SCI时时刷

search
+
Pold4 Subunit of Replicative Polymerase δ Promotes Fork Slowing at Broken Templates
Pold4 Subunit of Replicative Polymerase δ Promotes Fork Slowing at Broken Templates
The polymerase δ (Polδ) is a critical enzyme responsible for synthesizing nascent DNA strands in the eukaryotic genome [1]...
Associations between satellite-derived estimates of PM2.5 species concentrations for organic carbon, elemental carbon, nitrate, and sulfate with birth weight and preterm birth in California during 2005–2014
Associations between satellite-derived estimates of PM2.5 species concentrations for organic carbon, elemental carbon, nitrate, and sulfate with birth weight and preterm birth in California during 2005–2014
Characterizing the spatial distribution of PM2.5 species concentrations is challenging due to the geographic sparsity of t...
Diosmetin attenuates fibromyalgia-like symptoms in a reserpine-induced model in mice
Diosmetin attenuates fibromyalgia-like symptoms in a reserpine-induced model in mice
Fibromyalgia is a potentially disabling idiopathic disease characterized by widespread chronic pain associated with comorb...
The renoprotective activity of amikacin–gamma-amino butyric acid–chitosan nanoparticles: a comparative study
The renoprotective activity of amikacin–gamma-amino butyric acid–chitosan nanoparticles: a comparative study
The development of nanoparticles (NPs) with active components with upgraded stability, and prolonged release helps in enha...
Massive lignocaine overdose while on veno-arterial extracorporeal membrane oxygenation (VA ECMO)
Massive lignocaine overdose while on veno-arterial extracorporeal membrane oxygenation (VA ECMO)
AbbreviationsVA ECMOVeno-Arterial Extracorporeal Membrane OxygenationCABGCoronary Artery Bypass GraftVTVentricular Tachyca...
Developing a geographical–meteorological indicator system and evaluating prediction models for alveolar echinococcosis in China
Developing a geographical–meteorological indicator system and evaluating prediction models for alveolar echinococcosis in China
Geographical and meteorological factors have been reported to influence the prevalence of echinococcosis, but there’...
Neuroinflammation and the role of epigenetic-based therapies for Huntington’s disease management: the new paradigm
Neuroinflammation and the role of epigenetic-based therapies for Huntington’s disease management: the new paradigm
Huntington’s disease (HD) is an inherited, autosomal, neurodegenerative ailment that affects the striatum of the bra...
Adverse hematological profiles associated with chlorpromazine antipsychotic treatment in male rats: Preventive and reversal mechanisms of taurine and coenzyme-Q10
Adverse hematological profiles associated with chlorpromazine antipsychotic treatment in male rats: Preventive and reversal mechanisms of taurine and coenzyme-Q10
Chlorpromazine (CPZ) is one of the most effective antipsychotic drugs used for managing psychotic related disorders owing ...
Elongin B promotes breast cancer progression by ubiquitinating tumor suppressor p14/ARF
Elongin B promotes breast cancer progression by ubiquitinating tumor suppressor p14/ARF
Elongin B (ELOB), a pivotal element in the ELOB/c-Cullin2/5-SOCS-box E3 ubiquitin-protein ligase complex, plays a signific...
Molecular insights of Eucalyptol (1,8-Cineole) as an anti-arthritic agent: in vivo and in silico analysis of IL-17, IL-10, NF-κB, 5-LOX and COX-2
Molecular insights of Eucalyptol (1,8-Cineole) as an anti-arthritic agent: in vivo and in silico analysis of IL-17, IL-10, NF-κB, 5-LOX and COX-2
The monoterpene oxide, Eucalyptol (1,8-Cineole), a primary component of eucalyptus oil, has been evaluated pharmacological...
Combined effect of pantoprazole and mesenchymal stem cells on experimentally induced gastric ulcer: implication of oxidative stress, inflammation and apoptosis pathways
Combined effect of pantoprazole and mesenchymal stem cells on experimentally induced gastric ulcer: implication of oxidative stress, inflammation and apoptosis pathways
Gastric ulcer (GU) is one of the most common diseases of the upper gastrointestinal tract that affects millions of people ...
NEIL3: a unique DNA glycosylase involved in interstrand DNA crosslink repair
NEIL3: a unique DNA glycosylase involved in interstrand DNA crosslink repair
Endonuclease VIII-like 3 (NEIL3) is a versatile DNA glycosylase that repairs a diverse array of chemical modifications to ...
What is the safe noise exposure level to prevent noise-induced hearing loss?
What is the safe noise exposure level to prevent noise-induced hearing loss?
Natarajan N, Batts S, Stankovic KM. Noise-induced hearing loss. J Clin Med. 2023;12:2347.Article  CAS  PubMed  ...
Therapeutic effects and mechanisms of isoxanthohumol on DSS-induced colitis: regulating T cell development, restoring gut microbiota, and improving metabolic disorders
Therapeutic effects and mechanisms of isoxanthohumol on DSS-induced colitis: regulating T cell development, restoring gut microbiota, and improving metabolic disorders
Ulcerative colitis (UC) is a severe hazard to human health. Since pathogenesis of UC is still unclear, current therapy for...
