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Challenges and pitfalls in the management of endocrine toxicities from immune checkpoint inhibitors: a case presentation of synchronous thyrotoxicosis and primary adrenal insufficiency in a melanoma patient
Challenges and pitfalls in the management of endocrine toxicities from immune checkpoint inhibitors: a case presentation of synchronous thyrotoxicosis and primary adrenal insufficiency in a melanoma patient
Immune checkpoint inhibitors have revolutionized the therapeutic approach to several solid tumors, becoming the standard o...
Can a mobile application improve glucose-related and patient-reported outcome measures (PROMs) in people with type 1 diabetes mellitus? A randomized controlled trial using the mySugr® app
Can a mobile application improve glucose-related and patient-reported outcome measures (PROMs) in people with type 1 diabetes mellitus? A randomized controlled trial using the mySugr® app
Mobile applications (apps) have proven to be highly effective tools to empower patients with type 1 diabetes mellitus (T1D...
Obesity and overweight are common among hospitalized patients and are associated with specific causes of admission to an internal medicine department: a cross-sectional study
Obesity and overweight are common among hospitalized patients and are associated with specific causes of admission to an internal medicine department: a cross-sectional study
Data on the prevalence of obesity among hospitalized patients are limited. Our objective was to capture the rates of overw...
The molecular genetics of adrenal cushing
The molecular genetics of adrenal cushing
Adrenal Cushing represents 20% of cases of endogenous hypercorticism. Unilateral cortisol-producing adenoma (CPA), a benig...
Silencing LncRNA SNHG14 alleviates renal tubular injury via the miR-483-5p/HDAC4 axis in diabetic kidney disease
Silencing LncRNA SNHG14 alleviates renal tubular injury via the miR-483-5p/HDAC4 axis in diabetic kidney disease
This study explored the clinical value of long non-coding RNA small nucleolar RNA host gene 14 (SNHG14) in diabetic kidney...
Relationship between body adiposity parameters and insulin resistance: a preliminary study of surrogate markers in Japan
Relationship between body adiposity parameters and insulin resistance: a preliminary study of surrogate markers in Japan
According to the Japan National Health and Nutrition Survey 2019, the proportion of people with prediabetes is estimated t...
Harnessing the benefits of physical exercise-induced melatonin: a potential promising approach to combat Alzheimer’s disease by targeting beta-amyloid (Aβ)
Harnessing the benefits of physical exercise-induced melatonin: a potential promising approach to combat Alzheimer’s disease by targeting beta-amyloid (Aβ)
Alzheimer’s disease (AD) is a chronic neurogenerative disease that impairs cognition, learning, behavior, and memory...
CUL1 exacerbates glucocorticoid-induced osteoporosis by enhancing ASAP1 ubiquitination
CUL1 exacerbates glucocorticoid-induced osteoporosis by enhancing ASAP1 ubiquitination
Glucocorticoid-induced osteoporosis is a leading secondary cause of osteoporosis. Cullin-1 (CUL1) levels are abnormally el...
Joint effects of tobacco smoke exposure and heavy metals on serum sex hormones in adult males
Joint effects of tobacco smoke exposure and heavy metals on serum sex hormones in adult males
This study aimed to explore the associations of tobacco smoke exposure (TSE) and heavy metal exposure on sex hormones and ...
Spirulina supplementation and circuit resistance training (CRT) reduce serum asprosin and appetite and improve energy balance in men with obesity and overweight
Spirulina supplementation and circuit resistance training (CRT) reduce serum asprosin and appetite and improve energy balance in men with obesity and overweight
The present study aimed to investigate the effects of 8 weeks spirulina supplementation and circuit resistance training (C...
Screening tools for diabetic foot ulcers: a narrative review
Screening tools for diabetic foot ulcers: a narrative review
The prevalence of diabetic foot ulcers (DFUs) is 4 to 10% among people with diabetes mellitus. DFUs are associated with in...
Genetic determinants of age at menarche: does the LIN28B gene play a role? A narrative review
Genetic determinants of age at menarche: does the LIN28B gene play a role? A narrative review
Menarche, the first menstrual period marking the onset of female reproduction, is a milestone of female puberty. The timin...
Clinical application of cluster analysis in patients with newly diagnosed type 2 diabetes
Clinical application of cluster analysis in patients with newly diagnosed type 2 diabetes
Early prevention and treatment of type 2 diabetes mellitus (T2DM) is still a huge challenge for patients and clinicians. R...
The value of preoperative molecular testing in the management of Bethesda V and Bethesda VI thyroid tumors
The value of preoperative molecular testing in the management of Bethesda V and Bethesda VI thyroid tumors
The incidence of thyroid cancer has increased over recent years due to the fact that several diagnostic tools, such as nec...
TSH is independently associated with remnant cholesterol in euthyroid adults: a cross-sectional study based on 29,708 individuals
TSH is independently associated with remnant cholesterol in euthyroid adults: a cross-sectional study based on 29,708 individuals
The study aims to investigate the relationship between thyroid-stimulating hormone (TSH) and remnant cholesterol (RC) in e...
