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Sex-Specific Outcomes in a Rat Model of Early-Life Stress Due to Adverse Caregiving
Sex-Specific Outcomes in a Rat Model of Early-Life Stress Due to Adverse Caregiving
Early parental care is critical for the development of cortico-limbic circuits regulating stress responses and emotional w...
Restoration of MPTP-induced Dopamine and Tyrosine Hydroxylase Depletion in the Mouse Brain Through Ethanol and Nicotine
Restoration of MPTP-induced Dopamine and Tyrosine Hydroxylase Depletion in the Mouse Brain Through Ethanol and Nicotine
Dopamine (DA) has long been considered a major factor in the development of Parkinson's disease (PD). Ethanol (EtOH) a...
Cannabidiol-Induced Autophagy Ameliorates Tau Protein Clearance
Cannabidiol-Induced Autophagy Ameliorates Tau Protein Clearance
Tau is a neuronal protein that confers stability to microtubules; however, its hyperphosphorylation and accumulation can l...
Glioprotective Effects of Resveratrol Against Glutamate-Induced Cellular Dysfunction: The Role of Heme Oxygenase 1 Pathway
Glioprotective Effects of Resveratrol Against Glutamate-Induced Cellular Dysfunction: The Role of Heme Oxygenase 1 Pathway
Resveratrol, a natural polyphenol, has shown promising neuroprotective effects in several in vivo and in vitro experimenta...
Exploring the Different Impacts of Ketamine on Neurotrophic Factors and Inflammatory Parameters in a Cecal Ligation and Puncture-Induced Sepsis Model
Exploring the Different Impacts of Ketamine on Neurotrophic Factors and Inflammatory Parameters in a Cecal Ligation and Puncture-Induced Sepsis Model
Given ketamine’s conflicting impacts on the central nervous system, investigating its effects within an inflammatory...
Differentially Expressed Nedd4-binding Protein Ndfip1 Protects Neurons Against Methamphetamine-induced Neurotoxicity
Differentially Expressed Nedd4-binding Protein Ndfip1 Protects Neurons Against Methamphetamine-induced Neurotoxicity
To identify factors involved in methamphetamine (METH) neurotoxicity, we comprehensively searched for genes which were dif...
Curcumin Improves Hippocampal Cell Bioenergetics, Redox and Inflammatory Markers, and Synaptic Proteins, Regulating Mitochondrial Calcium Homeostasis
Curcumin Improves Hippocampal Cell Bioenergetics, Redox and Inflammatory Markers, and Synaptic Proteins, Regulating Mitochondrial Calcium Homeostasis
Mitochondria produces energy through oxidative phosphorylation (OXPHOS), maintaining calcium homeostasis, survival/death c...
Cannabigerol Mitigates Haloperidol-Induced Vacuous Chewing Movements in Mice
Cannabigerol Mitigates Haloperidol-Induced Vacuous Chewing Movements in Mice
Chronic use of typical antipsychotics can lead to varying motor effects depending on the timing of analysis. Acute treatme...
Implication of Pyrethroid Neurotoxicity for Human Health: A Lesson from Animal Models
Implication of Pyrethroid Neurotoxicity for Human Health: A Lesson from Animal Models
Pyrethroids, synthetic insecticides used in pest management, pose health risks, particularly neurotoxic effects, with stud...
No Benefit of 3% Hypertonic Saline Following Experimental Intracerebral Hemorrhage
No Benefit of 3% Hypertonic Saline Following Experimental Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) is a stroke subtype with a high mortality rate (~ 40%). After ICH, the mass effect of...
How is Excitotoxicity Being Modelled in iPSC-Derived Neurons?
How is Excitotoxicity Being Modelled in iPSC-Derived Neurons?
Excitotoxicity linked either to environmental causes (pesticide and cyanotoxin exposure), excitatory neurotransmitter imba...
Impact of 5-Lipoxygenase Deficiency on Dopamine-Mediated Behavioral Responses
Impact of 5-Lipoxygenase Deficiency on Dopamine-Mediated Behavioral Responses
The 5-lipoxygenase/leukotriene system has been implicated in both physiological and pathological states within the central...
