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Strep A: challenges, opportunities, vaccine-based solutions, and economics
This collection of articles focuses on Streptococcus pyogenes (Strep A) vaccine research and innovation, with a focus on e...
Author Correction: Enhanced attenuation of chikungunya vaccines expressing antiviral cytokines
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
The role of correlates of protection in overcoming barriers to vaccine development and demonstrating efficacy
Vaccine development requires the conduct of clinical trials to generate the necessary safety, quality and efficacy data ne...
FcRn regulates antigen presentation in dendritic cells downstream of DEC205-targeted vaccines
FcRn regulates antigen presentation in dendritic cells downstream of DEC205-targeted vaccines
Dendritic cell (DC)-targeted vaccination is a new mode of antigen delivery that relies on the use of monoclonal antibodies...
Insights into vaccines for elderly individuals: from the impacts of immunosenescence to delivery strategies
Insights into vaccines for elderly individuals: from the impacts of immunosenescence to delivery strategies
Immunosenescence increases the risk and severity of diseases in elderly individuals and leads to impaired vaccine-induced ...
Recovery from antibody-mediated biliary ductopenia and multiorgan inflammation after COVID-19 vaccination
Recovery from antibody-mediated biliary ductopenia and multiorgan inflammation after COVID-19 vaccination
The coronavirus disease 2019 (COVID-19) pandemic has caused significant morbidity and mortality. Spike messenger RNA (mRNA...
Triple tandem trimer immunogens for HIV-1 and influenza nucleic acid-based vaccines
Triple tandem trimer immunogens for HIV-1 and influenza nucleic acid-based vaccines
Recombinant native-like HIV-1 envelope glycoprotein (Env) trimers are used in candidate vaccines aimed at inducing broadly...
Potent and long-lasting humoral and cellular immunity against varicella zoster virus induced by mRNA-LNP vaccine
Potent and long-lasting humoral and cellular immunity against varicella zoster virus induced by mRNA-LNP vaccine
Varicella zoster virus (VZV) is a highly contagious human herpes virus responsible for causing chickenpox (varicella) and ...
COVID-19 vaccination induces distinct T-cell responses in pediatric solid organ transplant recipients and immunocompetent children
COVID-19 vaccination induces distinct T-cell responses in pediatric solid organ transplant recipients and immunocompetent children
Immune responses to COVID-19 vaccination are attenuated in adult solid organ transplant recipients (SOTRs) and additional ...
Reverse development of vaccines against antimicrobial-resistant pathogens
Reverse development of vaccines against antimicrobial-resistant pathogens
Vaccine R&D is typically a lengthy process taking >10 years. However, vaccines still fail in clinical...
Progress with COVID vaccine development and implementation
Division, U. S. COVID-19 Market Dashboard https://www.unicef.org/supply/covid-19-market-dashboard. (2024)Kyriakidis, N. C....
Transcriptional signature of durable effector T cells elicited by a replication defective HCMV vaccine
Transcriptional signature of durable effector T cells elicited by a replication defective HCMV vaccine
Human cytomegalovirus (HCMV) is a leading infectious cause of birth defects and the most common opportunistic infection th...
Heterologous cAd3-Ebola and MVA-EbolaZ vaccines are safe and immunogenic in US and Uganda phase 1/1b trials
Heterologous cAd3-Ebola and MVA-EbolaZ vaccines are safe and immunogenic in US and Uganda phase 1/1b trials
Ebola virus disease (EVD) is a filoviral infection caused by virus species of the Ebolavirus genus including Zaire ebolavi...
Highly stable and immunogenic CMV T cell vaccine candidate developed using a synthetic MVA platform
Highly stable and immunogenic CMV T cell vaccine candidate developed using a synthetic MVA platform
Human cytomegalovirus (CMV) is the most common infectious cause of complications post-transplantation, while a CMV vaccine...
An intranasal combination vaccine induces systemic and mucosal immunity against COVID-19 and influenza
An intranasal combination vaccine induces systemic and mucosal immunity against COVID-19 and influenza
Despite prolonged surveillance and interventions, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and inf...
Genomic analysis of lumpy skin disease virus asian variants and evaluation of its cellular tropism
Genomic analysis of lumpy skin disease virus asian variants and evaluation of its cellular tropism
Lumpy skin disease virus (LSDV) is a poxvirus that mainly affects cattle and can lead to symptoms such as severe reduction...
