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Brain clearance not increased during sleep
Clearance of molecules from the brain is not increased during sleep, according to new findings published in Nature Neurosc...
Microglial senescence is a potential therapeutic target for Alzheimer disease
A new study has identified prematurely senescent microglia in the vicinity of amyloid-β plaques in the brains of indi...
Genes associated with multiple system atrophy
Analysis of whole-genome data from people with multiple system atrophy (MSA) has identified novel genetic loci associated ...
Potassium regulation could be key to healthy brain ageing
Dysregulated extracellular K+ could be a determinant of unhealthy brain ageing, findings in mice suggest. Whereas extracel...
APOE α4 homozygosity — a genetic form of Alzheimer disease?
Apolipoprotein E (APOE) ε4 homozygosity should be considered a genetic form of Alzheimer disease (AD), researchers have pr...
Publisher Correction: The Miami Framework for ALS and related neurodegenerative disorders: an integrated view of phenotype and biology
Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL, USAMichael Benatar, Joanne Wuu, Nathan...
Clinical implications of brain asymmetries
Clinical implications of brain asymmetries
No two human brains are alike, and with the rise of precision medicine in neurology, we are seeing an increased emphasis o...
IDH inhibition in gliomas: from preclinical models to clinical trials
IDH inhibition in gliomas: from preclinical models to clinical trials
Gliomas are the most common malignant primary brain tumours in adults and cannot usually be cured with standard cancer tre...
The Miami Framework for ALS and related neurodegenerative disorders: an integrated view of phenotype and biology
The Miami Framework for ALS and related neurodegenerative disorders: an integrated view of phenotype and biology
Increasing appreciation of the phenotypic and biological overlap between amyotrophic lateral sclerosis (ALS) and frontotem...
Deciphering nociplastic pain: clinical features, risk factors and potential mechanisms
Deciphering nociplastic pain: clinical features, risk factors and potential mechanisms
Nociplastic pain is a mechanistic term used to describe pain that arises or is sustained by altered nociception, despite t...
CAR T cells offer hope in glioblastoma
CAR T cells offer hope in glioblastoma
Novel CAR T cells delivered directly to the CNS could have therapeutic effects in recurrent glioblastoma, according to two...
Genetic protection against Alzheimer disease
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obta...
Blood test for early Parkinson disease diagnosis
A blood-based α-synuclein (α-syn) seed amplification assay (SAA) can detect Parkinson disease (PD) up to 10 years before c...
Infant microbiome predicts neurodevelopmental disorders
A new study has identified significant differences in gut microbial communities between infants that are later diagnosed w...
Nanoprobe for blood–brain barrier changes
New research shows that labelling of laminin with a nanoparticle probe enables MRI assessment of blood–brain barrier (BBB)...
The clinical importance of suspected non-Alzheimer disease pathophysiology
The clinical importance of suspected non-Alzheimer disease pathophysiology
The development of biomarkers for Alzheimer disease (AD) has led to the origin of suspected non-AD pathophysiology (SNAP) ...
Artificial intelligence in epilepsy — applications and pathways to the clinic
Artificial intelligence in epilepsy — applications and pathways to the clinic
Artificial intelligence (AI) is rapidly transforming health care, and its applications in epilepsy have increased exponent...
Author Correction: The complex aetiology of cerebral palsy
In the version of the article initially published, in Fig. 1 the year “1868” is incorrect and should instead read “1897” i...
Neuronal activity drives glymphatic waste clearance
Two new studies show that clearance of waste, including pathogenic amyloid, through the glymphatic system is driven by syn...
Addressing disparities in neurology by identifying gaps in hospital care
Addressing disparities in neurology by identifying gaps in hospital care
Nature Reviews Neurology is interviewing individuals who are driving efforts to address disparities in neurology through a...
Neurofilaments as biomarkers in neurological disorders — towards clinical application
Neurofilaments as biomarkers in neurological disorders — towards clinical application
Neurofilament proteins have been validated as specific body fluid biomarkers of neuro-axonal injury. The advent of highly ...
BTK inhibitor falters in multiple sclerosis trials
Findings of phase III trials of the Bruton’s tyrosine kinase inhibitor evobrutinib in patients with relapsing multip...
EBV-specific T cells in multiple sclerosis
New data recently reported at the ACTRIMS Forum add to growing evidence of an aetiological role for Epstein–Barr vir...
Support for network theories of schizophrenia
Support for network theories of schizophrenia
A computational neuroimaging study has shed new light on the relationship between morphological changes in the brain in sc...
Diversity, equity and inclusion in neurology
In this issue of Nature Reviews Neurology, we launch a Series to highlight the importance of diversity, equity and inclusi...
Addressing disparities in neurology by building the workforce in LMICs
Addressing disparities in neurology by building the workforce in LMICs
Nature Reviews Neurology is interviewing individuals who are driving efforts to address disparities in neurology through a...
Approval of omaveloxolone for Friedreich ataxia
The recent approval of omaveloxolone for the treatment of Friedreich ataxia in the USA and Europe represents an important ...
Neurostimulation for treatment of post-stroke impairments
Neurostimulation for treatment of post-stroke impairments
Neurostimulation, the use of electrical stimulation to modulate the activity of the nervous system, is now commonly used f...
Insights into epileptogenesis from post-traumatic epilepsy
Insights into epileptogenesis from post-traumatic epilepsy
Post-traumatic epilepsy (PTE) accounts for 5% of all epilepsies. The incidence of PTE after traumatic brain injury (TBI) d...
Neurological care for LGBT+ people
Neurological care for LGBT+ people
Sexual and gender minority (LGBT+) people face unique health disparities that must be considered by health-care providers ...