Efficacy and safety of proton pump inhibitors on cardiovascular events and inflammatory factors in patients with upper gastrointestinal bleeding undergoing dual antiplatelet therapy
Efficacy and safety of proton pump inhibitors on cardiovascular events and inflammatory factors in patients with upper gastrointestinal bleeding undergoing dual antiplatelet therapy
This work evaluated the effects of proton pump inhibitors (PPIs) on cardiovascular events (CVEs) and inflammatory factors ...
circRNA-PTPN4 mediated regulation of FOXO3 and ZO-1 expression: implications for blood–brain barrier integrity and cognitive function in uremic encephalopathy
circRNA-PTPN4 mediated regulation of FOXO3 and ZO-1 expression: implications for blood–brain barrier integrity and cognitive function in uremic encephalopathy
Uremic encephalopathy (UE) poses a significant challenge in neurology, leading to the need to investigate the involvement ...
Activation of CTU2 expression by LXR promotes the development of hepatocellular carcinoma
Activation of CTU2 expression by LXR promotes the development of hepatocellular carcinoma
Cytosolic thiouridylase 2 (CTU2) is an enzyme modifying transfer RNAs post-transcriptionally, which has been implicated in...
Emerging contaminants in food matrices: An overview of the occurrence, pathways, impacts and detection techniques of per- and polyfluoroalkyl substances
Emerging contaminants in food matrices: An overview of the occurrence, pathways, impacts and detection techniques of per- and polyfluoroalkyl substances
Per- and polyfluoroalkyl substances (PFAS) have been used in industrial and consumer applications for ages. The pervasive ...
DNA repair deficiencies and neurodegeneration
DNA repair deficiencies and neurodegeneration
Neurodegenerative diseases are the second most prevalent cause of death in industrialized countries. Alzheimer’s Disease i...
Neuroprotective effect of Withania somnifera leaves extract nanoemulsion against penconazole-induced neurotoxicity in albino rats via modulating TGF-β1/Smad2 signaling pathway
Neuroprotective effect of Withania somnifera leaves extract nanoemulsion against penconazole-induced neurotoxicity in albino rats via modulating TGF-β1/Smad2 signaling pathway
Penconazole (PEN) is a systemic triazole fungicide used to control various fungal diseases on grapes, stone fruits, cucurb...
Comparison of different sources of mesenchymal stem cells: focus on inflammatory bowel disease
Comparison of different sources of mesenchymal stem cells: focus on inflammatory bowel disease
Inflammatory bowel disease (IBD) poses a significant challenge in modern medicine, with conventional treatments limited by...
Impact of prior antihypertensive treatment on COVID-19 outcomes, by active ingredient
Impact of prior antihypertensive treatment on COVID-19 outcomes, by active ingredient
To assess the impact of prior chronic treatment with angiotensin-converting enzyme inhibitors (ACEIs)/ angiotensin-recepto...
Evaluating the docetaxel effect in an animal model of polyarthritis
Evaluating the docetaxel effect in an animal model of polyarthritis
Rheumatoid arthritis (RA) is immune-mediated, inflammatory disease that affects synovial joints, and characterized by infl...
Piloting co-developed behaviour change interventions to reduce exposure to air pollution and improve self-reported asthma-related health
Piloting co-developed behaviour change interventions to reduce exposure to air pollution and improve self-reported asthma-related health
Exposure to air pollution can exacerbate asthma with immediate and long-term health consequences. Behaviour changes can re...
The effects of urban green space and road proximity to indoor traffic-related PM2.5, NO2, and BC exposure in inner-city schools
The effects of urban green space and road proximity to indoor traffic-related PM2.5, NO2, and BC exposure in inner-city schools
Since there are known adverse health impacts of traffic-related air pollution, while at the same time there are potential ...
Genomic stress and impaired DNA repair in Alzheimer disease
Genomic stress and impaired DNA repair in Alzheimer disease
Alzheimer disease (AD) was first described in 1906 by German psychiatrist and neuroanatomist Dr. Alois Alzheimer [1]. In t...
Artemisia herba-alba: antioxidant capacity and efficacy in preventing chronic arthritis in vivo
Artemisia herba-alba: antioxidant capacity and efficacy in preventing chronic arthritis in vivo
Arthritis is a debilitating condition impacting the quality of life for millions worldwide, characterized by pain and infl...
The addition of mammalian cell culture medium impacts nanoparticle toxicity in zebrafish
The addition of mammalian cell culture medium impacts nanoparticle toxicity in zebrafish
Engineered nanomaterials (ENMs) are ubiquitous in contemporary applications, yet their environmental and human health impa...
Maximum tolerated dose and toxicity evaluation of orally administered docetaxel granule in mice
Maximum tolerated dose and toxicity evaluation of orally administered docetaxel granule in mice
Oral delivery of chemotherapy drugs is the most favorable and preferred route of drug administration. However, because of ...
Leveraging low-cost sensors to predict nitrogen dioxide for epidemiologic exposure assessment
Leveraging low-cost sensors to predict nitrogen dioxide for epidemiologic exposure assessment
Statistical models of air pollution enable intra-urban characterization of pollutant concentrations, benefiting exposure a...
阅读更多
format_indent_increase