Pharmacology of Adenosine A1 Receptor Agonist in a Humanized Esterase Mouse Seizure Model Following Soman Intoxication
Pharmacology of Adenosine A1 Receptor Agonist in a Humanized Esterase Mouse Seizure Model Following Soman Intoxication
Recently a novel genetically modified mouse strain with serum carboxylesterase knocked-out and the human acetylcholinester...
The Role of Vitamin C on ATPases Activities in Monosodium Glutamate-Induced Oxidative Stress in Rat Striatum and Cerebellum
The Role of Vitamin C on ATPases Activities in Monosodium Glutamate-Induced Oxidative Stress in Rat Striatum and Cerebellum
Monosodium glutamate (MSG) is a silent excitotoxin used as a flavour enhancer but exerts serious health hazards to consume...
Blunted Melatonin Circadian Rhythm in Parkinson’s Disease: Express Bewilderment
Blunted Melatonin Circadian Rhythm in Parkinson’s Disease: Express Bewilderment
Melatonin (MTN) is a neuro-hormone released from the pineal gland. MTN secretion is regulated by different neuronal circui...
Methylphenidate Exposing During Neurodevelopment Alters Amino Acid Profile, Astrocyte Marker and Glutamatergic Excitotoxicity in the Rat Striatum
Methylphenidate Exposing During Neurodevelopment Alters Amino Acid Profile, Astrocyte Marker and Glutamatergic Excitotoxicity in the Rat Striatum
There is a public health concern about the use of methylphenidate (MPH) since the higher prescription for young individual...
Monomeric Amyloid Peptide-induced Toxicity in Human Oligodendrocyte Cell Line and Mouse Brain Primary Mixed-glial Cell Cultures: Evidence for a Neuroprotective Effect of Neurosteroid 3α-O-allyl-allopregnanolone
Monomeric Amyloid Peptide-induced Toxicity in Human Oligodendrocyte Cell Line and Mouse Brain Primary Mixed-glial Cell Cultures: Evidence for a Neuroprotective Effect of Neurosteroid 3α-O-allyl-allopregnanolone
Amyloid-peptide (Aβ) monomeric forms (ABM) occurring in presymptomatic Alzheimer’s disease (AD) brain are thoug...
FOXA1 Suppresses Endoplasmic Reticulum Stress, Oxidative Stress, and Neuronal Apoptosis in Parkinson's Disease by Activating PON2 Transcription
FOXA1 Suppresses Endoplasmic Reticulum Stress, Oxidative Stress, and Neuronal Apoptosis in Parkinson's Disease by Activating PON2 Transcription
Endoplasmic reticulum (ER) stress and oxidative stress (OS) are often related states in pathological conditions including ...
FABP3 Induces Mitochondrial Autophagy to Promote Neuronal Cell Apoptosis in Brain Ischemia-Reperfusion Injury
FABP3 Induces Mitochondrial Autophagy to Promote Neuronal Cell Apoptosis in Brain Ischemia-Reperfusion Injury
This study elucidates the molecular mechanisms by which FABP3 regulates neuronal apoptosis via mitochondrial autophagy in ...
The Role of Excitotoxicity, Oxidative Stress and Bioenergetics Disruption in the Neuropathology of Nonketotic Hyperglycinemia
The Role of Excitotoxicity, Oxidative Stress and Bioenergetics Disruption in the Neuropathology of Nonketotic Hyperglycinemia
Nonketotic hyperglycinemia (NKH) is an inherited disorder of amino acid metabolism biochemically characterized by the accu...
Cerebral White Matter Alterations Associated With Oligodendrocyte Vulnerability in Organic Acidurias: Insights in Glutaric Aciduria Type I
Cerebral White Matter Alterations Associated With Oligodendrocyte Vulnerability in Organic Acidurias: Insights in Glutaric Aciduria Type I
The white matter is an important constituent of the central nervous system, containing axons, oligodendrocytes, and its pr...
