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RIDR-PI-103, ROS-activated prodrug PI3K inhibitor inhibits cell growth and impairs the PI3K/Akt pathway in BRAF and MEK inhibitor-resistant BRAF-mutant melanoma cells
RIDR-PI-103, ROS-activated prodrug PI3K inhibitor inhibits cell growth and impairs the PI3K/Akt pathway in BRAF and MEK inhibitor-resistant BRAF-mutant melanoma cells
Reactive oxygen species (ROS) levels are elevated after acquisition of resistance to v-raf murine sa
A novel combination of isovanillin, curcumin, and harmine (GZ17-6.02) enhances cell death and alters signaling in actinic keratoses cells when compared to individual components and two-component combinations
A novel combination of isovanillin, curcumin, and harmine (GZ17-6.02) enhances cell death and alters signaling in actinic keratoses cells when compared to individual components and two-component combinations
Actinic keratosis is a pre-malignant skin disease caused by excessive exposure to ultraviolet light.
Uveitis, a rare but important complication of adjuvant zoledronic acid for early-stage breast cancer
Uveitis, a rare but important complication of adjuvant zoledronic acid for early-stage breast cancer
Bisphosphonates such as zoledronic acid are an important part of adjuvant therapy to reduce the risk
Synthesis and evaluation of novel thiazole moiety-containing compounds as antibreast cancer agents
Progesterone receptor (PR) agonists represent pivotal agents in trapping breast cancer cells through
Circular RNA circ-AGFG1 contributes to esophageal squamous cell carcinoma progression and glutamine catabolism by targeting microRNA-497-5p/solute carrier family 1 member 5 axis
Circular RNA circ-AGFG1 contributes to esophageal squamous cell carcinoma progression and glutamine catabolism by targeting microRNA-497-5p/solute carrier family 1 member 5 axis
Circular RNAs (circRNAs) have been shown to play important regulatory roles in human malignancies. H
Palbociclib enhances the effect of doxorubicin-induced apoptosis in activated B-cell–like diffuse large B-cell lymphoma cells
Palbociclib enhances the effect of doxorubicin-induced apoptosis in activated B-cell–like diffuse large B-cell lymphoma cells
Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma around the world. Whil
Identification and validation of RB1 as an immune-related prognostic signature based on tumor mutation burdens in bladder cancer
Identification and validation of RB1 as an immune-related prognostic signature based on tumor mutation burdens in bladder cancer
Bladder cancer (BCa) is one of the most common malignant tumors in the urinary system. Developing ef
Reuse of osimertinib after small cell lung cancer transformation in lung adenocarcinoma with de-novo epidermal growth factor receptor T790M mutation: case report
Reuse of osimertinib after small cell lung cancer transformation in lung adenocarcinoma with de-novo epidermal growth factor receptor T790M mutation: case report
Osimertinib is a third-generation tyrosine kinase inhibitor for non-small cell lung cancer (NSCLC) p
Treatment of metastatic alveolar soft part sarcoma with axitinib and pembrolizumab in an 80-year-old patient with a history of autoimmune disorders
Treatment of metastatic alveolar soft part sarcoma with axitinib and pembrolizumab in an 80-year-old patient with a history of autoimmune disorders
Alveolar soft part sarcoma (ASPS) is a rare malignancy with low sensitivity to chemotherapy. While l
CDKN2B-AS1 is overexpressed in polycystic ovary syndrome and sponges miR-181a to promote granulosa cell proliferation
CDKN2B-AS1 is overexpressed in polycystic ovary syndrome and sponges miR-181a to promote granulosa cell proliferation
MiR-181a suppresses the proliferation of mouse granulosa cells, which participate in polycystic ovar
Butyrate ameliorates colorectal cancer through regulating intestinal microecological disorders
Butyrate ameliorates colorectal cancer through regulating intestinal microecological disorders
The occurrence and progression of colorectal cancer (CRC) are closely related to intestinal microeco
Combination toripalimab and bevacizumab for an elderly urothelial carcinoma patient with brain metastasis who failed rapidly after radiotherapy: a case report and literature review
Combination toripalimab and bevacizumab for an elderly urothelial carcinoma patient with brain metastasis who failed rapidly after radiotherapy: a case report and literature review
Brain metastasis is a rare refractory event in patients with urothelial carcinoma. Platinum-based ch
FXR1 facilitates axitinib resistance in clear cell renal cell carcinoma via regulating KEAP1/Nrf2 signaling pathway
FXR1 facilitates axitinib resistance in clear cell renal cell carcinoma via regulating KEAP1/Nrf2 signaling pathway
Axitinib is emerging as a first-line combination treatment drug for metastatic renal cell carcinoma,
A case of lung adenocarcinoma with MET∆ex14 mutation regressed after preoperative treatment with savolitinib, and successfully underwent radical resection
A case of lung adenocarcinoma with MET∆ex14 mutation regressed after preoperative treatment with savolitinib, and successfully underwent radical resection
Non-small cell lung carcinoma (NSCLC) is a complex disease, with many different potential gene mutat
M2 macrophage-derived exosomal miR-1911-5p promotes cell migration and invasion in lung adenocarcinoma by down-regulating CELF2-activated ZBTB4 expression
M2 macrophage-derived exosomal miR-1911-5p promotes cell migration and invasion in lung adenocarcinoma by down-regulating CELF2-activated ZBTB4 expression
