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In vitro toxicological assessment of PhSeZnCl in human liver cells
In vitro toxicological assessment of PhSeZnCl in human liver cells
Phenylselenenylzinc chloride (PhSeZnCl) is an air-stable selenolate, easily synthesizable through oxidative insertion of e...
The effects of co-exposure to methyl paraben and dibutyl phthalate on cell line derived from human skin
The effects of co-exposure to methyl paraben and dibutyl phthalate on cell line derived from human skin
Data on the cumulative effects of chemical substances are necessary for the proper risk assessment, but their availability...
Theracurmin (Highly Bioavailable Curcumin) Prevents High Fat Diet-Induced Hepatic Steatosis Development in Mice
Theracurmin (Highly Bioavailable Curcumin) Prevents High Fat Diet-Induced Hepatic Steatosis Development in Mice
Curcumin, a hydrophobic polyphenol isolated from the Curcuma longa L. plant, has many pharmacological properties, includin...
Extrapolation of Hepatic Concentrations of Industrial Chemicals Using Pharmacokinetic Models to Predict Hepatotoxicity
Extrapolation of Hepatic Concentrations of Industrial Chemicals Using Pharmacokinetic Models to Predict Hepatotoxicity
In this review, we describe the absorption rates (Caco-2 cell permeability) and hepatic/plasma pharmacokinetics of 53 dive...
Alleviation of Ultraviolet B-Induced Photoaging by 7-MEGATM 500 in Hairless Mouse Skin
Alleviation of Ultraviolet B-Induced Photoaging by 7-MEGATM 500 in Hairless Mouse Skin
The purpose of this study was to investigate the effect of 7-MEGA™ 500 on the improvement of skin aging in an UVB-in...
Study on Consumer Exposure to Sun Spray and Sun Cream in South Korea
Study on Consumer Exposure to Sun Spray and Sun Cream in South Korea
When conducting risk assessments of cosmetic ingredients, it is important that reliable exposure information is obtained f...
Intracutaneous Delivery of Gelatins Reduces Fat Accumulation in Subcutaneous Adipose Tissue
Intracutaneous Delivery of Gelatins Reduces Fat Accumulation in Subcutaneous Adipose Tissue
Subcutaneous adipose tissue (SAT) accumulation is a constitutional disorder resulting from metabolic syndrome. Although su...
Molecular Markers in Sex Differences in Cancer
Molecular Markers in Sex Differences in Cancer
Cancer is one of the common causes of death with a high degree of mortality, worldwide. In many types of cancers, if not a...
Implications for the Predictivity of Cell-Based Developmental Toxicity Assays Developed Two Decades Apart
Implications for the Predictivity of Cell-Based Developmental Toxicity Assays Developed Two Decades Apart
Many in vitro developmental toxicity assays have been proposed over several decades. Since the late 1980s, we have made in...
1,2-Dichloropropane (1,2-DCP)-Induced Angiogenesis in Dermatitis
1,2-Dichloropropane (1,2-DCP)-Induced Angiogenesis in Dermatitis
1,2-Dichloropropane (1,2-DCP) has been used as an industrial solvent and a chemical intermediate, as well as in soil fumig...
Semi-automated approach for generation of biological networks on drug-induced cholestasis, steatosis, hepatitis, and cirrhosis
Semi-automated approach for generation of biological networks on drug-induced cholestasis, steatosis, hepatitis, and cirrhosis
Drug-induced liver injury (DILI) is one of the leading reasons for discontinuation of a new drug development project. Dive...
Toxicological and safety evaluations of Weissella cibaria strain CMU in animal toxicity and genotoxicity
Toxicological and safety evaluations of Weissella cibaria strain CMU in animal toxicity and genotoxicity
Weissella cibaria belongs to the Lactobacillaceae family and has been isolated from traditional fermented foods and saliva...
Effect of Combined Exposure to EDTA and Zinc Pyrithione on Pyrithione Absorption in Rats
Effect of Combined Exposure to EDTA and Zinc Pyrithione on Pyrithione Absorption in Rats
Zinc pyrithione (ZnPT) is a coordination complex of zinc and has been used widely as an anti-dandruff agent in shampoos. M...
Risk Assessment of Ethylhexyl Dimethyl PABA in Cosmetics
Risk Assessment of Ethylhexyl Dimethyl PABA in Cosmetics
Ethylhexyl dimethyl para-aminobenzoic acid (PABA) is an oily yellow liquid derivative of water-soluble PABA commonly used ...