PEG300 Protects Mitochondrial Function By Upregulating PGC-1α to Delay Central Nervous System Oxygen Toxicity in Mice
PEG300 Protects Mitochondrial Function By Upregulating PGC-1α to Delay Central Nervous System Oxygen Toxicity in Mice
Central nervous system oxygen toxicity (CNS-OT) is a complication of hyperbaric oxygen (HBO) treatment, with limited preve...
Assessment of Hippocampal-Related Behavioral Changes in Adolescent Rats of both Sexes Following Voluntary Intermittent Ethanol Intake and Noise Exposure: A Putative Underlying Mechanism and Implementation of a Non-pharmacological Preventive Strategy
Assessment of Hippocampal-Related Behavioral Changes in Adolescent Rats of both Sexes Following Voluntary Intermittent Ethanol Intake and Noise Exposure: A Putative Underlying Mechanism and Implementation of a Non-pharmacological Preventive Strategy
Ethanol (EtOH) intake and noise exposure are particularly concerning among human adolescents because the potential to harm...
Rotenone Induces a Neuropathological Phenotype in Cholinergic-like Neurons Resembling Parkinson’s Disease Dementia (PDD)
Rotenone Induces a Neuropathological Phenotype in Cholinergic-like Neurons Resembling Parkinson’s Disease Dementia (PDD)
Parkinson’s disease with dementia (PDD) is a neurological disorder that clinically and neuropathologically overlaps ...
Fer-1 Protects against Isoflurane-Induced Ferroptosis in Astrocytes and Cognitive Impairment in Neonatal Mice
Fer-1 Protects against Isoflurane-Induced Ferroptosis in Astrocytes and Cognitive Impairment in Neonatal Mice
Early and prolonged exposure to anesthetic agents could cause neurodevelopmental disorders in children. Astrocytes, heavil...
Hyperoxia and brain: the link between necessity and injury from a molecular perspective
Hyperoxia and brain: the link between necessity and injury from a molecular perspective
Oxygen (O2) supplementation is commonly used to treat hypoxia in patients with respiratory failure. However, indiscriminat...
Melatonin is a Neuroprotective and Antioxidant Agent against Neurotoxicity Induced by an Intrahippocampal Injection of Nickel in Rats
Melatonin is a Neuroprotective and Antioxidant Agent against Neurotoxicity Induced by an Intrahippocampal Injection of Nickel in Rats
The investigation into the hippocampal function and its response to heavy metal exposure is crucial for understanding the ...
Prenylated Flavanone Isolated from Dalea Species as a Potential Multitarget-Neuroprotector in an In Vitro Alzheimer’s Disease Mice Model
Prenylated Flavanone Isolated from Dalea Species as a Potential Multitarget-Neuroprotector in an In Vitro Alzheimer’s Disease Mice Model
Alzheimer’s disease (AD) involves a neurodegenerative process that has not yet been prevented, reversed, or stopped....
Enriched Environment Inhibits Neurotoxic Reactive Astrocytes via JAK2-STAT3 to Promote Glutamatergic Synaptogenesis and Cognitive Improvement in Chronic Cerebral Hypoperfusion Rats
Enriched Environment Inhibits Neurotoxic Reactive Astrocytes via JAK2-STAT3 to Promote Glutamatergic Synaptogenesis and Cognitive Improvement in Chronic Cerebral Hypoperfusion Rats
Chronic cerebral hypoperfusion (CCH) is a primary contributor to cognitive decline in the elderly. Enriched environment (E...
Effects of Exercise Training and L-Arginine Loaded Chitosan Nanoparticles on Hippocampus Histopathology, β-Secretase Enzyme Function, APP, Tau, Iba1and APOE-4 mRNA in Aging Rats
Effects of Exercise Training and L-Arginine Loaded Chitosan Nanoparticles on Hippocampus Histopathology, β-Secretase Enzyme Function, APP, Tau, Iba1and APOE-4 mRNA in Aging Rats
The objective of this study was to evaluate the combined and independent effects of exercise training and L-Arginine loade...
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