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Detection of DNA replication errors and 8-oxo-dGTP-mediated mutations in E. coli by Duplex DNA Sequencing
E. coli has been a model organism for genetic analysis for many decades [1], and it is still widely used to gain insights ...
The use of aflibercept (VEGF trap) in mitigating sulfur mustard-induced corneal neovascularization in a rabbit model
Sulfur mustard (SM)-induced ocular injury is characterized by an acute inflammatory response that may become chronic or en...
Pharmacological heat-shock protein inducers and chemical chaperones inhibit upregulation of interleukin-8 by oxidized phospholipids
Pharmacological heat-shock protein inducers and chemical chaperones inhibit upregulation of interleukin-8 by oxidized phospholipids
Oxidised phospholipids such as oxidised palmitoyl-arachidonoyl-phosphatidylcholine (OxPAPC) are increasingly recognised as...
The activation of spliced X-box binding protein 1 by isorhynchophylline therapy improves diabetic encephalopathy
The activation of spliced X-box binding protein 1 by isorhynchophylline therapy improves diabetic encephalopathy
The primary symptom of diabetic encephalopathy (DE), a kind of central diabetic neuropathy caused by diabetes mellitus (DM...
Preparation and characterization of activated carbon from agricultural wastes and their ability to remove chlorpyrifos from water
Chlorpyrifos is an organophosphate insecticide linked to neurological dysfunctions, endocrine disturbance, cardiovascular ...
An assessment of the ECETOC TRA Consumer tool performance as a screening level tool
An assessment of the ECETOC TRA Consumer tool performance as a screening level tool
The European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) Targeted Risk Assessment (TRA) Consumer tool wa...
Low-dose tributyltin triggers human chondrocyte senescence and mouse articular cartilage aging
Low-dose tributyltin triggers human chondrocyte senescence and mouse articular cartilage aging
Tributyltin (TBT) is known as an endocrine-disrupting chemical. This study investigated the effects and possible mechanism...
Development of a transcriptome-based determination of innate immune suppressor (TDIS) assay as an in vitro test for immunotoxicity
Development of a transcriptome-based determination of innate immune suppressor (TDIS) assay as an in vitro test for immunotoxicity
Immunotoxicity has been an important topic in toxicology since inadvertent exposures to xenobiotics were found to alter im...
Mycotoxins and cellular senescence: the impact of oxidative stress, hypoxia, and immunosuppression
Mycotoxins and cellular senescence: the impact of oxidative stress, hypoxia, and immunosuppression
Mycotoxins induce oxidative stress, hypoxia, and cause immunosuppressive effects. Moreover, emerging evidence show that my...
iNKT17 cells play a pathogenic role in ethinylestradiol-induced cholestatic hepatotoxicity
iNKT17 cells play a pathogenic role in ethinylestradiol-induced cholestatic hepatotoxicity
IL-17 is closely associated with inflammation in intrahepatic cholestasis (IHC). Targeting IL-17 ameliorates IHC in mice. ...
Toxicokinetics of plasmatic VX in a swine model: comparison of a simple enzymatic titration method with a mass spectrometry method
Toxicokinetics of plasmatic VX in a swine model: comparison of a simple enzymatic titration method with a mass spectrometry method
Recent events have shown that organophosphorus nerve agents (OPNAs) are a serious threat. Cholinesterase inhibition by OPN...
Opioid toxicity: histamine, hypersensitivity, and MRGPRX2
Opioid toxicity: histamine, hypersensitivity, and MRGPRX2
Insights into the pathophysiology of many non-immune-mediated drug reactions referred to as toxicities, sensitivities, int...
CRISPR-based DNA methylation editing of NNT rescues the cisplatin resistance of lung cancer cells by reducing autophagy
CRISPR-based DNA methylation editing of NNT rescues the cisplatin resistance of lung cancer cells by reducing autophagy
Cisplatin is recommended as a first-line chemotherapeutic agent against advanced non-small cell lung cancer (NSCLC), but a...
Organotin and organochlorine toxicants activate key translational regulatory proteins in human immune cells
Organotin and organochlorine toxicants activate key translational regulatory proteins in human immune cells
Environmental contaminant exposures occur due to the widespread use of synthetic chemicals. Tributyltin (TBT), dibutyltin ...
Isolation of human TRPA1 channel from transfected HEK293 cells and identification of alkylation sites after sulfur mustard exposure
Isolation of human TRPA1 channel from transfected HEK293 cells and identification of alkylation sites after sulfur mustard exposure
Transient receptor potential (TRP) channels are important in the sensing of pain and other stimuli. They may be triggered ...
Histo-anatomical mutilations of developing chick brain induced by in-ovo fluoride and bifenthrin exposure
Comparative developing brain histo-anatomical pathologies of Fluoride ions and Bifenthrin in-ovo exposures were explored i...
Pterostilbene attenuates hemin-induced dysregulation of macrophage M2 polarization via Nrf2 activation in experimental hyperglycemia
Pterostilbene attenuates hemin-induced dysregulation of macrophage M2 polarization via Nrf2 activation in experimental hyperglycemia
Macrophages exhibit a high degree of plasticity that is physiologically relevant in wound healing, and disruption in norma...
Interactions of Alcohol and Combination Antiretroviral (cART) drug in Diabetic Male Sprague Dawley Rats: Hippocampal Perturbations and Toxicosis
Hippocampal pathology in diabetes is constantly investigated but the resultant health impact of the concomitant presence o...