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Gallic acid mitigates lipopolysaccharide-induced testicular inflammation via regulation of the NF-κB and PK2/PKR1 pathway
Gallic acid mitigates lipopolysaccharide-induced testicular inflammation via regulation of the NF-κB and PK2/PKR1 pathway
Genital tract infections are common causes of male infertility, and most of diagnosed men are asymptomatic. This study exa...
Comparative analysis with stem cell therapy in rats with pharyngocutaneous fistula formation
Comparative analysis with stem cell therapy in rats with pharyngocutaneous fistula formation
Laryngocutaneous fistula is one of the most important complications encountered after larynx surgery. Stem cell therapy is...
MiRNAs and tempol therapeutic potential in prostate cancer: a preclinical approach
MiRNAs and tempol therapeutic potential in prostate cancer: a preclinical approach
This study investigated tempol action on genes and miRNAs related to NFκB pathway in androgen dependent or independen...
Activation of the WNT4/ β-catenin/FOXO1 pathway by PDK1 promotes cervical cancer metastasis and EMT process
Activation of the WNT4/ β-catenin/FOXO1 pathway by PDK1 promotes cervical cancer metastasis and EMT process
This study aimed to elucidate the role of pyruvate dehydrogenase kinase-1 (PDK1) in cervical cancer (CC) by investigating ...
The potential role of SCF combined with DPCs in facial nerve repair
The potential role of SCF combined with DPCs in facial nerve repair
Facial nerve injuries lead to significant functional impairments and psychological distress for affected patients. Effecti...
Additional benefits of combined ceftriaxone and adipose-derived mesenchymal stem cells on revamping the outcomes in rodent after acute spinal infection
Additional benefits of combined ceftriaxone and adipose-derived mesenchymal stem cells on revamping the outcomes in rodent after acute spinal infection
This study tested whether combined ceftriaxone and adipose-derived mesenchymal stem cells (ADMSCs) would defend the spinal...
The potential ameliorative effect of mesenchymal stem cells-derived exosomes on cerebellar histopathology and their modifying role on PI3k-mTOR signaling in rat model of autism spectrum disorder
The potential ameliorative effect of mesenchymal stem cells-derived exosomes on cerebellar histopathology and their modifying role on PI3k-mTOR signaling in rat model of autism spectrum disorder
Autism spectrum disorder (ASD) is a group of severe neurodevelopmental disorders. This study aimed to elucidate the potent...
Immunohistochemical evaluation of LGR5, CD71, CD138 and CXCR3 markers in the small bowel mucosa of participants with celiac disease and persons with normal bowel mucosa
Immunohistochemical evaluation of LGR5, CD71, CD138 and CXCR3 markers in the small bowel mucosa of participants with celiac disease and persons with normal bowel mucosa
Celiac disease (CD) is a chronic autoimmune disease of the small bowel mucosa that develops because of the altered immune ...
Dendritic pathology and overexpression of MAP2 in Purkinje cells from mice inoculated with rabies virus
Dendritic pathology and overexpression of MAP2 in Purkinje cells from mice inoculated with rabies virus
The effect of rabies virus infection on dendritic morphology and on the expression of the MAP2 protein in Purkinje cells i...
UCF-101 ameliorates traumatic brain injury by promoting microglia M2 polarization via AMPK/NF-κB pathways in LPS-induced BV2 cells
UCF-101 ameliorates traumatic brain injury by promoting microglia M2 polarization via AMPK/NF-κB pathways in LPS-induced BV2 cells
Traumatic brain injury (TBI) is a common neurosurgical emergency. As a macrophage in brain, microglia involves in secondar...
mir-330-5p from mesenchymal stem cell-derived exosomes targets SETD7 to reduce inflammation in rats with cerebral ischemia-reperfusion injury
mir-330-5p from mesenchymal stem cell-derived exosomes targets SETD7 to reduce inflammation in rats with cerebral ischemia-reperfusion injury
This study was to investigate the role of microRNA (miR)-330-5p derived from mesenchymal stem cells-secreted exosomes (MSC...
Bolanthus turcicus: a promising antidiabetic with in-vitro antioxidant, enzyme inhibitory and antiadipogenic activities
Bolanthus turcicus: a promising antidiabetic with in-vitro antioxidant, enzyme inhibitory and antiadipogenic activities
It is crucial to investigate new anti-diabetic agents and therapeutic approaches targeting molecules in potential signalin...
Silencing miR-126-5p protects trabecular meshwork cells against chronic oxidative injury by upregulating HSPB8 to activate PI3K/AKT pathway
Silencing miR-126-5p protects trabecular meshwork cells against chronic oxidative injury by upregulating HSPB8 to activate PI3K/AKT pathway
Chronic oxidative stress (COS) is related to the pathophysiology of the trabecular meshwork (TM) in glaucoma. MicroRNAs (m...
Signaling pathway regulators in preimplantation embryos
Signaling pathway regulators in preimplantation embryos
Embryonic development during the preimplantation stages is highly sensitive and critically dependent on the reception of s...
Effects of Moringa oleifera extract on biochemical and histological parameters of sodium valproate induced lungs damage
Effects of Moringa oleifera extract on biochemical and histological parameters of sodium valproate induced lungs damage
Sodium valproate– a salt of valproic acid (VPA), is an anticonvulsant used in the treatment of epilepsy and a range ...
Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the immune system maternal-fetal interface during palatal development
Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the immune system maternal-fetal interface during palatal development
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is an important environmental pollutant that disturbs the immune balance of the...
