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An exceptionally rare case of a giant parathyroid adenoma with carcinoma-like presentation
An exceptionally rare case of a giant parathyroid adenoma with carcinoma-like presentation
Giant parathyroid adenoma (GPA) is an extremely rare cause of primary hyperparathyroidism (PHPT) and may sometimes mimic p...
Immune checkpoint inhibitor-related diabetes mellitus associated with high signal intensity in diffusion-weighted magnetic resonance imaging of the pancreas at an early clinical stage
Immune checkpoint inhibitor-related diabetes mellitus associated with high signal intensity in diffusion-weighted magnetic resonance imaging of the pancreas at an early clinical stage
Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment but can give rise to immune-related adverse event...
Patient-reported outcomes, provider-reported outcomes, and physiologic parameters after gender-affirming hormone treatment in Canada: a systematic review
Patient-reported outcomes, provider-reported outcomes, and physiologic parameters after gender-affirming hormone treatment in Canada: a systematic review
Canada has experienced a ten-fold increase in referrals for gender-affirming care. Clinical guidelines emphasize the impor...
Deciphering the complex biological functions and regulatory mechanisms of melatonin
Deciphering the complex biological functions and regulatory mechanisms of melatonin
Conflict of interests The authors declare that they have no known c...
Assessing three novel composite anthropometric-metabolic indices for predicting 10-year incidence of metabolic syndrome: findings from the kerman coronary artery disease risk factors study (KERCADRS)
Assessing three novel composite anthropometric-metabolic indices for predicting 10-year incidence of metabolic syndrome: findings from the kerman coronary artery disease risk factors study (KERCADRS)
Metabolic syndrome (MetS) is a condition of high prevalence worldwide associated with increased risk of cardiovascular dis...
The Somogyi hypothesis: a parallelism with Michael Somogyi’s life
The Somogyi hypothesis: a parallelism with Michael Somogyi’s life
Michael Somogyi (Somogyi Mihály, 1883–1971) was a Hungarian biochemist who developed his scientific career in E...
Limited preventive effects of empagliflozin against metabolic dysfunction-associated steatotic liver disease in a mouse model of fast food diet
Limited preventive effects of empagliflozin against metabolic dysfunction-associated steatotic liver disease in a mouse model of fast food diet
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a highly prevalent disease with limited treatment opti...
Lateralization outcomes of bilateral inferior petrosal sinus sampling: desmopressin vs CRH
Lateralization outcomes of bilateral inferior petrosal sinus sampling: desmopressin vs CRH
Bilateral inferior petrosal sinus sampling (BIPSS) is the gold standard for localizing ACTH-dependent Cushing’s synd...
Metachronous metastasis of papillary thyroid carcinoma to the parotid gland: a case report and review of the literature
Metachronous metastasis of papillary thyroid carcinoma to the parotid gland: a case report and review of the literature
We present a case of metachronous metastasis of papillary thyroid carcinoma to the parotid gland, this being an extremely ...
A short review of current knowledge regarding long-term treatment of Graves’ disease with antithyroid drugs
A short review of current knowledge regarding long-term treatment of Graves’ disease with antithyroid drugs
Graves’ disease is the most common form of hyperthyroidism, especially in younger people. Current European guideline...
Challenges and pitfalls in the management of endocrine toxicities from immune checkpoint inhibitors: a case presentation of synchronous thyrotoxicosis and primary adrenal insufficiency in a melanoma patient
Challenges and pitfalls in the management of endocrine toxicities from immune checkpoint inhibitors: a case presentation of synchronous thyrotoxicosis and primary adrenal insufficiency in a melanoma patient
Immune checkpoint inhibitors have revolutionized the therapeutic approach to several solid tumors, becoming the standard o...
Can a mobile application improve glucose-related and patient-reported outcome measures (PROMs) in people with type 1 diabetes mellitus? A randomized controlled trial using the mySugr® app
Can a mobile application improve glucose-related and patient-reported outcome measures (PROMs) in people with type 1 diabetes mellitus? A randomized controlled trial using the mySugr® app
Mobile applications (apps) have proven to be highly effective tools to empower patients with type 1 diabetes mellitus (T1D...
Obesity and overweight are common among hospitalized patients and are associated with specific causes of admission to an internal medicine department: a cross-sectional study
Obesity and overweight are common among hospitalized patients and are associated with specific causes of admission to an internal medicine department: a cross-sectional study
Data on the prevalence of obesity among hospitalized patients are limited. Our objective was to capture the rates of overw...
The molecular genetics of adrenal cushing
The molecular genetics of adrenal cushing
Adrenal Cushing represents 20% of cases of endogenous hypercorticism. Unilateral cortisol-producing adenoma (CPA), a benig...
Silencing LncRNA SNHG14 alleviates renal tubular injury via the miR-483-5p/HDAC4 axis in diabetic kidney disease
Silencing LncRNA SNHG14 alleviates renal tubular injury via the miR-483-5p/HDAC4 axis in diabetic kidney disease
This study explored the clinical value of long non-coding RNA small nucleolar RNA host gene 14 (SNHG14) in diabetic kidney...
