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Peripheral serum iTRAQ-based proteomic characteristics of carbon tetrachloride-induced acute liver injury in Macaca fascicularis
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Assessing the impact of organic and inorganic Micropollutants released from a Wastewater Treatment Plant on humans and aquatic environment, Al-Hoceima city, Morocco
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Human translesion DNA polymerases ι and κ mediate tolerance to temozolomide in MGMT-deficient glioblastoma cells.
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Correction to: Screening for ferroptosis genes related to endometrial carcinoma and predicting of targeted drugs based on bioinformatics
Correction to: Screening for ferroptosis genes related to endometrial carcinoma and predicting of targeted drugs based on bioinformatics
Diagnostic and prognostic ROC curves based on the validated obtained hub genes. A–C Diagnostic ROC curves for CDKN2A, NRAS...
Identification of phase-I and phase-II metabolites and the metabolic pathway of the novel synthetic cannabinoid 5F-EDMB-PICA in vitro
Identification of phase-I and phase-II metabolites and the metabolic pathway of the novel synthetic cannabinoid 5F-EDMB-PICA in vitro
5F-EDMB-PICA is a newly emerged synthetic cannabinoid which has been characterized in relevant literature in recent years....
In vitro screening of understudied PFAS with a focus on lipid metabolism disruption
In vitro screening of understudied PFAS with a focus on lipid metabolism disruption
Per- and polyfluoroalkyl substances (PFAS) are man-made chemicals used in many industrial applications. Exposure to PFAS i...
Does a postmortem redistribution affect the concentrations of the 7 azaindole-derived synthetic cannabinoid 5F-MDMB-P7AICA in tissues and body fluids following pulmonary administration to pigs?
Does a postmortem redistribution affect the concentrations of the 7 azaindole-derived synthetic cannabinoid 5F-MDMB-P7AICA in tissues and body fluids following pulmonary administration to pigs?
Many fatal intoxications have been reported in connection with the consumption of newer, highly potent synthetic cannabino...
Atorvastatin exerts a preventive effect against steroid-induced necrosis of the femoral head by modulating Wnt5a release
Atorvastatin exerts a preventive effect against steroid-induced necrosis of the femoral head by modulating Wnt5a release
Steroid-induced osteonecrosis of the femoral head (SONFH) is a prevalent form of osteonecrosis in young individuals. More ...
Targeting ferroptosis by natural products in pathophysiological conditions
Targeting ferroptosis by natural products in pathophysiological conditions
Ferroptosis is a form of cell death that is induced by iron-mediated accumulation of lipid peroxidation. The involvement o...
A genetic variant in the TAPBP gene enhances cervical cancer susceptibility by increasing m6A modification
A genetic variant in the TAPBP gene enhances cervical cancer susceptibility by increasing m6A modification
Genetic variants can affect gene expression by altering the level of N6-methyladenosine (m6A) modifications. A better unde...
A multi-biomarker micronucleus assay using imaging flow cytometry
A multi-biomarker micronucleus assay using imaging flow cytometry
Genetic toxicity testing assesses the potential of compounds to cause DNA damage. There are many genetic toxicology screen...
Synthesis and in vitro assessment of the reactivation profile of clinically available oximes on the acetylcholinesterase model inhibited by A-230 nerve agent surrogate
Synthesis and in vitro assessment of the reactivation profile of clinically available oximes on the acetylcholinesterase model inhibited by A-230 nerve agent surrogate
The risk of the use of toxic chemicals for unlawful acts has been a matter of concern for different governments and multil...
Comparison of DNA damage in fresh and frozen blood samples: implications for the comet assay in human biomonitoring studies
Comparison of DNA damage in fresh and frozen blood samples: implications for the comet assay in human biomonitoring studies
The use of the comet assay in large biomonitoring studies may present logistical and technical challenges because of the p...
A new 3D model of L929 fibroblasts microtissues uncovers the effects of Bothrops erythromelas venom and its antivenom
A new 3D model of L929 fibroblasts microtissues uncovers the effects of Bothrops erythromelas venom and its antivenom
In Brazil, around 80% of snakebites are caused by snakes of the genus Bothrops. A three-dimensional culture model was stan...
Sirtuin 3-activated superoxide dismutase 2 mediates fluoride-induced osteoblastic differentiation in vitro and in vivo by down-regulating reactive oxygen species
Sirtuin 3-activated superoxide dismutase 2 mediates fluoride-induced osteoblastic differentiation in vitro and in vivo by down-regulating reactive oxygen species
Skeletal fluorosis is a chronic metabolic bone disease caused by long-term excessive fluoride intake. Abnormal differentia...
