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Anticancer activity of sinapic acid by inducing apoptosis in HT-29 human colon cancer cell line
Anticancer activity of sinapic acid by inducing apoptosis in HT-29 human colon cancer cell line
Colorectal cancer is the third most lethal and fourth most commonly diagnosed cancer worldwide. Sinapic acid, a derivative...
Thymidine phosphorylase as a molecular target for quercetin-incorporated collagen matrix in the prevention of hand–foot syndrome induced by capecitabine in rats
Thymidine phosphorylase as a molecular target for quercetin-incorporated collagen matrix in the prevention of hand–foot syndrome induced by capecitabine in rats
Hand–foot syndrome (HFS) is a common adverse effect of capecitabine affecting the quality of life of cancer patients. To e...
Naringin prevents diabetic nephropathy in rats through blockage of oxidative stress and attenuation of the mitochondrial dysfunction
Naringin prevents diabetic nephropathy in rats through blockage of oxidative stress and attenuation of the mitochondrial dysfunction
We have studied the effects of naringin (NAR), a flavonoid from citric fruits, on morphology, ultrastructure and function ...
Combined in silico strategy for repurposing DrugBank entries towards introducing potential anti-SARS-CoV-2 drugs
Combined in silico strategy for repurposing DrugBank entries towards introducing potential anti-SARS-CoV-2 drugs
The emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) from China in December 2019 led to the coron...
Protective role of nebivolol via AKT1/Hif-1α/eNOS signaling pathway: nephrotoxicity caused by methotrexate in a rat model
Protective role of nebivolol via AKT1/Hif-1α/eNOS signaling pathway: nephrotoxicity caused by methotrexate in a rat model
Methotrexate (MTX) is an antineoplastic and anti-inflammatory agent, which is used in severe diseases. Its use should be l...
The myokine decorin improves the cardiac function in a rat model of isoprenaline-induced myocardial infarction
The myokine decorin improves the cardiac function in a rat model of isoprenaline-induced myocardial infarction
Myocardial infarction is a common cause of disability. Decorin is a myokine that has anti-inflammatory, anti-apoptotic eff...
Chronic cannabis use is associated with altered monocyte phenotype, immune response, and depression in physically active individuals
Chronic cannabis use is associated with altered monocyte phenotype, immune response, and depression in physically active individuals
Introduction: This study evaluated depression, monocyte phenotype, and immune function in physically active cannabis users...
Pharmacological safety of dimethoxy curcumin-human serum albumin conjugate for potential therapeutic purpose
Pharmacological safety of dimethoxy curcumin-human serum albumin conjugate for potential therapeutic purpose
Medicinal properties of curcumin are widely published. Previously, researchers used curcuminoid mixture comprising three c...
Cardioprotective effects of liraglutide pretreatment on isoprenaline-induced myocardial injury in rats
Cardioprotective effects of liraglutide pretreatment on isoprenaline-induced myocardial injury in rats
Type 2 diabetes mellitus (T2DM) increases the risk of cardiovascular disease, especially myocardial injury. Due to their h...
A comparative study of acetyl-l-carnitine and caloric restriction impact on hippocampal autophagy, apoptosis, neurogenesis, and astroglial function in AlCl3-induced Alzheimer’s in rats
A comparative study of acetyl-l-carnitine and caloric restriction impact on hippocampal autophagy, apoptosis, neurogenesis, and astroglial function in AlCl3-induced Alzheimer’s in rats
Alzheimer’s disease (AD) is a worldwide chronic progressive neurodegenerative disease. We aimed to investigate and compare...
Neonatal treatment with fluoxetine alters locomotor activity and the cortical glial/neuron index in rats with cerebral palsy
Neonatal treatment with fluoxetine alters locomotor activity and the cortical glial/neuron index in rats with cerebral palsy
Cerebral palsy (CP) is characterized by motor disorders, including deficits in locomotor activity, coordination, and balan...
Delving into the death signaling pathway of hemp oil and gamma radiation in solid tumor bearing mice
Delving into the death signaling pathway of hemp oil and gamma radiation in solid tumor bearing mice
Many studies reported the diverse therapeutic potential of essential oils. They have a crucial role in cancer prevention a...
Mephedrone induced apoptosis and impaired neurogenesis in embryonic neural stem/progenitor cells
Mephedrone induced apoptosis and impaired neurogenesis in embryonic neural stem/progenitor cells
Mephedrone, a synthetic derivative of cathinone, is a commonly used psychoactive substance. Our previous study showed that...
Evaluation of liver stiffness using ultrasonic shear wave elastography in patients with COVID-19 induced pneumonia
Evaluation of liver stiffness using ultrasonic shear wave elastography in patients with COVID-19 induced pneumonia
In patients with COVID-19-induced pneumonia, shear wave elasticity (SWE) was used to assess liver stiffness. This study in...
Anti-inflammatory, antinociceptive, and vasorelaxant effects of a new pyrazole compound 5-(1-(2-fluorophenyl)-1H-pyrazol-4-yl)-1H-tetrazole: role of NO/cGMP pathway and calcium channels
Anti-inflammatory, antinociceptive, and vasorelaxant effects of a new pyrazole compound 5-(1-(2-fluorophenyl)-1H-pyrazol-4-yl)-1H-tetrazole: role of NO/cGMP pathway and calcium channels
Molecular modification of compounds remains important strategy towards the discovery of new drugs. In this sense, this stu...
