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Familial confounding or measurement error? How to interpret findings from sibling and co-twin control studies
Familial confounding or measurement error? How to interpret findings from sibling and co-twin control studies
Epidemiological researchers often examine associations between risk factors and health outcomes in non-experimental design...
Assessing the validity of a Parkinson’s care evaluation: the PRIME-NL study
Assessing the validity of a Parkinson’s care evaluation: the PRIME-NL study
The PRIME-NL study prospectively evaluates a new integrated and personalized care model for people with parkinsonism, incl...
Use of the instrumental inequalities in simulated mendelian randomization analyses with coarsened exposures
Use of the instrumental inequalities in simulated mendelian randomization analyses with coarsened exposures
Mendelian randomization (MR) requires strong unverifiable assumptions to estimate causal effects. However, for categorical...
Trends in incidence and mortality of early-onset cancer in Germany between 1999 and 2019
Trends in incidence and mortality of early-onset cancer in Germany between 1999 and 2019
Evidence on the recent temporal trend in the incidence and mortality of early-onset cancer, i.e., cancer diagnosed at ages...
Stress and anxiety during pregnancy and length of gestation: a federated study using data from five Canadian and European birth cohorts
Stress and anxiety during pregnancy and length of gestation: a federated study using data from five Canadian and European birth cohorts
While its etiology is not fully elucidated, preterm birth represents a major public health concern as it is the leading ca...
Source-specific nitrate intake and all-cause mortality in the Danish Diet, Cancer, and Health Study
Source-specific nitrate intake and all-cause mortality in the Danish Diet, Cancer, and Health Study
Nitrate and nitrite are naturally occurring in both plant- and animal-sourced foods, are used as additives in the processi...
Non-linear Mendelian randomization: detection of biases using negative controls with a focus on BMI, Vitamin D and LDL cholesterol
Non-linear Mendelian randomization: detection of biases using negative controls with a focus on BMI, Vitamin D and LDL cholesterol
Mendelian randomisation (MR) is an established technique in epidemiological investigation, using the principle of random a...
Serum neurofilament light chain as a prognostic marker of all-cause mortality in a national sample of US adults
Serum neurofilament light chain as a prognostic marker of all-cause mortality in a national sample of US adults
Neurofilament light chain (NfL) is a neuron-specific structural protein released into the extracellular space, including b...
The Chinese keratoconus (CKC) cohort study
The Chinese keratoconus (CKC) cohort study
The Chinese keratoconus (CKC) cohort study is a population-based longitudinal prospective cohort study in the Chinese popu...
Differences in metabolomic profiles between Black and White women in the U.S.: Analyses from two prospective cohorts
Differences in metabolomic profiles between Black and White women in the U.S.: Analyses from two prospective cohorts
There is growing interest in incorporating metabolomics into public health practice. However, Black women are under-repres...
Prospective benchmarking of an observational analysis in the SWEDEHEART registry against the REDUCE-AMI randomized trial
Prospective benchmarking of an observational analysis in the SWEDEHEART registry against the REDUCE-AMI randomized trial
Prospective benchmarking of an observational analysis against a randomized trial increases confidence in the benchmarking ...
A multidisciplinary and structured investigation of three suspected clusters of transverse upper limb reduction defects in France
A multidisciplinary and structured investigation of three suspected clusters of transverse upper limb reduction defects in France
Introduction: Between 2019–2021, facing public concern, a scientific expert committee (SEC) reanalysed suspected clu...
Continued decline in the incidence of myocardial infarction beyond the COVID-19 pandemic: a nationwide study of the Swedish population aged 60 and older during 2015–2022
Continued decline in the incidence of myocardial infarction beyond the COVID-19 pandemic: a nationwide study of the Swedish population aged 60 and older during 2015–2022
The number of myocardial infarctions declined during the early COVID-19 pandemic but mechanisms behind these declines are ...
The underestimated preventive effects of flexible sigmoidoscopy screening: re-analysis and meta-analysis of randomized trials
The underestimated preventive effects of flexible sigmoidoscopy screening: re-analysis and meta-analysis of randomized trials
Flexible sigmoidoscopy (FS), which is less invasive, resource intensive and costly than colonoscopy, is among the recommen...
