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Cell membrane-based nanomaterials for therapeutics of neurodegenerative diseases
Cell membrane-based nanomaterials for therapeutics of neurodegenerative diseases
Central nervous system (CNS) diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD...
BTD: A TRPC5 activator ameliorates mechanical allodynia in diabetic peripheral neuropathic rats by modulating TRPC5-CAMKII-ERK pathway
BTD: A TRPC5 activator ameliorates mechanical allodynia in diabetic peripheral neuropathic rats by modulating TRPC5-CAMKII-ERK pathway
Canonical transient receptor potential channel 5 (TRPC5) plays a key role in the regulation of central nervous system, car...
A review of studies on the implication of NLRP3 inflammasome for Parkinson’s disease and related candidate treatment targets
A review of studies on the implication of NLRP3 inflammasome for Parkinson’s disease and related candidate treatment targets
Parkinson's disease (PD) is a neurological disorder primarily affecting the elderly. Its clinical manifestations include m...
Mitigating neuroinflammation in Parkinson's disease: Exploring the role of proinflammatory cytokines and the potential of phytochemicals as natural therapeutics
Mitigating neuroinflammation in Parkinson's disease: Exploring the role of proinflammatory cytokines and the potential of phytochemicals as natural therapeutics
Neurodegenerative diseases (NDDs) are physical conditions characterized by the progressive loss of neurons and glial cells...
6-hydroxydopamine affects multiple pathways to induce cytotoxicity in differentiated LUHMES dopaminergic neurons
6-hydroxydopamine affects multiple pathways to induce cytotoxicity in differentiated LUHMES dopaminergic neurons
Parkinson's disease (PD) is the second most common neurological disorder, impacting more than ten million people worldwide...
HIF-1, an important regulator in potential new therapeutic approaches to ischemic stroke
HIF-1, an important regulator in potential new therapeutic approaches to ischemic stroke
Volume 170, November 2023, 105605Author links open overlay panel, AbstractIschemic stroke is a leading cause of disability...
BTD: A TRPC5 activatorameliorates mechanical allodynia in diabetic peripheral neuropathic rats by modulating TRPC5-CAMKII-ERK pathway
BTD: A TRPC5 activatorameliorates mechanical allodynia in diabetic peripheral neuropathic rats by modulating TRPC5-CAMKII-ERK pathway
The worldwide prevalence of diabetes is increasing and so is the occurrence of painful diabetic neuropathy (PDN). PDN is a...
Involvement of protein L-isoaspartyl methyltransferase in the physiopathology of neurodegenerative diseases: Possible substrates associated with synaptic function
Involvement of protein L-isoaspartyl methyltransferase in the physiopathology of neurodegenerative diseases: Possible substrates associated with synaptic function
Synapses are the major information transfer units in the nervous system. It is well known that normal synaptic function ma...
Tetramethylpyrazine promotes axonal remodeling and modulates microglial polarization via JAK2-STAT1/3 and GSK3-NFκB pathways in ischemic stroke
Tetramethylpyrazine promotes axonal remodeling and modulates microglial polarization via JAK2-STAT1/3 and GSK3-NFκB pathways in ischemic stroke
Ischemic stroke remains to be one of the most common causes of long-term disability all over the world. It should be noted...
The protective effects of EGCG was associated with HO-1 active and microglia pyroptosis inhibition in experimental intracerebral hemorrhage
The protective effects of EGCG was associated with HO-1 active and microglia pyroptosis inhibition in experimental intracerebral hemorrhage
Intracerebral hemorrhage (ICH) refers to non-traumatic spontaneous hemorrhage in the parenchyma of the brain.ICH is charac...
Disruption of histone acetylation homeostasis triggers cognitive dysfunction in experimental diabetes
Disruption of histone acetylation homeostasis triggers cognitive dysfunction in experimental diabetes
Diabetes is a metabolic disorder with consequential primary and secondary complications affecting central nervous system (...
