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Enriched environment treatment promotes neurofunctional recovery by regulating the ALK5/Smad2/3/Gadd45β signaling pathway in rats with cerebral ischemia /reperfusion injury
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The flavonoid fisetin reduces multiple physiological risk factors for dementia
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Modulating the biosynthesis and TLR4-interaction of lipopolysaccharide as an approach to counter gut dysbiosis and Parkinson's disease: Role of phyto-compounds
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Potential anxiolytic therapeutics from Hybanthus enneaspermus (L.) F. Muell. - mitigate anxiety by plausibly modulating the GABAA-Cl- channel
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Current multi-scale biomaterials for tissue regeneration following spinal cord injury
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Stroke triggers dynamic m6A reprogramming of cerebral circular RNAs
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Intermittent fasting induced cerebral ischemic tolerance altered gut microbiome and increased levels of short-chain fatty acids to a beneficial phenotype
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Astrocyte-secreted lipocalin-2 elicits bioenergetic failure-induced neuronal death that is causally related to high fatality in a mouse model of hepatic encephalopathy
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Naringenin mitigates nanoparticulate-aluminium induced neuronal degeneration in brain cortex and hippocampus through downregulation of oxidative stress and neuroinflammation
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Combating Parkinson's disease with plant-derived polyphenols: Targeting oxidative stress and neuroinflammation
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Interweaving the Numerical harmonic symmetry principles of the K+ Pore ion channel momentum
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Anticonvulsant and anxiolytic-like potential of the essential oil from the Ocimum basilicum Linn leaves and its major constituent estragole on adult zebrafish (Danio rerio)
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Inhibiting the activation of enteric glial cells alleviates intestinal inflammation and comorbid anxiety- and depressive-like behaviors in the ulcerative colitis mice
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p53 lysine-lactylated modification contributes to lipopolysaccharide-induced proinflammatory activation in BV2 cell under hypoxic conditions
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A2AR antagonists triggered the AMPK/m-TOR autophagic pathway to reverse the calcium-dependent cell damage in 6-OHDA induced model of PD
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Exposure to lipid mixture induces intracellular lipid droplet formation and impairs mitochondrial functions in astrocytes
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Thiazolium salt mimics the non-coenzyme effects of vitamin B1 in rat synaptosomes
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Curcumin as a potential therapeutic agent for treating neurodegenerative diseases
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Pharmacological inhibition of cGAS ameliorates postoperative cognitive dysfunction by suppressing caspase-3/GSDME-dependent pyroptosis
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Novel psychoplastogen DM506 reduces cue-induced heroin-seeking and inhibits tonic GABA currents in the Prelimbic Cortex
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IL-17A enhances the inflammatory response of glaucoma through Act1/TRAF6/NF-κB pathway
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Red nucleus mGluR1 and mGluR5 facilitate the development of neuropathic pain through stimulating the expressions of TNF-α and IL-1β
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Intracerebroventricular Infusion of Secretoneurin Inhibits Neuronal NLRP3-Apoptosis Pathway and Preserves Learning and Memory after Cerebral Ischemia
Intracerebroventricular Infusion of Secretoneurin Inhibits Neuronal NLRP3-Apoptosis Pathway and Preserves Learning and Memory after Cerebral Ischemia
Cardiac arrest stands out as a prominent contributor to both mortality and disability rates in the United States (Tsao et ...
Focus on brain-lung crosstalk: preventing or treating the pathological vicious circle between the brain and the lung
Focus on brain-lung crosstalk: preventing or treating the pathological vicious circle between the brain and the lung
The human body is a holistic system where organs work in a coordinated and orderly way to maintain a balance of physiologi...
Ferroptosis: A New Strategy for Targeting Alzheimer's Disease
Ferroptosis: A New Strategy for Targeting Alzheimer's Disease
Alzheimer's disease (AD) is a neurodegenerative disorder representing the major cause of dementia 1, 2. As per estimates, ...
Molecular mechanisms of the ambroxol action in Gaucher disease and GBA1 mutation-associated Parkinson disease
Molecular mechanisms of the ambroxol action in Gaucher disease and GBA1 mutation-associated Parkinson disease
The GBA1 gene encodes the lysosomal enzyme glucocerebrosidase (GCase). It is responsible for hydrolyzing the glycosphingol...
Nicotinic acid attenuates amyloid β1-42-induced mitochondrial dysfunction and inhibits the mitochondrial pathway of apoptosis in differentiated SH-SY5Y cells
Nicotinic acid attenuates amyloid β1-42-induced mitochondrial dysfunction and inhibits the mitochondrial pathway of apoptosis in differentiated SH-SY5Y cells
Alzheimer's disease (AD) is a chronic neurodegenerative disease characterized by progressive memory loss and behavioral di...
Amino acid transporters in neurological disorders and neuroprotective effects of cysteine derivatives
Amino acid transporters in neurological disorders and neuroprotective effects of cysteine derivatives
For most diseases and disorders occurring in the brain, the full causes behind them are yet unknown, but many show signs o...
Evaluation of the protective effect of capric acid on behavioral and biochemical alterations in valproic acid-induced model of autism
Evaluation of the protective effect of capric acid on behavioral and biochemical alterations in valproic acid-induced model of autism
Autism is defined as a multifaceted developmental disorder that is demonstrated by severe behavioral impairments including...
Astrocytic GDNF ameliorates anesthesia and surgery-induced cognitive impairment by promoting hippocampal synaptic plasticity in aged mice
Astrocytic GDNF ameliorates anesthesia and surgery-induced cognitive impairment by promoting hippocampal synaptic plasticity in aged mice
Perioperative neurocognitive disorders (PND) refer to changes in cognitive function, including cognitive and memory declin...
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