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Application of mixed phosphorus/sulfur ligands based on terpenoids to Pd-catalyzed asymmetric allylic substitution and Rh-catalyzed hydrogenation
A small library of easily prepared diamidophosphite-sulfides based on 1,3-thioether alcohols, primarily of terpenoid nature...
Entry to 4,5-Fused Coumarin frameworks via Radical-Promoted Alkylative Intramolecular C5-Annulation
An unprecedented radical-promoted strategy involving domino alkylation/intramolecular C5-annulation of N-acryloyl-4-amino ...
Design of C2 symmetric pseudopeptides for in vivo detection of Cu(II) through controlled supramolecular nano-assembly
Pseudopeptides are emerging next-generation soft bioinspired materials for biological applications. Therefore, a new class...
Water-Assisted Cascade Synthesis of Trifluoromethylated Dipyridodiazepinone Analogues: In vitro and In silico Antibacterial Studies
A base-promoted palladium-catalyzed cascade reaction is described to access the trifluoromethylated dipyridodiazepinone de...
Metal-free Synthesis of 1,1-Dimethyl-2,2,2-trifluoroethyl Substituted Quinazolinones via Tandem Radical Cyclization of Quinazolin-4(3H)-ones with 3,3,3-Trifluoro-2,2-dimethylpropanoic acid
A metal-free (NH4)2S2O8-mediated decarboxylative trifluoromethylation reaction of alkenes with 3,3,3-trifluoro-2,2-dimethy...
Copper(II)-catalyzed, Site Selective C(sp2)–H Amination using 8-Aminoimidazo[1,2-a]pyridine (AIP) as Directing group
An efficient copper(II)-catalyzed regioselective ortho C(sp2)–H amination of arenes/heteroarenes has been developed with t...
A Relay Ring-Closing Metathesis/Diels-Alder Approach to Sugar-Derived Pluramycin-Hybrids
We report a general approach to synthesize sugar-derived pluramycin hybrids analogous to the pluramycinone carbocyclic ske...
Visible-Light-Induced alkyl-arylation of olefins via a Halogen-Atom Transfer Process
Visible-light-induced three-component 1,2-alkylarylation of alkenes and alkyl radical addition/cyclization of acrylamides ...
Synthesis of fluorinated spiro-1,3-oxazines and spiro-1,3-thiazines via Selectfluor-mediated intramolecular spirocyclization
A fluorination-induced intramolecular cyclization for the synthesis of fluoro-substituted spiro-1,3-oxazine and spiro-1,3-...
Modular synthesis of 3,3-disubstituted oxindoles from nitrones and acrylic acids
We developed a modular synthesis for 3,3-disubstituted oxindoles, utilizing readily accessible nitrones and acrylic acids....
Unexpected Dearomatization of N-Protected 5-Aminopyrazoles at Ambient Temperature: A Simple Route to Highly Functionalized Pyrazolines
We present a new strategy for the dearomatized hydroxylation of 5-aminopyrazoles using a hypervalent iodine reagent at roo...
Recent advances in the synthesis of trifluoromethyl-containing heterocyclic compounds via trifluoromethyl building blocks
Trifluoromethylated heterocyclic compounds have played an increasingly significant role in pharmaceuticals, agrochemicals,...
Na2CO3-Promoted Synthesis of Thiocarbamates from Isocyanates and Thiols under Mild Conditions
Here, we developed an efficinet method for the synthesis of s-alkyl or aryl thiocarbamates catalyzed by Na2CO3 under mild ...
Synthesis of Diversely Substituted Quinazoline-2,4(1H,3H)-diones by Cyclization of tert-Butyl (2-Cyanoaryl) Carbamates
The synthesis of diversely substituted quinazoline-2,4(1H, 3H)-diones by cyclization of tert-butyl (2-cyanoaryl) carbamate...
