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Quantitative analysis of efficacy and safety of LABA/LAMA fixed-dose combinations in the treatment of stable COPD
Quantitative analysis of efficacy and safety of LABA/LAMA fixed-dose combinations in the treatment of stable COPD
Objective:This study aimed to quantitatively compare the efficacy and safety of long-acting β2-agonist (LABA)/long-acting ...
Physiological predictors of cardiorespiratory fitness in children and adolescents with cystic fibrosis without ventilatory limitation
Physiological predictors of cardiorespiratory fitness in children and adolescents with cystic fibrosis without ventilatory limitation
Objectives:[1] To investigate the cardiorespiratory fitness (CRF) levels in children and adolescents with cystic fibrosis ...
Inhibition of LC3-associated phagocytosis in COPD and in response to cigarette smoke
Inhibition of LC3-associated phagocytosis in COPD and in response to cigarette smoke
Introduction/Rationale:In chronic obstructive pulmonary disease (COPD), defective macrophage phagocytic clearance of cells...
Validation of a visual analog scale for assessing cough severity in patients with chronic cough
Validation of a visual analog scale for assessing cough severity in patients with chronic cough
Introduction:Patients with chronic cough experience considerable burden. The cough severity visual analog scale (VAS) reco...
The predictive role of lymphocyte subsets and laboratory measurements in COVID-19 disease: a retrospective study
The predictive role of lymphocyte subsets and laboratory measurements in COVID-19 disease: a retrospective study
Aim:The aim of this study was to investigate the predictive role of lymphocyte subsets and other laboratory measurements i...
Anti-interleukin 5 therapies failure criteria in severe asthma: a Delphi-consensus study
Anti-interleukin 5 therapies failure criteria in severe asthma: a Delphi-consensus study
Background:Current practices for assessing response to anti-interleukin 5/R treatment in severe asthma patients are hetero...
Severe COVID-19 among patients with asthma and COPD: a report from the Swedish National Airway Register
Severe COVID-19 among patients with asthma and COPD: a report from the Swedish National Airway Register
Background:Patients with obstructive lung diseases may be at risk of hospitalization and/or death due to COVID-19.Aim:To e...
A new protocol for exercise testing in COPD; improved prediction algorithm for WMAX and validation of the endurance test in a placebo-controlled double bronchodilator study
A new protocol for exercise testing in COPD; improved prediction algorithm for WMAX and validation of the endurance test in a placebo-controlled double bronchodilator study
Background:Two new protocols have been developed for bicycle exercise testing in chronic obstructive pulmonary disease (CO...
Manifesto on the overuse of SABA in the management of asthma: new approaches and new strategies
Manifesto on the overuse of SABA in the management of asthma: new approaches and new strategies
The risks of overusing short-acting β2-agonists (SABA), including an increase in asthma-related deaths, are many and well ...
Effectiveness of corticosteroids on chest high-resolution computed tomography features of COVID-19 pneumonia
Effectiveness of corticosteroids on chest high-resolution computed tomography features of COVID-19 pneumonia
Objective:The aim of our study was to assess the effect of a short-term treatment with low-moderate corticosteroid (CS) do...
The short-term effects of ORKAMBI (lumacaftor/ivacaftor) on regional and distal lung structures using functional respiratory imaging
The short-term effects of ORKAMBI (lumacaftor/ivacaftor) on regional and distal lung structures using functional respiratory imaging
Background:Lumacaftor/ivacaftor (LUM/IVA) has shown modest benefits in previous research, but the exact effects in the cys...
Gender differences in non-cystic fibrosis bronchiectasis severity and bacterial load: the potential role of hormones
Gender differences in non-cystic fibrosis bronchiectasis severity and bacterial load: the potential role of hormones
Non cystic-fibrosis bronchiectasis (NCFB) is a complex chronic respiratory disease, characterised by excessive sputum prod...
DSP rs2076295 variants influence nintedanib and pirfenidone outcomes in idiopathic pulmonary fibrosis: a pilot study
DSP rs2076295 variants influence nintedanib and pirfenidone outcomes in idiopathic pulmonary fibrosis: a pilot study
Background:The antifibrotic drugs nintedanib and pirfenidone are used for the treatment of idiopathic pulmonary fibrosis (...
Therapeutic closure of bronchopleural fistulas using ethanol
Therapeutic closure of bronchopleural fistulas using ethanol
Bronchopleural fistula (BPF) leading to persistent air leak (PAL), be it a complication of pulmonary resection, radiation,...
Monitoring and management of fibrosing interstitial lung diseases: a narrative review for practicing clinicians
Monitoring and management of fibrosing interstitial lung diseases: a narrative review for practicing clinicians
Close monitoring of patients with fibrosing interstitial lung diseases (ILDs) is important to enable prompt identification...
