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Gut microbiome changes linked to Parkinson disease
A new study used a metagenomic approach to survey the entire gut microbiome in people with Parkinson disease and identifie...
Glial response to Parkinson disease-like neurodegeneration is region-dependent
Glial response to Parkinson disease-like neurodegeneration is region-dependent
According to new findings in a mouse model of Parkinson disease, the glial response to nigrostriatal degeneration differs ...
Targeting connexin hemichannels to treat temporal lobe epilepsy
New research published in Proceedings of the National Academy of Sciences USA has shown that a connexin hemichannel inhibi...
New IDEAS about amyloid, race and dementia disparities
New IDEAS about amyloid, race and dementia disparities
In a study of 17,000 Medicare beneficiaries with mild cognitive impairment or dementia, non-Hispanic white older adults we...
Cell-based therapies for neurological disorders — the bioreactor hypothesis
Cell-based therapies for neurological disorders — the bioreactor hypothesis
Cell-based therapies are an emerging biopharmaceutical paradigm under investigation for the treatment of a range of neurol...
Looking for lights in the fog of long-term neurological COVID
Looking for lights in the fog of long-term neurological COVID
A new study provides evidence for an association between COVID-19 and long-term neurological syndromes. The findings highl...
Maximizing treatment efficacy through patient stratification in neuropathic pain trials
Maximizing treatment efficacy through patient stratification in neuropathic pain trials
Treatment of neuropathic pain remains inadequate despite the elucidation of multiple pathophysiological mechanisms and the...
Adaptive and maladaptive myelination in health and disease
Adaptive and maladaptive myelination in health and disease
Within the past decade, multiple lines of evidence have converged to identify a critical role for activity-regulated myeli...
social determinants of health in multiple sclerosis
social determinants of health in multiple sclerosis
Social determinants of health are the conditions in which people are born, grow, live, work and age. These circumstances a...
Impaired glymphatic drainage links amyloid and tau to cognitive dysfunction
Impaired glymphatic drainage links amyloid and tau to cognitive dysfunction
New findings suggest that glymphatic dysfunction mediates the effect of amyloid and tau pathology on cognition.
No seasonality in multiple sclerosis risk near the Equator
No seasonality in multiple sclerosis risk near the Equator
New findings indicate that seasonal differences in multiple sclerosis prevalence are latitude-dependent.
NUMB72 — a therapeutic target for tauopathies?
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Preventing COVID-19 neurological complications
Neurological complications are reported in approximately 4% of people with severe COVID-19. New data reveal that treatment...
Blood–brain barrier dysfunction following TBI
A new pilot investigation demonstrates the use of dynamic contrast-enhanced (DCE) MRI for characterization of blood–brain ...
Novel plasma markers for Parkinson disease
In an attempt to identify biomarkers for Parkinson disease (PD), researchers have assessed known plasma markers of neurona...
Dementia risk variants — hunting needles in a haystack
Genome-wide association studies have identified loci associated with neurodegenerative disease risk, but many of the impli...
FTD–ALS risk factors converge on the endolysosomal pathway
New research shows that variants in two FTD–ALS risk genes impair the functioning of the endolysosomal pathway, lead...
Observational studies in Alzheimer disease: bridging preclinical studies and clinical trials
Observational studies in Alzheimer disease: bridging preclinical studies and clinical trials
Recent high-profile failures of Alzheimer disease treatments at the clinical trial stage have led to renewed efforts to id...
Astrocytes in the initiation and progression of epilepsy
Astrocytes in the initiation and progression of epilepsy
Epilepsy affects ~65 million people worldwide. First-line treatment options include >20 antiseizure medications, bu...
Human cerebral organoids — a new tool for clinical neurology research
Human cerebral organoids — a new tool for clinical neurology research
The current understanding of neurological diseases is derived mostly from direct analysis of patients and from animal mode...
Gene therapy for primary mitochondrial diseases: experimental advances and clinical challenges
Gene therapy for primary mitochondrial diseases: experimental advances and clinical challenges
The variable clinical and biochemical manifestations of primary mitochondrial diseases (PMDs), and the complexity of mitoc...
Sodium channelopathy could underlie concussion symptoms
Sodium channelopathy could underlie concussion symptoms
A new study indicates that concussion leads to sodium channel loss at the nodes of Ranvier, which could contribute to neur...
Schizophrenia shares genetics with brain volume alterations
The genetic architecture of schizophrenia is shared with that of abnormalities in subcortical brain volumes, according to ...
Gene–environment interactions in Alzheimer disease: the emerging role of epigenetics
Gene–environment interactions in Alzheimer disease: the emerging role of epigenetics
With the exception of a few monogenic forms, Alzheimer disease (AD) has a complex aetiology that is likely to involve mult...
Engineered TREM2 antibody clears Aβ in mice
Microglia migrate towards and phagocytose amyloid-β (Aβ), both in its oligomeric form and in plaques. The microglial recep...
FDA-approved drug promotes remyelination
The FDA-approved drug edaravone could promote the repair of lesions in neuromyelitis optica spectrum disorder (NMOSD), sug...
Brain volume is associated with cognition in MS
Cognitive dysfunction occurs in many people with multiple sclerosis (MS), but the relationship between brain pathology and...
First trials test targeting of α-synuclein for Parkinson disease
In the first two phase II trials of therapies that target α-synuclein to treat Parkinson disease, the primary endpoin...
Daily step count linked to dementia risk
New findings from the UK Biobank indicate an association between a higher step count and lower risk of dementia. Researche...