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Identification of α-tubulin alpha-1B chain as target of asiatic acid by chemical proteomics in HepG2 hepatoma cells
Asiatic acid (AA) is a naturally occurring pentacyclic triterpene isolated from Centella asiatica and has various biologic...
CisPro stabilization in prolyl carbamates influenced by tetrel bonding interactions
NMR spectral and theoretical analyses of homologous prolyl carbamates reveal subtle charge transfer tetrel bonding interac...
Synthetic studies towards naturally occurring aporpinones: Asymmetric synthesis of 1'-deshydroxymethyl analogues of aporpinone A, aporpinone B and 4'-hydroxyaporpinone A
Herein, we disclose the asymmetric total synthesis of 1'-deshydroxymethyl analogues of naturally occurring aporpinone ...
[Au]/[Ag]-Catalysed Synthesis of Non-hydrolysable C-Glycosides
Many C-Glycosides are noticed in natural products, drugs and small molecule probes. Herein, we report the synthesis of C-g...
Pushing a bistable [2]rotaxane out of equilibrium and isolation of the metastable-state co-conformation
Incorporating a steric barrier between the two stations in a bistable [2]rotaxane based on monopyrrolotetrathiafulvalene a...
Construction of fused heterocycles by visible-light induced dearomatization of nonactivated arenes
A diverse array of fused [6-6-5] tricyclic heterocycles has been synthesized via the dimerization and dearomative cyclizat...
Base-Promoted Tandem Ring-Opening/Ring-Closing of N-Alkynyl-2-oxazolidinones Enables Facile Synthesis of 2-Oxazolines
A K2CO3-promoted tandem ring-opening/ring-closing of N-alkynyl-2-oxazolidinones has been described, affording 2-oxazolines...
Novel 1-Benzoazepine-Derived Michael Acceptor and Its Hetero-Adducts Active Against MRSA
Multidrug-resistant bacterial infections continue to be a rising global health concern. Herein, we describe the developmen...
Direct C-H functionalisation of azoles via Minisci reactions
Azoles have widespread applications in medicinal chemistry, for example, thiazoles, imidazoles, benzimidazoles, isoxazoles...
Efficient Synthesis of Promising Antidiabetic Triazinoindole Analogues via Solvent-Free Method: Investigating the Reaction of 1,3-Diketones and 2,5-Dihydro-3H-[1,2,4]triazino[5,6-b]indole-3-thione
Diabetes poses a significant global health challenge, driving the search for effective management strategies. In past year...
A chlorine-free microwave-assisted, ionic liquid-catalyzed esterification of arylsulfonic acids by alcohols; An experimental and theoretical study
In the line of the esterification of heteroatomic acids, after the microwave-assisted ionic liquid-catalyzed esterificatio...
Recent Advances in the Enantioselective Synthesis of Chiral Sulfones via Asymmetric Hydrogenation
Chiral sulfones are key structural motifs extensively exist in natural products, drugs, and biologically active compounds....
Assembly of Functionalized gem-Difluoroalkenes via Photocatalytic Defluorocyanoalkylation and Defluoroacylation of α-CF3 Styrenes with Oxime Esters
We have reported an efficient photocatalytic protocol for the defluorocyanoalkylation and defluoroacylation of α-trifluoro...
Visible-light Photoredox-Catalyzed Three-Component Radical Alkyl-Acylation of [1.1.1]Propellane
We described herein a three-component radical alkyl-acylation of [1.1.1]propellane reaction via a visible-light photochred...
Palladium-catalyzed cascade cyclization of α,β-unsaturated N-tosylhydrazones with iodoarenes : access to 2H-chromenes and 2H-quinolines
A palladium-catalyzed cascade reaction of α,β-unsaturated N-tosylhydrazones with iodoarene derivatives containing a nucleo...
