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Metal and solvent free one–pot arylation/ hetero arylation / hydroxylation: An efficient synthesis hetero/aryl substituted quinoxalin-2-ones/ pyrazin-2(1H)-one/ pyrimidin-4(3H)-one
Metal, solvent-free, one-pot and TFA Promoted method for the construction of hetero/aryl substituted quinoxalin-2-ones/ py...
L-amino acid ester as biomimetic reducing agent for the reduction of unsaturated C=C bonds
The first example of an efficient protocol for the reduction of disubstituted methyleneindolinones, isoindigos and tetrasu...
Asymmetric ‘Clip-Cycle’ Synthesis of 3-Spiropiperidines
3-Spiropiperidines can be synthesized in up to 87% yield and 96:4 er using a two step ‘Clip-Cycle’ approach. The ‘Clip’ st...
Rhodium(III)-Catalyzed direct C-H activation of 2-Aryl-3H-indoles: A strategy for 4-heteroaryl pyrazoles synthesis
A novel protocol for synthesizing 4-heteroaryl pyrazoles from readily available 2-Aryl-3H-indoles and diazopyrazolones thr...
Recent Advances in the Synthetic Applications of Nitrosoarene Chemistry
Nitroso groups are widely present in biologically active compounds in medicinal chemistry, and nitroso compounds serve as ...
Correction: Cu(II)-Mediated aerobic oxidative synthesis of sulfonated chromeno[4,3-c]pyrazol-4(2H)-ones
Correction for ‘Cu(ii)-Mediated aerobic oxidative synthesis of sulfonated chromeno[4,3-c]pyrazol-4(2H)-ones’ by Quan Zhou ...
Synthesis, Antitumoral and Antiviral Evaluation of Polyacetylene Glycoside Derivatives
A series of novel derivatives of Poliacetylene Glycosides (PAGs) were synthesized, and their antiproliferative and antivir...
Why Is Thiol Unexpectedly Less Reactive but More Selective Than Alcohol in Phenanthroline-Catalyzed 1,2-cis O- and S- Furanosylations?
The lack of catalytic stereoselective approaches for producing 1,2-cis S-furanosides emphasizes the critical need for furt...
Synthesis of 3,5-bis(fluoroalkyl)pyrazoles/pyrazolines from [3 + 2] cycloaddition of di/trifluoroacetohydrazonoyl bromides and trifluoromethyl-substituted alkenes
An efficient [3 + 2] cycloaddition reaction of difluoromethyl or trifluoromethyl hydrazonoyl bromides with trifluoromethyl...
Synthesis of N-benzyl pyridones from para-quinone methides (p-QMs) at room temperature: Evaluation of in vitro blood-stage antiplasmodial activity
We present a method for synthesizing N-benzyl pyridones from para-quinone methides (p-QMs) and 2- or 4-hydroxy pyridines i...
Iron-Catalyzed Ligand-Free Diazidation of Alkenes Controlled by the Ratio of TBHP to TMSN3
The diazidation of alkenes through an iron-catalyzed ligand-free system has been established, providing a straightforward ...
Cp*Co(III)-Catalyzed Synthesis of Isoquinolones via Controlled Annulation of Primary Arylamides with Internal Alkynes
In this study, we present the first cobalt(III)-catalyzed direct synthesis of isoquinolones from readily available primary...
Extended tetrathiafulvalene with a pentaleno[1,2-b:4,5-b']difluorene core – A donor-acceptor multi-redox system
A novel extended tetrathiafulvalene was prepared by introducing the large pentaleno[1,2-b:4,5-b’]difluorene as a central p...
Synthesis of β-lactam-zidovudine pronucleosides as potential selective narrow-spectrum antibacterial agents
Since the discovery of penicillin, the forerunner of the most widely used class of antibiotics (i.e. β-lactams), natural c...
Base-mediated denitrative C3-alkylation of quinoxaline derivatives
We have developed a novel base-mediated method for the selective C3-alkylation of quinoxalin-2(1H)-one and N-protected qui...
Synthetic Versatility: The C-P Bond Odyssey
This review article comprehensively examines the synthesis, application, and future of carbon-phosphorus (C-P) bond chemis...
Syntheses of Differentially Fluorinated Triazole-Based 1-Deoxysphingosine Analogues en route to SphK Inhibitors
This study focuses on the stereoselective syntheses of 1-deoxysphingosine analogues as potential inhibitors of sphingosine...
Innovations in Isocyanate Synthesis for a Sustainable Future
Isocyanates play a crucial role as key building blocks in the production of thermoplastic foams, elastomers, adhesives, ag...
HFIP Mediated Oxime Ether Synthesis: A Metal, Base and Additive Free Approach
Oxime ethers are extensively present as key components in numerous active pharmaceutical ingredients and many other synthe...
Photooxidative C-C double bond cleavage of β-enaminocarbonyl compounds: toward selective N-formylation of amines
Photooxidative C-C double bond cleavage of electron-deficient β-enaminocarbonyl compounds possessing a silyl group at the ...
Synthesis of diarylsulphide/diarylselenide embedded pyrazole-fused isocoumarins and isatin/ninhydrin hydrazones via acid catalyzed solvent and temperature controlled reactions
Room temperature stirring a mixture of chalcogenated arylhydrazones and ninhydrin in dichloromethane (DCM) in presence of ...
Cross-bridged cyclam derivatives with bis(phosphinate) and phosphinate-phosphonate pendant arms (cb-BPC) as chelators for copper radioisotopes
Copper radioisotopes can be used for imaging as well as for therapy and, thus, can form ideal theranostic pairs. The Cu(II...
Alkyl Groups in Organic Molecules are NOT Inductively Electron-Releasing
It is commonly stated that alkyl groups exert an inductive electron-releasing effect when compared to hydrogen. This infor...
Recent Advances for the Transformation of Maleimides via Annulation
Over the past five years, maleimide scaffolds have gained considerable attention in organic synthesis for their role in fo...
One-pot hydroaminomethylation of an alkene under formation of primary amines by combining hydroformylation at elevated syngas pressure and biocatalytic transamination in water
We report a novel one-pot chemoenzymatic synthesis of primary amines, combining rhodium-catalysed hydroformylation of styr...
Expeditious synthesis of CF3-phenanthridones through a base mediated cross-conjugated vinylogous benzannulation (VBA)
Herein, we have reported a mild, efficient, and strategic rapid approach for the preparation of CF3-phenanthridones throug...
Synthesis of benzosultams via Ag(I)-catalyzed alkylative cyclization of vinyl sulfonamides
A convenient method to access benzo-fused-γ-sultams via alkyl radical induced cyclization of vinyl sulfonamides is present...
Ferrocene-based P,P,N,N,O-ligands for ruthenium-catalyzed enantioselective hydrogenation
A new type of ferrocenyl P, P, N, N, O-ligand has been developed through a one-step transformation from (RC,SFC)-PPFOAc. T...
Chiral spherical aromatic amides: one-step synthesis and their stereochemical/chiroptical properties
Macrocyclic aromatic amides 2, in which the meta-positions of all four benzene rings are linked by tertiary amide bonds, w...
Enantioselective synthesis of -(3-pyrrolyl)methanamines with aza-tetrasubstituted center under metal-free conditions
Construction of a chiral methanamine unit at the C3 position of pyrrole is highly desirable; nevertheless, it remains chal...
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