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The 2021 IXA Keith Reemtsma Lecture: Moving xenotransplantation to the clinic
The 2021 IXA Keith Reemtsma Lecture: Moving xenotransplantation to the clinic
Abstract Keith Reemtsma was a pioneer in xenotransplantation, the Honorary Founding President of the International Xenotra...
Anti‐thymoglobulin induction improves neonatal porcine xenoislet engraftment and survival
Anti‐thymoglobulin induction improves neonatal porcine xenoislet engraftment and survival
Abstract Porcine islet xenotransplantation is a viable strategy to treat diabetes. Its translation has been limited by the...
Transgenic pigs expressing near infrared fluorescent protein—A novel tool for noninvasive imaging of islet xenotransplants
Transgenic pigs expressing near infrared fluorescent protein—A novel tool for noninvasive imaging of islet xenotransplants
Abstract Background Islet xenotransplantation is a promising concept for beta-cell replacement therapy. Reporter genes for...
Should you need an organ… Flemish secondary school students’ attitudes toward xenotransplantation and transgenetic organ donation
Should you need an organ… Flemish secondary school students’ attitudes toward xenotransplantation and transgenetic organ donation
Abstract Background The supply of human organs available for transplantation remains grossly inadequate globally. Animal-t...
Genetically engineered pig kidney transplantation in a brain‐dead human subject
Genetically engineered pig kidney transplantation in a brain‐dead human subject
Abstract In September 2021, a kidney (with donor-specific thymic tissue) from an α1, 3-galactosyltransferase gene-kn...
Scientific and psychosocial ethical considerations for initial clinical trials of kidney xenotransplantation
Scientific and psychosocial ethical considerations for initial clinical trials of kidney xenotransplantation
Abstract The initial clinical trials of pig solid organ xenotransplantation (XTx) are drawing closer and could begin in th...
Development and characterization of Gal KO porcine bone marrow‐derived mesenchymal stem cells
Development and characterization of Gal KO porcine bone marrow‐derived mesenchymal stem cells
Abstract Background We demonstrated that neonatal porcine bone marrow-derived mesenchymal stem cell (npBM-MSCs) could impr...
Humanized von Willebrand factor reduces platelet sequestration in ex vivo and in vivo xenotransplant models
Humanized von Willebrand factor reduces platelet sequestration in ex vivo and in vivo xenotransplant models
Abstract The transplantation of organs across species offers the potential to solve the shortage of human organs. While ac...
Histopathology of pig kidney grafts with/without expression of the carbohydrate Neu5Gc in immunosuppressed baboons
Histopathology of pig kidney grafts with/without expression of the carbohydrate Neu5Gc in immunosuppressed baboons
Abstract Introduction Pigs deficient in three glycosyltransferase enzymes (triple-knockout [TKO] pigs, that is, not expres...
Updateon xenotransplantation for May/June 2021
Updateon xenotransplantation for May/June 2021
Corresponding Author Centre for Transplant & Renal Research, Westmead Insti...
Expression of human CD47 in pig glomeruli prevents proteinuria and prolongs graft survival following pig‐to‐baboon xenotransplantation
Expression of human CD47 in pig glomeruli prevents proteinuria and prolongs graft survival following pig‐to‐baboon xenotransplantation
Abstract Background Nephrotic syndrome is a common complication of pig-to-baboon kidney xenotransplantation (KXTx) that ad...
Sensitive detection systems for infectious agents in xenotransplantation*
Sensitive detection systems for infectious agents in xenotransplantation*
Abstract Xenotransplantation of pig cells, tissues, or organs may be associated with transmission of porcine microorganism...
Xenotransplantation of tannic acid‐encapsulated neonatal porcine islets decreases proinflammatory innate immune responses
Xenotransplantation of tannic acid‐encapsulated neonatal porcine islets decreases proinflammatory innate immune responses
Abstract Background Islet transplantation with neonatal porcine islets (NPIs) is a promising treatment for type 1 diabetes...
Evidence that sensitization to triple‐knockout pig cells will not be detrimental to subsequent allotransplantation
Evidence that sensitization to triple‐knockout pig cells will not be detrimental to subsequent allotransplantation
Abstract The current evidence is that sensitization to a pig xenograft does not result in the development of antibodies th...
Xenotransplantation Literature Update January/February 2021
Xenotransplantation Literature Update January/February 2021
Corresponding Author Department of Surgery, Schulze Diabetes Institute, Univers...
High‐quality porcine islets isolated from aged miniature pigs
High‐quality porcine islets isolated from aged miniature pigs
Corresponding Author Islet Cell Transplantation Project, Diabetes Research Cent...
Peritoneal dissolved oxygen and function of encapsulated adult porcine islets transplanted in streptozotocin diabetic mice
Peritoneal dissolved oxygen and function of encapsulated adult porcine islets transplanted in streptozotocin diabetic mice
Abstract Background Alginate-encapsulated islet xenografts have restored normoglycemia in diabetic animals for various per...
The effects of necrostatin‐1 on the in vitro development and function of young porcine islets over 14‐day prolonged tissue culture
The effects of necrostatin‐1 on the in vitro development and function of young porcine islets over 14‐day prolonged tissue culture
Abstract Background Necrostatin-1 (Nec-1) supplementation to tissue culture media on day 3 has recently been shown to augm...
Selection of a novel AAV2/TNFAIP3 vector for local suppression of islet xenograft inflammation
Selection of a novel AAV2/TNFAIP3 vector for local suppression of islet xenograft inflammation
Abstract Background Neonatal porcine islets (NPIs) can restore glucose control in mice, pigs, and non-human primates, repr...
The evidence of a macrophage barrier in the xenotransplantation of human hematopoietic stem cells to severely immunodeficient rats
The evidence of a macrophage barrier in the xenotransplantation of human hematopoietic stem cells to severely immunodeficient rats
Abstract Background The human-to-rat hematopoietic stem cell transplantation (HSCT) model is rare, unlike its human-to-mou...