HnRNPK is involved in stress-induced depression-like behavior via ERK-BDNF pathway in mice
Available online 4 August 2023, 105589Author links open overlay panel, , , , , , , AbstractAs a ubiquitous RNA-binding pro...
Function and therapeutic value of astrocytes in diabetic cognitive impairment
Diabetic cognitive impairment (DCI), a central nervous system (CNS) complication of diabetes mellitus (DM), is characteriz...
Calcitriol protects against reductions in striatal serotonin in rats treated with neurotoxic doses of methamphetamine
Methamphetamine (METH) abuse and addiction is a major public health issue in the United States, with the abuse potential o...
Glabridin mitigates TiO2NP induced cognitive deficit in adult zebrafish
Nanomaterials (NP) are employed in cosmetics, optics, catalysis, and medicine as of their distinctive physiochemical featu...
Discovery and validation of circulating stroke metabolites by NMR-based analyses using patients from the MISS and UK Biobank
Despite a significant reduction in stroke mortality rates over the past five decades, stroke is still the second-highest c...
Glutamate-aspartate transporter dysfunction enhances aminoglycoside-induced cochlear hair cell death via NMDA receptor activation
Glutamate has long been considered to be the primary fast excitatory neurotransmitter and to be a potential excitotoxin in...
Time-dependent dual effect of microglia in ischemic stroke
Stroke is categorized into two types: ischemic and hemorrhagic, with ischemic strokes making up 85% of all stroke cases, w...
Antidepressants escitalopram and venlafaxine up-regulate BDNF promoter IV but down-regulate neurite outgrowth in differentiating SH-SY5Y neurons
Antidepressants are used to treat depression and some anxiety disorders, including use in pregnant patients. The pharmacol...
Comprehensive analysis of sex differences in the function and ultrastructure of hippocampal presynaptic terminals
Numerous studies have reported sex differences in the brains of various species, including humans, Drosophila melanogaster...
The ER chaperone, BIP protects Microglia from ER stress-mediated Apoptosis in Hyperglycemia
The binding of Immunoglobulin heavy chain Protein (BIP) is one of the major endoplasmic reticulum (ER) chaperones and is a...
Identification of D359-0396 as a novel inhibitor of the activation of NLRP3 inflammasome
AimsPyroptosis is a unique pro-inflammatory form of programmed cell death which plays a critical role in promoting the pat...
Downregulation of Preso protects against ischemic/reperfusion-mediated neuronal injury through regulating PSD95-nNOS/YAP pathways
Stroke has emerged as one of the leading causes of death and long-term disability worldwide, bringing a heavy burden to th...
Addictive drugs modify neurogenesis, synaptogenesis and synaptic plasticity to impair memory formation through neurotransmitter imbalances and signaling dysfunction
Drug abuse is a public health problem worldwide, which has adverse outcomes affecting the individual and society. The drug...
Deletions of Cacna2d3 in parvalbumin-expressing neurons leads to autistic-like phenotypes in mice
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by deficits in social interaction a...
Identification D359-0396 as a novel inhibitor of the activation of NLRP3 inflammasome
Pyroptosis is a unique form of programmed cell death accompanied by robust inflammation and occurred frequently during the...
Neonatal treatment with resveratrol decreases postural and strength impairments and improves mitochondrial function in the somatosensory cortex rats submitted to cerebral palsy
Cerebral palsy (CP) is a heterogeneous group of diseases that result from non-progressive damage to the brain at an early ...
Neuromuscular defects after infection with a beta coronavirus in mice
COVID-19 affects primarily the lung. However, several other systemic alterations, including muscle weakness, fatigue and m...
The 5-HT7 receptors in the VLO contribute to the development of morphine-induced behavioral sensitization in rats
Drug addiction is a chronic, relapsing brain disease characterized by compulsive drug seeking and taking (Lüscher et al., ...
Mutant Tau protein-induced abnormalities in the Na+-dependent glutamine translocation and recycling and their impact on astrocyte-neuron integrity in vitro
The presence of neurofibrillary tangles (NFTs) composed of the microtubule-associated protein Tau is one of the features o...
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