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ASM is a therapeutic target in dermatomyositis by regulating the differentiation of naive CD4 + T cells into Th17 and Treg subsets
ASM is a therapeutic target in dermatomyositis by regulating the differentiation of naive CD4 + T cells into Th17 and Treg subsets
This study aims to investigate the involvement of acid sphingomyelinase (ASM) in the pathology of dermatomyositis (DM), ma...
Targeted expression of heme oxygenase-1 in satellite cells improves skeletal muscle pathology in dystrophic mice
Targeted expression of heme oxygenase-1 in satellite cells improves skeletal muscle pathology in dystrophic mice
Adult muscle-resident myogenic stem cells, satellite cells (SCs), that play non-redundant role in muscle regeneration, are...
Studying intramuscular fat deposition and muscle regeneration: insights from a comparative analysis of mouse strains, injury models, and sex differences
Studying intramuscular fat deposition and muscle regeneration: insights from a comparative analysis of mouse strains, injury models, and sex differences
Intramuscular fat (IMAT) infiltration, pathological adipose tissue that accumulates between muscle fibers, is a shared hal...
CaMKIIβ deregulation contributes to neuromuscular junction destabilization in Myotonic Dystrophy type I
CaMKIIβ deregulation contributes to neuromuscular junction destabilization in Myotonic Dystrophy type I
Myotonic Dystrophy type I (DM1) is the most common muscular dystrophy in adults. Previous reports have highlighted that ne...
Cellular and molecular alterations to muscles and neuromuscular synapses in a mouse model of MEGF10-related myopathy
Cellular and molecular alterations to muscles and neuromuscular synapses in a mouse model of MEGF10-related myopathy
Loss-of-function mutations in MEGF10 lead to a rare and understudied neuromuscular disorder known as MEGF10-related myopat...
Comparative in vivo characterization of newly discovered myotropic adeno-associated vectors
Comparative in vivo characterization of newly discovered myotropic adeno-associated vectors
Adeno-associated virus (AAV)-based gene therapy is a promising strategy to treat muscle diseases. However, this strategy i...
Pannexin 1 dysregulation in Duchenne muscular dystrophy and its exacerbation of dystrophic features in mdx mice
Pannexin 1 dysregulation in Duchenne muscular dystrophy and its exacerbation of dystrophic features in mdx mice
Duchenne muscular dystrophy (DMD) is associated with impaired muscle regeneration, progressive muscle weakness, damage, an...
Dimorphic effect of TFE3 in determining mitochondrial and lysosomal content in muscle following denervation
Dimorphic effect of TFE3 in determining mitochondrial and lysosomal content in muscle following denervation
Muscle atrophy is a common consequence of the loss of innervation and is accompanied by mitochondrial dysfunction. Mitopha...
IL-33-ST2 signaling in fibro-adipogenic progenitors alleviates immobilization-induced muscle atrophy in mice
IL-33-ST2 signaling in fibro-adipogenic progenitors alleviates immobilization-induced muscle atrophy in mice
The regenerative and adaptive capacity of skeletal muscles reduces with age, leading to severe disability and frailty in t...
Motor neurons and endothelial cells additively promote development and fusion of human iPSC-derived skeletal myocytes
Motor neurons and endothelial cells additively promote development and fusion of human iPSC-derived skeletal myocytes
Neurovascular cells have wide-ranging implications on skeletal muscle biology regulating myogenesis, maturation, and regen...
Metabolic signatures and potential biomarkers of sarcopenia in suburb-dwelling older Chinese: based on untargeted GC–MS and LC–MS
Metabolic signatures and potential biomarkers of sarcopenia in suburb-dwelling older Chinese: based on untargeted GC–MS and LC–MS
Untargeted metabolomics can be used to expand our understanding of the pathogenesis of sarcopenia. However, the metabolic ...
A knock down strategy for rapid, generic, and versatile modelling of muscular dystrophies in 3D-tissue-engineered-skeletal muscle
A knock down strategy for rapid, generic, and versatile modelling of muscular dystrophies in 3D-tissue-engineered-skeletal muscle
Human iPSC-derived 3D-tissue-engineered-skeletal muscles (3D-TESMs) offer advanced technology for disease modelling. Howev...
N-terminal titin fragment: a non-invasive, pharmacodynamic biomarker for microdystrophin efficacy
N-terminal titin fragment: a non-invasive, pharmacodynamic biomarker for microdystrophin efficacy
Multiple clinical trials to assess the efficacy of AAV-directed gene transfer in participants with Duchenne muscular dystr...
The MuSK-BMP pathway maintains myofiber size in slow muscle through regulation of Akt-mTOR signaling
The MuSK-BMP pathway maintains myofiber size in slow muscle through regulation of Akt-mTOR signaling
Myofiber size regulation is critical in health, disease, and aging. MuSK (muscle-specific kinase) is a BMP (bone morphogen...
Restoring skeletal muscle mass as an independent determinant of liver fat deposition improvement in MAFLD
Restoring skeletal muscle mass as an independent determinant of liver fat deposition improvement in MAFLD
Cross-sectional studies have demonstrated the association of skeletal muscle mass with metabolic-associated fatty liver di...
