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Centrin-deficient Leishmania mexicana confers protection against Old World visceral leishmaniasis
Centrin-deficient Leishmania mexicana confers protection against Old World visceral leishmaniasis
Leishmaniasis is one of the top neglected tropical diseases with significant morbidity and mortality in low and middle-inc...
Non-human primate to human immunobridging demonstrates a protective effect of Ad26.ZEBOV, MVA-BN-Filo vaccine against Ebola
Non-human primate to human immunobridging demonstrates a protective effect of Ad26.ZEBOV, MVA-BN-Filo vaccine against Ebola
Without clinical efficacy data, vaccine protective effect may be extrapolated from animals to humans using an immunologic ...
mRNA-LNP expressing PfCSP and Pfs25 vaccine candidates targeting infection and transmission of Plasmodium falciparum
mRNA-LNP expressing PfCSP and Pfs25 vaccine candidates targeting infection and transmission of Plasmodium falciparum
Malaria is a deadly disease responsible for between 550,000 and 627,000 deaths annually. There is a pressing need to devel...
A highly immunogenic vaccine platform against encapsulated pathogens using chimeric probiotic Escherichia coli membrane vesicles
A highly immunogenic vaccine platform against encapsulated pathogens using chimeric probiotic Escherichia coli membrane vesicles
Vaccines against infectious diseases should elicit potent and long-lasting immunity, ideally even in those with age-relate...
Immune gene expression analysis indicates the potential of a self-amplifying Covid-19 mRNA vaccine
Immune gene expression analysis indicates the potential of a self-amplifying Covid-19 mRNA vaccine
Remarkable potency has been demonstrated for mRNA vaccines in reducing the global burden of the ongoing COVID-19 pandemic....
Fine-mapping the immunodominant antibody epitopes on consensus sequence-based HIV-1 envelope trimer vaccine candidates
Fine-mapping the immunodominant antibody epitopes on consensus sequence-based HIV-1 envelope trimer vaccine candidates
The HIV-1 envelope glycoprotein (Env) trimer is the key target for vaccines aimed at inducing neutralizing antibodies (NAb...
Author Correction: A self-amplifying RNA vaccine against COVID-19 with long-term room-temperature stability
Author Correction: A self-amplifying RNA vaccine against COVID-19 with long-term room-temperature stability
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Impaired neutralizing antibodies and preserved cellular immunogenicity against SARS-CoV-2 in systemic autoimmune rheumatic diseases
Impaired neutralizing antibodies and preserved cellular immunogenicity against SARS-CoV-2 in systemic autoimmune rheumatic diseases
Reports on vaccine immunogenicity in patients with systemic autoimmune rheumatic diseases (SARDs) have been inconclusive. ...
Systematic review of primary and booster COVID-19 sera neutralizing ability against SARS-CoV-2 omicron variant
Systematic review of primary and booster COVID-19 sera neutralizing ability against SARS-CoV-2 omicron variant
Virus neutralization data using post-vaccination sera are an important tool in informing vaccine use policy decisions, how...
Two-component vaccine consisting of virus-like particles displaying hepatitis C virus envelope protein 2 oligomers
Two-component vaccine consisting of virus-like particles displaying hepatitis C virus envelope protein 2 oligomers
Development of B-cell-based hepatitis C virus (HCV) vaccines that induce broadly neutralizing antibodies (bNAbs) is hinder...
Anti-Ad26 humoral immunity does not compromise SARS-COV-2 neutralizing antibody responses following Gam-COVID-Vac booster vaccination
Anti-Ad26 humoral immunity does not compromise SARS-COV-2 neutralizing antibody responses following Gam-COVID-Vac booster vaccination
Replication-incompetent adenoviral vectors have been extensively used as a platform for vaccine design, with at least four...
Sequential use of Ad26-based vaccine regimens in NHP to induce immunity against different disease targets
Sequential use of Ad26-based vaccine regimens in NHP to induce immunity against different disease targets
The adenovirus (Ad)26 serotype–based vector vaccine Ad26.COV2.S has been used in millions of subjects for the preven...
Bordetella pertussis whole cell immunization protects against Pseudomonas aeruginosa infections
Bordetella pertussis whole cell immunization protects against Pseudomonas aeruginosa infections
Whole cell vaccines are complex mixtures of antigens, immunogens, and sometimes adjuvants that can trigger potent and prot...
A potent, broadly protective vaccine against SARS-CoV-2 variants of concern
A potent, broadly protective vaccine against SARS-CoV-2 variants of concern
Since the first outbreak in December 2019, SARS-CoV-2 has been constantly evolving and five variants have been classified ...