USP37 promotes diffuse large B-cell lymphoma progression by deubiquitinating and stabilizing c-myc
USP37 promotes diffuse large B-cell lymphoma progression by deubiquitinating and stabilizing c-myc
A poorer prognosis is thought to be associated with “double expressor lymphomas,” which are a subtype of diffu...
Inhibitory effect of andrographolide on the expression of key regulatory genes in Staphylococcus epidermidis biofilm formation
Inhibitory effect of andrographolide on the expression of key regulatory genes in Staphylococcus epidermidis biofilm formation
The purpose of this study was to explore the inhibitory effect of andrographolide on the expression of key regulatory gene...
Neuroprotective effect of red dragon fruit extract ameliorates oxidative stress and inflammation in D-galactose-induced aging rat model: biochemical, histological and immunohistochemical study
Neuroprotective effect of red dragon fruit extract ameliorates oxidative stress and inflammation in D-galactose-induced aging rat model: biochemical, histological and immunohistochemical study
Aging is a worldwide socioeconomic burden. Cerebellar aging is an enigma contributing to many behavioral aging disorders, ...
Differential effects of liraglutide naltrexone/bupropion, and caloric restriction on metabolic parameters and beta-cell regeneration in type 2 diabetic rat model: role of beta arrestin 1
Differential effects of liraglutide naltrexone/bupropion, and caloric restriction on metabolic parameters and beta-cell regeneration in type 2 diabetic rat model: role of beta arrestin 1
Traditional antidiabetic treatments often carry the risk of beta-cell exhaustion, highlighting the need for therapies that...
Exploration of plasma tryptophan levels along with Ki-67 expression binomial investigation for forecasting tumor aggressiveness within invasive ductal breast cancer
Exploration of plasma tryptophan levels along with Ki-67 expression binomial investigation for forecasting tumor aggressiveness within invasive ductal breast cancer
Ki-67 is a histological marker indicating cancer aggressiveness, while tryptophan (TRP) depletion modulates immune respons...
Possible protective effect of quercetin on lung injury induced by skeletal muscle ischemia reperfusion (IR) injury of adult male albino rats: Histological and biochemical study
Possible protective effect of quercetin on lung injury induced by skeletal muscle ischemia reperfusion (IR) injury of adult male albino rats: Histological and biochemical study
When a lower limb is injured, the most delicate organs that are at risk of harm are the lungs. Among the flavonoids, querc...
Variations in liver histology and P-gp expression among fish species in Doce River Basin, Brazil: implications for pollution sensitivity
Variations in liver histology and P-gp expression among fish species in Doce River Basin, Brazil: implications for pollution sensitivity
Fish may have different sensitivity to pollutants present in the water. We analyzed the liver histology, and P-gp expressi...
Hyperbaric oxygen therapy prevents epithelial atrophy in distal tubules and TGF-β1 overexpression in diabetic rat kidneys
Hyperbaric oxygen therapy prevents epithelial atrophy in distal tubules and TGF-β1 overexpression in diabetic rat kidneys
Diabetic nephropathy (DN) is one of the most relevant and prevalent microvascular complications associated with Diabetes M...
Rosmarinic acid protects against cyclophosphamide-induced hepatotoxicity via inhibition of oxidative stress, inflammation, and apoptosis and upregulation of Nrf2 in mice
Rosmarinic acid protects against cyclophosphamide-induced hepatotoxicity via inhibition of oxidative stress, inflammation, and apoptosis and upregulation of Nrf2 in mice
Cyclophosphamide (CP) is widely used in chemotherapy to treat various types of cancer. However, it is toxic to the liver a...
Effects of FGFR2b-ligand signaling on pancreatic branching morphogenesis and postnatal islet function
Effects of FGFR2b-ligand signaling on pancreatic branching morphogenesis and postnatal islet function
Pancreatic development is a complex process vital for maintaining metabolic balance, requiring intricate interactions amon...
Hepatoprotective effects of olive leaf extract against carbon tetrachloride-induced oxidative stress: in vivo and in-silico insights into the Nrf2-NFκB pathway
Hepatoprotective effects of olive leaf extract against carbon tetrachloride-induced oxidative stress: in vivo and in-silico insights into the Nrf2-NFκB pathway
Olive Leaves Extract (OLE) holds therapeutic potential, traditionally used to treat hepatic ailments, though its molecular...
Morphometric analysis of the female reproductive tract: influence of long-term inhalation of trace amounts of sevoflurane
Morphometric analysis of the female reproductive tract: influence of long-term inhalation of trace amounts of sevoflurane
Sevoflurane is extensively employed as an inhalation anesthetic in medical practices, due to its promising pharmacokinetic...
TFDP1 transcriptionally activates KIF22 to enhance aggressiveness and stemness in endometrial cancer: implications for prognosis and targeted therapy
TFDP1 transcriptionally activates KIF22 to enhance aggressiveness and stemness in endometrial cancer: implications for prognosis and targeted therapy
This study aims to elucidate the role of Kinesin Family Member 22 (KIF22) as a critical regulator of aggressive behavior i...
Investigation of the effects of rainbow trout (Oncorhynchus mykiss) skin mucus against indomethacin-induced gastric damage in rats
Investigation of the effects of rainbow trout (Oncorhynchus mykiss) skin mucus against indomethacin-induced gastric damage in rats
A peptic ulcer is a stomach lesion. It is generally caused by malnutrition, the use of anti-inflammatory medications, and ...
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