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Sustained inactivation of the Polycomb PRC1 complex induces DNA repair defects and genomic instability in epigenetic tumors
Sustained inactivation of the Polycomb PRC1 complex induces DNA repair defects and genomic instability in epigenetic tumors
Cancer initiation and progression are typically associated with the accumulation of driver mutations and genomic instabili...
Glyoxal-methyl-ethylene sulfonic acid fixative enhances the fixation of cytoskeletal structures for Förster resonance energy transfer measurements
Glyoxal-methyl-ethylene sulfonic acid fixative enhances the fixation of cytoskeletal structures for Förster resonance energy transfer measurements
Förster resonance energy transfer (FRET) serves as a tool for measuring protein–protein interactions using vari...
The emerging role of the semaphorin family in cartilage and osteoarthritis
The emerging role of the semaphorin family in cartilage and osteoarthritis
In the pathogenesis of osteoarthritis, various signaling pathways may influence the bone joint through a common terminal p...
Dynamic chromosome association with nuclear organelles in living cells
Dynamic chromosome association with nuclear organelles in living cells
The development of progressively sophisticated tools complemented by the integration of live cell imaging enhances our und...
Effect of elevated temperature and hydrocortisone addition on the proliferation of fibroblasts
Effect of elevated temperature and hydrocortisone addition on the proliferation of fibroblasts
Hyperthermia along with hydrocortisone (HC) are proven teratogens that can negatively influence embryo development during ...
Visualizing histone H4K20me1 in knock-in mice expressing the mCherry-tagged modification-specific intracellular antibody
Visualizing histone H4K20me1 in knock-in mice expressing the mCherry-tagged modification-specific intracellular antibody
During development and differentiation, histone modifications dynamically change locally and globally, associated with tra...
CCAT1 lncRNA is chromatin-retained and post-transcriptionally spliced
CCAT1 lncRNA is chromatin-retained and post-transcriptionally spliced
Super-enhancers are unique gene expression regulators widely involved in cancer development. Spread over large DNA segment...
From feulgen to modern methods: marking a century of DNA imaging advances
From feulgen to modern methods: marking a century of DNA imaging advances
The mystery of how human DNA is compactly packaged into a nucleus—a space a hundred thousand times smaller—whi...
DNA choreography: correlating mobility and organization of DNA across different resolutions from loops to chromosomes
DNA choreography: correlating mobility and organization of DNA across different resolutions from loops to chromosomes
The dynamics of DNA in the cell nucleus plays a role in cellular processes and fates but the interplay of DNA mobility wit...
Crossing boundaries of light microscopy resolution discerns novel assemblies in the nucleolus
Crossing boundaries of light microscopy resolution discerns novel assemblies in the nucleolus
The nucleolus is the largest membraneless organelle and nuclear body in mammalian cells. It is primarily involved in the b...
Behaviors of nucleosomes with mutant histone H4s in euchromatic domains of living human cells
Behaviors of nucleosomes with mutant histone H4s in euchromatic domains of living human cells
Since Robert Feulgen first stained DNA in the cell, visualizing genome chromatin has been a central issue in cell biology ...
Allele-level visualization of transcription and chromatin by high-throughput imaging
Allele-level visualization of transcription and chromatin by high-throughput imaging
The spatial arrangement of the genome within the nucleus is a pivotal aspect of cellular organization and function with im...
Differential expression of small bowel TGFβ1 and TGFβ3 characterizes intestinal strictures in patients with fibrostenotic Crohn’s disease
Differential expression of small bowel TGFβ1 and TGFβ3 characterizes intestinal strictures in patients with fibrostenotic Crohn’s disease
Small bowel strictures remain a debilitating consequence of Crohn’s disease and contribute to poor outcomes for pati...
Development and functional testing of a novel in vitro delayed scratch closure assay
Development and functional testing of a novel in vitro delayed scratch closure assay
As the development of chronic wound therapeutics continues to expand, the demand for advanced assay systems mimicking the ...
Effect of N-acetylcysteine on hair follicle changes in mouse model of cyclophosphamide-induced alopecia: histological and biochemical study
Effect of N-acetylcysteine on hair follicle changes in mouse model of cyclophosphamide-induced alopecia: histological and biochemical study
Chemotherapy-induced alopecia (CIA) represents one of the most severe side effects of chemotherapy, which forces some pati...
Imaging extrachromosomal DNA (ecDNA) in cancer
Imaging extrachromosomal DNA (ecDNA) in cancer
Extrachromosomal DNA (ecDNA) are circular regions of DNA that are found in many cancers. They are an important means of on...
