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Establishment of isotype-switched, antigen-specific B cells in multiple mucosal tissues using non-mucosal immunization
Establishment of isotype-switched, antigen-specific B cells in multiple mucosal tissues using non-mucosal immunization
Although most pathogens infect the human body via mucosal surfaces, very few injectable vaccines can specifically target i...
ASP-2/Trans-sialidase chimeric protein induces robust protective immunity in experimental models of Chagas’ disease
ASP-2/Trans-sialidase chimeric protein induces robust protective immunity in experimental models of Chagas’ disease
Immunization with the Amastigote Surface Protein-2 (ASP-2) and Trans-sialidase (TS) antigens either in the form of recombi...
Recombinant lipidated FLIPr effectively enhances mucosal and systemic immune responses for various vaccine types
Recombinant lipidated FLIPr effectively enhances mucosal and systemic immune responses for various vaccine types
Formyl peptide receptor-like 1 inhibitor protein (FLIPr) is an immune evasion protein produced by Staphylococcus aureus, a...
Antiviral effect of SARS-CoV-2 N-specific CD8+ T cells induced in lungs by engineered extracellular vesicles
Antiviral effect of SARS-CoV-2 N-specific CD8+ T cells induced in lungs by engineered extracellular vesicles
Induction of effective immunity in the lungs should be a requisite for any vaccine designed to control the severe pathogen...
Assessment of African swine fever vaccine candidate ASFV-G-∆MGF in a reversion to virulence study
Assessment of African swine fever vaccine candidate ASFV-G-∆MGF in a reversion to virulence study
African swine fever (ASF) has gained panzootic dimensions and commercial vaccines are still unavailable. Recently, a serie...
Immunization against arthropod protein impairs transmission of rickettsial pathogen from ticks to the vertebrate host
Immunization against arthropod protein impairs transmission of rickettsial pathogen from ticks to the vertebrate host
Human anaplasmosis caused by Anaplasma phagocytophilum is one of the most common tick-borne diseases in the United States....
A candidate subunit vaccine induces protective immunity against Mycobacterium avium subspecies paratuberculosis in mice
A candidate subunit vaccine induces protective immunity against Mycobacterium avium subspecies paratuberculosis in mice
Mycobacterium avium subspecies paratuberculosis (MAP) causes paratuberculosis (PTB), which is a granulomatous enteritis in...
GP38 as a vaccine target for Crimean-Congo hemorrhagic fever virus
GP38 as a vaccine target for Crimean-Congo hemorrhagic fever virus
Crimean-Congo Hemorrhagic Fever Virus (CCHFV) is a tick-borne virus that causes severe hemorrhagic disease in humans. Ther...
Developmental and reproductive toxicity of a recombinant protein subunit COVID-19 vaccine (ZF2001) in rats
Developmental and reproductive toxicity of a recombinant protein subunit COVID-19 vaccine (ZF2001) in rats
ZF2001, a protein subunit vaccine against coronavirus disease 2019 (COVID-19), contains recombinant tandem repeat of dimer...
Strong immune responses and protection of PcrV and OprF-I mRNA vaccine candidates against Pseudomonas aeruginosa
Strong immune responses and protection of PcrV and OprF-I mRNA vaccine candidates against Pseudomonas aeruginosa
Pseudomonas aeruginosa (PA) is a leading cause of hospital-acquired and ventilator-associated pneumonia. The multidrug-res...
Bridging the immunogenicity of a tetravalent dengue vaccine (TAK-003) from children and adolescents to adults
Bridging the immunogenicity of a tetravalent dengue vaccine (TAK-003) from children and adolescents to adults
Immunobridging is an important methodology that can be used to extrapolate vaccine efficacy estimates to populations not e...
DNA based neoepitope vaccination induces tumor control in syngeneic mouse models
DNA based neoepitope vaccination induces tumor control in syngeneic mouse models
Recent findings have positioned tumor mutation-derived neoepitopes as attractive targets for cancer immunotherapy. Cancer ...
Calibration of a serum reference standard for Group B streptococcal polysaccharide conjugate vaccine development using surface plasmon resonance
Calibration of a serum reference standard for Group B streptococcal polysaccharide conjugate vaccine development using surface plasmon resonance
Group B streptococcus (GBS) is a leading cause of neonatal morbidity and mortality worldwide. Development of a maternal va...
Th1-dominant cytokine responses in kidney patients after COVID-19 vaccination are associated with poor humoral responses
Th1-dominant cytokine responses in kidney patients after COVID-19 vaccination are associated with poor humoral responses
Cytokines are regulators of the immune response against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Howe...