Integrated systematic functional screen and fine-mapping decipher the role and genetic regulation of RPS19 in colorectal cancer development
Integrated systematic functional screen and fine-mapping decipher the role and genetic regulation of RPS19 in colorectal cancer development
Despite genome-wide association studies (GWAS) have identified more than 200 risk loci associated with colorectal cancer (...
The relative nature of the standards for proof of safety: a review of FDA’s safety standards for various consumer products
The relative nature of the standards for proof of safety: a review of FDA’s safety standards for various consumer products
Are all food ingredients, dietary supplement ingredients and even foods, required to meet the same safety standards? Are t...
Identification of reversible OATP1B1 and time-dependent CYP3A4 inhibition as the major risk factors for drug-induced cholestasis (DIC)
Identification of reversible OATP1B1 and time-dependent CYP3A4 inhibition as the major risk factors for drug-induced cholestasis (DIC)
Hepatic bile acid regulation is a multifaceted process modulated by several hepatic transporters and enzymes. Drug-induced...
Differences in endocrine and reproductive responses to substance exposure across generations: highlighting the importance of complementary findings
Differences in endocrine and reproductive responses to substance exposure across generations: highlighting the importance of complementary findings
This article analyzes the results from 112 Extended One-Generation Reproductive Toxicity studies. The objective was to det...
Trivalent chromium versus baricitinib for rheumatoid arthritis treatment: first phase 2/3 randomized controlled trial, is trivalent chromium the upcoming immune-modulator?
Trivalent chromium versus baricitinib for rheumatoid arthritis treatment: first phase 2/3 randomized controlled trial, is trivalent chromium the upcoming immune-modulator?
Rheumatoid arthritis (RA) is a debilitating disease mainly treated by DMARDs. Baricitinib is one of the emerging DMARDs wi...
Down-regulation of NF-κB signalling by methanolic extract of Viola odorata (L.) attenuated in vivo inflammatory and angiogenic responses
Down-regulation of NF-κB signalling by methanolic extract of Viola odorata (L.) attenuated in vivo inflammatory and angiogenic responses
Intractable inflammation plays a key role in the progression of autoimmune diseases such as rheumatoid arthritis. Oedema a...
Hesperetin-7-O-rhamnoglucoside ameliorates dichlorvos-facilitated cardiotoxicity in rats by counteracting ionoregulatory, ion pumps, redox, and lipid homeostasis disruptions
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Zinc oxide nanoparticles induces cell death and consequently leading to incomplete neural tube closure through oxidative stress during embryogenesis
Zinc oxide nanoparticles induces cell death and consequently leading to incomplete neural tube closure through oxidative stress during embryogenesis
The implementation of Zinc oxide nanoparticles (ZnO NPs) raises concerns regarding their potential toxic effects on human ...
TRAF6 promotes spinal microglial M1 polarization to aggravate neuropathic pain by activating the c-JUN/NF-kB signaling pathway
TRAF6 promotes spinal microglial M1 polarization to aggravate neuropathic pain by activating the c-JUN/NF-kB signaling pathway
The neuropathic pain with complex networks of neuroinflammatory activation severely limits clinical therapeutic research. ...
HMGB1 as an extracellular pro-inflammatory cytokine: Implications for drug-induced organic damage
HMGB1 as an extracellular pro-inflammatory cytokine: Implications for drug-induced organic damage
Drug-induced organic damage encompasses various intricate mechanisms, wherein HMGB1, a non-histone chromosome-binding prot...
Efficacy and safety of infliximab and adalimumab in inflammatory bowel disease patients
Efficacy and safety of infliximab and adalimumab in inflammatory bowel disease patients
Inflammatory bowel disease (IBD), consists of two primary types: Ulcerative Colitis (UC) and Crohn’s Disease (CD). I...
Crosstalk between gut–brain axis: unveiling the mysteries of gut ROS in progression of Parkinson’s disease
Crosstalk between gut–brain axis: unveiling the mysteries of gut ROS in progression of Parkinson’s disease
“Path to a good mood lies through the gut.” This statement seems to imply that it has long been believed that ...
Pharmacological insights and role of bufalin (bufadienolides) in inflammation modulation: a narrative review
Pharmacological insights and role of bufalin (bufadienolides) in inflammation modulation: a narrative review
Bufadienolides, specifically bufalin, have garnered attention for their potential therapeutic application in modulating in...
‘Comprehensive review of emerging drug targets in traumatic brain injury (TBI): challenges and future scope
‘Comprehensive review of emerging drug targets in traumatic brain injury (TBI): challenges and future scope
Traumatic brain injury (TBI) is a complex brain problem that causes significant morbidity and mortality among people of al...
A review on toxic effects of pesticides in Zebrafish, Danio rerio and Common Carp, Cyprinus carpio, emphasising Atrazine herbicide
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