Risk Assessment of Triclosan, a Cosmetic Preservative
Risk Assessment of Triclosan, a Cosmetic Preservative
Triclosan (TCS) is an antimicrobial compound used in consumer products. The purpose of current study was to examine toxico...
Risk Assessment of Drometrizole, a Cosmetic Ingredient used as an Ultraviolet Light Absorber
Risk Assessment of Drometrizole, a Cosmetic Ingredient used as an Ultraviolet Light Absorber
As the use of cosmetics has greatly increased in a daily life, safety issues with cosmetic ingredients have drawn an atten...
α-Mangostin and Apigenin Induced Cell Cycle Arrest and Programmed Cell Death in SKOV-3 Ovarian Cancer Cells
α-Mangostin and Apigenin Induced Cell Cycle Arrest and Programmed Cell Death in SKOV-3 Ovarian Cancer Cells
Ovarian cancer is the fifth main cause of pre-senescent death in women. Although chemotherapy is generally an efficient tr...
Simultaneous Determination of Cysteamine and Cystamine in Cosmetics by Ion-Pairing Reversed-Phase High-Performance Liquid Chromatography
Simultaneous Determination of Cysteamine and Cystamine in Cosmetics by Ion-Pairing Reversed-Phase High-Performance Liquid Chromatography
Cysteamine has been used in cosmetics as an antioxidant, a hair straightening agent, and a hair waving agent. However, rec...
Comparative In Vitro Toxicity Study of Docetaxel and Nanoxel, a Docetaxel-Loaded Micellar Formulation Using Cultured and Blood Cells
Comparative In Vitro Toxicity Study of Docetaxel and Nanoxel, a Docetaxel-Loaded Micellar Formulation Using Cultured and Blood Cells
Nanoxel-PMTM (Nanoxel) is a docetaxel-loaded methoxy-poly(ethylene glycol)-block-poly(D,L-lactide) (mPEG-PDLLA). This newl...
Risk Assessment of 5-Chloro-2-Methylisothiazol-3(2H)-One/2-Methylisothiazol-3(2H)-One (CMIT/MIT) Used as a Preservative in Cosmetics
Risk Assessment of 5-Chloro-2-Methylisothiazol-3(2H)-One/2-Methylisothiazol-3(2H)-One (CMIT/MIT) Used as a Preservative in Cosmetics
The mixture of 5-chloro-2-methylisothiazol-3(2H)-one (CMIT) and 2-methylisothiazol-3(2H)-one (MIT), CMIT/MIT, is a preserv...
Toxicological Evaluation of Phytochemical Characterized Aqueous Extract of Wild Dried Lentinus squarrosulus (Mont.) Mushroom in Rats
Toxicological Evaluation of Phytochemical Characterized Aqueous Extract of Wild Dried Lentinus squarrosulus (Mont.) Mushroom in Rats
Lentinus squarrosulus (Mont.) is an edible wild mushroom with tough fruiting body that belongs to the family Polyporaceae....
A 90-Day Repeated Oral Dose Toxicity Study of Alismatis Rhizoma Aqueous Extract in Rats
A 90-Day Repeated Oral Dose Toxicity Study of Alismatis Rhizoma Aqueous Extract in Rats
Alismatis rhizoma (AR), the dried rhizome of Alisma orientale (Sam.) Juzep, is a well-known, traditional medicine that is ...
Role of glutathione redox system on the susceptibility to deoxynivalenol of pheasant (Phasianus colchicus)
Role of glutathione redox system on the susceptibility to deoxynivalenol of pheasant (Phasianus colchicus)
There are only a few reports on the effects of mycotoxins on pheasant (Phasianus colchicus) and the susceptibility to deox...
Urinary 1-aminopyrene level in Koreans as a biomarker for the amount of exposure to atmospheric 1-nitropyrene
Urinary 1-aminopyrene level in Koreans as a biomarker for the amount of exposure to atmospheric 1-nitropyrene
1-Nitropyrene (1-NP) is a major nitro-polycyclic aromatic hydrocarbon (nitro-PAH), and a common constituent in diesel exha...
The in vitro toxicity evaluation of halloysite nanotubes (HNTs) in human lung cells
The in vitro toxicity evaluation of halloysite nanotubes (HNTs) in human lung cells
Halloysite nanotubes (HNTs) have been increasingly used in many industrial and biomedical fields. Therefore, the assessmen...