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Biomarkers for Duchenne muscular dystrophy progression: impact of age in the mdx tongue spared muscle
Biomarkers for Duchenne muscular dystrophy progression: impact of age in the mdx tongue spared muscle
Duchenne muscular dystrophy (DMD) is a severe form of muscular dystrophy without an effective treatment, caused by mutatio...
Sox11 is enriched in myogenic progenitors but dispensable for development and regeneration of the skeletal muscle
Sox11 is enriched in myogenic progenitors but dispensable for development and regeneration of the skeletal muscle
Transcription factors (TFs) play key roles in regulating differentiation and function of stem cells, including muscle sate...
MuscleJ2: a rebuilding of MuscleJ with new features for high-content analysis of skeletal muscle immunofluorescence slides
MuscleJ2: a rebuilding of MuscleJ with new features for high-content analysis of skeletal muscle immunofluorescence slides
Histological analysis of skeletal muscle is of major interest for understanding its behavior in different pathophysiologic...
Fusion of myofibre branches is a physiological feature of healthy human skeletal muscle regeneration
Fusion of myofibre branches is a physiological feature of healthy human skeletal muscle regeneration
The occurrence of hyperplasia, through myofibre splitting, remains a widely debated phenomenon. Structural alterations and...
Development of muscle weakness in a mouse model of critical illness: does fibroblast growth factor 21 play a role?
Development of muscle weakness in a mouse model of critical illness: does fibroblast growth factor 21 play a role?
Critical illness is hallmarked by severe stress and organ damage. Fibroblast growth factor 21 (FGF21) has been shown to ri...
Age-related gene expression signatures from limb skeletal muscles and the diaphragm in mice and rats reveal common and species-specific changes
Age-related gene expression signatures from limb skeletal muscles and the diaphragm in mice and rats reveal common and species-specific changes
As a result of aging, skeletal muscle undergoes atrophy and a decrease in function. This age-related skeletal muscle weakn...
TRIM32 biallelic defects cause limb-girdle muscular dystrophy R8: identification of two novel mutations and investigation of genotype–phenotype correlation
TRIM32 biallelic defects cause limb-girdle muscular dystrophy R8: identification of two novel mutations and investigation of genotype–phenotype correlation
Limb-girdle muscular dystrophy R8 (LGMD R8) is a rare autosomal recessive muscle disease caused by TRIM32 gene biallelic d...
Rapid restitution of contractile dysfunction by synthetic copolymers in dystrophin-deficient single live skeletal muscle fibers
Rapid restitution of contractile dysfunction by synthetic copolymers in dystrophin-deficient single live skeletal muscle fibers
Duchenne muscular dystrophy (DMD) is caused by the lack of dystrophin, a cytoskeletal protein essential for the preservati...
Expression of Myomaker and Myomerger in myofibers causes muscle pathology
Expression of Myomaker and Myomerger in myofibers causes muscle pathology
Skeletal muscle development and regeneration depend on cellular fusion of myogenic progenitors to generate multinucleated ...
New tools for the investigation of muscle fiber-type spatial distributions across histological sections
New tools for the investigation of muscle fiber-type spatial distributions across histological sections
The functional and metabolic properties of skeletal muscles are partly a function of the spatial arrangement of fibers acr...
Extracellular vesicle distribution and localization in skeletal muscle at rest and following disuse atrophy
Extracellular vesicle distribution and localization in skeletal muscle at rest and following disuse atrophy
Skeletal muscle (SkM) is a large, secretory organ that produces and releases myokines that can have autocrine, paracrine, ...
An updated C. elegans nuclear body muscle transcriptome for studies in muscle formation and function
An updated C. elegans nuclear body muscle transcriptome for studies in muscle formation and function
The body muscle is an important tissue used in organisms for proper viability and locomotion. Although this tissue is gene...
The double homeodomain protein DUX4c is associated with regenerating muscle fibers and RNA-binding proteins
The double homeodomain protein DUX4c is associated with regenerating muscle fibers and RNA-binding proteins
 We have previously demonstrated that double homeobox 4 centromeric (DUX4C) encoded for a functional DUX4c protei...
Angiogenesis precedes myogenesis during regeneration following biopsy injury of skeletal muscle
Angiogenesis precedes myogenesis during regeneration following biopsy injury of skeletal muscle
Acute injury to skeletal muscle damages myofibers and fragment capillaries, impairing contractile function and local perfu...
Sarcopenia: investigation of metabolic changes and its associated mechanisms
Sarcopenia: investigation of metabolic changes and its associated mechanisms
Sarcopenia is one of the most predominant musculoskeletal diseases of the elderly, defined as age-related progressive and ...
