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Limb-girdle muscular dystrophy type 2B causes HDL-C abnormalities in patients and statin-resistant muscle wasting in dysferlin-deficient mice
Limb-girdle muscular dystrophy type 2B causes HDL-C abnormalities in patients and statin-resistant muscle wasting in dysferlin-deficient mice
Limb-girdle muscular dystrophy (MD) type 2B (LGMD2B) and Duchenne MD (DMD) are caused by mutations to the Dysferlin and Dy...
Macroglossia and less advanced dystrophic change in the tongue muscle of the Duchenne muscular dystrophy rat
Macroglossia and less advanced dystrophic change in the tongue muscle of the Duchenne muscular dystrophy rat
Duchenne muscular dystrophy (DMD) is an X-linked muscle disease caused by a complete lack of dystrophin, which stabilizes ...
Megaconial congenital muscular dystrophy due to novel CHKB variants: a case report and literature review
Megaconial congenital muscular dystrophy due to novel CHKB variants: a case report and literature review
Choline kinase beta (CHKB) catalyzes the first step in the de novo biosynthesis of phosphatidyl choline and phosphatidylet...
Mouse models of SMA show divergent patterns of neuronal vulnerability and resilience
Mouse models of SMA show divergent patterns of neuronal vulnerability and resilience
Spinal muscular atrophy (SMA) is a form of motor neuron disease affecting primarily children characterised by the loss of ...
Oxidative stress-induced premature senescence and aggravated denervated skeletal muscular atrophy by regulating progerin–p53 interaction
Oxidative stress-induced premature senescence and aggravated denervated skeletal muscular atrophy by regulating progerin–p53 interaction
Progerin elevates atrophic gene expression and helps modify the nuclear membrane to cause severe muscle pathology, which i...
Dysregulation of Tweak and Fn14 in skeletal muscle of spinal muscular atrophy mice
Dysregulation of Tweak and Fn14 in skeletal muscle of spinal muscular atrophy mice
Spinal muscular atrophy (SMA) is a childhood neuromuscular disorder caused by depletion of the survival motor neuron (SMN)...
Differences in muscle satellite cell dynamics during muscle hypertrophy and regeneration
Differences in muscle satellite cell dynamics during muscle hypertrophy and regeneration
Skeletal muscle homeostasis and function are ensured by orchestrated cellular interactions among several types of cells. A...
High-throughput muscle fiber typing from RNA sequencing data
High-throughput muscle fiber typing from RNA sequencing data
Skeletal muscle fiber type distribution has implications for human health, muscle function, and performance. This knowledg...
The Myotube Analyzer: how to assess myogenic features in muscle stem cells
The Myotube Analyzer: how to assess myogenic features in muscle stem cells
The analysis of in vitro cultures of human adult muscle stem cells obtained from biopsies delineates the potential of skel...
The influence of age, sex, and exercise on autophagy, mitophagy, and lysosome biogenesis in skeletal muscle
The influence of age, sex, and exercise on autophagy, mitophagy, and lysosome biogenesis in skeletal muscle
Aging decreases skeletal muscle mass and quality. Maintenance of healthy muscle is regulated by a balance between protein ...
Alternative splicing diversifies the skeletal muscle transcriptome during prolonged spaceflight
Alternative splicing diversifies the skeletal muscle transcriptome during prolonged spaceflight
As the interest in manned spaceflight increases, so does the requirement to understand the transcriptomic mechanisms that ...
Growth differentiation factor 11 induces skeletal muscle atrophy via a STAT3-dependent mechanism in pulmonary arterial hypertension
Growth differentiation factor 11 induces skeletal muscle atrophy via a STAT3-dependent mechanism in pulmonary arterial hypertension
Skeletal muscle wasting is a clinically remarkable phenotypic feature of pulmonary arterial hypertension (PAH) that increa...
The Notch signaling network in muscle stem cells during development, homeostasis, and disease
The Notch signaling network in muscle stem cells during development, homeostasis, and disease
Skeletal muscle stem cells have a central role in muscle growth and regeneration. They reside as quiescent cells in restin...
Endurance exercise attenuates juvenile irradiation-induced skeletal muscle functional decline and mitochondrial stress
Endurance exercise attenuates juvenile irradiation-induced skeletal muscle functional decline and mitochondrial stress
Radiotherapy is commonly used to treat childhood cancers and can have adverse effects on muscle function, but the underlyi...
Functional replacement of myostatin with GDF-11 in the germline of mice
Functional replacement of myostatin with GDF-11 in the germline of mice
Myostatin (MSTN) is a transforming growth factor-ß superfamily member that acts as a major regulator of skeletal musc...
Muscle stem cell adaptations to cellular and environmental stress
Muscle stem cell adaptations to cellular and environmental stress
Lifelong regeneration of the skeletal muscle is dependent on a rare population of resident skeletal muscle stem cells, als...
Metabolomic signatures for the longitudinal reduction of muscle strength over 10 years
Metabolomic signatures for the longitudinal reduction of muscle strength over 10 years
Skeletal muscles are essential components of the neuromuscular skeletal system that have an integral role in the structure...
Skeletal muscle transcriptomics identifies common pathways in nerve crush injury and ageing
Skeletal muscle transcriptomics identifies common pathways in nerve crush injury and ageing
Motor unit remodelling involving repeated denervation and re-innervation occurs throughout life. The efficiency of this pr...
Novel γ-sarcoglycan interactors in murine muscle membranes
Novel γ-sarcoglycan interactors in murine muscle membranes
The sarcoglycan complex (SC) is part of a network that links the striated muscle cytoskeleton to the basal lamina across t...
Meeting report: the 2021 FSHD International Research Congress
Meeting report: the 2021 FSHD International Research Congress
Facioscapulohumeral muscular dystrophy (FSHD) is the second most common genetic myopathy, characterized by slowly progress...
ViaFuse: Fiji macros to calculate skeletal muscle cell viability and fusion index
ViaFuse: Fiji macros to calculate skeletal muscle cell viability and fusion index
Measuring biological features of skeletal muscle cells is difficult because of their unique morphology and multinucleate n...
Evaluation of the mechanisms of sarcopenia in chronic inflammatory disease: protocol for a prospective cohort study
Evaluation of the mechanisms of sarcopenia in chronic inflammatory disease: protocol for a prospective cohort study
Several chronic inflammatory diseases co-exist with and accelerate sarcopenia (reduction in muscle strength, function and ...
Six1 promotes skeletal muscle thyroid hormone response through regulation of the MCT10 transporter
Six1 promotes skeletal muscle thyroid hormone response through regulation of the MCT10 transporter
The Six1 transcription factor is implicated in controlling the development of several tissue types, notably skeletal muscl...
The SarcoEndoplasmic Reticulum Calcium ATPase (SERCA) pump: a potential target for intervention in aging and skeletal muscle pathologies
The SarcoEndoplasmic Reticulum Calcium ATPase (SERCA) pump: a potential target for intervention in aging and skeletal muscle pathologies
As a key regulator of cellular calcium homeostasis, the Sarcoendoplasmic Reticulum Calcium ATPase (SERCA) pump acts to tra...
Protein profile of fiber types in human skeletal muscle: a single-fiber proteomics study
Protein profile of fiber types in human skeletal muscle: a single-fiber proteomics study
Human skeletal muscle is composed of three major fiber types, referred to as type 1, 2A, and 2X fibers. This heterogeneous...