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3D-environment and muscle contraction regulate the heterogeneity of myonuclei
3D-environment and muscle contraction regulate the heterogeneity of myonuclei
Skeletal muscle formation involves tight interactions between muscle cells and associated connective tissue fibroblasts. E...
Spiny mice are primed but fail to regenerate volumetric skeletal muscle loss injuries
The information you’re looking for cannot be found, it may be temporarily unavailable or...
Decreased number of satellite cells-derived myonuclei in both fast- and slow-twitch muscles in HeyL-KO mice during voluntary running exercise
Decreased number of satellite cells-derived myonuclei in both fast- and slow-twitch muscles in HeyL-KO mice during voluntary running exercise
Skeletal muscles possess unique abilities known as adaptation or plasticity. When exposed to external stimuli, such as mec...
Metabolic pathways for removing reactive aldehydes are diminished in the skeletal muscle during heart failure
Metabolic pathways for removing reactive aldehydes are diminished in the skeletal muscle during heart failure
Muscle wasting is a serious complication in heart failure patients. Oxidative stress and inflammation are implicated in th...
Exercise, disease state and sex influence the beneficial effects of Fn14-depletion on survival and muscle pathology in the SOD1G93A amyotrophic lateral sclerosis (ALS) mouse model
Exercise, disease state and sex influence the beneficial effects of Fn14-depletion on survival and muscle pathology in the SOD1G93A amyotrophic lateral sclerosis (ALS) mouse model
Amyotrophic lateral sclerosis (ALS) is a devastating and incurable neurodegenerative disease. Accumulating evidence strong...
Isolation of small extracellular vesicles from regenerating muscle tissue using tangential flow filtration and size exclusion chromatography
Isolation of small extracellular vesicles from regenerating muscle tissue using tangential flow filtration and size exclusion chromatography
We have recently made the strikingly discovery that upon a muscle injury, Wnt7a is upregulated and secreted from new regen...
Deletion of exons 45 to 55 in the DMD gene: from the therapeutic perspective to the in vitro model
Deletion of exons 45 to 55 in the DMD gene: from the therapeutic perspective to the in vitro model
Gene editing therapies in development for correcting out-of-frame DMD mutations in Duchenne muscular dystrophy aim to repl...
Muscle degeneration in aging Drosophila flies: the role of mechanical stress
Muscle degeneration in aging Drosophila flies: the role of mechanical stress
Muscle wasting is a universal hallmark of aging which is displayed by a wide range of organisms, although the causes and m...
Pilot investigations into the mechanistic basis for adverse effects of glucocorticoids in dysferlinopathy
Pilot investigations into the mechanistic basis for adverse effects of glucocorticoids in dysferlinopathy
Dysferlinopathies are a clinically heterogeneous group of muscular dystrophies caused by gene mutations resulting in defic...
Age-related differences in the loss and recovery of serial sarcomere number following disuse atrophy in rats
Age-related differences in the loss and recovery of serial sarcomere number following disuse atrophy in rats
Older adults exhibit a slower recovery of muscle mass following disuse atrophy than young adults. At a smaller scale, musc...
Skeletal muscle vulnerability in a child with Pitt-Hopkins syndrome
Skeletal muscle vulnerability in a child with Pitt-Hopkins syndrome
TCF4 acts as a transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5 motif. Dominant variants in TCF4 a...
AAV-NRIP gene therapy ameliorates motor neuron degeneration and muscle atrophy in ALS model mice
AAV-NRIP gene therapy ameliorates motor neuron degeneration and muscle atrophy in ALS model mice
Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron (MN) degeneration, leading to neuromuscul...
ASM is a therapeutic target in dermatomyositis by regulating the differentiation of naive CD4 + T cells into Th17 and Treg subsets
ASM is a therapeutic target in dermatomyositis by regulating the differentiation of naive CD4 + T cells into Th17 and Treg subsets
This study aims to investigate the involvement of acid sphingomyelinase (ASM) in the pathology of dermatomyositis (DM), ma...
Targeted expression of heme oxygenase-1 in satellite cells improves skeletal muscle pathology in dystrophic mice
Targeted expression of heme oxygenase-1 in satellite cells improves skeletal muscle pathology in dystrophic mice
Adult muscle-resident myogenic stem cells, satellite cells (SCs), that play non-redundant role in muscle regeneration, are...
Studying intramuscular fat deposition and muscle regeneration: insights from a comparative analysis of mouse strains, injury models, and sex differences
Studying intramuscular fat deposition and muscle regeneration: insights from a comparative analysis of mouse strains, injury models, and sex differences
Intramuscular fat (IMAT) infiltration, pathological adipose tissue that accumulates between muscle fibers, is a shared hal...
CaMKIIβ deregulation contributes to neuromuscular junction destabilization in Myotonic Dystrophy type I
CaMKIIβ deregulation contributes to neuromuscular junction destabilization in Myotonic Dystrophy type I
Myotonic Dystrophy type I (DM1) is the most common muscular dystrophy in adults. Previous reports have highlighted that ne...
