SCI时时刷

search
+
TLR7/8/9 agonists and low-dose cisplatin synergistically promotes tertiary lymphatic structure formation and antitumor immunity
TLR7/8/9 agonists and low-dose cisplatin synergistically promotes tertiary lymphatic structure formation and antitumor immunity
In situ vaccination (ISV) triggers antitumor immune responses using the patient’s own cancer antigens, yet limited n...
Antibody responses against influenza A decline with successive years of annual influenza vaccination
Antibody responses against influenza A decline with successive years of annual influenza vaccination
Influenza vaccine effectiveness and immunogenicity can be compromised with repeated vaccination. We assessed immunological...
HLA I immunopeptidome of synthetic long peptide pulsed human dendritic cells for therapeutic vaccine design
HLA I immunopeptidome of synthetic long peptide pulsed human dendritic cells for therapeutic vaccine design
Synthetic long peptides (SLPs) are a promising vaccine modality that exploit dendritic cells (DC) to treat chronic infecti...
Influenza A virus in dairy cattle: infection biology and potential mammary gland-targeted vaccines
Influenza A virus in dairy cattle: infection biology and potential mammary gland-targeted vaccines
Influenza, a major “One Health” threat, has gained heightened attention following recent reports of highly pat...
A synthetic cyclic peptide for promoting antigen presentation and immune activation
A synthetic cyclic peptide for promoting antigen presentation and immune activation
Cyclic peptides are often used as scaffolds for the multivalent presentation of drug molecules due to their structural sta...
Rational selection of TbpB variants yields a bivalent vaccine with broad coverage against Neisseria gonorrhoeae
Rational selection of TbpB variants yields a bivalent vaccine with broad coverage against Neisseria gonorrhoeae
Neisseria gonorrhoeae is an on-going public health problem due in part to the lack of success with efforts to develop an e...
mRNA vaccines with RBD mutations have broad-spectrum activity against SARS-CoV-2 variants in mice
mRNA vaccines with RBD mutations have broad-spectrum activity against SARS-CoV-2 variants in mice
The emergence of SARS-CoV-2 variants with defined mutations that enhance pathogenicity or facilitate immune evasion has re...
A broad spectrum Shigella vaccine based on VirG53–353 multiepitope region produced in a cell-free system
A broad spectrum Shigella vaccine based on VirG53–353 multiepitope region produced in a cell-free system
Dysentery caused by Shigella species remains a major health threat to children in low- and middle-income countries. There ...
Novel oral adjuvant to enhance cytotoxic memory like NK cell responses in HIV vaccine platform
Novel oral adjuvant to enhance cytotoxic memory like NK cell responses in HIV vaccine platform
Natural killer (NK) cell-driven effector mechanisms, such as antibody-dependent cell-mediated cytotoxicity, emerged as a s...
Development of broadly protective influenza B vaccines
Development of broadly protective influenza B vaccines
Influenza B viruses pose a significant threat to global public health, leading to severe respiratory infections in humans ...
Incremental benefit of high dose compared to standard dose influenza vaccine in reducing hospitalizations
Incremental benefit of high dose compared to standard dose influenza vaccine in reducing hospitalizations
Evidence regarding the high-dose (HD) vaccine’s relative vaccine effectiveness (rVE) and absolute benefit in reducin...
A bivalent COVID-19 mRNA vaccine elicited broad immune responses and protection against Omicron subvariants infection
A bivalent COVID-19 mRNA vaccine elicited broad immune responses and protection against Omicron subvariants infection
Continuously emerging SARS-CoV-2 Omicron subvariants pose a threat thwarting the effectiveness of approved COVID-19 vaccin...
A KIF20A-based thermosensitive hydrogel vaccine effectively potentiates immune checkpoint blockade therapy for hepatocellular carcinoma
A KIF20A-based thermosensitive hydrogel vaccine effectively potentiates immune checkpoint blockade therapy for hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a highly prevalent malignancy with limited treatment efficacy despite advances in immune...
Immunogenicity and safety of the 15-valent pneumococcal conjugate vaccine, a systematic review and meta-analysis
Immunogenicity and safety of the 15-valent pneumococcal conjugate vaccine, a systematic review and meta-analysis
Pneumococcal infections are a serious health issue associated with increased morbidity and mortality. This systematic revi...
DS2 designer pre-fusion F vaccine induces strong and protective antibody response against RSV infection
DS2 designer pre-fusion F vaccine induces strong and protective antibody response against RSV infection
DS-Cav1, SC-TM, and DS2 are distinct designer pre-fusion F proteins (pre-F) of respiratory syncytial virus (RSV) developed...
