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Structural insights into regulation of CCN protein activities and functions
Structural insights into regulation of CCN protein activities and functions
CCN proteins play important functions during development, in repair mechanisms following tissue injury, as well as in path...
The regulation and functions of the matricellular CCN proteins induced by shear stress
The regulation and functions of the matricellular CCN proteins induced by shear stress
Shear stress is a frictional drag generated by the flow of fluid, such as blood or interstitial fluid, and plays a critica...
CCN–Hippo YAP signaling in vision and its role in neuronal, glial and vascular cell function and behavior
CCN–Hippo YAP signaling in vision and its role in neuronal, glial and vascular cell function and behavior
The retina is a highly specialized tissue composed of a network of neurons, glia, and vascular and epithelial cells; all w...
CCN proteins: opportunities for clinical studies—a personal perspective
CCN proteins: opportunities for clinical studies—a personal perspective
The diverse members of the CCN family now designated as CCN1(CYR61), CCN2 (CTGF), CCN3(NOV), CCN4(WISP1), CCN5(WISP2), CCN...
The impact of cellular senescence in human adipose tissue
The impact of cellular senescence in human adipose tissue
In the last decades the prevalence of obesity has increased dramatically, and the worldwide epidemic of obesity and relate...
Significance of CCNs in liver regeneration
Significance of CCNs in liver regeneration
The liver has an inherent regenerative capacity via hepatocyte proliferation after mild-to-modest damage. When hepatocytes...
Quinacrine inhibits cMET-mediated metastasis and angiogenesis in breast cancer stem cells
Quinacrine inhibits cMET-mediated metastasis and angiogenesis in breast cancer stem cells
A trans-membrane receptor tyrosine kinase, cMET, belonging to the MET proto-oncogene family, is responsible for cancer met...
Cooperation is the key: the CCN biological system as a gate to high complex protein superfamilies’ signaling
Cooperation is the key: the CCN biological system as a gate to high complex protein superfamilies’ signaling
Cellular signaling is generally understood as the support of communication between contiguous cells belonging to the same ...
Expression and biological function of the cellular communication network factor 5 (CCN5) in primary liver cells
Expression and biological function of the cellular communication network factor 5 (CCN5) in primary liver cells
The cellular (centralized) communication network (CCN) factor protein family contains six small secreted cysteine-rich pro...
Temperal and spatial expression of CCN1, CCN3, CCN4, CCN5 and CCN6 proteins in the developing postnatal teeth
Temperal and spatial expression of CCN1, CCN3, CCN4, CCN5 and CCN6 proteins in the developing postnatal teeth
CCN proteins are matricellular proteins and are important modulators of development and function of adult organs. However,...
A network map of macrophage-stimulating protein (MSP) signaling
A network map of macrophage-stimulating protein (MSP) signaling
Macrophage-stimulating protein (MSP), a serum-derived growth factor belonging to the plasminogen-related kringle domain fa...
CD40 induces selective routing of Ras isoforms to subcellular compartments
CD40 induces selective routing of Ras isoforms to subcellular compartments
Ras GTPases are central to cellular signaling and oncogenesis. The three loci of the Ras gene encode for four protein isof...
Ephrin–Eph receptor tyrosine kinases for potential therapeutics against hepatic pathologies
Ephrin–Eph receptor tyrosine kinases for potential therapeutics against hepatic pathologies
Hepatic fibrosis is the common pathological change that occurs due to increased synthesis and accumulation of extracellula...
Three generations of mTOR kinase inhibitors in the activation of the apoptosis process in melanoma cells
Three generations of mTOR kinase inhibitors in the activation of the apoptosis process in melanoma cells
Many signaling pathways are involved in the mammalian target of rapamycin (mTOR), and this serine/threonine kinase regulat...
Activation of AMPK promotes cardiac differentiation by stimulating the autophagy pathway
Activation of AMPK promotes cardiac differentiation by stimulating the autophagy pathway
Autophagy, a critical catabolic process for cell survival against different types of stress, has a role in the differentia...
The growth hormone receptor interacts with transcriptional regulator HMGN1 upon GH-induced nuclear translocation
The growth hormone receptor interacts with transcriptional regulator HMGN1 upon GH-induced nuclear translocation
Growth hormone (GH) actions are mediated through binding to its cell-surface receptor, the GH receptor (GHR), with consequ...
An assembly of TROP2-mediated signaling events
An assembly of TROP2-mediated signaling events
Trophoblast cell surface antigen 2 (TROP2) is a calcium-transducing transmembrane protein mainly involved in embryo develo...
Advances in research of biological functions of Isthmin-1
Advances in research of biological functions of Isthmin-1
Isthmin-1 (ISM1) was initially thought to be a brain secretory factor, but with the development of technical means of rese...