Lung adenocarcinoma (LUAD) is one of the most aggressive, lethal cancers, comprising around 40% of l
MiR-302c-5p affects the stemness and cisplatin resistance of nasopharyngeal carcinoma cells by regulating HSP90AA1
MiR-302c-5p affects the stemness and cisplatin resistance of nasopharyngeal carcinoma cells by regulating HSP90AA1
Nasopharyngeal carcinoma (NPC) is one of the most frequent malignant tumors diagnosed in China. Cisp
Hsa_circ_0007380 silencing restrains the growth and enhances radiosensitivity in esophagus cancer by miR-644a/Spindlin 1 axis
Hsa_circ_0007380 silencing restrains the growth and enhances radiosensitivity in esophagus cancer by miR-644a/Spindlin 1 axis
Circular RNAs are frequently dysregulated and show important regulatory function of tumorigenesis in
Cetuximab severe cutaneous toxicity… a gateway for bacteremia: case report
Cetuximab severe cutaneous toxicity… a gateway for bacteremia: case report
EGFR inhibitors used in the treatment of metastatic wild-RAS colorectal cancer in combination with c
CircPIM3 regulates taxol resistance in non-small cell lung cancer via miR-338-3p/TNFAIP8 axis
CircPIM3 regulates taxol resistance in non-small cell lung cancer via miR-338-3p/TNFAIP8 axis
Numerous work has revealed the involvement of circular RNA (circRNA) in regulating chemotherapy resi
MiR-30a-5p/CHD1 axis enhances cisplatin sensitivity of ovarian cancer cells via inactivating the Wnt/β-catenin pathway
MiR-30a-5p/CHD1 axis enhances cisplatin sensitivity of ovarian cancer cells via inactivating the Wnt/β-catenin pathway
Oovarian cancer is a common lethal gynecological malignancy with a high occurrence and dismal progno
LncRNA MSC-AS1, as an oncogene in melanoma, promotes the proliferation and glutaminolysis by regulating the miR-330-3p/YAP1 axis
LncRNA MSC-AS1, as an oncogene in melanoma, promotes the proliferation and glutaminolysis by regulating the miR-330-3p/YAP1 axis
Melanoma is a kind of aggressive skin neoplasms with high mortality. The purpose of this present res
Circ_0003998 upregulates ARK5 expression to elevate 5-Fluorouracil resistance in hepatocellular carcinoma through binding to miR-513a-5p
Circ_0003998 upregulates ARK5 expression to elevate 5-Fluorouracil resistance in hepatocellular carcinoma through binding to miR-513a-5p
Chemoresistance has limited clinical treatment of cancer patients. This study aimed to research the
Exosomal circPRRX1 functions as a ceRNA for miR-596 to promote the proliferation, migration, invasion, and reduce radiation sensitivity of gastric cancer cells via the upregulation of NF-κB activating protein
Exosomal circPRRX1 functions as a ceRNA for miR-596 to promote the proliferation, migration, invasion, and reduce radiation sensitivity of gastric cancer cells via the upregulation of NF-κB activating protein
Exosomes, which are small extracellular vesicles, have been unveiled to carry circular RNAs (circRNA
Hsa_circ_0000877 facilitates the progression of diffuse large B-cell lymphoma by miR-370-3p/mitogen-activated protein kinase kinase kinase kinase 4/Hippo pathway
Hsa_circ_0000877 facilitates the progression of diffuse large B-cell lymphoma by miR-370-3p/mitogen-activated protein kinase kinase kinase kinase 4/Hippo pathway
Diffuse large B-cell lymphoma (DLBCL) originates from B lymphocytes and is a fatal hematological mal
Blocking circ_0010235 suppresses acquired paclitaxel resistance of non-small cell lung cancer by sponging miR-512-5p to modulate FAM83F expression
Blocking circ_0010235 suppresses acquired paclitaxel resistance of non-small cell lung cancer by sponging miR-512-5p to modulate FAM83F expression
The occurrence of paclitaxel (PTX) resistance in nonsmall cell lung cancer (NSCLC) is a major challe
G protein subunit gamma 5 promotes the proliferation, metastasis and glycolysis of breast cancer cells through the Wnt/β-catenin pathway
G protein subunit gamma 5 promotes the proliferation, metastasis and glycolysis of breast cancer cells through the Wnt/β-catenin pathway
GNG5 is suggested to exert a critical effect on tumor development in human beings; however, its func
LncRNA MYMLR promotes pituitary adenoma development by upregulating carbonyl reductase 1 via sponging miR-197-3p
LncRNA MYMLR promotes pituitary adenoma development by upregulating carbonyl reductase 1 via sponging miR-197-3p
Long noncoding RNAs (lncRNAs) have been demonstrated to participate in various biological processes
Exosome-mediated transfer of circ_0063526 enhances cisplatin resistance in gastric cancer cells via regulating miR-449a/SHMT2 axis
Exosome-mediated transfer of circ_0063526 enhances cisplatin resistance in gastric cancer cells via regulating miR-449a/SHMT2 axis
Exosomes are critical mediators of intercellular communication. Exosomal circular RNAs (circRNAs) ha
Thoracic radiotherapy may improve the outcome of extensive stage small cell lung carcinoma patients treated with first-line immunotherapy plus chemotherapy
Thoracic radiotherapy may improve the outcome of extensive stage small cell lung carcinoma patients treated with first-line immunotherapy plus chemotherapy
Objective Immunotherapy plus etoposide and platinum (EP)-based chemotherapy is the standard of ca
Circ_0026123 promotes cisplatin resistance and progression of ovarian cancer by upregulating RAB1A through sequestering miR-543
Circ_0026123 promotes cisplatin resistance and progression of ovarian cancer by upregulating RAB1A through sequestering miR-543
Background Circular RNAs can act as critical regulators in the tumorigenesis and chemoresistance
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