Eldecalcitol prevents muscle loss and osteoporosis in disuse muscle atrophy via NF-κB signaling in mice
Eldecalcitol prevents muscle loss and osteoporosis in disuse muscle atrophy via NF-κB signaling in mice
We investigated the effect of eldecalcitol on disuse muscle atrophy. C57BL/6J male mice aged 6 weeks were randomly assigne...
Hypoxia enhances human myoblast differentiation: involvement of HIF1α and impact of DUX4, the FSHD causal gene
Hypoxia enhances human myoblast differentiation: involvement of HIF1α and impact of DUX4, the FSHD causal gene
Hypoxia is known to modify skeletal muscle biological functions and muscle regeneration. However, the mechanisms underlyin...
Replenishing NAD+ content reduces aspects of striated muscle disease in a dog model of Duchenne muscular dystrophy
Replenishing NAD+ content reduces aspects of striated muscle disease in a dog model of Duchenne muscular dystrophy
Duchenne muscular dystrophy (DMD) is an X-linked disease caused by mutations in DMD gene and loss of the protein dystrophi...
Electrical impedance myography detects dystrophin-related muscle changes in mdx mice
Electrical impedance myography detects dystrophin-related muscle changes in mdx mice
The lack of functional dystrophin protein in Duchenne muscular dystrophy (DMD) causes chronic skeletal muscle inflammation...
DNA methylation of insulin signaling pathways is associated with HOMA2-IR in primary myoblasts from older adults
DNA methylation of insulin signaling pathways is associated with HOMA2-IR in primary myoblasts from older adults
While ageing is associated with increased insulin resistance (IR), the molecular mechanisms underlying increased IR in the...
Tropomyosin 3 (TPM3) function in skeletal muscle and in myopathy
Tropomyosin 3 (TPM3) function in skeletal muscle and in myopathy
The tropomyosin genes (TPM1-4) contribute to the functional diversity of skeletal muscle fibers. Since its discovery in 19...
Biomarkers for Duchenne muscular dystrophy progression: impact of age in the mdx tongue spared muscle
Biomarkers for Duchenne muscular dystrophy progression: impact of age in the mdx tongue spared muscle
Duchenne muscular dystrophy (DMD) is a severe form of muscular dystrophy without an effective treatment, caused by mutatio...
Sox11 is enriched in myogenic progenitors but dispensable for development and regeneration of the skeletal muscle
Sox11 is enriched in myogenic progenitors but dispensable for development and regeneration of the skeletal muscle
Transcription factors (TFs) play key roles in regulating differentiation and function of stem cells, including muscle sate...
MuscleJ2: a rebuilding of MuscleJ with new features for high-content analysis of skeletal muscle immunofluorescence slides
MuscleJ2: a rebuilding of MuscleJ with new features for high-content analysis of skeletal muscle immunofluorescence slides
Histological analysis of skeletal muscle is of major interest for understanding its behavior in different pathophysiologic...
Fusion of myofibre branches is a physiological feature of healthy human skeletal muscle regeneration
Fusion of myofibre branches is a physiological feature of healthy human skeletal muscle regeneration
The occurrence of hyperplasia, through myofibre splitting, remains a widely debated phenomenon. Structural alterations and...
Development of muscle weakness in a mouse model of critical illness: does fibroblast growth factor 21 play a role?
Development of muscle weakness in a mouse model of critical illness: does fibroblast growth factor 21 play a role?
Critical illness is hallmarked by severe stress and organ damage. Fibroblast growth factor 21 (FGF21) has been shown to ri...
Age-related gene expression signatures from limb skeletal muscles and the diaphragm in mice and rats reveal common and species-specific changes
Age-related gene expression signatures from limb skeletal muscles and the diaphragm in mice and rats reveal common and species-specific changes
As a result of aging, skeletal muscle undergoes atrophy and a decrease in function. This age-related skeletal muscle weakn...
TRIM32 biallelic defects cause limb-girdle muscular dystrophy R8: identification of two novel mutations and investigation of genotype–phenotype correlation
TRIM32 biallelic defects cause limb-girdle muscular dystrophy R8: identification of two novel mutations and investigation of genotype–phenotype correlation
Limb-girdle muscular dystrophy R8 (LGMD R8) is a rare autosomal recessive muscle disease caused by TRIM32 gene biallelic d...
Rapid restitution of contractile dysfunction by synthetic copolymers in dystrophin-deficient single live skeletal muscle fibers
Rapid restitution of contractile dysfunction by synthetic copolymers in dystrophin-deficient single live skeletal muscle fibers
Duchenne muscular dystrophy (DMD) is caused by the lack of dystrophin, a cytoskeletal protein essential for the preservati...
Expression of Myomaker and Myomerger in myofibers causes muscle pathology
Expression of Myomaker and Myomerger in myofibers causes muscle pathology
Skeletal muscle development and regeneration depend on cellular fusion of myogenic progenitors to generate multinucleated ...
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