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Screening of glycosylase activity on oxidative derivatives of methylcytosine: Pedobacter heparinus SMUG2 as a formylcytosine- and carboxylcytosine-DNA glycosylase
5-Methylcytosine (mC) is an epigenetic mark that impacts transcription, development, diseases including cancer and aging. ...
Simulations of radioiodine exposure and protective thyroid blocking in a new biokinetic model of the mother–fetus unit at different pregnancy ages
Simulations of radioiodine exposure and protective thyroid blocking in a new biokinetic model of the mother–fetus unit at different pregnancy ages
In the case of nuclear incidents, radioiodine may be released. After incorporation, it accumulates in the thyroid and enha...
Commentary: cumulative risk assessment of perfluoroalkyl carboxylic acids and perfluoralkyl sulfonic acids: what is the scientific support for deriving tolerable exposures by assembling 27 PFAS into 1 common assessment group?
Commentary: cumulative risk assessment of perfluoroalkyl carboxylic acids and perfluoralkyl sulfonic acids: what is the scientific support for deriving tolerable exposures by assembling 27 PFAS into 1 common assessment group?
This commentary proposes an approach to risk assessment of mixtures of per- and polyfluorinated alkyl substances (PFAS) as...
Potential of the zebrafish (Danio rerio) embryo test to discriminate between chemicals of similar molecular structure—a study with valproic acid and 14 of its analogues
Potential of the zebrafish (Danio rerio) embryo test to discriminate between chemicals of similar molecular structure—a study with valproic acid and 14 of its analogues
Valproic acid is a frequently used antiepileptic drug and known pediatric hepatotoxic agent. In search of pharmaceuticals ...
Migration of styrene oligomers from food contact materials: in silico prediction of possible genotoxicity
Migration of styrene oligomers from food contact materials: in silico prediction of possible genotoxicity
Styrene oligomers (SO) are well-known side products formed during styrene polymerization. They consist mainly of dimers (S...
Development of an adverse outcome pathway network for breast cancer: a comprehensive representation of the pathogenesis, complexity and diversity of the disease
Development of an adverse outcome pathway network for breast cancer: a comprehensive representation of the pathogenesis, complexity and diversity of the disease
Adverse outcome pathways (AOPs), introduced in modern toxicology, intend to provide an evidence-based representation of to...
Deoxynivalenol induces caspase-3/GSDME-dependent pyroptosis and inflammation in mouse liver and HepaRG cells
Deoxynivalenol induces caspase-3/GSDME-dependent pyroptosis and inflammation in mouse liver and HepaRG cells
Deoxynivalenol (DON), a frequent food and feed contaminant, poses a severe threat to human and livestock health. Some stud...
A review and assessment of cyanobacterial toxins as cardiovascular health hazards
A review and assessment of cyanobacterial toxins as cardiovascular health hazards
Eutrophicated waters frequently support bloom-forming cyanobacteria, many of which produce potent cyanobacterial toxins (c...
Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s
Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s
Many nitrosamines are recognized as mutagens and potent rodent carcinogens. Over the past few years, nitrosamine impuritie...
CuO-NPs-triggered heterophil extracellular traps exacerbate liver injury in chicks by promoting oxidative stress and inflammatory responses
CuO-NPs-triggered heterophil extracellular traps exacerbate liver injury in chicks by promoting oxidative stress and inflammatory responses
With the widespread use of copper oxide nanoparticles (CuO-NPs), their potential toxicity to the environment and biologica...
Hypoalbuminemia affects the spatio-temporal tissue distribution of ochratoxin A in liver and kidneys: consequences for organ toxicity
Hypoalbuminemia affects the spatio-temporal tissue distribution of ochratoxin A in liver and kidneys: consequences for organ toxicity
Hypoalbuminemia (HA) is frequently observed in systemic inflammatory diseases and in liver disease. However, the influence...
