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FYCO1 regulates migration, invasion, and invadopodia formation in HeLa cells through CDC42/N-WASP/Arp2/3 signaling pathway
FYCO1 regulates migration, invasion, and invadopodia formation in HeLa cells through CDC42/N-WASP/Arp2/3 signaling pathway
FYCO1, an autophagy adaptor, plays an essential role in the trafficking toward the plus-end of microtubules and the fusion...
NCAPG2 contributes to the progression of malignant melanoma through regulating proliferation and metastasis
NCAPG2 contributes to the progression of malignant melanoma through regulating proliferation and metastasis
Malignant melanoma is a highly aggressive cutaneous neoplasm with increasing incidence worldwide. Non-SMC condensin II com...
Community-led risk analysis of direct-to-consumer whole-genome sequencing
Community-led risk analysis of direct-to-consumer whole-genome sequencing
Direct-to-consumer (DTC) genetic testing is cheaper and more accessible than ever before; however, the intention to combin...
How to become a successful scientist: the 2022 CSMB Arthur Wynne Gold Medal Lecture
How to become a successful scientist: the 2022 CSMB Arthur Wynne Gold Medal Lecture
There are many pathways to success. Mine followed a traditional one to an academic faculty position, but this pathway is n...
Purification and characterization of inorganic pyrophosphatase for in vitro RNA transcription
Purification and characterization of inorganic pyrophosphatase for in vitro RNA transcription
Inorganic pyrophosphatase (iPPase) is an enzyme that cleaves pyrophosphate into two phosphate molecules. This enzyme is an...
43rd International Asilomar Chromatin, Chromosomes, and Epigenetics Conference
43rd International Asilomar Chromatin, Chromosomes, and Epigenetics Conference
The 43rd Asilomar Chromatin, Chromosomes, and Epigenetics Conference was held in an entirely online format from 9 to 11 De...
HER2 induces cell scattering and invasion through ∆Np63α and E-cadherin
HER2 induces cell scattering and invasion through ∆Np63α and E-cadherin
Human epidermal growth factor receptor 2 (HER2)-positive breast cancer constitutes approximately 30% of human breast cance...
Decursin ameliorates carbon-tetrachloride-induced liver fibrosis by facilitating ferroptosis of hepatic stellate cells
Decursin ameliorates carbon-tetrachloride-induced liver fibrosis by facilitating ferroptosis of hepatic stellate cells
Decursin possesses the potential to alleviate transforming growth factor (TGF)-β-induced hepatic stellate cells (HSCs) act...
Cholecalciferol induces apoptosis via autocrine metabolism in epidermoid cervical cancer cells
Cholecalciferol induces apoptosis via autocrine metabolism in epidermoid cervical cancer cells
The anti-cancer effects of vitamin D are of fundamental interest. Cholecalciferol is sequentially hydroxylated endogenousl...
Electrophoretic mobility of individual molecules of alkaline phosphatase
Electrophoretic mobility of individual molecules of alkaline phosphatase
The electrophoretic mobilities and catalytic rates of individual molecules of bovine intestinal alkaline phosphatase were ...
Bovine lactoferrin increases the poly(I:C)-induced antiviral response in vitro
Bovine lactoferrin increases the poly(I:C)-induced antiviral response in vitro
Bovine lactoferrin (bLF) is a naturally occurring glycoprotein with antibacterial and antiviral activities. We evaluated w...
Tetraspanin-29 activates Notch signaling by interacting with ADAM10 to enhance its activity in colorectal cancer
Tetraspanin-29 activates Notch signaling by interacting with ADAM10 to enhance its activity in colorectal cancer
ADAM10 acts upstream of Notch signaling and plays oncogenic roles in various cancers. Tetraspanin family proteins regulate...
Introduction: Dual use in life science research
Introduction: Dual use in life science research
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The search for genetic dark matter and lessons learned from the journey
The search for genetic dark matter and lessons learned from the journey
In this review, I describe our scientific journey to unearth the impact of RNA metabolism in cancer using the eukaryotic t...
Targeting FHL1 impairs cell proliferation and differentiation of acute myeloid leukemia cells
Targeting FHL1 impairs cell proliferation and differentiation of acute myeloid leukemia cells
The four and a half LIM domains 1 (FHL1) is considered to play important roles in tumors. This study aims to investigate t...
Bone marrow granulocytes downregulate IL-1β and TNF production and the microbicidal activity of inflammatory macrophages
Bone marrow granulocytes downregulate IL-1β and TNF production and the microbicidal activity of inflammatory macrophages
Macrophages play critical roles in inflammation and defense against pathogens, as well as in the return to tissue homeosta...
Evaluation of HZX-960, a novel DCN1–UBC12 interaction inhibitor, as a potential antifibrotic compound for liver fibrosis
Evaluation of HZX-960, a novel DCN1–UBC12 interaction inhibitor, as a potential antifibrotic compound for liver fibrosis
Liver fibrosis is a very common health problem and currently lacks effective treatments. Cullin RING E3 ligases (CRLs) reg...
Reflections on antifreeze proteins and their evolution
Reflections on antifreeze proteins and their evolution
The discovery of radically different antifreeze proteins (AFPs) in fishes during the 1970s and 1980s suggested that these ...
Establishing an incentive-based multistakeholder approach to dual-use DNA screening
Establishing an incentive-based multistakeholder approach to dual-use DNA screening
Fast, accessible, and high-quality deoxyribonucleic acid (DNA) is fundamental to advancement in the life sciences that wil...
Curcumin attenuates intracerebral hemorrhage-induced neuronal apoptosis and neuroinflammation by suppressing JAK1/STAT1 pathway
Curcumin attenuates intracerebral hemorrhage-induced neuronal apoptosis and neuroinflammation by suppressing JAK1/STAT1 pathway
Intracerebral hemorrhage (ICH) is a kind of fatal stroke with the highest mortality and morbidity in the world. To date, t...
The biological relevance of PCSK9: when less is better…
The biological relevance of PCSK9: when less is better…
Proprotein Convertase Subtilisin/Kexin-type 9 (PCSK9) is a circulating negative regulator of hepatic low-density lipoprote...
Small proline-rich protein 1A promotes lung adenocarcinoma progression and indicates unfavorable clinical outcomes
Small proline-rich protein 1A promotes lung adenocarcinoma progression and indicates unfavorable clinical outcomes
Small proline-rich protein 1A (SPRR1A) plays a critical role in regulating squamous cell differentiation. SPRR1A overexpre...
Alloimperatorin activates apoptosis, ferroptosis, and oxeiptosis to inhibit the growth and invasion of breast cancer cells in vitro
Alloimperatorin activates apoptosis, ferroptosis, and oxeiptosis to inhibit the growth and invasion of breast cancer cells in vitro
Breast cancer is the most common malignant tumour in women. Our research on alloimperatorin from Angelica dahurica showed ...
Pristimerin alleviates cigarette smoke-induced inflammation in chronic obstructive pulmonary disease via inhibiting NF-κB pathway
Pristimerin alleviates cigarette smoke-induced inflammation in chronic obstructive pulmonary disease via inhibiting NF-κB pathway
Cigarette smoke (CS) is a risk factor for chronic obstructive pulmonary disease (COPD), which can exacerbate inflammation ...