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Enrolment patterns in a randomized controlled trial of probiotics in critically ill patients: a retrospective analysis of the PROSPECT trial
Enrolment patterns in a randomized controlled trial of probiotics in critically ill patients: a retrospective analysis of the PROSPECT trial
Understanding site-related factors that influence enrolment within multicenter randomized controlled trials (RCT) may help...
Comparison of different puncture needles used for endoscopic ultrasound-guided fine-needle biopsy of Gastrointestinal subepithelial lesions (≤ 2 cm) with respect to the adequacy of specimen collection: study protocol for a multicenter randomized prospective trial
Comparison of different puncture needles used for endoscopic ultrasound-guided fine-needle biopsy of Gastrointestinal subepithelial lesions (≤ 2 cm) with respect to the adequacy of specimen collection: study protocol for a multicenter randomized prospective trial
Gastrointestinal subepithelial lesions (SELs) range from benign to malignant. Endoscopic ultrasound (EUS)-guided fine-need...
Effect of individualized versus conventional perioperative blood pressure management on postoperative major complications in high-risk patients undergoing noncardiac surgery: study protocol for the SPROUT-4 multicenter randomized controlled trial
Effect of individualized versus conventional perioperative blood pressure management on postoperative major complications in high-risk patients undergoing noncardiac surgery: study protocol for the SPROUT-4 multicenter randomized controlled trial
Intraoperative hypotension is very common during surgery and is linked to major organ dysfunction and mortality. Current p...
A multi-center, open-label, randomized clinical trial evaluating the preventive effect of perampanel on craniotomy-induced epileptogenesis in seizure-naive patients with supratentorial brain tumors: study protocol for a GRAMPAS trial
A multi-center, open-label, randomized clinical trial evaluating the preventive effect of perampanel on craniotomy-induced epileptogenesis in seizure-naive patients with supratentorial brain tumors: study protocol for a GRAMPAS trial
Early seizures after craniotomy are significant perioperative complications that can adversely impact patient outcomes. De...
The effect of Sarcomeal® oral supplementation plus vitamin D3 on muscle parameters and metabolic factors in diabetic sarcopenia patients: study protocol of a randomized controlled clinical trial
The effect of Sarcomeal® oral supplementation plus vitamin D3 on muscle parameters and metabolic factors in diabetic sarcopenia patients: study protocol of a randomized controlled clinical trial
Diabetes is a significant risk factor for sarcopenia, a muscle dystrophy affecting older individuals. Sarcopenia managemen...
Application of indocyanine green–human serum albumin complex in fluorescence image-guided laparoscopic anatomical liver resection: study protocol for a randomized controlled trial
Application of indocyanine green–human serum albumin complex in fluorescence image-guided laparoscopic anatomical liver resection: study protocol for a randomized controlled trial
Indocyanine green (ICG) is a near-infrared fluorescent dye widely used for intraoperative navigation during liver surgerie...
Factors associated with male recruitment in a multi-site randomized behavioral clinical trial targeting the metabolic syndrome: analysis of screening and recruitment data from the ELM trial
Factors associated with male recruitment in a multi-site randomized behavioral clinical trial targeting the metabolic syndrome: analysis of screening and recruitment data from the ELM trial
Males are underrepresented in behavioral clinical trials of lifestyle. The aim of this exploratory study was to investigat...
Effect of transcutaneous electro-stimulation in postoperative rehabilitation pain treatment in thoracic surgery: a randomized clinical trial
Effect of transcutaneous electro-stimulation in postoperative rehabilitation pain treatment in thoracic surgery: a randomized clinical trial
Chest pain is one of the most difficult problems to solve after thoracic surgery. Its correct control is often quite diffi...
Process-based therapy vs. routine-CBT for difficult-to-treat mood and anxiety disorders: study protocol for a randomized controlled trial
Process-based therapy vs. routine-CBT for difficult-to-treat mood and anxiety disorders: study protocol for a randomized controlled trial
Process-based therapy (PBT) is a new framework to intervention planning, based on the use of ecological momentary assessme...