Linking in vitro and ex vivo CB1 activity with serum concentrations and clinical features in 5F-MDMB-PICA users to better understand SCRAs and their metabolites
Linking in vitro and ex vivo CB1 activity with serum concentrations and clinical features in 5F-MDMB-PICA users to better understand SCRAs and their metabolites
Synthetic cannabinoid receptor agonists (SCRAs) pose a danger to public health. This study focused on individuals experien...
Association between lead exposure and DNA damage (genotoxicity): systematic review and meta-analysis
Association between lead exposure and DNA damage (genotoxicity): systematic review and meta-analysis
Studies suggest that chronic lead (Pb) exposure may induce deoxyribonucleic acid (DNA) damage. However, there is no synthe...
Differences in β-naphthylamine metabolism and toxicity in Chinese hamster ovary cell lines transfected with human CYP1A2 and NAT2*4, NAT2*5B or NAT2*7B N-acetyltransferase 2 haplotypes
Differences in β-naphthylamine metabolism and toxicity in Chinese hamster ovary cell lines transfected with human CYP1A2 and NAT2*4, NAT2*5B or NAT2*7B N-acetyltransferase 2 haplotypes
β-naphthylamine (BNA) is an important aromatic amine carcinogen. Current exposures derive primarily from cigarette sm...
Rubiarbonol B induces RIPK1-dependent necroptosis via NOX1-derived ROS production
Rubiarbonol B induces RIPK1-dependent necroptosis via NOX1-derived ROS production
The activation of receptor-interacting protein kinase 1 (RIPK1) by death-inducing signaling complex (DISC) formation is es...
Comparative analysis of single cell lung atlas of bat, cat, tiger, and pangolin
Comparative analysis of single cell lung atlas of bat, cat, tiger, and pangolin
Horseshoe bats (Rhinolophus sinicus) might help maintain coronaviruses severely affecting human health, such as severe acu...
Toxins, Vol. 14, Pages 663: Therapeutic Effect of Bee Venom and Melittin on Skin Infection Caused by Streptococcus pyogenes
Toxins, Vol. 14, Pages 663: Therapeutic Effect of Bee Venom and Melittin on Skin Infection Caused by Streptococcus pyogenes
Streptococcus pyogenes (S. pyogenes) bacteria cause almost all primary skin infections in humans. Bee venom (BV) and melit...
Toxins, Vol. 14, Pages 672: Optimization of Aflatoxin B1-Lysine Analysis for Public Health Exposure Studies
Toxins, Vol. 14, Pages 672: Optimization of Aflatoxin B1-Lysine Analysis for Public Health Exposure Studies
Aflatoxin B1 is a potent human carcinogen produced by several species of Aspergillus mainly found on nuts and maize. Expos...
Toxins, Vol. 14, Pages 669: sPLA2 Wobbles on the Lipid Bilayer between Three Positions, Each Involved in the Hydrolysis Process
Toxins, Vol. 14, Pages 669: sPLA2 Wobbles on the Lipid Bilayer between Three Positions, Each Involved in the Hydrolysis Process
Secreted phospholipases A2 (sPLA2s) are peripheral membrane enzymes that hydrolyze phospholipids in the sn-2 position. The...
Toxins, Vol. 14, Pages 671: Influence of Season and Food Type on Bacterial and Entero-Toxigenic Prevalence of Staphylococcus aureus
Toxins, Vol. 14, Pages 671: Influence of Season and Food Type on Bacterial and Entero-Toxigenic Prevalence of Staphylococcus aureus
Staphylococcus (S.) aureus is a coagulase-positive pathogen of interest for human health and food safety in particular. It...
Toxins, Vol. 14, Pages 670: Effect of the Combined Compound Probiotics with Glycyrrhinic Acid on Alleviating Cytotoxicity of IPEC-J2 Cells Induced by Multi-Mycotoxins
Toxins, Vol. 14, Pages 670: Effect of the Combined Compound Probiotics with Glycyrrhinic Acid on Alleviating Cytotoxicity of IPEC-J2 Cells Induced by Multi-Mycotoxins
Aflatoxins B1 (AFB1), deoxynivalenol (DON) and zearalenone (ZEA) are the three most prevalent mycotoxins, whose contaminat...