Cellular and molecular alterations to muscles and neuromuscular synapses in a mouse model of MEGF10-related myopathy
Cellular and molecular alterations to muscles and neuromuscular synapses in a mouse model of MEGF10-related myopathy
Loss-of-function mutations in MEGF10 lead to a rare and understudied neuromuscular disorder known as MEGF10-related myopat...
Comparative in vivo characterization of newly discovered myotropic adeno-associated vectors
Comparative in vivo characterization of newly discovered myotropic adeno-associated vectors
Adeno-associated virus (AAV)-based gene therapy is a promising strategy to treat muscle diseases. However, this strategy i...
Pannexin 1 dysregulation in Duchenne muscular dystrophy and its exacerbation of dystrophic features in mdx mice
Pannexin 1 dysregulation in Duchenne muscular dystrophy and its exacerbation of dystrophic features in mdx mice
Duchenne muscular dystrophy (DMD) is associated with impaired muscle regeneration, progressive muscle weakness, damage, an...
Dimorphic effect of TFE3 in determining mitochondrial and lysosomal content in muscle following denervation
Dimorphic effect of TFE3 in determining mitochondrial and lysosomal content in muscle following denervation
Muscle atrophy is a common consequence of the loss of innervation and is accompanied by mitochondrial dysfunction. Mitopha...
IL-33-ST2 signaling in fibro-adipogenic progenitors alleviates immobilization-induced muscle atrophy in mice
IL-33-ST2 signaling in fibro-adipogenic progenitors alleviates immobilization-induced muscle atrophy in mice
The regenerative and adaptive capacity of skeletal muscles reduces with age, leading to severe disability and frailty in t...
Motor neurons and endothelial cells additively promote development and fusion of human iPSC-derived skeletal myocytes
Motor neurons and endothelial cells additively promote development and fusion of human iPSC-derived skeletal myocytes
Neurovascular cells have wide-ranging implications on skeletal muscle biology regulating myogenesis, maturation, and regen...
Metabolic signatures and potential biomarkers of sarcopenia in suburb-dwelling older Chinese: based on untargeted GC–MS and LC–MS
Metabolic signatures and potential biomarkers of sarcopenia in suburb-dwelling older Chinese: based on untargeted GC–MS and LC–MS
Untargeted metabolomics can be used to expand our understanding of the pathogenesis of sarcopenia. However, the metabolic ...
A knock down strategy for rapid, generic, and versatile modelling of muscular dystrophies in 3D-tissue-engineered-skeletal muscle
A knock down strategy for rapid, generic, and versatile modelling of muscular dystrophies in 3D-tissue-engineered-skeletal muscle
Human iPSC-derived 3D-tissue-engineered-skeletal muscles (3D-TESMs) offer advanced technology for disease modelling. Howev...
N-terminal titin fragment: a non-invasive, pharmacodynamic biomarker for microdystrophin efficacy
N-terminal titin fragment: a non-invasive, pharmacodynamic biomarker for microdystrophin efficacy
Multiple clinical trials to assess the efficacy of AAV-directed gene transfer in participants with Duchenne muscular dystr...
The MuSK-BMP pathway maintains myofiber size in slow muscle through regulation of Akt-mTOR signaling
The MuSK-BMP pathway maintains myofiber size in slow muscle through regulation of Akt-mTOR signaling
Myofiber size regulation is critical in health, disease, and aging. MuSK (muscle-specific kinase) is a BMP (bone morphogen...
Restoring skeletal muscle mass as an independent determinant of liver fat deposition improvement in MAFLD
Restoring skeletal muscle mass as an independent determinant of liver fat deposition improvement in MAFLD
Cross-sectional studies have demonstrated the association of skeletal muscle mass with metabolic-associated fatty liver di...
Eldecalcitol prevents muscle loss and osteoporosis in disuse muscle atrophy via NF-κB signaling in mice
Eldecalcitol prevents muscle loss and osteoporosis in disuse muscle atrophy via NF-κB signaling in mice
We investigated the effect of eldecalcitol on disuse muscle atrophy. C57BL/6J male mice aged 6 weeks were randomly assigne...
Hypoxia enhances human myoblast differentiation: involvement of HIF1α and impact of DUX4, the FSHD causal gene
Hypoxia enhances human myoblast differentiation: involvement of HIF1α and impact of DUX4, the FSHD causal gene
Hypoxia is known to modify skeletal muscle biological functions and muscle regeneration. However, the mechanisms underlyin...
Replenishing NAD+ content reduces aspects of striated muscle disease in a dog model of Duchenne muscular dystrophy
Replenishing NAD+ content reduces aspects of striated muscle disease in a dog model of Duchenne muscular dystrophy
Duchenne muscular dystrophy (DMD) is an X-linked disease caused by mutations in DMD gene and loss of the protein dystrophi...
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