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A Novel CFD Model of SMX Static Mixer Used in Advanced Continuous Manufacturing of Active Pharmaceutical Ingredients (API)
A Novel CFD Model of SMX Static Mixer Used in Advanced Continuous Manufacturing of Active Pharmaceutical Ingredients (API)
The growing demand for effective pharmaceutical treatments, notably amidst health challenges like COVID, highlights the ur...
Fluconazole Microsponges Loaded Bioadhesive Vaginal Film to Treat Vulvovaginal Candidiasiss
Fluconazole Microsponges Loaded Bioadhesive Vaginal Film to Treat Vulvovaginal Candidiasiss
The purpose of this study was to develop fluconazole microsponges loaded bioadhesive film, rolled into a torpedo-shaped ca...
Integrated Continuous Process Design for Crystallisation, Spherical Agglomeration, and Filtration of Lovastatin
Integrated Continuous Process Design for Crystallisation, Spherical Agglomeration, and Filtration of Lovastatin
This work seeks to improve the particle processability of needle-like lovastatin crystals and develop a small-footprint co...
Enhanced Oral Bioavailability of Isoformononetin Through Nanoemulsion: Development, Optimization, and Characterization
Enhanced Oral Bioavailability of Isoformononetin Through Nanoemulsion: Development, Optimization, and Characterization
Isoformononetin (IFN) is a methoxyl derivative of daidzein and has been stated as a potent osteogenic isoflavone. However,...
Repurposing of IL 33/ST2 Modulating Drugs as a Cardioprotective Agent: A Promising Approach
Repurposing of IL 33/ST2 Modulating Drugs as a Cardioprotective Agent: A Promising Approach
Drug repurposing has emerged as an enigmatic clinical approach in disorders affecting the cardiovascular system. The conce...
Development and Characterization of Glimepiride-Loaded Polymeric Nanoparticles: Formulation Design and Evaluation
Development and Characterization of Glimepiride-Loaded Polymeric Nanoparticles: Formulation Design and Evaluation
This study was aimed to develop polymeric nanoparticles (PNPs) using chitosan (CTN), polyvinyl pyrrolidone (PVP), and Twee...
Formulation, Characterization, and Optimization of Transethosomes for Enhanced Transdermal Delivery of Methotrexate
Formulation, Characterization, and Optimization of Transethosomes for Enhanced Transdermal Delivery of Methotrexate
Methotrexate (MTX) is an antineoplastic drug used in the treatment of rheumatoid arthritis (RA). Given that it is a class ...
Elucidation of Tartaric Acid-Assisted Supersaturation Maintenance of Dipyridamole by Eudragit® E100
Elucidation of Tartaric Acid-Assisted Supersaturation Maintenance of Dipyridamole by Eudragit® E100
The purpose of this study was to investigate the effect of tartaric acid on the maintenance of dipyridamole supersaturatio...
Coloaded Surface–Modified PLGA Nanoparticles for Sustained Ocular Delivery of Levofloxacin and Flurbiprofen
Coloaded Surface–Modified PLGA Nanoparticles for Sustained Ocular Delivery of Levofloxacin and Flurbiprofen
The purpose of the present work was to develop levofloxacin-flurbiprofen coloaded PLGA (LEV-FLU-PLGA) nanoparticles with s...
A Systems Evaluation Model for the Development of Companion Diagnostics and Associated Molecularly Targeted Therapies
A Systems Evaluation Model for the Development of Companion Diagnostics and Associated Molecularly Targeted Therapies
Monoclonal antibodies (mAbs) are important active ingredients of molecularly targeted drugs, which are only effective for ...
Loss-on-Drying Prediction for a Vibrated Fluidised Bed Dryer by Means of Mass and Energy Balances
Loss-on-Drying Prediction for a Vibrated Fluidised Bed Dryer by Means of Mass and Energy Balances
Continuous wet granulation and drying require an adequate process control strategy to ensure the product quality. The most...
Formulation and Characterization of Luliconazole Microsponge Gel for Diaper Dermatitis
Formulation and Characterization of Luliconazole Microsponge Gel for Diaper Dermatitis
Many current drug delivery technologies are ineffective and require high concentrations of active drugs for effective ther...
Mechanism Changes with High Temperature: Significance for Use of Accelerated Aging Modeling of Pharmaceuticals
Mechanism Changes with High Temperature: Significance for Use of Accelerated Aging Modeling of Pharmaceuticals
This work evaluates the probability and impact of using high-temperature accelerated aging for determining shelf life base...
QBD Approach for Design and Characterization of Pramlintide Microspheres for Controlled Drug Release
QBD Approach for Design and Characterization of Pramlintide Microspheres for Controlled Drug Release
The research was centered on the optimization of the microsphere formulation through a systematic quality-by-design (QBD) ...