Multi-omics analysis of sarcospan overexpression in mdx skeletal muscle reveals compensatory remodeling of cytoskeleton-matrix interactions that promote mechanotransduction pathways
Multi-omics analysis of sarcospan overexpression in mdx skeletal muscle reveals compensatory remodeling of cytoskeleton-matrix interactions that promote mechanotransduction pathways
The dystrophin-glycoprotein complex (DGC) is a critical adhesion complex of the muscle cell membrane, providing a mechanic...
The prevalence of low muscle mass associated with obesity in the USA
The prevalence of low muscle mass associated with obesity in the USA
Sarcopenia is defined as age-related low muscle mass and function, and can also describe the loss of muscle mass in certai...
Limb-girdle muscular dystrophy type 2B causes HDL-C abnormalities in patients and statin-resistant muscle wasting in dysferlin-deficient mice
Limb-girdle muscular dystrophy type 2B causes HDL-C abnormalities in patients and statin-resistant muscle wasting in dysferlin-deficient mice
Limb-girdle muscular dystrophy (MD) type 2B (LGMD2B) and Duchenne MD (DMD) are caused by mutations to the Dysferlin and Dy...
Macroglossia and less advanced dystrophic change in the tongue muscle of the Duchenne muscular dystrophy rat
Macroglossia and less advanced dystrophic change in the tongue muscle of the Duchenne muscular dystrophy rat
Duchenne muscular dystrophy (DMD) is an X-linked muscle disease caused by a complete lack of dystrophin, which stabilizes ...
Megaconial congenital muscular dystrophy due to novel CHKB variants: a case report and literature review
Megaconial congenital muscular dystrophy due to novel CHKB variants: a case report and literature review
Choline kinase beta (CHKB) catalyzes the first step in the de novo biosynthesis of phosphatidyl choline and phosphatidylet...
Identification of the co-differentially expressed hub genes involved in the endogenous protective mechanism against ventilator-induced diaphragm dysfunction
Identification of the co-differentially expressed hub genes involved in the endogenous protective mechanism against ventilator-induced diaphragm dysfunction
In intensive care units (ICU), mechanical ventilation (MV) is commonly applied to save patients’ lives. However, ven...
Mouse models of SMA show divergent patterns of neuronal vulnerability and resilience
Mouse models of SMA show divergent patterns of neuronal vulnerability and resilience
Spinal muscular atrophy (SMA) is a form of motor neuron disease affecting primarily children characterised by the loss of ...
Prolonged FOS activity disrupts a global myogenic transcriptional program by altering 3D chromatin architecture in primary muscle progenitor cells
Prolonged FOS activity disrupts a global myogenic transcriptional program by altering 3D chromatin architecture in primary muscle progenitor cells
The AP-1 transcription factor, FBJ osteosarcoma oncogene (FOS), is induced in adult muscle satellite cells (SCs) within ho...
Oxidative stress-induced premature senescence and aggravated denervated skeletal muscular atrophy by regulating progerin–p53 interaction
Oxidative stress-induced premature senescence and aggravated denervated skeletal muscular atrophy by regulating progerin–p53 interaction
Progerin elevates atrophic gene expression and helps modify the nuclear membrane to cause severe muscle pathology, which i...
Dysregulation of Tweak and Fn14 in skeletal muscle of spinal muscular atrophy mice
Dysregulation of Tweak and Fn14 in skeletal muscle of spinal muscular atrophy mice
Spinal muscular atrophy (SMA) is a childhood neuromuscular disorder caused by depletion of the survival motor neuron (SMN)...
Differences in muscle satellite cell dynamics during muscle hypertrophy and regeneration
Differences in muscle satellite cell dynamics during muscle hypertrophy and regeneration
Skeletal muscle homeostasis and function are ensured by orchestrated cellular interactions among several types of cells. A...
High-throughput muscle fiber typing from RNA sequencing data
High-throughput muscle fiber typing from RNA sequencing data
Skeletal muscle fiber type distribution has implications for human health, muscle function, and performance. This knowledg...
The Myotube Analyzer: how to assess myogenic features in muscle stem cells
The Myotube Analyzer: how to assess myogenic features in muscle stem cells
The analysis of in vitro cultures of human adult muscle stem cells obtained from biopsies delineates the potential of skel...
The influence of age, sex, and exercise on autophagy, mitophagy, and lysosome biogenesis in skeletal muscle
The influence of age, sex, and exercise on autophagy, mitophagy, and lysosome biogenesis in skeletal muscle
Aging decreases skeletal muscle mass and quality. Maintenance of healthy muscle is regulated by a balance between protein ...
Absence of the Z-disc protein α-actinin-3 impairs the mechanical stability of Actn3KO mouse fast-twitch muscle fibres without altering their contractile properties or twitch kinetics
Absence of the Z-disc protein α-actinin-3 impairs the mechanical stability of Actn3KO mouse fast-twitch muscle fibres without altering their contractile properties or twitch kinetics
A common polymorphism (R577X) in the ACTN3 gene results in the complete absence of the Z-disc protein α-actinin-3 fro...
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