Reversible encapsulation and release of fullerenes using calix[n]phenoxazines
This investigation presents the synthesis of butyl-decorated calix[n]phenoxazines of varying sizes by kinetic control and ...
Triflic-acid promoted post-Ugi condensation for the assembly of 2,6-diarylmorpholin-3-ones
We report a two-step one-pot synthesis of 2,6-diarylmorpholin-3-one core based on Ugi reaction of 2-oxoaldehyde with 2-hyd...
Synthesis of di/tri-substituted carbazoles involving Pd-Mediated Sonogashira coupling of 2-(trimethylamino)methylindolyltriflates with aryl acetylenes followed by thermal electrocyclization
In this study, we present our preliminary findings on the synthesis of carbazole derivatives involving Sonogashira couplin...
Highly Selective Synthesis of Selenium-Containing (E)-N-Propenolquinazolinones via FeCl3-Mediated Cascade Reaction of Propargyl Quinazoline-4-yl Ethers with Diselenides
An effective approach for highly selective construction of selenium-containing (E)-N-propenplquinazolinones has been devel...
Synthesis of 1,4-Benzodioxepines via Electrochemical Oxyselenenylation of 2-O-tethered Alkenyl Phenylmethanol and Diselenides
A highly efficient methodology has been developed for the synthesis of 1,4-benzodioxepines through electrochemical oxysele...
Radical alkylation of acrylamides with peroxides to access mono/dialkylated fused N-heterocycles
A simple mono/dialkylation of acrylamide derivatives was finished, which gave diverse mono/dialkylated benzo[4,5]imidazo[2...
Theoretical mechanistic insights on the thermal and acid-catalyzed rearrangements of N-methyl-N-nitroanilines
The thermal and acid-catalyzed rearrangement mechanisms of N-methyl-N-nitroanilines were investigated theoretically via de...
Ruthenium-catalyzed Heck coupling of 3-arylidene-oxindoles with alkenes: a facile synthesis of 3-allylidene-2(3H)-oxindoles
A simple and efficient Ru(II)-catalyzed olefination of 3-(arylbenzylidene)indolin-2-ones with alkenes is described. This i...
β-meso-Fused Pyrene-Porphyrin Scaffolds with Panchromatic Absorption Features
The π-extension of porphyrins with pyrenes through fusion of five-membered rings is demonstrated. Three architectures resu...
Asymmetric [3+3] Cycloaddition of Cinnamaldehyde-derived N-Aryl Nitrones with 2-Indolemethanols Enabled by Chiral Phosphoric Acid
We described a chiral phosphoric acid (CPA) catalyzed asymmetric [3+3] cycloaddition of cinnamaldehyde-derived N-aryl nitr...
Effective self-assembly of 21- and 14-membered azamacrocycles via condition-controlled cyclotrimerization or cyclodimerization of different thiosemicarbazide-based precursors
A preparative synthesis of previously unknown 21- and 14-membered azamacrocycles via acid-promoted cyclotrimerization or c...
Visible-light-driven catalyst-free C-S cross-coupling of thiol deriva-tives and aryl halides
A mild, scalable, and high-yielding visible-light-promoted C-S cross-coupling between alkyl thiol derivatives and (hetero)...
The synthesis of aryl amines enabled by rearrangement and demethylaromatization of cyclohexadienimines
The rearrangement and demethylaromatization of cyclohexadienimines (namely cyclohexadienone imines) were detailedly invest...
A one-pot Synthesis of 2,3-Dihydrobenzofurans, Benzofuran-2(3H)-ones, and Indoles via [4 + 1] Annulation Reaction of ortho-substituted para-Quinone Methides and Bromonitromethane
Under mild and metal-free reaction conditions a facile one-pot synthesis of oxygen and nitrogen-containing benzoheterocycl...
Recognition of mixed-sequence double-stranded DNA regions using chimeric Invader/LNA probes
Development of robust oligonucleotide-based probe technologies, capable of recognizing specific regions of double-stranded...
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