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Frailty, mortality, and health care utilization after liver transplantation: From the Multicenter Functional Assessment in Liver Transplantation (FrAILT) Study
Frailty, mortality, and health care utilization after liver transplantation: From the Multicenter Functional Assessment in Liver Transplantation (FrAILT) Study
Abstract Background and Aims Frailty is a well-established risk factor for poor outcomes in patients with cirrhosis awaiti...
Programmed death 1 expressing CD8+CXCR5+ follicular T cells constitute effector rather than exhaustive phenotype in patients with chronic hepatitis B
Programmed death 1 expressing CD8+CXCR5+ follicular T cells constitute effector rather than exhaustive phenotype in patients with chronic hepatitis B
Abstract Background and Aims Classical CD8 T cells are implicated for protective and pathogenic roles in chronic hepatitis...
Reply to the review «On the mechanisms of biliary flux»
Reply to the review «On the mechanisms of biliary flux»
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Letter to the Editor: Evidence on the use of L‐ornithine L‐aspartate in overt hepatic encephalopathy – but does it really improve prognosis?
Letter to the Editor: Evidence on the use of L‐ornithine L‐aspartate in overt hepatic encephalopathy – but does it really improve prognosis?
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Mapping the conformational epitope of a therapeutic monoclonal antibody against HBsAg by in vivo selection of HBV escape variants
Mapping the conformational epitope of a therapeutic monoclonal antibody against HBsAg by in vivo selection of HBV escape variants
Abstract Background & Aims Hepatitis B immunoglobulin (HBIG) has been routinely applied in the liver transplantation setti...
Novel low‐avidity glypican‐3 specific CARTs resist exhaustion and mediate durable antitumor effects against HCC
Novel low‐avidity glypican‐3 specific CARTs resist exhaustion and mediate durable antitumor effects against HCC
Abstract Background and Aims Chimeric antigen receptor engineered T cells (CARTs) for HCC and other solid tumors are not a...
Influence of liver stiffness heterogeneity on staging fibrosis in patients with nonalcoholic fatty liver disease
Influence of liver stiffness heterogeneity on staging fibrosis in patients with nonalcoholic fatty liver disease
Abstract Background & Aims While hepatic fibrosis often affects the liver globally, the spatial distribution can be hetero...
Reply To: HEP‐21‐1196.R3
Reply To: HEP‐21‐1196.R3
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Letter to the Editor: Importance of Universal Screening for Chronic Hepatitis B Infection in Adults in the United States
Letter to the Editor: Importance of Universal Screening for Chronic Hepatitis B Infection in Adults in the United States
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Hepatitis B screening—Universal or simplified semi‐targeted but not the status quo
Hepatitis B screening—Universal or simplified semi‐targeted but not the status quo
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Letter to the editor: Episodic‐precipitant induced hepatic encephalopathy treatment: look at new and old precipitants!
Letter to the editor: Episodic‐precipitant induced hepatic encephalopathy treatment: look at new and old precipitants!
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REPLY TO HEP‐21‐2202: Analysis and limits of detection of biliary flux
REPLY TO HEP‐21‐2202: Analysis and limits of detection of biliary flux
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Survival of the Less‐fit
Survival of the Less‐fit
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Ultra‐Sensitive and Affordable Assay for Early Detection of Primary Liver Cancer Using Plasma cfDNA Fragmentomics
Ultra‐Sensitive and Affordable Assay for Early Detection of Primary Liver Cancer Using Plasma cfDNA Fragmentomics
Abstract Background & Aims Early detection of primary liver cancer (PLC), including hepatocellular carcinoma (HCC), intrah...
Reply to "The Role of Aquaporin 9 in Modeling of Ornithine Transcarbamylase Deficiency"
Reply to "The Role of Aquaporin 9 in Modeling of Ornithine Transcarbamylase Deficiency"
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A phase 2 dose‐finding study of lonafarnib and ritonavir with or without interferon alpha for chronic delta hepatitis
A phase 2 dose‐finding study of lonafarnib and ritonavir with or without interferon alpha for chronic delta hepatitis
Abstract Background and Aims Proof-of-concept studies demonstrated lonafarnib (LNF), a first-in-class oral prenylation inh...
A New Strategy of Vascular‐targeted Therapy for Liver Fibrosis
A New Strategy of Vascular‐targeted Therapy for Liver Fibrosis
Abstract Background & Aims No effective treatments are available for liver fibrosis. Angiogenesis is deeply involved in li...
