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Restoring synaptic plasticity after stroke
Gamma oscillations induced by optogenetic stimulation restore functional synaptic plasticity in a mouse model of stroke, a...
CD11c+ macrophages mediate brain-to-gut α-synuclein trafficking
CD11c+ macrophages mediate brain-to-gut α-synuclein trafficking
New research indicates that in a mouse model of Parkinson disease, α-synuclein is trafficked from the brain to the gu...
ALS pathogenesis linked to actin barrier collapse
Repulsive guidance molecule A (RGMa) regulates actin dynamics via neogenin 1 signalling. A new study found that the cerebr...
A tale of race and B cells in multiple sclerosis
A new study indicates that African American people with multiple sclerosis have higher markers of humoral disease patholog...
Rare genetic brain disorders with overlapping neurological and psychiatric phenotypes
Rare genetic brain disorders with overlapping neurological and psychiatric phenotypes
Understanding rare genetic brain disorders with overlapping neurological and psychiatric phenotypes is of increasing impor...
A new biological classification for Parkinson disease
In a plenary lecture at the XXVI World Congress of Neurology, Anthony Lang presented a new biological classification model...
Metformin protects against dementia in diabetes
Use of metformin in people aged ≥60 years with type 2 diabetes mellitus (T2DM) is associated with a reduced risk of develo...
Glioblastoma tackled with oncolytic virus
A first-in-human trial indicates that treatment with an oncolytic virus is associated with increased survival in people wi...
Myelination mediates benefits of ketamine
Restoration of impaired myelination underlies the long-lasting antidepressant effects of ketamine, new research suggests. ...
Peripheral B cells altered in Parkinson disease
The findings of an immunophenotyping study suggest that abnormal peripheral B cell responses could contribute to Parkinson...
Biomarkers in amyotrophic lateral sclerosis: current status and future prospects
Biomarkers in amyotrophic lateral sclerosis: current status and future prospects
Disease heterogeneity in amyotrophic lateral sclerosis poses a substantial challenge in drug development. Categorization b...
Molecular biomarkers for vascular cognitive impairment and dementia
Molecular biomarkers for vascular cognitive impairment and dementia
As disease-specific interventions for dementia are being developed, the ability to identify the underlying pathology and d...
Idiopathic intracranial hypertension: a step change in understanding the disease mechanisms
Idiopathic intracranial hypertension: a step change in understanding the disease mechanisms
The understanding of idiopathic intracranial hypertension (IIH) has evolved over the past few years. Previously, IIH was c...
PD pathology spread linked to mtDNA damage
A new study suggests that damaged mitochondrial DNA (mtDNA) can trigger and aid the spread of Parkinson disease (PD)-like ...
Neuropsychological impairment in amyotrophic lateral sclerosis–frontotemporal spectrum disorder
Neuropsychological impairment in amyotrophic lateral sclerosis–frontotemporal spectrum disorder
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with a rapid course, characterized by motor neuron dysf...
Seizure-associated changes in the Golgi apparatus
Seizure activity in the brain induces reversible structural changes in the neuronal Golgi apparatus, according to new rese...
Prodromal psychiatric symptoms in MS
Psychiatric symptoms such as mood and anxiety disorders are common in the years leading up to multiple sclerosis (MS) onse...
ApoE attracts microglia to amyloid-β plaques
ApoE attracts microglia to amyloid-β plaques
A new study reveals that VCAM1–ApoE signalling directs microglia to amyloid-β plaques, mediating removal of the...
Vaccine shows promise in diffuse midline glioma
A small first-in-human trial indicates that a vaccine targeting the histone H3 mutation H3K27M is safe and can induce a mu...
Regrowth and recovery in mice with spinal cord injury
Regrowth and recovery in mice with spinal cord injury
Directed axonal regeneration has restored walking function in mice with complete spinal cord injury.
Mechanisms underlying HIV-associated cognitive impairment and emerging therapies for its management
Mechanisms underlying HIV-associated cognitive impairment and emerging therapies for its management
People living with HIV are affected by the chronic consequences of neurocognitive impairment (NCI) despite antiretroviral ...
Linking the cerebellum to Parkinson disease: an update
Linking the cerebellum to Parkinson disease: an update
Parkinson disease (PD) is characterized by heterogeneous motor and non-motor symptoms, resulting from neurodegeneration in...
Rapid AQP4-IgG detection in neuromyelitis optica spectrum disorder
Researchers in China and South Korea have developed a rapid immunodot assay to detect aquaporin 4-targeting IgG autoantibo...
The murky waters of sex differences in post-stroke cognitive impairment
A new study indicates that although men and women are equally likely to experience cognitive impairment after acute ischae...
Insights into the toxic effects of mutant huntingtin
A new study published in Brain reports that the toxic effects of mutant huntingtin (mHTT) in Huntington disease (HD) are m...
Amyloid plaques: hotspots for microglial turnover
Microglial division and death rates are highest in the vicinity of amyloid plaques, according to new research in a mouse m...
Lymphatic propagation of α-synuclein
Mutant α-synuclein monomers propagate via the lymphatic system of the brain, new research indicates. Two weeks after the i...
Clinical outcomes evolve years after traumatic brain injury
The TRACK-TBI LONG study has shown that outcomes are highly variable in the 7 years after traumatic brain injury (TBI). Al...
The amyotrophic lateral sclerosis exposome: recent advances and future directions
The amyotrophic lateral sclerosis exposome: recent advances and future directions
Amyotrophic lateral sclerosis (ALS) is a fatal disease of motor neuron degeneration with typical survival of only 2–...
Evidence-based clinical care and policy making for schizophrenia
Two recent studies leverage the same French population-based disease registry to describe real-world medication prescripti...
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