Synthesis of Indolines via Palladium-Catalyzed [4+1] Annulation of (2-Aminophenyl) Methanols with Sulfoxonium Ylides
A facile strategy for the synthesis of valuable indolines has been developed, involving the palladium(II)/Brønsted ac...
Visible-light induced selenocyclization of 2-ethynylanilines under ambient conditions: simple FeBr3 as a dual-functional catalyst
We report herein a visible-light induced, Fe-catalyzed selenocyclization of 2-ethynylanilines with diselenides under ambie...
Preparative Scale Achmatowicz and aza-Achmatowicz Rearrangements Catalyzed by Agrocybe aegerita Unspecific Peroxygenase
The unspecific peroxygenase (UPO) from Agrocybe aegerita (rAaeUPO-PaDa-I-H) is an effective and practical biocatalyst for ...
Highly Efficient Esterification of Carboxylic Acids with O-H Nucleophiles through Acid/Iodide Cooperative Catalysis
The esterification of carboxylic acids is an important reaction for preparing esters which find wide applications in vario...
Electrochemical oxidative selective halogenation of pyrazolones for the synthesis of 4-halopyrazolones
An efficient and environmentally friendly electrochemical oxidative selective halogenation of pyrazolones has been develop...
Organocatalytic Hydrogen Bond Donor/Lewis Base (HBD/LB) Synthesis and Chiroptical Properties of Thiabridged [5]Helicenes
Thiabridged [5]helicenes are obtained from thioary-N-phthalimido benzo[a]phenothiazines using a Hydrogen Brond Donor/Lewis...
Development of boronic acid catalyst for direct amidation of aromatic carboxylic acids using fluorescent-based screening
Direct amidation of carboxylic acids with amines holds significant importance; therefore, catalytic processes involving bo...
Facile synthesis and antifungal evaluation of hypervalent organoantimony(III) and -bismuth(III) thioates with tridentate C,N,C-coordinating ligands
In the present work, a series of organometallic thioates bearing a 5,6,7,12-tetrahydrodibenzo[c,f][1,5]azastibocine or -az...
Recent Developments in Thiochromene Chemistry
Thiochromenes are versatile sulfur-containing heterocyclic compounds that have received considerable interest in drug disc...
A general approach to construct selenopheno[3,2-b]indole-cored molecules using Fischer indolization
A wide series of various selenopheno[3,2-b]indole-based compounds, including 2-aryl-substituted selenopheno[3,2-b]indoles ...
Iron and Base Catalyzed C(α)-Alkylation and One-pot Sequential Alkylation-Hydroxylation of Oxindoles with Secondary Alcohols
The utilization of economical and environmentally benign transition metals in crucial catalytic processes is pivotal for s...
DFT study of electron donor-acceptor (EDA) complexes: mechanism exploration and theoretical prediction
Organic synthesis methods initiated by visible light have received increasing attention from synthetic chemists. Reactions...
Synthesis of pyrrolo[2,3-d]pyridazines and pyrrolo[2,3-c]pyridines (6-azaindoles). Experimental and theoretical study
A new synthetic route towards the synthesis of 6-azaindoles (pyrrolo[2,3-c]pyridines) and pyrrolo[2,3-d]pyridazines starti...
Alkali Metal-Hydroxide-Catalyzed Mechanisms of Csp-H Silylation of Alkyne: A DFT Investigation
Mechanisms for the Csp-H silylation between prop-2-yn-1-ylcyclohexane and triethylsilane, catalyzed by MOH/MH (M=Li, Na, o...
Diastereoselective Cyclopropanation of α,β- Unsaturated Carbonyl Compounds with Vinyl Sulfoxonium Ylides
Herein, we report a three-component stereoselective cyclopropanation of vinyl sulfoxonium ylides with indane 1,3-dione and...
Atropisomeric 1-phenylbenzimidazoles affecting microtubule organization: influence of axial chirality
Benzimidazoles are frequently used in medicinal chemistry. Their anticancer effect is among the most prominent biological ...
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