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Routine elastin staining improves venous invasion detection in colorectal carcinoma
Colorectal carcinoma (CRC) is the second most common cause of cancer-related deaths in North America [1]. Invasion of tumo...
Adult-onset Langerhans cell histiocytosis of bone: A case series highlighting a rare entity
Langerhans cell histiocytosis (LCH) is a myeloid neoplastic disorder characterized by a clonal proliferation of modified d...
Primary aneurysmal bone cyst of hands and feet: A series of 14 cases
Aneurysmal bone cyst (ABC) is a relatively rare benign bone tumor first described by Jaffe and Lichtenstein in 1942 [1]. A...
Combined expression of HIF1α, VEGF and HER2 predicts metastasis, relapse and response to combination chemotherapy in colorectal cancer patients
Cancer variability is the primary source of relapse and treatment failure. Hence, determining the optimal chemotherapeutic...
Myc rearrangement and concurrent high protein expression of C-Myc/Bcl2 carry an adverse prognosis in diffuse large B-cell lymphoma
Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous group of lymphomas that accounts for 30 %–40 % of all non-Hodgkin...
The prognostic significance of tumor budding and the expression of focal adhesion kinase and survivin in lung adenocarcinoma
Lung cancer is the most common cancer and the leading cause of cancer-related death worldwide [[1], [2], [3]]. Non-small c...
A high-performance xylene-free tissue-clearing agent for routine histology: Preliminary histomorphological results
In histology, diaphanisation is the chemical process by which a tissue sample is modified by decolouring and dehydrating w...
Immunoglobulin G deposition on proximal tubules and the tubular basement membrane in acute tubular injury complicated with focal segmental glomerulosclerosis (FSGS): A possible prediction tool for subclinical FSGS
Immunofluorescence (IF) is an important diagnostic tool for renal biopsies, especially evaluating glomerular immune comple...
Some concerns about the prognostic significance of non-lymphoid immune cells of the tumor microenvironment in breast carcinomas
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The clinicopathological significance of TOP2A expression in malignant peritoneal mesothelioma
KeywordsMalignant peritoneal mesotheliomaTOP2AKi-67SurvivalAbbreviationsMPMMalignant peritoneal mesotheliomaHIPECHyperther...
Clinicopathological features of five cases of CIC::DUX4 positive sarcomas, including literature review
According to the recent World Health Organization (WHO) classification, CIC-rearranged sarcomas, including CIC::DUX4-posit...
Primary Ewing sarcoma of the lung: A systematic review of the recent literature
Ewing sarcoma (ES), often reported also as primitive neuroectodermal tumour (PNET), is an uncommon neuroectodermal maligna...
The prognostic significance of non-lymphoid immune cells of the tumor microenvironment, including neutrophils, eosinophils, and mast cells in breast carcinomas
Breast carcinomas are the most prevalent type of cancer in women and the most common cause of mortality worldwide. The fiv...
Improving fine needle aspiration to predict the tumor biological aggressiveness in pancreatic neuroendocrine tumors using Ki-67 proliferation index, phosphorylated histone H3 (PHH3), and BCL-2
Pancreatic neuroendocrine tumors (PNETs) are rare; they account for <3 % of all pancreatic tumors [1]. While the surviv...
Discordances in expression of human epidermal growth factor receptor 2 between primary and metastatic uterine carcinosarcoma: A proposal for HER2-targeted therapy specimen selection
Uterine carcinosarcoma (UCS), a rare and aggressive malignant neoplasm [1], is characterized by biphasic histology contain...
Application of lean methodology to frozen section workflow – An audit of present practices at a single large oncology center
This study was conceived to access laboratory Lean concepts (methodology) to assess the process flow for frozen sections i...
From the archives of MD Anderson Cancer Center Castleman disease involving the thymus gland: Case report and literature review
Castleman disease (CD) is a term that encompasses a group of uncommon lymphoproliferative disorders that have heterogeneou...
The expression of programmed death-ligand 1 and programmed death-ligand 2 in endometrial carcinosarcoma: Correlation with mismatch repair protein expression status, tumor-infiltrating lymphocyte infiltration, and clinical outcomes
Endometrial carcinosarcoma, also known as malignant mixed Mullerian tumor, is defined as a biphasic, malignant tumor compo...
Chondroblastoma of foot bones; a clinicopathological study of 29 cases confirming the diagnostic utility of H3K36M and H3G34W antibodies at an uncommon site
Chondroblastoma (CB) is a rare benign bone tumor which commonly involves epiphysis or apophysis of long bone in adolescent...
“Brunner gland inflammation in Crohn's disease and Celiac disease: Overlapping inflammatory patterns suggest a possible link”
: Penicillin (PCN) allergy is frequently mislabeled and inaccurately diagnosed in children. Successful implementation of p...
Histological subtypes of hepatocellular carcinoma: Their clinical and prognostic significance
The histology of a tumor still matters in the era of molecular medicine because almost all solid cancers are managed accor...
Glycogenic hepatopathy is associated with type 1 diabetes mellitus in only a minority of cases in a contemporary adult population
Glycogen accumulation in hepatocytes has been described in children with poorly-controlled diabetes mellitus, type 1 (DM1)...
Bronchial cytology of pulmonary adenoid cystic carcinoma – A multi-institute series with emphasis on immunocytochemistry
Adenoid cystic carcinoma (AdCC) is a salivary-gland type neoplasm that can be found in extra-salivary sites including the ...
Corrigendum to “Idiopathic pulmonary fibrosis and intestinal disorders: An observational study” [Ann Diagn Pathol 62 (2023) 152072]
Volume 64, June 2023, 152131Author links open overlay panelStefania Caramaschi a, Angela Bertani b, Stefania Cerri c, Anto...
A new practical method of estimating tumoral microenvironment parameters of possible prognostic significance in patients with invasive breast carcinoma: Combined microenvironment score
Advances in cancer treatment have increased dramatically in recent years. In cancer treatment, it is emphasized that the t...
Pathological complete response and prognosis after neoadjuvant chemotherapy in patients with HER2-low breast cancer
An estimated 287,850 women living in the United States will be newly diagnosed with breast cancer in 2022 [1]. Breast canc...
Score system for cytological evaluation of fine-needle aspiration specimens to predict the diagnosis of papillary thyroid carcinomas
In 2020, there were 586,202 new cases of thyroid cancer worldwide, 448,915 in women and 137,287 in men. It was the ninth m...
Urothelial carcinoma metastases impacting the CNS: A 20-year retrospective series
Brain metastases are the most common adult brain tumor, with the breast, lung, skin (melanoma) being the most frequent pri...
Complex glandular pattern is an aggressive morphology that predicts poor prognosis of pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease, with a 5-year survival rate of only 10 % for all cases, and 3...
Grading system for medullary thyroid carcinoma; an institutional experience
Medullary thyroid carcinoma (MTC) is a rare neuroendocrine tumor that originates from the calcitonin secreting C cells of ...
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