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Aminoguanidine hemisulfate improves mitochondrial autophagy, oxidative stress, and muscle force in Duchenne muscular dystrophy via the AKT/FOXO1 pathway in mdx mice
Aminoguanidine hemisulfate improves mitochondrial autophagy, oxidative stress, and muscle force in Duchenne muscular dystrophy via the AKT/FOXO1 pathway in mdx mice
Duchenne muscular dystrophy (DMD) is a prevalent, fatal degenerative muscle disease with no effective treatments. Mdx mous...
Sarcolemma resilience and skeletal muscle health require O-mannosylation of dystroglycan
Sarcolemma resilience and skeletal muscle health require O-mannosylation of dystroglycan
Maintaining the connection between skeletal muscle fibers and the surrounding basement membrane is essential for muscle fu...
Fully-automated segmentation of muscle and inter-/intra-muscular fat from magnetic resonance images of calves and thighs: an open-source workflow in Python
Fully-automated segmentation of muscle and inter-/intra-muscular fat from magnetic resonance images of calves and thighs: an open-source workflow in Python
INTER- and INTRAmuscular fat (IMF) is elevated in high metabolic states and can promote inflammation. While magnetic reson...
Comparative lipidomic and metabolomic profiling of mdx and severe mdx-apolipoprotein e-null mice
Comparative lipidomic and metabolomic profiling of mdx and severe mdx-apolipoprotein e-null mice
Despite its notoriously mild phenotype, the dystrophin-deficient mdx mouse is the most common model of Duchenne muscular d...
Mll4 in skeletal muscle fibers maintains muscle stem cells
Mll4 in skeletal muscle fibers maintains muscle stem cells
Muscle stem cells (MuSCs) undergo numerous state transitions throughout life, which are critical for supporting normal mus...
Wnt7a is required for regeneration of dystrophic skeletal muscle
Wnt7a is required for regeneration of dystrophic skeletal muscle
Intramuscular injection of Wnt7a has been shown to accelerate and augment skeletal muscle regeneration and to ameliorate d...
Intramuscular fatty infiltration and its correlation with muscle composition and function in hip osteoarthritis
Intramuscular fatty infiltration and its correlation with muscle composition and function in hip osteoarthritis
Hip osteoarthritis patients display higher levels of fatty infiltration (FI) in the gluteus minimus (GM) compared to other...
Regulation of injury-induced skeletal myofiber regeneration by glucose transporter 4 (GLUT4)
Regulation of injury-induced skeletal myofiber regeneration by glucose transporter 4 (GLUT4)
Insulin resistance and type 2 diabetes impair cellular regeneration in multiple tissues including skeletal muscle. The mol...
Fibro-adipogenic progenitor cells in skeletal muscle unloading: metabolic and functional impairments
Fibro-adipogenic progenitor cells in skeletal muscle unloading: metabolic and functional impairments
Skeletal muscle resident fibro-adipogenic progenitor cells (FAPs) control skeletal muscle regeneration providing a support...
SIX transcription factors are necessary for the activation of DUX4 expression in facioscapulohumeral muscular dystrophy
SIX transcription factors are necessary for the activation of DUX4 expression in facioscapulohumeral muscular dystrophy
Facioscapulohumeral muscular dystrophy (FSHD) is a common and progressive muscle wasting disease that is characterized by ...
Role and mechanism of myonectin in severe acute pancreatitis: a crosstalk between skeletal muscle and pancreas
Role and mechanism of myonectin in severe acute pancreatitis: a crosstalk between skeletal muscle and pancreas
Severe acute pancreatitis (SAP) is characterized by high mortality rates and various complications, including skeletal mus...
Golodirsen restores DMD transcript imbalance in Duchenne Muscular Dystrophy patient muscle cells
Golodirsen restores DMD transcript imbalance in Duchenne Muscular Dystrophy patient muscle cells
Antisense oligonucleotides (AON) represent a promising treatment for Duchenne muscular dystrophy (DMD) carrying out-of-fra...
3D-environment and muscle contraction regulate the heterogeneity of myonuclei
3D-environment and muscle contraction regulate the heterogeneity of myonuclei
Skeletal muscle formation involves tight interactions between muscle cells and associated connective tissue fibroblasts. E...
Spiny mice are primed but fail to regenerate volumetric skeletal muscle loss injuries
The information you’re looking for cannot be found, it may be temporarily unavailable or...
Decreased number of satellite cells-derived myonuclei in both fast- and slow-twitch muscles in HeyL-KO mice during voluntary running exercise
Decreased number of satellite cells-derived myonuclei in both fast- and slow-twitch muscles in HeyL-KO mice during voluntary running exercise
Skeletal muscles possess unique abilities known as adaptation or plasticity. When exposed to external stimuli, such as mec...