SPA14 liposomes combining saponin with fully synthetic TLR4 agonist provide adjuvanticity to hCMV vaccine candidate
SPA14 liposomes combining saponin with fully synthetic TLR4 agonist provide adjuvanticity to hCMV vaccine candidate
In the aim of designing and developing a novel saponin-based adjuvant system, we combined the QS21 saponin with low microg...
A Phase 1 randomized trial of homologous and heterologous filovirus vaccines with a late booster dose
A Phase 1 randomized trial of homologous and heterologous filovirus vaccines with a late booster dose
Filoviruses, including Ebola, Marburg, Sudan, and Taï Forest viruses, are zoonotic pathogens that can cause severe vi...
Mpox mRNA-1769 vaccine inhibits orthopoxvirus replication at intranasal, intrarectal, and cutaneous sites of inoculation
Mpox mRNA-1769 vaccine inhibits orthopoxvirus replication at intranasal, intrarectal, and cutaneous sites of inoculation
We previously reported that mice immunized twice with a lipid nanoparticle vaccine comprising four monkeypox viral mRNAs r...
Persistence of hepatitis E vaccine-induced antibody response across different dosage schedules and baseline serostatus
Persistence of hepatitis E vaccine-induced antibody response across different dosage schedules and baseline serostatus
Hepatitis E virus (HEV) infection is a major cause of acute viral hepatitis worldwide. The efficacy and safety of the HEV2...
Use of equine H3N8 hemagglutinin as a broadly protective influenza vaccine immunogen
Use of equine H3N8 hemagglutinin as a broadly protective influenza vaccine immunogen
Development of an efficacious universal influenza vaccines remains a long-sought goal. Current vaccines have shortfalls su...
The adjuvant effect of manganese on tuberculosis subunit vaccine Bfrb-GrpE
The adjuvant effect of manganese on tuberculosis subunit vaccine Bfrb-GrpE
Protein subunit vaccines, lacking pathogen-associated molecular patterns that trigger immune responses, rely on adjuvants ...
Downregulation of IRF7-mediated type-I interferon response by LmCen–/– parasites is necessary for protective immunity
Downregulation of IRF7-mediated type-I interferon response by LmCen–/– parasites is necessary for protective immunity
Leishmaniasis is a tropical disease caused by Leishmania parasites and currently has no licensed vaccines. We developed a ...
A safe insect-based chikungunya fever vaccine affords rapid and durable protection in cynomolgus macaques
A safe insect-based chikungunya fever vaccine affords rapid and durable protection in cynomolgus macaques
Eilat (EILV)/chikungunya virus (CHIKV), an insect-based chimeric alphavirus was previously reported to protect mice months...
Replicating RNA vaccine confers durable immunity against Crimean Congo hemorrhagic fever virus challenge in mice
Replicating RNA vaccine confers durable immunity against Crimean Congo hemorrhagic fever virus challenge in mice
Spread by Hyalomma genus ticks, Crimean-Congo hemorrhagic fever virus (CCHFV) causes a severe hemorrhagic disease endemic ...
Systematic review of the impact of intestinal microbiota on vaccine responses
Systematic review of the impact of intestinal microbiota on vaccine responses
The intestinal microbiota plays a critical role in host immunity and might contribute to the significant variation between...
Immunogenic recombinant Mayaro virus-like particles present natively assembled glycoprotein
Immunogenic recombinant Mayaro virus-like particles present natively assembled glycoprotein
Virus-like particles (VLPs) are an established vaccine platform and can be strong immunogens capable of eliciting both hum...
Publisher Correction: The dengue-specific immune response and antibody identification with machine learning
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Identifying Plasmodium P36 and P52 antigens for coadministration with circumsporozoite protein to enhance vaccine efficacy
Identifying Plasmodium P36 and P52 antigens for coadministration with circumsporozoite protein to enhance vaccine efficacy
Vaccines targeting the complex pre-erythrocytic stage of Plasmodium parasites may benefit from the inclusion of multiple a...
Neutralizing antibodies elicited in macaques recognize V3 residues on altered conformations of HIV-1 Env trimer
Neutralizing antibodies elicited in macaques recognize V3 residues on altered conformations of HIV-1 Env trimer
Eliciting broadly neutralizing antibodies that protect against diverse HIV-1 strains is a primary goal of AIDS vaccine res...
Modeling the persistence of 4CMenB vaccine protection against real world meningococcal B disease in adolescents
Modeling the persistence of 4CMenB vaccine protection against real world meningococcal B disease in adolescents
The efficacy of the four-component 4CMenB vaccine is measured through the serum bactericidal antibody (SBA) assay on four ...
阅读更多
format_indent_increase