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Molecular pathways modulated by phytochemicals in head and neck cancer
Molecular pathways modulated by phytochemicals in head and neck cancer
In the last few years, natural dietary phytochemicals have shown immense potential in the suppression and incidence of Hea...
A network map of discoidin domain receptor 1(DDR1)-mediated signaling in pathological conditions
A network map of discoidin domain receptor 1(DDR1)-mediated signaling in pathological conditions
Discoidin domain receptor 1 (DDR1) is one of the receptors that belong to a family of non-integrin collagen receptors. In ...
Single-cell RNA-Seq analysis of diabetic wound macrophages in STZ-induced mice
Single-cell RNA-Seq analysis of diabetic wound macrophages in STZ-induced mice
The crucial role of macrophages in the healing of chronic diabetic wounds is widely known, but previous in vitro classific...
Lipin-1 stability and its adipogenesis functions are regulated in contrasting ways by AKT1 and LKB1
Lipin-1 stability and its adipogenesis functions are regulated in contrasting ways by AKT1 and LKB1
Lipin-1 is a protein that plays a critical role in many cellular functions. At molecular level, it acts as a phosphatidic ...
Targeting PI3K/Akt signaling in prostate cancer therapy
Targeting PI3K/Akt signaling in prostate cancer therapy
Urological cancers have obtained much attention in recent years due to their mortality and morbidity. The most common and ...
The cryptic role of CXCL17/CXCR8 axis in the pathogenesis of cancers: a review of the latest evidence
The cryptic role of CXCL17/CXCR8 axis in the pathogenesis of cancers: a review of the latest evidence
Chemokines are immune system mediators that mediate various activities and play a role in the pathogenesis of several canc...
Advances in studies of circulating microRNAs: origination, transportation, and distal target regulation
Advances in studies of circulating microRNAs: origination, transportation, and distal target regulation
In the past few years, numerous advances emerged in terms of circulating microRNA(miRNA) regulating gene expression by cir...
Quinacrine and Curcumin in combination decreased the breast cancer angiogenesis by modulating ABCG2 via VEGF A
Quinacrine and Curcumin in combination decreased the breast cancer angiogenesis by modulating ABCG2 via VEGF A
Cancer stem cells (CSCs) cause drug resistance in cancer due to its extensive drug efflux, DNA repair and self-renewal cap...
Dehydrozingerone promotes healing of diabetic foot ulcers: a molecular insight
Dehydrozingerone promotes healing of diabetic foot ulcers: a molecular insight
One of the most common problems of diabetes are diabetic foot ulcers (DFUs). According to National Institute for Health, i...
Friend and foe: the regulation network of ascites components in ovarian cancer progression
Friend and foe: the regulation network of ascites components in ovarian cancer progression
The tumor microenvironment (TME) and its complex role in cancer progression have been hotspots of cancer research in recen...
How does the same ligand activate signaling of different receptors in TNFR superfamily: a computational study
How does the same ligand activate signaling of different receptors in TNFR superfamily: a computational study
TNFα is a highly pleiotropic cytokine inducing inflammatory signaling pathways. It is initially presented on plasma m...
SHP2 regulates adipose maintenance and adipocyte-pancreatic cancer cell crosstalk via PDHA1
SHP2 regulates adipose maintenance and adipocyte-pancreatic cancer cell crosstalk via PDHA1
Adipocytes are the most abundant cell type in the adipose tissue, and their dysfunction is a significant driver of obesity...
tRNA-derived fragments (tRFs) in cancer
tRNA-derived fragments (tRFs) in cancer
tRNA fragments (tRNA derived fragments or tRFs) are small single stranded RNA molecules derived from pre-tRNAs and mature ...
Another Step Forward to the understanding of Biological Signaling Networks
Another Step Forward to the understanding of Biological Signaling Networks
In this editorial I briefly review the new JCCS scientific directions that have emerged from the complicated situations cr...
METTL13 facilitates cell growth and metastasis in gastric cancer via an eEF1A/HN1L positive feedback circuit
METTL13 facilitates cell growth and metastasis in gastric cancer via an eEF1A/HN1L positive feedback circuit
Although improved treatment could inhibit progression of gastric cancer (GC), the recurrence and metastasis remain challen...
A comprehensive network map of IL-17A signaling pathway
A comprehensive network map of IL-17A signaling pathway
Interleukin-17A (IL-17A) is one of the member of IL-17 family consisting of other five members (IL-17B to IL-17F). The Gam...
ROR2 promotes epithelial-mesenchymal transition by hyperactivating ERK in melanoma
ROR2 promotes epithelial-mesenchymal transition by hyperactivating ERK in melanoma
Receptor tyrosine kinase-like orphan receptor 2 (ROR2) is a protein with important functions during embryogenesis that is ...
The role of CCNs in controlling cellular communication in the tumor microenvironment
The role of CCNs in controlling cellular communication in the tumor microenvironment
The Cellular communication network (CCN) family of growth regulatory factors comprises six secreted matricellular proteins...