Metabolic pathways for removing reactive aldehydes are diminished in the skeletal muscle during heart failure
Metabolic pathways for removing reactive aldehydes are diminished in the skeletal muscle during heart failure
Muscle wasting is a serious complication in heart failure patients. Oxidative stress and inflammation are implicated in th...
Exercise, disease state and sex influence the beneficial effects of Fn14-depletion on survival and muscle pathology in the SOD1G93A amyotrophic lateral sclerosis (ALS) mouse model
Exercise, disease state and sex influence the beneficial effects of Fn14-depletion on survival and muscle pathology in the SOD1G93A amyotrophic lateral sclerosis (ALS) mouse model
Amyotrophic lateral sclerosis (ALS) is a devastating and incurable neurodegenerative disease. Accumulating evidence strong...
Isolation of small extracellular vesicles from regenerating muscle tissue using tangential flow filtration and size exclusion chromatography
Isolation of small extracellular vesicles from regenerating muscle tissue using tangential flow filtration and size exclusion chromatography
We have recently made the strikingly discovery that upon a muscle injury, Wnt7a is upregulated and secreted from new regen...
Deletion of exons 45 to 55 in the DMD gene: from the therapeutic perspective to the in vitro model
Deletion of exons 45 to 55 in the DMD gene: from the therapeutic perspective to the in vitro model
Gene editing therapies in development for correcting out-of-frame DMD mutations in Duchenne muscular dystrophy aim to repl...
Muscle degeneration in aging Drosophila flies: the role of mechanical stress
Muscle degeneration in aging Drosophila flies: the role of mechanical stress
Muscle wasting is a universal hallmark of aging which is displayed by a wide range of organisms, although the causes and m...
Pilot investigations into the mechanistic basis for adverse effects of glucocorticoids in dysferlinopathy
Pilot investigations into the mechanistic basis for adverse effects of glucocorticoids in dysferlinopathy
Dysferlinopathies are a clinically heterogeneous group of muscular dystrophies caused by gene mutations resulting in defic...
Age-related differences in the loss and recovery of serial sarcomere number following disuse atrophy in rats
Age-related differences in the loss and recovery of serial sarcomere number following disuse atrophy in rats
Older adults exhibit a slower recovery of muscle mass following disuse atrophy than young adults. At a smaller scale, musc...
Skeletal muscle vulnerability in a child with Pitt-Hopkins syndrome
Skeletal muscle vulnerability in a child with Pitt-Hopkins syndrome
TCF4 acts as a transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5 motif. Dominant variants in TCF4 a...
AAV-NRIP gene therapy ameliorates motor neuron degeneration and muscle atrophy in ALS model mice
AAV-NRIP gene therapy ameliorates motor neuron degeneration and muscle atrophy in ALS model mice
Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron (MN) degeneration, leading to neuromuscul...
ASM is a therapeutic target in dermatomyositis by regulating the differentiation of naive CD4 + T cells into Th17 and Treg subsets
ASM is a therapeutic target in dermatomyositis by regulating the differentiation of naive CD4 + T cells into Th17 and Treg subsets
This study aims to investigate the involvement of acid sphingomyelinase (ASM) in the pathology of dermatomyositis (DM), ma...
Targeted expression of heme oxygenase-1 in satellite cells improves skeletal muscle pathology in dystrophic mice
Targeted expression of heme oxygenase-1 in satellite cells improves skeletal muscle pathology in dystrophic mice
Adult muscle-resident myogenic stem cells, satellite cells (SCs), that play non-redundant role in muscle regeneration, are...
Studying intramuscular fat deposition and muscle regeneration: insights from a comparative analysis of mouse strains, injury models, and sex differences
Studying intramuscular fat deposition and muscle regeneration: insights from a comparative analysis of mouse strains, injury models, and sex differences
Intramuscular fat (IMAT) infiltration, pathological adipose tissue that accumulates between muscle fibers, is a shared hal...
CaMKIIβ deregulation contributes to neuromuscular junction destabilization in Myotonic Dystrophy type I
CaMKIIβ deregulation contributes to neuromuscular junction destabilization in Myotonic Dystrophy type I
Myotonic Dystrophy type I (DM1) is the most common muscular dystrophy in adults. Previous reports have highlighted that ne...
Cellular and molecular alterations to muscles and neuromuscular synapses in a mouse model of MEGF10-related myopathy
Cellular and molecular alterations to muscles and neuromuscular synapses in a mouse model of MEGF10-related myopathy
Loss-of-function mutations in MEGF10 lead to a rare and understudied neuromuscular disorder known as MEGF10-related myopat...
Comparative in vivo characterization of newly discovered myotropic adeno-associated vectors
Comparative in vivo characterization of newly discovered myotropic adeno-associated vectors
Adeno-associated virus (AAV)-based gene therapy is a promising strategy to treat muscle diseases. However, this strategy i...
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