Safety and immunogenicity of an AS03-adjuvanted plant-based SARS-CoV-2 vaccine in Adults with and without Comorbidities
Safety and immunogenicity of an AS03-adjuvanted plant-based SARS-CoV-2 vaccine in Adults with and without Comorbidities
The rapid spread of SARS-CoV-2 continues to impact humanity on a global scale with rising total morbidity and mortality. D...
Understanding thrombosis with thrombocytopenia syndrome after COVID-19 vaccination
Understanding thrombosis with thrombocytopenia syndrome after COVID-19 vaccination
Safety and efficacy of vaccines against the SARS-CoV-2 coronavirus has been demonstrated in clinical trials and next by th...
Feasibility of novel adult tuberculosis vaccination in South Africa: a cost-effectiveness and budget impact analysis
Feasibility of novel adult tuberculosis vaccination in South Africa: a cost-effectiveness and budget impact analysis
Early trials of novel vaccines against tuberculosis (TB) in adults have suggested substantial protection against TB. Howev...
Predicting vaccine effectiveness against invasive pneumococcal disease in children using immunogenicity data
Predicting vaccine effectiveness against invasive pneumococcal disease in children using immunogenicity data
The strength of the immune response, as measured by antibody concentrations, varies between pneumococcal conjugate vaccine...
B cells oppose Mycoplasma pneumoniae vaccine enhanced disease and limit bacterial colonization of the lungs
B cells oppose Mycoplasma pneumoniae vaccine enhanced disease and limit bacterial colonization of the lungs
Development of an effective vaccine for Mycoplasma pneumoniae has been hindered by reports of Vaccine Enhanced Disease (VE...
TAFA4-IL-10 axis potentiate immunotherapy for airway allergy by induction of specific regulatory T cells
TAFA4-IL-10 axis potentiate immunotherapy for airway allergy by induction of specific regulatory T cells
Allergen-specific immunotherapy (AIT) is the main treatment for allergic diseases. The therapeutic efficacy of AIT has to ...
Characterization of an Escherichia coli-derived triple-type chimeric vaccine against human papillomavirus types 39, 68 and 70
Characterization of an Escherichia coli-derived triple-type chimeric vaccine against human papillomavirus types 39, 68 and 70
In vaccinology, a potent immunogen has two prerequisite attributes—antigenicity and immunogenicity. We have rational...
Characterization of B-cell and T-cell responses to a tetravalent dengue purified inactivated vaccine in healthy adults
Characterization of B-cell and T-cell responses to a tetravalent dengue purified inactivated vaccine in healthy adults
The increasing global impact of dengue underscores the need for a dengue virus (DENV) vaccine. We assessed B-cell and T-ce...
DYNAMIC cohort study evaluating metabolic predictors of influenza vaccine immune response in older adults
DYNAMIC cohort study evaluating metabolic predictors of influenza vaccine immune response in older adults
Immunosenescence (age-related immune dysfunction) and inflamm-aging contribute to suboptimal immune responses in older adu...
Yellow fever resurgence: An avoidable crisis?
Yellow fever resurgence: An avoidable crisis?
Yellow fever (YF), an acute viral hemorrhagic disease transmitted by infected mosquitoes, has the potenti...
A self-amplifying RNA vaccine against COVID-19 with long-term room-temperature stability
A self-amplifying RNA vaccine against COVID-19 with long-term room-temperature stability
mRNA vaccines were the first to be authorized for use against SARS-CoV-2 and have since demonstrated high efficacy against...
Creation and preclinical evaluation of genetically attenuated malaria parasites arresting growth late in the liver
Creation and preclinical evaluation of genetically attenuated malaria parasites arresting growth late in the liver
Whole-sporozoite (WSp) malaria vaccines induce protective immune responses in animal malaria models and in humans. A recen...
Development of antibody-dependent cellular cytotoxicity in response to recombinant and live-attenuated herpes zoster vaccines
Development of antibody-dependent cellular cytotoxicity in response to recombinant and live-attenuated herpes zoster vaccines
Zoster vaccines generate antibody responses against varicella-zoster virus (VZV). We compared antibody-dependent cell cyto...
CD4 T cell epitope abundance in ferritin core potentiates responses to hemagglutinin nanoparticle vaccines
CD4 T cell epitope abundance in ferritin core potentiates responses to hemagglutinin nanoparticle vaccines
Nanoparticle vaccines based on H. pylori ferritin are increasingly used as a vaccine platform for many pathogens, includin...
Sterile protection against relapsing malaria with a single-shot vaccine
Sterile protection against relapsing malaria with a single-shot vaccine
Vaccine development for Plasmodium vivax, an important human relapsing malaria, is lagging behind. In the case of the most...