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A Bifunctional Pasteurella multocida β1–3-Galactosyl/N-Acetylgalactosaminyltransferase (PmNatB) for Highly Efficient Chemoenzymatic Synthesis of Disaccharides
Glycosyltransferases are nature’s key biocatalysts for the formation of glycosidic bonds. Discovery and characterization o...
Reactions of Alkynes with C–S Bond Formation: Recent Developments
Alkynes are important in organic synthesis. This review mainly focus on recent advances (2013-2023) of alkynes with C-S bo...
N-Confused Strapped Calix[4]pyrrole: The Missing Member of Calix[4]pyrrole Chemistry
The first example of N-confused strapped calix[4]pyrrole 5 is presented. Structural integrity of 5 and its regular isomer ...
Catalyst-free Regioselective Photoarylation of 2-Aryl-2H-indazoles by Carbon-Halogen Bond Activation
A photocatalyst-free visible-light induced regioselective arylation of 2-aryl-2H-indazoles has been developed for the firs...
Visible-light-induced C-H alkylation reactions of 2-amino-1,4-naphthoquinones
A Simple and practical strategies for visible-light-induced C-H alkylation of 2-amino-1,4-naphthoquinones with cyclobutano...
Metal-free oxidative coupling of aryl acetylene with elemental sulphur and amines: A facile access to α-ketothioamides
A simple and efficient oxidative coupling of aromatic alkynes with elemental sulphur and secondary amines has been reporte...
Recent advances in the palladium-catalyzed sulfonylation via SO2 insertion
Sulfonyl-group-containing compounds such as sulfinates, sulfones, sulfonamides and sulfonyl fluorides are omnipresent in p...
Computational Methods for Investigating Organic Radical Species
Computational analysis of organic radical species presents significant challenges. This study compares the efficacy of var...
In(OTf)3-Catalyzed Formal (4 + 3) Cycloaddition Reactions of 3-Benzylideneindoline-2-thiones with 2-Indolylmethanols
We report the In(OTf)3-catalyzed formal (4 + 3) cycloaddition of 3-benzylideneindoline-2-thiones with 2-indolylmethanols. ...
Electrochemical Oxidative Thioetherification of Aldehyde Hydrazones with Thiophenols
Electrochemical promoted oxidative dehydrogenation cross-coupling reaction between aldehyde hydrazones with thiophenols is...
Copper-Catalyzed Asymmetric 1,2-Arylboration of Enamines: Ac-cess to Chiral Borate-Containing 3,3’-Disubstituted Isoindolinones
An enantioselective copper-catalyzed 1,2-arylboration reaction of enamines has been developed by employing (R)-xyl-BINAP a...
Ammonium carboxylates in ammonia-Ugi reaction: one-pot synthesis of α,α-disubstituted amino acid derivatives including unnatural dipeptides
Despite the remarkable developments of Ugi reactions and its variants, the use of ammonia in the Ugi reaction has long bee...
Key Role of Cycloalkyne Nature in Alkyne-Dye Reagents for Enhanced Specificity of Intracellular Imaging by Bioorthogonal Bioconjugation
Conjugates of benzothiophene-fused azacyclononyne BT9N-NH2 with fluorescent dyes were developed to visualise azidoglycans ...
Micelle-mediated Synthesis of Quinoxaline, 1,4-Benzoxazine and 1,4-Benzothiazine Scaffolds from Styrenes
A range of heterocycles based on quinoxalines, 1,4-benzoxazines and 1,4-benzothiazines have been accessed from styrenes by...
Trifunctionalization of C=C Bonds in Vinyl Azides to Access Densely Functionalized Phenanthridines Enabled by the NCS/AgNO2 System
An unprecedented trifunctionalization of C=C bonds in 2-(1-azidovinyl)-1,1'-biphenyls has been successfully achieved b...
Synthesis of fluorinated curcumin derivatives for detecting amyloid plaques by 19F-MRI
The most prominent pathophysiological hallmark of Alzheimer’s disease is the aggregation of amyloid-β (Aβ) peptides into s...
Silylene Acetals from Cheap Reagents: Synthesis and Regioselective Opening
In this communication a practical method for using cheap and easily available silylene chlorides for diol protection is pr...
Metal-free efficient synthesis of aryl sulfonamides from N-hydroxy sulfonamide and amines
A simple and novel approach for the synthesis of sulfonamides has been developed from N-hydroxy sulfonamide. Notably, the ...
Chemoselective One-pot Cleavage and Oxidation of Silyl Ethers into Corresponding Carbonyl Compounds Using IBX and Acid Catalyst
Herein, we describe the chemoselective one-pot cleavage and oxidation of silyl ethers using catalytic amount of TsOH·...
Palladium-Catalyzed Amidation of Carbazole Derivatives via Hydroamination of Isocyanates
The first amidation of carbazoles on N9 position via palladium-catalyzed hydroamination of isocyanates is demonstrated. Th...
Light-induced ligand-to-metal charge transfer of Fe(III)-OR species in organic synthesis
Light-induced ligand-to-metal charge transfer (LMCT) has been utilized as a powerful strategy in various organic reactions...
Diselenide metathesis in selenocysteine-substituted biologically active peptides
Substitution of disulfide bond to diselenide bond in peptides and proteins is a often-used strategy to increase the stabil...
Accessing diverse bicyclic peptide conformations using 1,2,3-TBMB as a linker
Bicyclic peptides are a powerful modality for engaging challenging drug targets such as protein-protein interactions. Here...
HMPA-H2O mediated oxygenative carbocyclization of 2-alkynylphenyl-substituted p-quinone methides to indenones
Herein, we report a transition-metal and base free protocol to access a wide range of functionalized indenone derivatives ...
Electrochemical selenylative ipso-Annulation of N-benzylacrylamides to seleno-azaspiro[4.5]decadienones
Herein, we presented the electrochemical synthesis of selenylated azaspiro[4.5]decadienones through a domino selenylation/...
Highly specific aptamer for SARS-CoV-2 Spike protein from the authentic strain
DNA aptamers are oligonucleotides specifically bound to target molecules that serve as antibodies of nucleic acid nature. ...
Synthesis of 3-sulfonylisoindolin-1-ones from olefinic amides and sodium sulfinates via electrooxidative tandem cyclization
Sulfonyl groups are widely found motifs in biologically active compounds and drug molecules, many isolated natural product...
Enzymatic synthesis of ligand-bearing oligonucleotides for the development of metal-responsive DNA materials
Metal-mediated artificial base pairs are one of the most promising building blocks for constructing DNA-based supramolecul...
Kinetic study of the reaction of thiophene-tocopherols with peroxyl radicals enlighten the role of S---O noncovalent interactions on H-atom transfer
Three new α-tocopherol thiophene derivatives were efficiently synthesized, characterized and used for the first time as ch...
Chloroformate-Mediated Ring Cleavage of Indole Alkaloids Leads to Re-engineered Antiplasmodial Agents
Natural product ring distortion strategies have enabled rapid access to unique libraries of stereochemically complex compo...
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