Autophagy Promotes Hepatic Cystogenesis in Polycystic Liver Disease via Depletion of Cholangiocyte Ciliogenic Proteins
Autophagy Promotes Hepatic Cystogenesis in Polycystic Liver Disease via Depletion of Cholangiocyte Ciliogenic Proteins
ABSTRACT Backgrounds & Aims Polycystic liver disease (PLD) is characterized by defective cholangiocyte cilia that regulate...
Mucosal‐associated invariant T‐cell tumor infiltration predicts long‐term survival in cholangiocarcinoma
Mucosal‐associated invariant T‐cell tumor infiltration predicts long‐term survival in cholangiocarcinoma
Abstract Background and Aims Cholangiocarcinoma (CCA) is a malignancy arising from biliary epithelial cells of intra- and ...
Letter to the editor: Reactivation of HBV triggered by SARS‐CoV‐2 in a patient with cirrhosis
Letter to the editor: Reactivation of HBV triggered by SARS‐CoV‐2 in a patient with cirrhosis
To the editor, HBV reactivation can occur spontaneously, but it is more frequently triggered by immuno...
ACE inhibitors prevent liver‐related events in non‐alcoholic fatty liver disease
ACE inhibitors prevent liver‐related events in non‐alcoholic fatty liver disease
ABSTRACT Background & Aims Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) can i...
Rise above the stress—Endoplasmic reticulum stress and autophagy enhance the release of hepatitis B virus subparticles
Rise above the stress—Endoplasmic reticulum stress and autophagy enhance the release of hepatitis B virus subparticles
Corresponding Author Alexander Ploss Department of Molecul...
Global burden of NAFLD and chronic liver disease among adolescents and young adults
Global burden of NAFLD and chronic liver disease among adolescents and young adults
Abstract Background and Aim The causes of chronic liver disease (CLD) among adults have changed. Data are lacking on trend...
IL‐6–induced cGGNBP2 encodes a protein to promote cell growth and metastasis in intrahepatic cholangiocarcinoma
IL‐6–induced cGGNBP2 encodes a protein to promote cell growth and metastasis in intrahepatic cholangiocarcinoma
Abstract Background and Aims IL-6–induced tumor progression has been well established through the induction of anti...
Letter to the editor: The impact of donor liver fibrosis on early allograft dysfunction and ischemia‐reperfusion injury
Letter to the editor: The impact of donor liver fibrosis on early allograft dysfunction and ischemia‐reperfusion injury
Early View CORRESPONDENCE Yuki Bekki, Corresponding Author Yuki Bekki ...
DDX17‐regulated alternative splicing that produced an oncogenic isoform of PXN‐AS1 to promote HCC metastasis
DDX17‐regulated alternative splicing that produced an oncogenic isoform of PXN‐AS1 to promote HCC metastasis
Abstract Background and Aims The mechanism underlying HCC metastasis remains unclear, many oncogenes are known to regulate...
Reply to letter to the editor by Zhang et al (HEP‐21‐2372) regarding our recently published article entitled Aquaporin 9 Induction in Human iPSC‐derived Hepatocytes Facilitates Modeling of Ornithine Transcarbamylase Deficiency (HEP‐21‐1274)
Reply to letter to the editor by Zhang et al (HEP‐21‐2372) regarding our recently published article entitled Aquaporin 9 Induction in Human iPSC‐derived Hepatocytes Facilitates Modeling of Ornithine Transcarbamylase Deficiency (HEP‐21‐1274)
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Letter to the Editor: Serum Thrombospondin‐2 as biomarker in liver diseases, a look beyond NASH
Letter to the Editor: Serum Thrombospondin‐2 as biomarker in liver diseases, a look beyond NASH
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Reply; Transcriptomics identify thrombospondin‐2 as a biomarker for nonalcoholic steatohepatitis and advanced liver fibrosis
Reply; Transcriptomics identify thrombospondin‐2 as a biomarker for nonalcoholic steatohepatitis and advanced liver fibrosis
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Loss of bile salt export pump aggravates lipopolysaccharide‐induced liver injury in mice due to impaired hepatic endotoxin clearance
Loss of bile salt export pump aggravates lipopolysaccharide‐induced liver injury in mice due to impaired hepatic endotoxin clearance
Abstract Background and Aims LPS clearance is delayed in cholestatic liver diseases. While compromised clearance by Kupffe...
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