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CCNs and other extracellular matrix proteins: an introduction to the special issue
CCNs and other extracellular matrix proteins: an introduction to the special issue
The extracellular matrix (ECM) is a specialized, highly organized and dynamic three-d...
Tripartite motif–containing 9 promoted proliferation and migration of bladder cancer cells through CEACAM6-Smad2/3 axis
Tripartite motif–containing 9 promoted proliferation and migration of bladder cancer cells through CEACAM6-Smad2/3 axis
Studies have shown that tripartite motif–containing (TRIM) family proteins function as E3 ubiquitin ligases and play...
Recent progress on the role of cellular communication network factors (CCN) 3, 4 and 6 in regulating adiposity, liver fibrosis and pancreatic islets
Recent progress on the role of cellular communication network factors (CCN) 3, 4 and 6 in regulating adiposity, liver fibrosis and pancreatic islets
CCN/WISP (cellular communication network factors, or Wnt-inducted secreted proteins) family of proteins consists of six ex...
CCN1 is predominantly elevated in human skin dermis by solar-simulated ultraviolet irradiation and accumulated in dermal extracellular matrix
CCN1 is predominantly elevated in human skin dermis by solar-simulated ultraviolet irradiation and accumulated in dermal extracellular matrix
Skin primarily comprises a collagen-rich extracellular matrix (ECM) that provides structural and functional support to the...
Structural insights into regulation of CCN protein activities and functions
Structural insights into regulation of CCN protein activities and functions
CCN proteins play important functions during development, in repair mechanisms following tissue injury, as well as in path...
High glucose-induced IL-7/IL-7R upregulation of dermal fibroblasts inhibits angiogenesis in a paracrine way in delayed diabetic wound healing
High glucose-induced IL-7/IL-7R upregulation of dermal fibroblasts inhibits angiogenesis in a paracrine way in delayed diabetic wound healing
It is widely acknowledged that diabetes leads to slow wound healing and ulceration, and severe serious diabetic foot ulcer...
The regulation and functions of the matricellular CCN proteins induced by shear stress
The regulation and functions of the matricellular CCN proteins induced by shear stress
Shear stress is a frictional drag generated by the flow of fluid, such as blood or interstitial fluid, and plays a critica...
MiR-218-5p promotes trophoblast infiltration and inhibits endoplasmic reticulum/oxidative stress by reducing UBE3A-mediated degradation of SATB1
MiR-218-5p promotes trophoblast infiltration and inhibits endoplasmic reticulum/oxidative stress by reducing UBE3A-mediated degradation of SATB1
This research evaluated the effects of miR-218-5p on trophoblast infiltration and endoplasmic reticulum/oxidative stress d...
CCN–Hippo YAP signaling in vision and its role in neuronal, glial and vascular cell function and behavior
CCN–Hippo YAP signaling in vision and its role in neuronal, glial and vascular cell function and behavior
The retina is a highly specialized tissue composed of a network of neurons, glia, and vascular and epithelial cells; all w...
Potential of extracellular vesicles for early prediction of severity and potential risk stratification in critical inflammatory diseases
Potential of extracellular vesicles for early prediction of severity and potential risk stratification in critical inflammatory diseases
Some acute inflammatory diseases are often exacerbated during or after hospitalization, leading to some severe manifestati...
CCN proteins: opportunities for clinical studies—a personal perspective
CCN proteins: opportunities for clinical studies—a personal perspective
The diverse members of the CCN family now designated as CCN1(CYR61), CCN2 (CTGF), CCN3(NOV), CCN4(WISP1), CCN5(WISP2), CCN...
The impact of cellular senescence in human adipose tissue
The impact of cellular senescence in human adipose tissue
In the last decades the prevalence of obesity has increased dramatically, and the worldwide epidemic of obesity and relate...
Significance of CCNs in liver regeneration
Significance of CCNs in liver regeneration
The liver has an inherent regenerative capacity via hepatocyte proliferation after mild-to-modest damage. When hepatocytes...
Quinacrine inhibits cMET-mediated metastasis and angiogenesis in breast cancer stem cells
Quinacrine inhibits cMET-mediated metastasis and angiogenesis in breast cancer stem cells
A trans-membrane receptor tyrosine kinase, cMET, belonging to the MET proto-oncogene family, is responsible for cancer met...
Cooperation is the key: the CCN biological system as a gate to high complex protein superfamilies’ signaling
Cooperation is the key: the CCN biological system as a gate to high complex protein superfamilies’ signaling
Cellular signaling is generally understood as the support of communication between contiguous cells belonging to the same ...
