Neovascular glaucoma (NVG) is a type of secondary glaucoma in which there is progressive growth of new blood vessels in bo...
Single-cell profiling transcriptomic reveals cellular heterogeneity and cellular crosstalk in choroidal neovascularization model
Single-cell profiling transcriptomic reveals cellular heterogeneity and cellular crosstalk in choroidal neovascularization model
Age-related macular degeneration (AMD) remains a major cause of irreversible vision loss in the elderly people (Wong et al...
Role of mRNA-binding proteins in retinal neovascularization
Role of mRNA-binding proteins in retinal neovascularization
Angiogenesis is crucial in physiological processes, such as embryonic development and tissue repair. An imbalance in its r...
Local administration of myeloid-derived suppressor cells prevents progression of immune-mediated dry eye disease
Local administration of myeloid-derived suppressor cells prevents progression of immune-mediated dry eye disease
Dry Eye Disease (DED) is a highly prevalent multifactorial disorder of the ocular surface (“DEWS, 2007 Definition and Clas...
Rho-kinase inhibitor alleviates CD4+T cell mediated corneal graft rejection by modulating its STAT3 and STAT5 activation
Rho-kinase inhibitor alleviates CD4+T cell mediated corneal graft rejection by modulating its STAT3 and STAT5 activation
Globally, there are approximately 4 million people with vision loss due to corneal diseases, of whom 90% are in developing...
Screening and evaluation of antioxidants for retinal pigment epithelial cell protection: L-ergothioneine as a novel therapeutic candidate through NRF2 activation
Screening and evaluation of antioxidants for retinal pigment epithelial cell protection: L-ergothioneine as a novel therapeutic candidate through NRF2 activation
Age-related macular degeneration (AMD) is categorized into two types: wet and dry. Wet AMD is characterized by the develop...
Mesenchymal stem cell-based adjunctive therapy for Pseudomonas aeruginosa-induced keratitis: A proof-of-concept in-vitro
Mesenchymal stem cell-based adjunctive therapy for Pseudomonas aeruginosa-induced keratitis: A proof-of-concept in-vitro
Bacterial keratitis represents a serious ocular concern, carrying the potential for sight-threatening complications, inclu...
Modeling autosomal dominant retinitis pigmentosa by using patient-specific retinal organoids with a class-3 RHO mutation
Modeling autosomal dominant retinitis pigmentosa by using patient-specific retinal organoids with a class-3 RHO mutation
Retinitis pigmentosa (RP) is a group of hereditary retinal degenerative diseases in which patients typically lose night vi...
Optical development in the murine eye lens of accelerated senescence-prone SAMP8 and senescence-resistant SAMR1 strains
Optical development in the murine eye lens of accelerated senescence-prone SAMP8 and senescence-resistant SAMR1 strains
The eye lens is a transparent optical structure the major function of which is to focus light onto the retina. The lens co...
Drp1-dependent mitochondrial fragmentation mediates photoreceptor abnormalities in type 1 diabetic retina
Drp1-dependent mitochondrial fragmentation mediates photoreceptor abnormalities in type 1 diabetic retina
In 2019, 463 million adults globally grappled with diabetes, as reported by the International Diabetes Federation (Saeedi ...
Stop codon variant in EFEMP1 is associated with primary open-angle glaucoma due to impaired regulation of aqueous humor outflow
Stop codon variant in EFEMP1 is associated with primary open-angle glaucoma due to impaired regulation of aqueous humor outflow
Primary open angle glaucoma (POAG), the most prevalent subtype of glaucoma, is considered as a lifelong disease involving ...
Sphingolipid biosynthetic inhibitor L-cycloserine prevents oxidative-stress-mediated death in an in vitro model of photoreceptor-derived 661W cells
Sphingolipid biosynthetic inhibitor L-cycloserine prevents oxidative-stress-mediated death in an in vitro model of photoreceptor-derived 661W cells
The irreversible loss of vision in various retinal degenerative diseases, such as Retinitis Pigmentosa (RP) and Age-relate...
Causal associations of refractive error and early age-related macular degeneration: A Mendelian randomization study
Causal associations of refractive error and early age-related macular degeneration: A Mendelian randomization study
Age-related macular degeneration (AMD) constitutes a degenerative condition impacting the macula, resulting in the gradual...
Extracellular vesicle biomarkers in ocular fluids associated with ophthalmic diseases
Extracellular vesicle biomarkers in ocular fluids associated with ophthalmic diseases
Extracellular vesicles (EVs) are released as highly stable lipid bilayer particles carrying proteins, lipids, glycans and ...
Analysis of the mucosal chemokines CCL28, CXCL14, and CXCL17 in dry eye disease: An in vitro and clinical investigation
Analysis of the mucosal chemokines CCL28, CXCL14, and CXCL17 in dry eye disease: An in vitro and clinical investigation
Mucosal chemokines have antimicrobial properties and play an important role in mucosal immunity. However, little is known ...
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