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Reductive cross-coupling of N-acyl pyrazole and nitroarene: synthesis of secondary amides
We report on a new method for the synthesis of amides using acyl pyrazoles and nitroarenes under reducing conditions. It w...
(Aminoalkyl)diphenylphosphine sulfides: synthesis and application as building blocks in the design of multidentate ligands for cytotoxic Pd(II) complexes
Amino-functionalized phosphoryl compounds are among the most useful molecular scaffolds in medicinal chemistry, while the ...
Palladium-Catalyzed [4+2] Cycloaddition of 2-Methylidenetrimethylene Carbonate or Methylene cyclic Carbamate with Sulfamate-Derived Cyclic Imines
A palladium-catalyzed [4+2] cycloaddition of 2-methylidenetrimethylene carbonate or methylene cyclic carbamate with sulfam...
One pot synthesis of thioethers from indoles and p-quinone methides using thiourea as a sulfur source
Thiourea is a cheap and friendly sulfur reagent that acts as a sulfur source. A simple and efficient protocol has been dev...
Relative stereochemical determination of the C61–C83 fragment of symbiodinolide using a stereodivergent synthetic approach
Structural determination is required in the use of marine natural products to create novel drugs and drug leads in medicin...
Natural epoxyquinoids: isolation, biological activity and synthesis. An update
Epoxyquinoids are of continuing interest due to their wide natural distribution and diverse biological activities, includi...
Synthesis of methylphosphorylated oligomannosides structurally related to lipopolisaccharide O-antigens of Klebsiella pneumoniae serotype O3 and their application for detection of specific antibodies in rabbit and human sera
Methylphosphorylated mono-, di- and trimannosides structurally related to the lipopolysaccharide (LPS) O-antigens of Klebs...
Dithioallyl cation (3+2) cycloadditions under aprotic reaction conditions: rapid access to spiro-fused cyclopentane scaffolds
We report a general method to effect all-carbon (3+2) cycloadditions that can elaborate cyclopentenes from a range of olef...
Structural Isomers of Di-P-Benzidithiaoctaphyrins
Cis- and trans-isomers of di-p-benzidithiaoctaphyrins, the two structural isomers were synthesized by adopting two differe...
Sulfonylpyrazole and pyrazole directed ortho-selective C–H functionalization/alkenylation and desulfenylative olefination of aryl(sulfonyl)pyrazoles
Ortho-selective C–H alkenylation of arenes has been achieved using sulfonylpyrazoles and pyrazoles as directing groups, fa...
A Facile Approach to Phenothiazinones via Catalytic Aerobic Oxidation: Discovery of Antiproliferative Agent
The production of bioactive pharmaceutical ingredients in a sustainable manner has become an essential in the modern acade...
Direct Organocatalytic Transfer Hydrogenation and C-H Oxidation: High-Yielding Synthesis of 3-Hydroxy-3-alkyloxindoles
Readily available 3-alkylideneoxindoles were effectively reduced to 3-alkyloxindoles through transfer hydrogenation using ...
Alscholarines A and B, two rearranged monoterpene indole alkaloids from Alstonia scholaris
Alscholarines A and B (1 and 2), two unprecedented rearranged monoterpene indole alkaloids, were isolated from Alstonia sc...
Sequential annulation and isomerisation reaction of 3-acylmethylidene oxindoles with Huisgen zwitterions and synthesis of 5-(3-oxindolyl)oxazoles
Herein, we report a facile synthesis of 5-(3-oxindolyl)oxazole derivatives via sequential annulation and isomerisation rea...
High Atomic Utilization Conversion of Ethers to Furancarbaldehydes via Oxidation Iminium-ion Activation Cascade Strategy
A novel organocatalytic one-pot cascade ether oxidation iminium-ion activation strategy for the synthesis of naphtho[2,1-b...
Visible-light-induced halocyclization of 2-alkynylthioanisoles with simple alkyl halides towards 3-halobenzo[b]thiophenes without an external photocatalyst
A new strategy for the preparation of 3-halobenzo[b]thiophenes via a photo-driven halocyclization/demethylation of 2-alkyn...
Rhodium-catalyzed C-H carboxymethylation of anilines with vinylene carbonate
A Rhodium-catalyzed synthesis of phenylacetate has been realized by direct C−H carboxymethylation of anilines bearing remo...
Phosphine-catalysed transformations of ortho- and para- quinone methides
The organocatalytic methodologies for the derivatization of o-QM, p-QM and the analogous aza-QM have been recently develop...
Visible-Light-Promoted Organic-Dye-Catalyzed Sulfonylation/Cyclization to Access Indolo[2,1-α]isoquinoline Derivatives
An efficient visible-light-promoted organic-dye-catalyzed radical cascade cyclization was developed for the rapid synthesi...
A Safety-Catch Protecting Group Strategy compatible with Boc-Chemistry for the Synthesis of Peptide Nucleic Acids (PNAs)
Peptide Nucleic Acids (PNAs) are an intriguing class of synthetic biomolecules with great potential in medicine. Although ...
InCl3-Catalyzed intramolecular Carbonyl−Olefin Metathesis
An efficient and novel synthetic strategy for the generation of different carbocyclic moieties by ring closing carbonyl-ol...
Studies on the [4+2] Cycloaddition and Allylic Substitution of Indole-fused Zwitterionic π-allylpalladium
The zwitterionic π-allylpalladium species, also known as dipoles, are important synthons widely used in various reactions ...
A turn-on fluorescent probe for selective detection of H2S in environmental samples and bio-imaging in human breast cancer cells
A triphenylamine-benzothaizole-based turn-on fluorescent probe TPB-NO2 was designed and synthesized for tracking H2S in bo...
Phosphite-Imidazole Catalyzed N-Formylation and N-Acylation of Amines
A novel and convenient method for the N-formylation reaction of amines with DMF as a formylating agent has been developed,...
Electrochemical Fe-catalysed radical cyclization for the synthesis of oxindoles
We report an efficient and sustainable electrocatalytic approach for the synthesis of 3,3-disubstituted 2-oxindoles bearin...
A Kinetics Study of Copper-Catalysed Click Reactions in Ionic Liquids
Copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reactions are of extensive interest in chemical synthesis. While th...
Functional Characterization of Two Efficient Glycosyltransferases Catalysing the Formation of Rutin from Sophora japonica L.
Two efficient and selective glycosyltransferases were identified from Sophora japonica L. Sj3GT could regio-selectively ca...
Pd@GO catalyzed stereo- and regio-selective addition of arenes to alkynes and synthesis of coumarins via C-H functionalization
A stereo- and regio-selective addition of arenes to alkynes via C-H bond functionalization has been developed using pallad...
Multicomponent cyclization with azides to synthesize N-heterocycles
Heterocyclic compounds, both naturally derived and synthetically produced, constitute a wide variety of biologically activ...
Improve emission performance of benzo[a]phenoxazine in aqueous solution through Host-Guest interaction
To evaluate the contribution of Host-Guest chemistry in fluorescent enhancement under aqueous condition, two benzo[a]pheno...
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