Irregular assessment times in pragmatic randomized clinical trials
Irregular assessment times in pragmatic randomized clinical trials
Deviation from protocolized assessment times is commonplace in pragmatic randomized clinical trials. Working with a stakeh...
Perioperative methadone compared to placebo in elderly hip fracture patients: a study protocol for a randomized controlled trial (MetaHip trial)
Perioperative methadone compared to placebo in elderly hip fracture patients: a study protocol for a randomized controlled trial (MetaHip trial)
Hip fractures are a source of severe pain among the elderly population and pose challenges due to limited analgesic tolera...
Limitation of site-stratified cox regression analysis in survival data: a cautionary tale of the PANAMO phase III randomized, controlled study in critically ill COVID-19 patients
Limitation of site-stratified cox regression analysis in survival data: a cautionary tale of the PANAMO phase III randomized, controlled study in critically ill COVID-19 patients
Current guidelines tend to focus on a p-value threshold of a pre-specified primary endpoint tested in randomized controlle...
Effects of trehalose on bone healing, physical function, and pain in patients with pertrochanteric fractures: a randomized controlled trial protocol
Effects of trehalose on bone healing, physical function, and pain in patients with pertrochanteric fractures: a randomized controlled trial protocol
Appropriate management of fractures is crucial for restoring natural bone function and preventing long-term complications....
Induction treatments with and without addition of one dose anthracycline to all-trans retinoid acid and arsenic in pediatric non-high-risk acute promyelocytic leukemia: study protocol for a randomized controlled trial
Induction treatments with and without addition of one dose anthracycline to all-trans retinoid acid and arsenic in pediatric non-high-risk acute promyelocytic leukemia: study protocol for a randomized controlled trial
The treatment of all-trans retinoic acid (ATRA) and arsenical agent has revolutionarily improved the prognosis of acute pr...
All I want for Christmas…is a precisely defined research question
All I want for Christmas…is a precisely defined research question
World Health Organization. Ageing and health, https://www.who.int/news-room/fact-sheets/detail/ageing-and-health, Accessed...
Stent Omission after Ureteroscopy and Lithotripsy (SOUL) in the Michigan Urological Surgery Improvement Collaborative (MUSIC): study protocol for a pragmatic prospective combined randomized and observational clinical trial
Stent Omission after Ureteroscopy and Lithotripsy (SOUL) in the Michigan Urological Surgery Improvement Collaborative (MUSIC): study protocol for a pragmatic prospective combined randomized and observational clinical trial
Ureteral stents are placed by urologists to ensure ureteral patency in the postoperative period following ureteroscopy to ...
Effect of esketamine on postoperative quality of recovery in patients undergoing arthroscopic rotator cuff repair: protocol for a prospective, randomized, double-blind study
Effect of esketamine on postoperative quality of recovery in patients undergoing arthroscopic rotator cuff repair: protocol for a prospective, randomized, double-blind study
The utilization of shoulder arthroscopic surgery has progressively increased as a prevalent surgical approach for the trea...
A review of UK publicly funded non-inferiority trials: is the design more inferior than it should be?
A review of UK publicly funded non-inferiority trials: is the design more inferior than it should be?
The number of non-inferiority (NI) trials, those aiming to show a new treatment is no worse than a comparator, is increasi...
Safety and effectiveness of transcutaneous auricular vagus nerve stimulation on patients with depersonalization-derealization disorder: study protocol for a randomized controlled trial
Safety and effectiveness of transcutaneous auricular vagus nerve stimulation on patients with depersonalization-derealization disorder: study protocol for a randomized controlled trial
Depersonalization-derealization disorder (DPD) is a complex psychiatric condition marked by profound and often relentless ...
