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Neuronal activity drives glymphatic waste clearance
Two new studies show that clearance of waste, including pathogenic amyloid, through the glymphatic system is driven by syn...
Addressing disparities in neurology by identifying gaps in hospital care
Addressing disparities in neurology by identifying gaps in hospital care
Nature Reviews Neurology is interviewing individuals who are driving efforts to address disparities in neurology through a...
Neurofilaments as biomarkers in neurological disorders — towards clinical application
Neurofilaments as biomarkers in neurological disorders — towards clinical application
Neurofilament proteins have been validated as specific body fluid biomarkers of neuro-axonal injury. The advent of highly ...
BTK inhibitor falters in multiple sclerosis trials
Findings of phase III trials of the Bruton’s tyrosine kinase inhibitor evobrutinib in patients with relapsing multip...
EBV-specific T cells in multiple sclerosis
New data recently reported at the ACTRIMS Forum add to growing evidence of an aetiological role for Epstein–Barr vir...
Support for network theories of schizophrenia
Support for network theories of schizophrenia
A computational neuroimaging study has shed new light on the relationship between morphological changes in the brain in sc...
Diversity, equity and inclusion in neurology
In this issue of Nature Reviews Neurology, we launch a Series to highlight the importance of diversity, equity and inclusi...
Addressing disparities in neurology by building the workforce in LMICs
Addressing disparities in neurology by building the workforce in LMICs
Nature Reviews Neurology is interviewing individuals who are driving efforts to address disparities in neurology through a...
Approval of omaveloxolone for Friedreich ataxia
The recent approval of omaveloxolone for the treatment of Friedreich ataxia in the USA and Europe represents an important ...
Neurostimulation for treatment of post-stroke impairments
Neurostimulation for treatment of post-stroke impairments
Neurostimulation, the use of electrical stimulation to modulate the activity of the nervous system, is now commonly used f...
Insights into epileptogenesis from post-traumatic epilepsy
Insights into epileptogenesis from post-traumatic epilepsy
Post-traumatic epilepsy (PTE) accounts for 5% of all epilepsies. The incidence of PTE after traumatic brain injury (TBI) d...
Neurological care for LGBT+ people
Neurological care for LGBT+ people
Sexual and gender minority (LGBT+) people face unique health disparities that must be considered by health-care providers ...
Towards the era of biological biomarkers for Parkinson disease
Since its instigation in cancer research in the 1930s, the disease-staging concept has become a crucial tool in clinical r...
Metabolic changes in status epilepticus
Status epilepticus is associated with changes in metabolic pathways, a new study has shown.
α-Synuclein seeds in amyotrophic lateral sclerosis
New evidence that α-synuclein can contribute to the pathogenesis of amyotrophic lateral sclerosis has come from analy...
Marker provides 10-year warning of dementia
Changes in plasma levels of specific proteins could predict the development of dementia more than 10 years before clinical...
Parkinson disease pathology in inflammatory bowel disease
Parkinson disease pathology in inflammatory bowel disease
A new study has found evidence of α-synuclein aggregates — a key pathological hallmark of Parkinson disease ...
Mitochondrial DNA marks multiple sclerosis
Mitochondrial DNA has been identified as a potential biomarker of multiple sclerosis disease activity and treatment response.
Biomarker-based staging of Alzheimer disease: rationale and clinical applications
Biomarker-based staging of Alzheimer disease: rationale and clinical applications
Disease staging, whereby the spatial extent and load of brain pathology are used to estimate the severity of Alzh...
Is Alzheimer disease a disease?
Dementia, a prevalent condition among older individuals, has profound societal implications. Extensive research has result...
Building an ethnically and racially diverse neurology workforce
Building an ethnically and racially diverse neurology workforce
As diversity among patient populations continues to grow, racial and ethnic diversity in the neurology workforce is increa...
Ultrasound and antibodies — a potentially powerful combination for Alzheimer disease therapy
Ultrasound and antibodies — a potentially powerful combination for Alzheimer disease therapy
Success in a trial of low-intensity ultrasound combined with an amyloid-β antibody represents a major stride towards ...
Epilepsy and epileptiform activity in late-onset Alzheimer disease: clinical and pathophysiological advances, gaps and conundrums
Epilepsy and epileptiform activity in late-onset Alzheimer disease: clinical and pathophysiological advances, gaps and conundrums
A growing body of evidence has demonstrated a link between Alzheimer disease (AD) and epilepsy. Late-onset epilepsy and ep...
Neurosteroids alleviate seizures in rats
Treatment with trilostane, a 3β-hydroxysteroid dehydrogenase inhibitor, has been shown to reduce the number of spontaneous...
Regional vulnerability to Aβ and tau pathology
The vulnerability of specific brain regions to Alzheimer disease (AD) pathology is associated with expression profiles of ...
Reply to: Questioning the cycad theory of Kii ALS–PDC causation
Department of Neurology and Clinical Neuroscience Center, Faculty of Medicine and Dentistry, Palacky University, Olomouc, ...
Questioning the cycad theory of Kii ALS–PDC causation
In a recent Review by Menšíková and colleagues (Menšíková, K. et al. Endemic parkinsonism: clusters, ...
Mitochondrial DNA instability in Huntington disease
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obta...
T cells implicate Epstein–Barr virus in multiple sclerosis pathogenesis
T cells implicate Epstein–Barr virus in multiple sclerosis pathogenesis
T cells that are specific for B cells infected with Epstein–Barr virus are enriched in the cerebrospinal fluid of pe...
TREM2 mediates phagocytosis in glioblastoma
A new study indicates that triggering receptor expressed on myeloid cells 2 (TREM2) is an important phagocytic immunomodul...
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