Improvements in lung function with budesonide/glycopyrrolate/formoterol fumarate metered dose inhaler versus dual therapies in patients with COPD: a sub-study of the ETHOS trial
Improvements in lung function with budesonide/glycopyrrolate/formoterol fumarate metered dose inhaler versus dual therapies in patients with COPD: a sub-study of the ETHOS trial
Background:In the phase III, 52-week ETHOS study in patients with moderate to very severe chronic obstructive pulmonary di...
PINK1/Parkin-mediated mitophagy in mechanical ventilation-induced diaphragmatic dysfunction
PINK1/Parkin-mediated mitophagy in mechanical ventilation-induced diaphragmatic dysfunction
Background:Mechanical ventilation (MV) often leads to ventilation-induced diaphragm dysfunction (VIDD). Although the devel...
Impact of COVID-19 on social determinants of health for adults with cystic fibrosis
Impact of COVID-19 on social determinants of health for adults with cystic fibrosis
Introduction:Outcomes in cystic fibrosis are influenced by multiple factors, including social determinants of health. Low ...
A non-interventional switch study in adult patients with asthma or COPD on clinical effectiveness of salmeterol/fluticasone Easyhaler® in routine clinical practice
A non-interventional switch study in adult patients with asthma or COPD on clinical effectiveness of salmeterol/fluticasone Easyhaler® in routine clinical practice
Background:Selection of the most appropriate device for a switch from one inhaler to an equivalent product is known to hav...
The perplexing role of RAGE in pulmonary fibrosis: causality or casualty?
The perplexing role of RAGE in pulmonary fibrosis: causality or casualty?
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease in which most patients die within 3 years of d...
LncRNA CASC2 is involved in the development of chronic obstructive pulmonary disease via targeting miR-18a-5p/IGF1 axis
LncRNA CASC2 is involved in the development of chronic obstructive pulmonary disease via targeting miR-18a-5p/IGF1 axis
Aims:Chronic obstructive pulmonary disease (COPD) is a systemic disease. Several long non-coding RNAs (lncRNAs) have been ...
Clinical effectiveness of convalescent plasma in hospitalized patients with COVID-19: a systematic review and meta-analysis
Clinical effectiveness of convalescent plasma in hospitalized patients with COVID-19: a systematic review and meta-analysis
Aims:Given the variability of previously reported results, this systematic review aims to determine the clinical effective...
An increased risk of lung cancer in combined pulmonary fibrosis and emphysema patients with usual interstitial pneumonia compared with patients with idiopathic pulmonary fibrosis alone: a systematic review and meta-analysis
An increased risk of lung cancer in combined pulmonary fibrosis and emphysema patients with usual interstitial pneumonia compared with patients with idiopathic pulmonary fibrosis alone: a systematic review and meta-analysis
Background:Lung cancer is an important complication of combined pulmonary fibrosis and emphysema (CPFE). Whether the risk ...
Self-expanding covered metallic stents as a transition to silicone stent implantation in management of severe post-tuberculosis bronchial stenosis
Self-expanding covered metallic stents as a transition to silicone stent implantation in management of severe post-tuberculosis bronchial stenosis
Background and aims:Post-tuberculosis bronchial stenosis (PTBS) is one of the most common complications of tracheobronchia...
Virtual bronchoscopic navigation versus non-virtual bronchoscopic navigation assisted bronchoscopy for the diagnosis of peripheral pulmonary lesions: a systematic review and meta-analysis
Virtual bronchoscopic navigation versus non-virtual bronchoscopic navigation assisted bronchoscopy for the diagnosis of peripheral pulmonary lesions: a systematic review and meta-analysis
Background:Image-guided bronchoscopy techniques such as virtual bronchoscopic navigation (VBN) has emerged as a means of a...
High flow nasal cannula oxygenation in COVID-19 related acute respiratory distress syndrome: a safe way to avoid endotracheal intubation?
High flow nasal cannula oxygenation in COVID-19 related acute respiratory distress syndrome: a safe way to avoid endotracheal intubation?
Backgrounds:High flow nasal cannula (HFNC) is an alternative therapy for acute respiratory distress syndrome (ARDS) due to...
Pyogenic lung abscess in an infectious disease unit: a 20-year retrospective study
Pyogenic lung abscess in an infectious disease unit: a 20-year retrospective study
Background:Pyogenic lung abscesses are rare and poorly described infections. This study aimed to describe their prognostic...
Does pre-existent physical inactivity have a role in the severity of COVID-19?
Does pre-existent physical inactivity have a role in the severity of COVID-19?
Background and Aims:Physical inactivity is considered an important lifestyle factor for overweight and cardiovascular dise...
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