Immunization-induced antigen archiving enhances local memory CD8+ T cell responses following an unrelated viral infection
Immunization-induced antigen archiving enhances local memory CD8+ T cell responses following an unrelated viral infection
Antigens from viruses or immunizations can persist or are archived in lymph node stromal cells such as lymphatic endotheli...
Design of hepadnavirus core protein-based chimeric virus-like particles carrying epitopes from respiratory syncytial virus
Design of hepadnavirus core protein-based chimeric virus-like particles carrying epitopes from respiratory syncytial virus
Respiratory syncytial virus (RSV) is one of the most important pathogens causing respiratory tract infection in humans, es...
Expansion of memory Vδ2 T cells following SARS-CoV-2 vaccination revealed by temporal single-cell transcriptomics
Expansion of memory Vδ2 T cells following SARS-CoV-2 vaccination revealed by temporal single-cell transcriptomics
γδ T cells provide rapid cellular immunity against pathogens. Here, we conducted matched single-cell RNA-sequenc...
Author Correction: Exploring synergies between B- and T-cell vaccine approaches to optimize immune responses against HIV—workshop report
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Enhanced attenuation of chikungunya vaccines expressing antiviral cytokines
Enhanced attenuation of chikungunya vaccines expressing antiviral cytokines
Alphaviruses are vector-borne, medically relevant, positive-stranded RNA viruses that cause disease in animals and humans ...
Recent progress on gene-deleted live-attenuated African swine fever virus vaccines
African Swine Fever (ASF) is a highly lethal viral disease in swine, with mortality rates approaching 100%. The disease ha...
Antigen identification strategies and preclinical evaluation models for advancing tuberculosis vaccine development
Antigen identification strategies and preclinical evaluation models for advancing tuberculosis vaccine development
In its myriad devastating forms, Tuberculosis (TB) has existed for centuries, and humanity is still affected by it. Mycoba...
Human immunoglobulin gene allelic variation impacts germline-targeting vaccine priming
Human immunoglobulin gene allelic variation impacts germline-targeting vaccine priming
Vaccine priming immunogens that activate germline precursors for broadly neutralizing antibodies (bnAbs) have promise for ...
BCG-booster vaccination with HSP90-ESAT-6-HspX-RipA multivalent subunit vaccine confers durable protection against hypervirulent Mtb in mice
BCG-booster vaccination with HSP90-ESAT-6-HspX-RipA multivalent subunit vaccine confers durable protection against hypervirulent Mtb in mice
The quest for effective and enhanced multiantigenic tuberculosis (TB) subunit vaccine necessitates the induction of a prot...
Immune response induced by standard and fractional doses of 17DD yellow fever vaccine
Immune response induced by standard and fractional doses of 17DD yellow fever vaccine
The re-emergence of yellow fever (YF) urged new mass vaccination campaigns and, in 2017, the World Health Organization app...
Putative correlates of protection against shigellosis assessing immunomarkers across responses to S. sonnei investigational vaccine
Putative correlates of protection against shigellosis assessing immunomarkers across responses to S. sonnei investigational vaccine
Shigella spp. are a leading bacterial cause of diarrhea. No widely licensed vaccines are available and there is no general...
Modulating the immune response to SARS-CoV-2 by different nanocarriers delivering an mRNA expressing trimeric RBD of the spike protein: COVARNA Consortium
Modulating the immune response to SARS-CoV-2 by different nanocarriers delivering an mRNA expressing trimeric RBD of the spike protein: COVARNA Consortium
Vaccines based on mRNA technology have revolutionized the field. In fact, lipid nanoparticles (LNP) formulated with mRNA a...
A register and questionnaire study of long-term general health symptoms following SARS-CoV-2 vaccination in Denmark
A register and questionnaire study of long-term general health symptoms following SARS-CoV-2 vaccination in Denmark
Many individuals who refuse COVID-19 vaccination have concerns about long-term side effects. Here, we report findings on s...
Prospective cohort study evaluating the association between influenza vaccination and neurodegenerative diseases
Prospective cohort study evaluating the association between influenza vaccination and neurodegenerative diseases
The effect of influenza vaccination (FluVac) on the risk of neurodegenerative diseases has not been well evaluated in pros...
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