Design, cohort profile and comparison of the KTD-Innov study: a prospective multidimensional biomarker validation study in kidney allograft rejection
Design, cohort profile and comparison of the KTD-Innov study: a prospective multidimensional biomarker validation study in kidney allograft rejection
There is an unmet need for robust and clinically validated biomarkers of kidney allograft rejection. Here we present the K...
A population-based cohort of drug exposures and adverse pregnancy outcomes in China (DEEP): rationale, design, and baseline characteristics
A population-based cohort of drug exposures and adverse pregnancy outcomes in China (DEEP): rationale, design, and baseline characteristics
The DEEP cohort is the first population-based cohort of pregnant population in China that longitudinally documented drug u...
Congenital anomalies during Covid-19: artifact of surveillance or a real TORCH?
Congenital anomalies during Covid-19: artifact of surveillance or a real TORCH?
Infections in the first trimester of pregnancy can be teratogenic, but the possibility that Covid-19 could lead to birth d...
The AccelerAge framework: a new statistical approach to predict biological age based on time-to-event data
The AccelerAge framework: a new statistical approach to predict biological age based on time-to-event data
Aging is a multifaceted and intricate physiological process characterized by a gradual decline in functional capacity, lea...
Metabolic profiling of smoking, associations with type 2 diabetes and interaction with genetic susceptibility
Metabolic profiling of smoking, associations with type 2 diabetes and interaction with genetic susceptibility
Smokers are at increased risk of type 2 diabetes (T2D), but the underlying mechanisms are unclear. We investigated if the ...
Prevalence of functional disorders across Europe: a systematic review and meta-analysis
Prevalence of functional disorders across Europe: a systematic review and meta-analysis
Functional Disorders (FD) refer to persistent somatic symptoms caused by changes in the functioning of bodily processes. P...
A prospective study of smoking-related white blood cell DNA methylation markers and risk of bladder cancer
A prospective study of smoking-related white blood cell DNA methylation markers and risk of bladder cancer
Bladder cancer, a common neoplasm, is primarily caused by tobacco smoking. Epigenetic alterations including DNA methylatio...
Diabetes and the risk of bladder cancer subtypes in men and women: results from the Netherlands Cohort Study
Diabetes and the risk of bladder cancer subtypes in men and women: results from the Netherlands Cohort Study
Meta-analyses have shown modest positive associations between diabetes mellitus (DM) and bladder cancer risk, but results ...
Using the global randomization test as a Mendelian randomization falsification test for the exclusion restriction assumption
Using the global randomization test as a Mendelian randomization falsification test for the exclusion restriction assumption
Mendelian randomization may give biased causal estimates if the instrument affects the outcome not solely via the exposure...
On the study of fetal growth restriction: time to abandon SGA
On the study of fetal growth restriction: time to abandon SGA
Wilcox AJ, Skjaerven R. Birth weight and perinatal mortality: the effect of gestational age. AJPH. 1992;82(3):378–82.Artic...
The Danish Nationwide Electrocardiogram (ECG) Cohort
The Danish Nationwide Electrocardiogram (ECG) Cohort
The electrocardiogram (ECG) is a non-invasive diagnostic tool holding significant clinical importance in the diagnosis and...
Residential exposure to mold, dampness, and indoor air pollution and risk of respiratory tract infections: a study among children ages 11 and 12 in the Danish National Birth Cohort
Residential exposure to mold, dampness, and indoor air pollution and risk of respiratory tract infections: a study among children ages 11 and 12 in the Danish National Birth Cohort
The burden of respiratory tract infections (RTIs) is high in childhood. Several residential exposures may affect relative ...
Antihypertensive drug targets and breast cancer risk: a two-sample Mendelian randomization study
Antihypertensive drug targets and breast cancer risk: a two-sample Mendelian randomization study
Findings on the correlation between the use of antihypertensive medication and the risk of breast cancer (BC) have been in...
Dimensions of health data Integrity
Dimensions of health data Integrity
Health data integrity, as an emergent concept, stands to reshape the lifecycle of data-driven healthcare and research, ens...
Does having siblings really protect against childhood atopic diseases? A total population and within-family analysis
Does having siblings really protect against childhood atopic diseases? A total population and within-family analysis
The association between having older siblings and decreased risk for atopic symptoms is well-established. This has been in...
The Rotterdam Study. Design update and major findings between 2020 and 2024
The Rotterdam Study. Design update and major findings between 2020 and 2024
The Rotterdam Study is a population-based cohort study, started in 1990 in the district of Ommoord in the city of Rotterda...
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