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Proteomic Mapping of Intercellular Synaptic Environments via Flavin-Dependent Photoredox Catalysis
Receptor-ligand interactions play essential signaling roles within intercellular contact regions. This is particularly imp...
Asymmetric synthesis of perhydroepoxyethanoindole core via sequential [4+2]-addition/reduction/fluoroannulation reactions
Herein, we present the sequential aminocatalytic [4+2]-addition/reduction and fluoroannulation reaction to afford a novel ...
Catecholase catalyzed synthesis of wedelolactone, a natural coumestan and its analogs
Biocatalysis plays an important role in synthesis of complex organic molecules. Wedelolactone, a natural coumestan has bee...
A TD-DFT Study on a Class of D-π-A Fluorescent Probes for Typical Oxidants Detection
A deep understanding of the fluorescent respond mechanisms is the foundation for the design-orientated strategies of D-π-A...
Brønsted Acid-Catalysed Desilylative Heterocyclisation to form Substituted Furans
Heterocyclisation of tert-butyldimethylsilyl (TBS) protected γ-hydroxy-α,β-unsaturated ketones catalysed by para-toluenesu...
A 4-state acid-base controlled molecular switch based on a host-guest system
A novel ZnII funnel complex that presents three phenol functions within the calix[6]arene macrocycle is described. Host-gu...
Cobalt(Ⅲ)-Catalyzed weakly coordinating arylurea-directed regio-selective mono-olefination
Herein, we reported air stable, earth-abundant cobalt (III)-catalyzed regio-selective mono-olefination of arenes directed ...
Arynes as Synthetic Linchpins Towards the Construction of Diversely Functionalized Natural Product Skeletons
Arynes are a privileged class of reactive intermediates in synthetic organic chemistry, and their unusual reactivities hav...
Cyrene: A Bio-based Solvent for the Mizoroki-Heck Reaction of Aryl Iodides
The development of greener and more sustainable methods, as well as the adaptation of already existing protocols to more e...
Palladium-Catalyzed Cascade Cyclization of Allenamide with 2-Iodoanilines to Access Functionalized Indoloquinolines
A novel and efficient palladium-catalyzed cascade cyclization to indoloquinolines derivates in one pot has been developed ...
Redox-neutral rhodium(III)-catalyzed divergent synthesis of tetrasubstituted 1,3-enynes and alkynylated benzofurans
With the assistance of the acetamido directing group (DG), a rhodium-catalyzed C−H alkenylation/DG migration cascade for t...
Cytotoxic alkaloids from the twigs and leaves of Cephalotaxus sinensis
Twelve new Cephalotaxus alkaloids (1–12) and nine known analogues (13–21) were isolated and identified from the twigs and ...
Targeting tubulin C-terminal tail by charged small molecules
The disordered tubulin C-terminal tail (CTT), which possesses higher degree of heterogeneity, is the target for the intera...
Selective Reduction of Nitroarenes using Ru/C and CaH2.
Herein we report an efficient and highly selective method for the reduction of aromatic, heteroaromatic and halo- nitrocom...
Catalytic enantioselective desymmetrization of meso-aziridines
As a type of readily available small strained-ring heterocycles, meso-aziridines may undergo catalytic desymmetrizing tran...
Nickel-Catalyzed Alkylation of Ketones and Nitriles with Primary Alcohols
The nickel(II)-salen or nickel(II)-salphen catalyzed α-alkylation of ketones and nitriles with primary alcohols is reporte...
Enantio- and Diastereoselective Boron Conjugate Addition to α‑Alkyl α,β-Unsaturated Esters
We developed a copper-catalyzed enantio- and diastereoselective boron conjugate addition to α‑alkyl α,β-unsaturated esters...
Progress in Copper Catalyzed/Mediated Intramolecular Dehydrogenative Coupling
Transition metal-catalyzed C-H functionalization reactions are one of the most efficient synthetic methodologies to constr...
Palladium-Catalyzed C(sp3)−H Nitrooxylation of Masked Alcohols
A palladium-catalyzed β-C(sp3)−H nitrooxylation of aliphatic alcohols with AgNO2 is reported. The 8-formylquinoline-derive...
Direct synthesis of tetrahydropyran-4-ones via O3ReOH-catalyzed Prins cyclization of 3-chlorohomoallylic alcohols
A new variation of Prins cyclization to directly and stereoselectively synthesize cis-2,6-disubstituted tetrahydropyran-4-...
Synthesis of Acridines via Copper-Catalyzed Amination/Annulation Cascades between Arylboronic Acids and Anthranils
Copper-catalyzed tandem cyclization reactions between arylboronic acids and anthranils have been established, providing ne...
Biocatalytic approach to chiral fluoroaromatic scaffolds
Ten different fluorinated aromatic epoxides have been tested as potential substrates for halohydrin dehalogenase (HHDH) Hh...
Ce-Catalyzed Regioselective Synthesis of Pyrazoles from 1,2-diols via Tandem Oxidation and C-C/C-N Bond Formation
A novel and efficient cerium catalyzed tandem oxidation and intermolecular ring cyclization of vicinal diols with hydrazon...
Controllable transformation of indoles using iodine(III) reagent
An efficient and highly functional group compatible procedure for controllable transformation of indoles by the combinatio...