Hepatalin: the missing link in prediabetes, obesity, and type 2 diabetes
Hepatalin: the missing link in prediabetes, obesity, and type 2 diabetes
Hepatalin is a hormone secreted by the liver in response to pulses of insulin after a mixed nutrient meal, but only if the...
Female-biased association of NOS2-c.1823C>T (rs2297518) with co-susceptibility to metabolic syndrome and asthma
Female-biased association of NOS2-c.1823C>T (rs2297518) with co-susceptibility to metabolic syndrome and asthma
The nitric oxide (NO) pathway contributes to the pathogeneses of metabolic syndrome (MetS) and asthma. NOS2 encodes induci...
Correction: Pilot study of jadomycin B pharmacokinetics and anti-tumoral effects in zebrafish larvae and mouse breast cancer xenograft models
Correction: Pilot study of jadomycin B pharmacokinetics and anti-tumoral effects in zebrafish larvae and mouse breast cancer xenograft models
Department of Pharmacology, Faculty of Medicine, Dalhousie University, Halifax, NS B3H 4R2, CanadaBeatrice Hunter Cancer R...
Colorectal and bladder prokinetic activity of [Lys5, MeLeu9, Nle10]-NKA(4–10) after intranasal or sublingual delivery in dogs
Colorectal and bladder prokinetic activity of [Lys5, MeLeu9, Nle10]-NKA(4–10) after intranasal or sublingual delivery in dogs
The feasibility of eliciting defecation and urination after intranasal (IN) or sublingual (SL) delivery of a small peptide...
Influence of permeability enhancers on the paracellular permeability of metformin hydrochloride and furosemide across Caco-2 cells
Influence of permeability enhancers on the paracellular permeability of metformin hydrochloride and furosemide across Caco-2 cells
Permeability enhancers can affect absorption of paracellularly transported drugs. This study aims to evaluate effects of p...
Chronic intermittent hypobaric hypoxia ameliorates vascular reactivity through upregulating adiponectin expression of PVAT in metabolic syndrome rats
Chronic intermittent hypobaric hypoxia ameliorates vascular reactivity through upregulating adiponectin expression of PVAT in metabolic syndrome rats
Cumulating evidence demonstrated that chronic intermittent hypobaric hypoxia (CIHH) had beneficial effects on the body. Th...
The antioxidant and anti-inflammatory activities of caffeine effectively attenuate nonalcoholic steatohepatitis and thioacetamide-induced hepatic injury in male rats
The antioxidant and anti-inflammatory activities of caffeine effectively attenuate nonalcoholic steatohepatitis and thioacetamide-induced hepatic injury in male rats
The antioxidant effect of caffeine, associated with its ability to upregulate the nuclear factor-E2-related factor-2 (Nrf2...
The circadian clock protein PER1 is important in maintaining endothelin axis regulation in Dahl salt-sensitive rats
The circadian clock protein PER1 is important in maintaining endothelin axis regulation in Dahl salt-sensitive rats
Endothelin-1 (ET-1) is a peptide hormone that acts on its receptors to regulate sodium handling in the kidney's collecting...
Gallic acid markedly stimulates GLUT1-mediated glucose uptake by the AsPC-1 pancreatic cancer cell line
Gallic acid markedly stimulates GLUT1-mediated glucose uptake by the AsPC-1 pancreatic cancer cell line
Phenolic acids are recognized as chemopreventive and chemotherapeutic agents. Altered glucose and glutamine metabolism are...
Influence of carvedilol and thyroid hormones on inflammatory proteins and cardioprotective factor HIF-1α in the infarcted heart
Influence of carvedilol and thyroid hormones on inflammatory proteins and cardioprotective factor HIF-1α in the infarcted heart
Inflammatory pathways of Toll-like receptor 4 (TLR4) and NLRP3 inflammasome contribute to acute myocardial infarction (AMI...
The effect of dapagliflozin on myocardial ischemia–reperfusion injury in diabetic rats
The effect of dapagliflozin on myocardial ischemia–reperfusion injury in diabetic rats
The incidence of ischemic heart disease is 2–3 times higher in diabetic patients. However, the effect of dapagliflozin on ...
Circadian regulation of genetic and hormonal risk factors of cardiovascular disease in women
Circadian regulation of genetic and hormonal risk factors of cardiovascular disease in women
Cardiovascular disease is the leading cause of morbidity and mortality worldwide. However, sex differences can impact diff...
Preventive effects of antenatal CDP-choline in a rat model of neonatal hyperoxia-induced lung injury
Preventive effects of antenatal CDP-choline in a rat model of neonatal hyperoxia-induced lung injury
Antenatal steroid administration to pregnant women at risk of prematurity provides pulmonary maturation in infants, while ...
Activation of the Akt/FoxO3 signaling pathway enhances oxidative stress-induced autophagy and alleviates brain damage in a rat model of ischemic stroke
Activation of the Akt/FoxO3 signaling pathway enhances oxidative stress-induced autophagy and alleviates brain damage in a rat model of ischemic stroke
Autophagy has been implicated in stroke. Our previous study showed that the FoxO3 transcription factor promotes autophagy ...
Therapeutic metformin concentrations positively regulate proliferation in endometrial epithelial cells via mTOR activation and augmented mitochondrial strength
Therapeutic metformin concentrations positively regulate proliferation in endometrial epithelial cells via mTOR activation and augmented mitochondrial strength
Metformin, an antidiabetic drug, has recently been repositioned in the treatment of several nondiabetic disorders, includi...
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