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A proposal for using benefit-risk methods to improve the prominence of adverse event results when reporting trials
A proposal for using benefit-risk methods to improve the prominence of adverse event results when reporting trials
Adverse events suffer from poor reporting within randomised controlled trials, despite them being crucial to the evaluatio...
Disagreements in risk of bias assessment for randomized controlled trials in hypertension-related Cochrane reviews
Disagreements in risk of bias assessment for randomized controlled trials in hypertension-related Cochrane reviews
The inter-reviewer reliability of the risk of bias (RoB) assessment lacked agreement in previous studies. It is important ...
The effect of exercise rehabilitation with exergames combined with ice therapy in the treatment of obese patients with gout: protocol for a clinical trial
The effect of exercise rehabilitation with exergames combined with ice therapy in the treatment of obese patients with gout: protocol for a clinical trial
Gout remains a leading cause of inflammatory arthritis worldwide, and the main risk factor for gout is persistent hyperuri...
Accounting for center-level effects in multicenter randomized controlled trials
Accounting for center-level effects in multicenter randomized controlled trials
Investigators often conduct randomized controlled trials (RCTs) at multiple centers/sites when determining the effect of a...
Defatting of donor transplant livers during normothermic perfusion—a randomised clinical trial: study protocol for the DeFat study
Defatting of donor transplant livers during normothermic perfusion—a randomised clinical trial: study protocol for the DeFat study
Liver disease is the third leading cause of premature death in the UK. Transplantation is the only successful treatment fo...
Effectiveness of remote risk-based monitoring and potential benefits for combination with direct data capture
Effectiveness of remote risk-based monitoring and potential benefits for combination with direct data capture
In recent years, alternative monitoring approaches, such as risk-based and remote monitoring techniques, have been recomme...
Generalized music therapy to reduce neuroactive drug needs in critically ill patients. Study protocol for a randomized trial
Generalized music therapy to reduce neuroactive drug needs in critically ill patients. Study protocol for a randomized trial
Critically ill patients are exposed to several physical and emotional stressors, needing analgesic and sedative drugs to t...
The effect of an improved ICU physical environment on outcomes and post-ICU recovery—a protocol
The effect of an improved ICU physical environment on outcomes and post-ICU recovery—a protocol
Intensive care medicine continues to improve, with advances in technology and care provision leading to improved patient s...
Registry-based randomised controlled trials: conduct, advantages and challenges—a systematic review
Registry-based randomised controlled trials: conduct, advantages and challenges—a systematic review
Registry-based randomised controlled trials (rRCTs) have been described as pragmatic studies utilising patient data embedd...
Lomustine with or without reirradiation for first progression of glioblastoma, LEGATO, EORTC-2227-BTG: study protocol for a randomized phase III study
Lomustine with or without reirradiation for first progression of glioblastoma, LEGATO, EORTC-2227-BTG: study protocol for a randomized phase III study
Chemotherapy with lomustine is widely considered as standard treatment option for progressive glioblastoma. The value of a...