Optimized multiplex immunofluorescence for the characterization of tumor immune microenvironment in neoplastic paraffin-preserved tissues
Optimized multiplex immunofluorescence for the characterization of tumor immune microenvironment in neoplastic paraffin-preserved tissues
The study of neoplastic cells enabled the discovery of important tumor-related biomarkers which resulted in new forms of e...
Expression and biological function of the cellular communication network factor 5 (CCN5) in primary liver cells
Expression and biological function of the cellular communication network factor 5 (CCN5) in primary liver cells
The cellular (centralized) communication network (CCN) factor protein family contains six small secreted cysteine-rich pro...
Correction to: Three generations of mTOR kinase inhibitors in the activation of the apoptosis process in melanoma cells
Correction to: Three generations of mTOR kinase inhibitors in the activation of the apoptosis process in melanoma cells
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which ...
Temperal and spatial expression of CCN1, CCN3, CCN4, CCN5 and CCN6 proteins in the developing postnatal teeth
Temperal and spatial expression of CCN1, CCN3, CCN4, CCN5 and CCN6 proteins in the developing postnatal teeth
CCN proteins are matricellular proteins and are important modulators of development and function of adult organs. However,...
A network map of macrophage-stimulating protein (MSP) signaling
A network map of macrophage-stimulating protein (MSP) signaling
Macrophage-stimulating protein (MSP), a serum-derived growth factor belonging to the plasminogen-related kringle domain fa...
GSKIP modulates cell aggregation through EMT/MET signaling rather than differentiation in SH-SY5Y human neuroblastoma cells
GSKIP modulates cell aggregation through EMT/MET signaling rather than differentiation in SH-SY5Y human neuroblastoma cells
GSK3β interacting protein (GSKIP) is a small A-kinase anchor protein previously reported to mediate the N-cadherin/&#...
CD40 induces selective routing of Ras isoforms to subcellular compartments
CD40 induces selective routing of Ras isoforms to subcellular compartments
Ras GTPases are central to cellular signaling and oncogenesis. The three loci of the Ras gene encode for four protein isof...
Ephrin–Eph receptor tyrosine kinases for potential therapeutics against hepatic pathologies
Ephrin–Eph receptor tyrosine kinases for potential therapeutics against hepatic pathologies
Hepatic fibrosis is the common pathological change that occurs due to increased synthesis and accumulation of extracellula...
Three generations of mTOR kinase inhibitors in the activation of the apoptosis process in melanoma cells
Three generations of mTOR kinase inhibitors in the activation of the apoptosis process in melanoma cells
Many signaling pathways are involved in the mammalian target of rapamycin (mTOR), and this serine/threonine kinase regulat...
Skin aging from the perspective of dermal fibroblasts: the interplay between the adaptation to the extracellular matrix microenvironment and cell autonomous processes
Skin aging from the perspective of dermal fibroblasts: the interplay between the adaptation to the extracellular matrix microenvironment and cell autonomous processes
This article summarizes important molecular mechanisms that drive aging in human skin from the perspective of dermal fibro...
Activation of AMPK promotes cardiac differentiation by stimulating the autophagy pathway
Activation of AMPK promotes cardiac differentiation by stimulating the autophagy pathway
Autophagy, a critical catabolic process for cell survival against different types of stress, has a role in the differentia...
AMPK targets a proto-oncogene TPD52 (isoform 3) expression and its interaction with LKB1 suppress AMPK-GSK3β signaling axis in prostate cancer
AMPK targets a proto-oncogene TPD52 (isoform 3) expression and its interaction with LKB1 suppress AMPK-GSK3β signaling axis in prostate cancer
Tumor protein D52 (TPD52) is a proto-oncogene overexpressed in prostate cancer (PCa) due to gene amplification and it is i...
The growth hormone receptor interacts with transcriptional regulator HMGN1 upon GH-induced nuclear translocation
The growth hormone receptor interacts with transcriptional regulator HMGN1 upon GH-induced nuclear translocation
Growth hormone (GH) actions are mediated through binding to its cell-surface receptor, the GH receptor (GHR), with consequ...
An assembly of TROP2-mediated signaling events
An assembly of TROP2-mediated signaling events
Trophoblast cell surface antigen 2 (TROP2) is a calcium-transducing transmembrane protein mainly involved in embryo develo...
Advances in research of biological functions of Isthmin-1
Advances in research of biological functions of Isthmin-1
Isthmin-1 (ISM1) was initially thought to be a brain secretory factor, but with the development of technical means of rese...
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