Relationship between body adiposity parameters and insulin resistance: a preliminary study of surrogate markers in Japan
Relationship between body adiposity parameters and insulin resistance: a preliminary study of surrogate markers in Japan
According to the Japan National Health and Nutrition Survey 2019, the proportion of people with prediabetes is estimated t...
Harnessing the benefits of physical exercise-induced melatonin: a potential promising approach to combat Alzheimer’s disease by targeting beta-amyloid (Aβ)
Harnessing the benefits of physical exercise-induced melatonin: a potential promising approach to combat Alzheimer’s disease by targeting beta-amyloid (Aβ)
Alzheimer’s disease (AD) is a chronic neurogenerative disease that impairs cognition, learning, behavior, and memory...
CUL1 exacerbates glucocorticoid-induced osteoporosis by enhancing ASAP1 ubiquitination
CUL1 exacerbates glucocorticoid-induced osteoporosis by enhancing ASAP1 ubiquitination
Glucocorticoid-induced osteoporosis is a leading secondary cause of osteoporosis. Cullin-1 (CUL1) levels are abnormally el...
Joint effects of tobacco smoke exposure and heavy metals on serum sex hormones in adult males
Joint effects of tobacco smoke exposure and heavy metals on serum sex hormones in adult males
This study aimed to explore the associations of tobacco smoke exposure (TSE) and heavy metal exposure on sex hormones and ...
Spirulina supplementation and circuit resistance training (CRT) reduce serum asprosin and appetite and improve energy balance in men with obesity and overweight
Spirulina supplementation and circuit resistance training (CRT) reduce serum asprosin and appetite and improve energy balance in men with obesity and overweight
The present study aimed to investigate the effects of 8 weeks spirulina supplementation and circuit resistance training (C...
Screening tools for diabetic foot ulcers: a narrative review
Screening tools for diabetic foot ulcers: a narrative review
The prevalence of diabetic foot ulcers (DFUs) is 4 to 10% among people with diabetes mellitus. DFUs are associated with in...
Genetic determinants of age at menarche: does the LIN28B gene play a role? A narrative review
Genetic determinants of age at menarche: does the LIN28B gene play a role? A narrative review
Menarche, the first menstrual period marking the onset of female reproduction, is a milestone of female puberty. The timin...
Clinical application of cluster analysis in patients with newly diagnosed type 2 diabetes
Clinical application of cluster analysis in patients with newly diagnosed type 2 diabetes
Early prevention and treatment of type 2 diabetes mellitus (T2DM) is still a huge challenge for patients and clinicians. R...
The value of preoperative molecular testing in the management of Bethesda V and Bethesda VI thyroid tumors
The value of preoperative molecular testing in the management of Bethesda V and Bethesda VI thyroid tumors
The incidence of thyroid cancer has increased over recent years due to the fact that several diagnostic tools, such as nec...
TSH is independently associated with remnant cholesterol in euthyroid adults: a cross-sectional study based on 29,708 individuals
TSH is independently associated with remnant cholesterol in euthyroid adults: a cross-sectional study based on 29,708 individuals
The study aims to investigate the relationship between thyroid-stimulating hormone (TSH) and remnant cholesterol (RC) in e...
Low serum CTRP3 is related to more severe distal symmetric polyneuropathy in type 2 diabetes patients
Low serum CTRP3 is related to more severe distal symmetric polyneuropathy in type 2 diabetes patients
Distal symmetric polyneuropathy (DSPN) is one of the most common chronic complications in patients with type 2 diabetes me...
Fibroblast growth-factor 23-Klotho axis is associated with systemic inflammation and myokine profile in children with chronic kidney disease
Fibroblast growth-factor 23-Klotho axis is associated with systemic inflammation and myokine profile in children with chronic kidney disease
Chronic kidney disease is linked to a disturbed fibroblast growth factor-23 (FGF23)-Klotho axis and an imbalance between m...
Testosterone therapy for functional hypogonadism in middle-aged and elderly males: current evidence and future perspectives
Testosterone therapy for functional hypogonadism in middle-aged and elderly males: current evidence and future perspectives
Population aging is a global phenomenon driving research focus toward preventing and managing age-related disorders. Funct...
A toddler with severe vitamin D-dependent rickets type 1 A (VDDR1A), hungry bone syndrome, and severe RSV infection: presentation and therapeutic challenges
A toddler with severe vitamin D-dependent rickets type 1 A (VDDR1A), hungry bone syndrome, and severe RSV infection: presentation and therapeutic challenges
Vitamin D-dependent rickets type 1 A (VDDR1A) is an autosomal recessive disorder due to mutations in the CYP27B1 ...
46,ΧΥ DSD in an adolescent with a novel de novo variant of the NR5A1 gene - case report and literature review
46,ΧΥ DSD in an adolescent with a novel de novo variant of the NR5A1 gene - case report and literature review
In addition to chromosomal abnormalities, several genes have been implicated as causes of disorders of sex development (DS...
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