Toxins, Vol. 14, Pages 662: Investigation of the Adverse Events Associated with Bee Venom Pharmacopuncture in Patients Hospitalized in a Korean Hospital: A Retrospective Chart Review Study
Toxins, Vol. 14, Pages 662: Investigation of the Adverse Events Associated with Bee Venom Pharmacopuncture in Patients Hospitalized in a Korean Hospital: A Retrospective Chart Review Study
In bee venom pharmacopuncture (BVP), bee venom isolated from the venom sac of bees is injected into the acupoint or muscle...
Toxins, Vol. 14, Pages 666: Effects of Flexor Digitorum Longus Muscle Anatomical Structure on the Response to Botulinum Toxin Treatment in Patients with Post-Stroke Claw Foot Deformity
Toxins, Vol. 14, Pages 666: Effects of Flexor Digitorum Longus Muscle Anatomical Structure on the Response to Botulinum Toxin Treatment in Patients with Post-Stroke Claw Foot Deformity
(1) Background: The purpose of this retrospective case-control study was to determine the relationship between the control...
Toxins, Vol. 14, Pages 667: Botulinum Toxin, a Drug with Potential Interest for Dentists—An Introduction
Toxins, Vol. 14, Pages 667: Botulinum Toxin, a Drug with Potential Interest for Dentists—An Introduction
The review is an introduction to medical, non-cosmetic treatments with botulinum neurotoxin (BoNT) in the orofacial region...
Toxins, Vol. 14, Pages 668: Potassium Bioaccessibility in Uncooked and Cooked Plant Foods: Results from a Static In Vitro Digestion Methodology
Toxins, Vol. 14, Pages 668: Potassium Bioaccessibility in Uncooked and Cooked Plant Foods: Results from a Static In Vitro Digestion Methodology
Hyperkalemia is a major concern in chronic kidney disease and in end-stage renal disease, representing a predictor of hosp...
Adult and children’s use of hand sanitizer during a pandemic – an observational study
Adult and children’s use of hand sanitizer during a pandemic – an observational study
The use of hand sanitizers has been one of the key public health measures recommended to reduce the transmission of SARS-C...
Retraction Note to: Phytofabricated silver nanoparticles of Phyllanthus emblica attenuated diethylnitrosamine‑induced hepatic cancer via knock‑down oxidative stress and inflammation
Retraction Note to: Phytofabricated silver nanoparticles of Phyllanthus emblica attenuated diethylnitrosamine‑induced hepatic cancer via knock‑down oxidative stress and inflammation
The Editor-in-Chief has retracted this article because of the following concerns with three of the figures: ...
Role of the NRG1/ErbB4 and PI3K/AKT/mTOR signaling pathways in the anti-psychotic effects of aripiprazole and sertindole in ketamine-induced schizophrenia-like behaviors in rats
Role of the NRG1/ErbB4 and PI3K/AKT/mTOR signaling pathways in the anti-psychotic effects of aripiprazole and sertindole in ketamine-induced schizophrenia-like behaviors in rats
Schizophrenia is a common mental disorder affecting patients’ thoughts, behavior, and cognition. Recently, the NRG1/...
Diapocynin neuroprotective effects in 3-nitropropionic acid Huntington’s disease model in rats: emphasis on Sirt1/Nrf2 signaling pathway
Diapocynin neuroprotective effects in 3-nitropropionic acid Huntington’s disease model in rats: emphasis on Sirt1/Nrf2 signaling pathway
Huntington's disease (HD) is a rare inherited disease portrayed with marked cognitive and motor decline owing to exten...
Role of neopterin as an inflammatory biomarker in congestive heart failure with insights on effect of drug therapies on its level
Role of neopterin as an inflammatory biomarker in congestive heart failure with insights on effect of drug therapies on its level
Inflammation has a major role in the pathogenesis of heart failure (HF). It triggers a cascade that leads to the release o...
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