Interim safety and immunogenicity results from an NDV-based COVID-19 vaccine phase I trial in Mexico
Interim safety and immunogenicity results from an NDV-based COVID-19 vaccine phase I trial in Mexico
There is still a need for safe, efficient, and low-cost coronavirus disease 2019 (COVID-19) vaccines that can stop transmi...
Intranasal COVID-19 vaccine induces respiratory memory T cells and protects K18-hACE mice against SARS-CoV-2 infection
Intranasal COVID-19 vaccine induces respiratory memory T cells and protects K18-hACE mice against SARS-CoV-2 infection
Current COVID-19 vaccines prevent severe disease, but do not induce mucosal immunity or prevent infection with SARS-CoV-2,...
Global economic burden per episode for multiple diseases caused by group A Streptococcus
Global economic burden per episode for multiple diseases caused by group A Streptococcus
Considering the lack of existing evidence on economic burden for diseases caused by group A Streptococcus, we estimated th...
Risk assessment of retinal vascular occlusion after COVID-19 vaccination
Risk assessment of retinal vascular occlusion after COVID-19 vaccination
Coronavirus disease 2019 (COVID-19) vaccines are associated with several ocular manifestations. Emerging evidence has been...
Microfluidic cell squeeze-based vaccine comes into clinical investigation
Microfluidic cell squeeze-based vaccine comes into clinical investigation
Taken together, these advances provide the basis for a potent, rapid turnaround model and highlight the significant clinic...
A protective, single-visit TB vaccination regimen by co-administration of a subunit vaccine with BCG
A protective, single-visit TB vaccination regimen by co-administration of a subunit vaccine with BCG
The only licensed tuberculosis (TB) vaccine, Bacillus Calmette Guerin (BCG), fails to reliably protect adolescents and adu...
Resistance to COVID-19 vaccination and the social contract: evidence from Italy
Resistance to COVID-19 vaccination and the social contract: evidence from Italy
Confronted with stalled vaccination efforts against COVID-19, many governments embraced mandates and other measures to inc...
Adverse effects, perceptions and attitudes related to BNT162b2, mRNA-1273 or JNJ-78436735 SARS-CoV-2 vaccines: Population-based cohort
Adverse effects, perceptions and attitudes related to BNT162b2, mRNA-1273 or JNJ-78436735 SARS-CoV-2 vaccines: Population-based cohort
Long-term control of SARS-CoV-2 requires effective vaccination strategies. This has been challenged by public mistrust and...
Immunization with a Trypanosoma cruzi cyclophilin-19 deletion mutant protects against acute Chagas disease in mice
Immunization with a Trypanosoma cruzi cyclophilin-19 deletion mutant protects against acute Chagas disease in mice
Human infection with the protozoan parasite Trypanosoma cruzi causes Chagas disease for which there are no prophylactic va...
Optimal global spending for group A Streptococcus vaccine research and development
Optimal global spending for group A Streptococcus vaccine research and development
Group A Streptococcus (Strep A) leads to 600,000 deaths and 600 million cases of pharyngitis annually. Although long a pro...
Modalities of group A streptococcal prevention and treatment and their economic justification
Modalities of group A streptococcal prevention and treatment and their economic justification
Infection by group A Streptococcus (Strep A) results in a diverse range of clinical conditions, including pharyngitis, imp...
Long-term humoral response following Delta and Omicron BA.1 co-infection
Long-term humoral response following Delta and Omicron BA.1 co-infection
This study reports the 6-month humoral immune response in vaccinated patients concomitantly infected with Delta and Omicro...
An optimized messenger RNA vaccine candidate protects non-human primates from Zika virus infection
An optimized messenger RNA vaccine candidate protects non-human primates from Zika virus infection
Zika virus (ZIKV), an arbovirus transmitted by mosquitoes, was identified as a cause of congenital disease during a major ...
Structural and immunological differences in Plasmodium falciparum sexual stage transmission-blocking vaccines comprised of Pfs25-EPA nanoparticles
Structural and immunological differences in Plasmodium falciparum sexual stage transmission-blocking vaccines comprised of Pfs25-EPA nanoparticles
Development of a malaria vaccine that blocks transmission of different parasite stages to humans and mosquitoes is conside...
Is new dengue vaccine efficacy data a relief or cause for concern?
Is new dengue vaccine efficacy data a relief or cause for concern?
Dengue is a major global public health problem requiring a safe and efficacious vaccine as the foundation of a comprehensi...
OpcA and PorB are novel bactericidal antigens of the 4CMenB vaccine in mice and humans
OpcA and PorB are novel bactericidal antigens of the 4CMenB vaccine in mice and humans
The ability of Neisseria meningitidis Outer Membrane Vesicles (OMV) to induce protective responses in humans is well estab...
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