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Intracerebral haemorrhage — mechanisms, diagnosis and prospects for treatment and prevention
Intracerebral haemorrhage — mechanisms, diagnosis and prospects for treatment and prevention
Intracerebral haemorrhage (ICH) is a devastating condition associated with high mortality and substantial residual disabil...
Glymphatic dysfunction in PD clinical progression
Risk of clinical milestones in Parkinson disease (PD) is associated with reduced glymphatic drainage, according to new res...
Dementia risk scores in diverse populations
A recent analysis of dementia risk scores across diverse populations found that the validity of scores can differ between ...
High prevalence of hepatitis B in NMOSD
A new study of a Taiwanese cohort found a high prevalence of resolved hepatitis B virus (HBV) infection in people with neu...
Immune responses influence sex differences in Alzheimer disease
Sex differences in Alzheimer disease could be influenced by differences in immune responses, new research suggests.
Oligodendrocyte progenitor cell transplant for MS
Transplantation of genetically modified oligodendrocyte progenitor cells (OPCs) into a mouse model of MS improves remyelin...
Parkinson disease therapy: current strategies and future research priorities
Parkinson disease therapy: current strategies and future research priorities
Parkinson disease (PD) is the fastest growing neurological disorder globally and poses substantial management cha...
The Digitized Memory Clinic
The Digitized Memory Clinic
Several major challenges, including an ageing population and declining workforce and the implementation of recent breakthr...
BCAS1+ oligodendrocytes aid remyelination in MS
A recent report has identified a population of brain-enriched myelin-associated protein 1 (BCAS1)-expressing oligodendrocy...
Altered muscle cholesterol transport in ALS
A paper recently published in Brain indicates that muscle cholesterol transport is dysregulated in amyotrophic lateral scl...
Engineered T cells show therapeutic potential for CNS injury
A study in a mouse model of spinal cord injury helps to elucidate the neuroprotective mechanisms of autoimmune T cells dur...
Evidence for an NMOSD prodrome
Two new studies have produced evidence of a prodromal phase that precedes the clinical onset of neuromyelitis optica spect...
Lewy body pathology accelerates AD progression
The presence of Lewy body (LB) pathology in addition to Alzheimer disease (AD) pathology is associated with acceleration o...
Coeliac disease as a model for understanding multiple sclerosis
Coeliac disease as a model for understanding multiple sclerosis
The genetic architecture of multiple sclerosis (MS) is similar to that of coeliac disease, with human leukocyte antigen (H...
Continuing evolution of migraine-specific therapies — targeting migraine with precision and persistence
Treatment options for migraine have expanded rapidly over the past few years. The latest success in a phase II trial of a ...
Disease-modifying therapies for Parkinson disease: lessons from multiple sclerosis
Disease-modifying therapies for Parkinson disease: lessons from multiple sclerosis
The development of disease-modifying therapies (DMTs) for neurological disorders is an important goal in modern neurology,...
Systemic determinants of brain health in ageing
Systemic determinants of brain health in ageing
Preservation of brain health is a worldwide priority. The traditional view is that the major threats to the ageing brain l...
Fluid biomarkers of chronic traumatic brain injury
Fluid biomarkers of chronic traumatic brain injury
Traumatic brain injury (TBI) is a leading cause of long-term disability across the world. Evidence for the usefulness of i...
Preparing for disease-modifying dementia therapies in the UK
Although lecanemab has been licensed for use in the UK, the systems to deliver this or similar disease-modifying therapies...
NMOSD and MOGAD: an evolving disease spectrum
NMOSD and MOGAD: an evolving disease spectrum
Neuromyelitis optica (NMO) spectrum disorder (NMOSD) is a relapsing inflammatory disease of the CNS, characterized by the ...
Tau phosphorylation correlates with multiple sclerosis disease course
New research adds to growing evidence of altered tau phosphorylation in multiple sclerosis.
Hijacked macrophages sustain glioblastoma cells
Metabolic rewiring of a population of tumour-associated macrophages facilitates progression of glioblastoma, new research ...
Free DNA activates secondary stroke mechanism
After a stroke, circulating, cell-free DNA causes inflammasome activation in atherosclerotic plaques that can lead to recu...
Adaptive deep brain stimulation shows promise
Adaptive deep brain stimulation (DBS) improves motor symptoms and quality of life in people with Parkinson disease compare...
Blood profile indicates central inflammation in frontotemporal lobar degeneration
A pro-inflammatory serum profile has been associated with frontotemporal lobar degeneration (FLTD) in new research, increa...
Pituitary adenylate cyclase-activating polypeptide signalling as a therapeutic target in migraine
Pituitary adenylate cyclase-activating polypeptide signalling as a therapeutic target in migraine
Migraine is a disabling neurological disorder that affects more than one billion people worldwide. The clinical presentati...
Assessing disease progression and treatment response in progressive multiple sclerosis
Progressive multiple sclerosis poses a considerable challenge in the evaluation of disease progression and treatment respo...
Stiff-person syndrome and related disorders — diagnosis, mechanisms and therapies
Stiff-person syndrome and related disorders — diagnosis, mechanisms and therapies
Stiff-person syndrome (SPS) is the prototypical and most common autoimmune neuronal hyperexcitability disorder. It present...
The influence of MOGAD on diagnosis of multiple sclerosis using MRI
The influence of MOGAD on diagnosis of multiple sclerosis using MRI
Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) is an immune-mediated demyelinating disease ...
Author Correction: Neurological care for LGBT+ people
Authors and AffiliationsCollege of Medicine, SUNY Downstate Health Sciences University, New York City, NY, USASalvatore Gi...
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