Low serum CTRP3 is related to more severe distal symmetric polyneuropathy in type 2 diabetes patients
Low serum CTRP3 is related to more severe distal symmetric polyneuropathy in type 2 diabetes patients
Distal symmetric polyneuropathy (DSPN) is one of the most common chronic complications in patients with type 2 diabetes me...
Fibroblast growth-factor 23-Klotho axis is associated with systemic inflammation and myokine profile in children with chronic kidney disease
Fibroblast growth-factor 23-Klotho axis is associated with systemic inflammation and myokine profile in children with chronic kidney disease
Chronic kidney disease is linked to a disturbed fibroblast growth factor-23 (FGF23)-Klotho axis and an imbalance between m...
Testosterone therapy for functional hypogonadism in middle-aged and elderly males: current evidence and future perspectives
Testosterone therapy for functional hypogonadism in middle-aged and elderly males: current evidence and future perspectives
Population aging is a global phenomenon driving research focus toward preventing and managing age-related disorders. Funct...
A toddler with severe vitamin D-dependent rickets type 1 A (VDDR1A), hungry bone syndrome, and severe RSV infection: presentation and therapeutic challenges
A toddler with severe vitamin D-dependent rickets type 1 A (VDDR1A), hungry bone syndrome, and severe RSV infection: presentation and therapeutic challenges
Vitamin D-dependent rickets type 1 A (VDDR1A) is an autosomal recessive disorder due to mutations in the CYP27B1 ...
46,ΧΥ DSD in an adolescent with a novel de novo variant of the NR5A1 gene - case report and literature review
46,ΧΥ DSD in an adolescent with a novel de novo variant of the NR5A1 gene - case report and literature review
In addition to chromosomal abnormalities, several genes have been implicated as causes of disorders of sex development (DS...
Examining aldosterone plasma concentration alterations post-ACTH stimulation in healthy subjects: a systematic literature review and meta-analysis on ACTH’s role in aldosterone secretion
Examining aldosterone plasma concentration alterations post-ACTH stimulation in healthy subjects: a systematic literature review and meta-analysis on ACTH’s role in aldosterone secretion
Adrenocorticotropic hormone (ACTH), in addition to the renin–angiotensin–aldosterone axis, is a potent aldoste...
Thyroid complications after hemopoietic stem cell transplantation in children and adolescents
Thyroid complications after hemopoietic stem cell transplantation in children and adolescents
To evaluate the prevalence of thyroid dysfunction and its association with possible contributing factors related to diagno...
Performance of ACR-TIRADS in assessing thyroid nodules does not vary according to patient age
Performance of ACR-TIRADS in assessing thyroid nodules does not vary according to patient age
A few studies have evaluated the performance of the American College of Radiology Thyroid Imaging Reporting And Data Syste...
Goiter in the Qing Dynasty
Goiter in the Qing Dynasty
Empress Dowager Cixi, the supreme ruler of China’s Qing Dynasty, along with Imperial Concubine Jin, may hav...
Serum phosphate levels at diagnosis predict long-term risk for hypopituitarism in patients with acromegaly
Serum phosphate levels at diagnosis predict long-term risk for hypopituitarism in patients with acromegaly
Excess growth hormone (GH) secretion in acromegaly has a major impact on mineral balance and serum phosphate levels. Howev...
Endocrine-disrupting effects of bisphenol-A, thiamethoxam, and fipronil in hormone-naïve transmen compared to cis-women
Endocrine-disrupting effects of bisphenol-A, thiamethoxam, and fipronil in hormone-naïve transmen compared to cis-women
Current evidence suggests that the etiology of gender dysphoria (GD) is multifactorial: this, however, remains unclear. En...
Female-specific risk factors for cardiovascular disease: an update
Female-specific risk factors for cardiovascular disease: an update
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. While it was previously believed t...
Highlighting the contribution of the Greek physician Theodoros Aretaios to the history of thyroidectomy
Highlighting the contribution of the Greek physician Theodoros Aretaios to the history of thyroidectomy
Theodoros Aretaios (1829–1893), having pursued advanced studies at home and abroad and possessing a wide range of co...
The value of ACR, European, Korean, and ATA ultrasound risk stratification systems combined with RAS mutations for detecting thyroid carcinoma in cytologically indeterminate and suspicious for malignancy thyroid nodules
The value of ACR, European, Korean, and ATA ultrasound risk stratification systems combined with RAS mutations for detecting thyroid carcinoma in cytologically indeterminate and suspicious for malignancy thyroid nodules
The aim of this study was to evaluate the diagnostic value of four commonly utilized ultrasound (US) RSSs, namely, the Ame...
Effect of TSH on aromatase expression of ovarian granulosa cells in obese mice
Effect of TSH on aromatase expression of ovarian granulosa cells in obese mice
Aromatase plays an important role in ovarian development, the normal progress of the menstrual cycle, and fertility status...
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