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The time dimension to stroke: Circadian effects on stroke outcomes and mechanisms
Cerebral ischemia is one of the leading causes of death and disability in the United States and worldwide. Circadian rhyth...
S-adenosyl-l-methionine antidepressant-like effects involve activation of 5-HT1A receptors
Major depressive disorder (MDD) is a recurrent and complex psychiatric disorder. The available pharmacological therapies f...
Potential application of heat shock proteins as therapeutic targets in Parkinson's disease
Parkinson's disease (PD) is a chronic neurodegenerative disease and the second most common neurodegenerative disease after...
The potential role of the cholecystokinin system in declarative memory
As one of the most abundant neuropeptides in the central nervous system, cholecystokinin (CCK) has been suggested to be as...
Juvenile social isolation affects the structure of the tanycyte–vascular interface in the hypophyseal portal system of the adult mice
Accumulating evidence indicates that social stress in the juvenile period affects hypothalamic–pituitary–adrenal (HPA) axi...
DARPP-32/protein phosphatase 1 regulates Rasgrp2 as a novel component of dopamine D1 receptor signaling in striatum
Dopamine regulates psychomotor function by D1 receptor/PKA-dependent phosphorylation of DARPP-32. DARPP-32, phosphorylated...
Activation of HCN channels caused by elevated cAMP levels in periaqueductal gray promotes bone cancer pain
The periaqueductal gray (PAG) is an important relay center for the descending pathways that regulate nociceptive informati...
The interplay between MMP-12 and t-PA in the brain after ischemic stroke
Tissue-type plasminogen activator (t-PA) expression is known to increase following transient focal cerebral ischemia and r...
An HPLC-based assay for improved measurement of glutamate decarboxylase inhibition/activation
L-Glutamic acid decarboxylase (GAD) is an enzyme that ensures the balance between the levels of two neurotransmitters, γ-a...
NAD+ metabolism in peripheral neuropathic pain
Nicotinamide adenine dinucleotide (NAD+) is an omnipresent metabolite that participates in redox reactions. Multiple NAD+-...
MMP-12 knockdown prevents secondary brain damage after ischemic stroke in mice
We previously reported that increased expression of matrix metalloproteinase-12 (MMP-12) mediates blood-brain barrier disr...
Social isolation induces succinate dehydrogenase dysfunction in anxious mice
We have previously reported social isolation induces anxiety-like behavior, cognition decline, and reduction in brain ATP ...
Verapamil inhibits TXNIP-NLRP3 inflammasome activation and preserves functional recovery after intracerebral hemorrhage in mice
Intracerebral hemorrhage (ICH) is the second most common type of stroke with no satisfactory treatment. Recent studies fro...
Plasma protein alterations during human large vessel stroke: A controlled comparison study
BackgroundStroke is a major cause of death and disability in the United States. Mechanical thrombectomy (MT) and tissue pl...
Hippocampal metabolic recovery as a manifestation of the protective effect of ischemic preconditioning in rats
The ever-present risk of brain ischemic events in humans and its full prevention make the detailed studies of an organism'...
Intact amphetamine-induced behavioral sensitization in mice with increased or decreased neuronal glutamate transporter SLC1A1/EAAT3
Repeated amphetamine treatment results in locomotor sensitization, a phenomenon that may relate to the development of psyc...
The role of LRP1 in Aβ efflux transport across the blood-brain barrier and cognitive dysfunction in diabetes mellitus
Available online 5 September 2022, 105417Highlights•Diabetic mice exhibit cognitive dysfunction.•Diabetes induced Aβ depos...
Prenatal exposure to valproic acid causes allodynia associated with spinal microglial activation
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social communication and soci...
Prenatal exposure to Cannabis smoke induces early and lasting damage to the brain
Cannabis is the most widely used illegal drug during pregnancy, however, the effects of gestational exposure to Cannabis s...
The role of NAD metabolism in neuronal differentiation
Volume 159, October 2022, 105402Highlights•Understanding neuronal differentiation is crucial for the development of novel ...
Insights for Alzheimer's disease pharmacotherapy and current clinical trials
Over the years, the scientific community has sought improvements in the life quality of patients diagnosed with Alzheimer'...
Isolation and characterization of neurotoxic astrocytes derived from adult triple transgenic Alzheimer's disease mice
Alzheimer's disease has been considered mostly as a neuronal pathology, although increasing evidence suggests that glial c...