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Brain–body mechanisms contribute to sexual dimorphism in amyotrophic lateral sclerosis
Brain–body mechanisms contribute to sexual dimorphism in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is the most common form of human motor neuron disease. It is characterized by the prog...
Additive effects of EBV and HHV-6A on MS risk
Epstein–Barr virus (EBV) infection in adulthood is a well-established risk factor for multiple sclerosis (MS), and new res...
Immune rejuvenation — a potential AD therapy
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obta...
Diabetes could hasten MCI-to-AD conversion
People with diabetes mellitus (DM) have an increased probability of progressing to Alzheimer disease (AD) in the first yea...
Plasma extracellular vesicle biomarkers for frontotemporal dementia and related disorders
Plasma extracellular vesicle biomarkers for frontotemporal dementia and related disorders
Concentrations of TDP-43 and tau in extracellular vesicles extracted from blood show potential as biomarkers for frontotem...
RAB32 variant is associated with PD susceptibility
A variant of the RAB32 gene is a risk factor for developing Parkinson disease (PD), according to a report published in Nat...
Environmental–genetic interactions in ageing and dementia across Latin America
Environmental–genetic interactions in ageing and dementia across Latin America
Current dementia research has developed complex models of environmental–genetic interactions to better address multi...
Spinal cord stimulation for the treatment of chronic pain
Spinal cord stimulation is an invasive therapy for chronic neuropathic pain, usually used as a last-resort treatment when ...
Focused ultrasound brain therapy is a new tool in the box
Similar to any innovation that disrupts the status quo, the advent of magnetic resonance-guided focused ultrasound in neur...
Precision neuroimmunology in multiple sclerosis — the horizon is near
Immunological profiling has revealed biological signatures of multiple sclerosis (MS) that could help with early, accurate...
Non-invasive deep brain stimulation: interventional targeting of deep brain areas in neurological disorders
Recently developed non-invasive deep brain stimulation methods have sufficient focal specificity to target deep brain stru...
Non-invasive stimulation for treating cognitive impairment in Alzheimer disease
Some device-based non-invasive brain stimulation methods have been recommended as probably effective for cognitive treatme...
Sensory feedback in upper limb prosthetics: advances and challenges
Advanced sensory feedback from upper limb prostheses would provide multiple benefits to people with upper limb amputations...
Neuromodulation for severe brain injury: time for a paradigm shift?
Neuromodulation represents a promising approach for promoting neural plasticity following a brain injury, especially for n...
Multifaceted roles of APOE in Alzheimer disease
Multifaceted roles of APOE in Alzheimer disease
For the past three decades, apolipoprotein E (APOE) has been known as the single greatest genetic modulator of sporadic Al...
Neurology under the midnight sun: EAN Congress 2024 comes to Helsinki
Neurology under the midnight sun: EAN Congress 2024 comes to Helsinki
The 10th Congress of the European Academy of Neurology is being held in Helsinki, Finland from 29 June to 2 July 2024, and...
From spreading depolarization to blood–brain barrier dysfunction: navigating traumatic brain injury for novel diagnosis and therapy
From spreading depolarization to blood–brain barrier dysfunction: navigating traumatic brain injury for novel diagnosis and therapy
Considerable strides in medical interventions during the acute phase of traumatic brain injury (TBI) have brought improved...
Alzheimer disease blood biomarkers: considerations for population-level use
Alzheimer disease blood biomarkers: considerations for population-level use
In the past 5 years, we have witnessed the first approved Alzheimer disease (AD) disease-modifying therapy and the develop...
Acceptable performance of blood biomarker tests of amyloid pathology — recommendations from the Global CEO Initiative on Alzheimer’s Disease
Acceptable performance of blood biomarker tests of amyloid pathology — recommendations from the Global CEO Initiative on Alzheimer’s Disease
Anti-amyloid treatments for early symptomatic Alzheimer disease have recently become clinically available in some countrie...
Brain clearance not increased during sleep
Clearance of molecules from the brain is not increased during sleep, according to new findings published in Nature Neurosc...
Microglial senescence is a potential therapeutic target for Alzheimer disease
A new study has identified prematurely senescent microglia in the vicinity of amyloid-β plaques in the brains of indi...
Genes associated with multiple system atrophy
Analysis of whole-genome data from people with multiple system atrophy (MSA) has identified novel genetic loci associated ...
Potassium regulation could be key to healthy brain ageing
Dysregulated extracellular K+ could be a determinant of unhealthy brain ageing, findings in mice suggest. Whereas extracel...
APOE α4 homozygosity — a genetic form of Alzheimer disease?
Apolipoprotein E (APOE) ε4 homozygosity should be considered a genetic form of Alzheimer disease (AD), researchers have pr...
Publisher Correction: The Miami Framework for ALS and related neurodegenerative disorders: an integrated view of phenotype and biology
Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL, USAMichael Benatar, Joanne Wuu, Nathan...
Clinical implications of brain asymmetries
Clinical implications of brain asymmetries
No two human brains are alike, and with the rise of precision medicine in neurology, we are seeing an increased emphasis o...
IDH inhibition in gliomas: from preclinical models to clinical trials
IDH inhibition in gliomas: from preclinical models to clinical trials
Gliomas are the most common malignant primary brain tumours in adults and cannot usually be cured with standard cancer tre...
The Miami Framework for ALS and related neurodegenerative disorders: an integrated view of phenotype and biology
The Miami Framework for ALS and related neurodegenerative disorders: an integrated view of phenotype and biology
Increasing appreciation of the phenotypic and biological overlap between amyotrophic lateral sclerosis (ALS) and frontotem...
Deciphering nociplastic pain: clinical features, risk factors and potential mechanisms
Deciphering nociplastic pain: clinical features, risk factors and potential mechanisms
Nociplastic pain is a mechanistic term used to describe pain that arises or is sustained by altered nociception, despite t...
CAR T cells offer hope in glioblastoma
CAR T cells offer hope in glioblastoma
Novel CAR T cells delivered directly to the CNS could have therapeutic effects in recurrent glioblastoma, according to two...
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