Antioxidant supplementation may effect DNA methylation patterns, apoptosis, and ROS levels in developing mouse embryos
Antioxidant supplementation may effect DNA methylation patterns, apoptosis, and ROS levels in developing mouse embryos
This study was designed to address the question: does antioxidant-containing embryo culture media affect DNA methyltransfe...
A brief history of the Feulgen reaction
A brief history of the Feulgen reaction
One hundred years ago, Robert Feulgen published a landmark paper in which he described the first method to stain DNA in ce...
Circ_100549 promotes tumor progression in lung adenocarcinoma through upregulation of BIRC6
Circ_100549 promotes tumor progression in lung adenocarcinoma through upregulation of BIRC6
Lung adenocarcinoma (LUAD) is a subtype of lung cancer with high incidence and mortality globally. Emerging evidence sugge...
Chromatin structure and dynamics: one nucleosome at a time
Chromatin structure and dynamics: one nucleosome at a time
Eukaryotic genomes store information on many levels, including their linear DNA sequence, the posttranslational modificati...
Reliable detection of RNA in hippocampus sections of mice by FISH up to a post-mortem delay of 24 h
Reliable detection of RNA in hippocampus sections of mice by FISH up to a post-mortem delay of 24 h
Proteins can be successfully localized in post-mortem (PM) brain tissue sections if the time until PM tissue sampling is n...
Identification of neutrophils and eosinophils in upper airway mucosa with immunofluorescence multiplex image cytometry
Identification of neutrophils and eosinophils in upper airway mucosa with immunofluorescence multiplex image cytometry
Characterization of inflammation in chronic rhinosinusitis with (CRSwNP) and without nasal polyps (CRSsNP) is an ongoing r...
Inhibition of Notch3/Hey1 ameliorates peribiliary hypoxia by preventing hypertrophic hepatic arteriopathy in biliary atresia progression
Inhibition of Notch3/Hey1 ameliorates peribiliary hypoxia by preventing hypertrophic hepatic arteriopathy in biliary atresia progression
Emerging evidence indicates the presence of vascular abnormalities and ischemia in bil...
Increased endocytosis rate and enhanced lysosomal pathway of silica-coated superparamagnetic nanoparticles into M-HeLa cells compared with cultured primary motor neurons
Increased endocytosis rate and enhanced lysosomal pathway of silica-coated superparamagnetic nanoparticles into M-HeLa cells compared with cultured primary motor neurons
The unique properties of superparamagnetic iron oxide nanoparticles (SPIONs) enable their use as magnetic biosensors, targ...
Oxygen levels affect oviduct epithelium functions in air–liquid interface culture
Oxygen levels affect oviduct epithelium functions in air–liquid interface culture
Key reproductive events such as fertilization and early embryonic development occur in the lumen of the oviduct. Since inv...
MOTS-c regulates pancreatic alpha and beta cell functions in vitro
MOTS-c regulates pancreatic alpha and beta cell functions in vitro
The aim of this study is to determine the influence of the mitochondrial open-reading-frame of the twelve S rRNA-c (MOTS-c...
Molecular characterization of ANKRD1 in rhabdomyosarcoma cell lines: expression, localization, and proteasomal degradation
Molecular characterization of ANKRD1 in rhabdomyosarcoma cell lines: expression, localization, and proteasomal degradation
Rhabdomyosarcoma (RMS) is the most common soft tissue malignancy in children and adolescents. Respecting the age of the pa...
The secretome from human-derived mesenchymal stem cells augments the activity of antitumor plant extracts in vitro
The secretome from human-derived mesenchymal stem cells augments the activity of antitumor plant extracts in vitro
Cancer is understood as a multifactorial disease that involve multiple cell types and phenotypes in the tumor microenviron...
Role of Wisteria floribunda agglutinin binding glycans in carcinogenesis and metastasis of cholangiocarcinoma
Role of Wisteria floribunda agglutinin binding glycans in carcinogenesis and metastasis of cholangiocarcinoma
Aberrant glycosylation is an important factor in facilitating tumor progression and therapeutic resistance. In this study,...
The impact of apelin-13 on cisplatin-induced endocrine pancreas damage in rats: an in vivo study
The impact of apelin-13 on cisplatin-induced endocrine pancreas damage in rats: an in vivo study
Apelin-13 is a peptide hormone that regulates pancreatic endocrine functions, and its benefits on the endocrine pancreas a...
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