The clinical effects of pulsed electromagnetic field therapy for the management of chronic ankle instability: a study protocol for a double-blind randomized controlled trial
The clinical effects of pulsed electromagnetic field therapy for the management of chronic ankle instability: a study protocol for a double-blind randomized controlled trial
Chronic ankle instability is associated with long-term neuromuscular deficits involving poor postural control and peroneal...
Assessing the efficacy and safety of STOP (successful treatment for paranoia)—an app-based cognitive bias modification therapy for paranoia: a randomised clinical trial protocol
Assessing the efficacy and safety of STOP (successful treatment for paranoia)—an app-based cognitive bias modification therapy for paranoia: a randomised clinical trial protocol
Paranoia, the belief that you are at risk of significant physical or emotional harm from others, is a common difficulty, w...
Agile monitoring dashboard for clinical research studies
Agile monitoring dashboard for clinical research studies
Clinical trial success hinges on efficient participant recruitment and retention. However, slow accrual and attrition freq...
Implementation and evaluation of a navigation program for people with cancer in old age and their family caregivers: study protocol for the EU NAVIGATE International Pragmatic Randomized Controlled Trial
Implementation and evaluation of a navigation program for people with cancer in old age and their family caregivers: study protocol for the EU NAVIGATE International Pragmatic Randomized Controlled Trial
Cancer navigation programs aim to support, educate, and empower patients and families, addressing barriers to diagnostics,...
Comparisons of efficacy and safety of 400 or 800 ml bacterial count fecal microbiota transplantation in the treatment of recurrent hepatic encephalopathy: a multicenter prospective randomized controlled trial in China
Comparisons of efficacy and safety of 400 or 800 ml bacterial count fecal microbiota transplantation in the treatment of recurrent hepatic encephalopathy: a multicenter prospective randomized controlled trial in China
Hepatic encephalopathy (HE) represents a critical complications of end-stage liver disease, serving as an independent pred...
A study protocol for a multi-country cluster randomized controlled trial of the impact of a multi-component One Health strategy to eliminate Opisthorchis viverrini and soil transmitted helminths in the Lower Mekong Basin
A study protocol for a multi-country cluster randomized controlled trial of the impact of a multi-component One Health strategy to eliminate Opisthorchis viverrini and soil transmitted helminths in the Lower Mekong Basin
Opisthorchis viverrini (OV) and soil-transmitted helminths (STH) are two of the most common helminths contributing to the ...
Clinical efficacy and safety of the superpulse thulium fiber laser and holmium laser for ureteroscopic lithotripsy in the treatment of upper urinary tract calculi: a randomized, positive control, blinded, single-center clinical study {1}
Clinical efficacy and safety of the superpulse thulium fiber laser and holmium laser for ureteroscopic lithotripsy in the treatment of upper urinary tract calculi: a randomized, positive control, blinded, single-center clinical study {1}
Kidney stone disease is a common problem. The holmium: yttrium–aluminum–garnet (HO:YAG) laser is currently the...
Care bundles to improve enteral nutrition management in stroke patients: study protocol for a stepped wedge cluster randomised trial
Care bundles to improve enteral nutrition management in stroke patients: study protocol for a stepped wedge cluster randomised trial
Enteral nutrition for stroke patients in China presents major shortcomings. This aspect of care involves multiple componen...
Intracoronary administration of tenecteplase to prevent PCI-related myocardial infarction in patients with echo-attenuated coronary plaques: study protocol for a multicenter, prospective, randomized controlled trial
Intracoronary administration of tenecteplase to prevent PCI-related myocardial infarction in patients with echo-attenuated coronary plaques: study protocol for a multicenter, prospective, randomized controlled trial
Percutaneous coronary intervention (PCI)-related myocardial infarction (MI), especially the distal type associated with mi...
Effects of prebiotics on microbial diversity and abundance in young children with acute malnutrition: study protocol for a multi-centered, double-blinded randomized controlled trial
Effects of prebiotics on microbial diversity and abundance in young children with acute malnutrition: study protocol for a multi-centered, double-blinded randomized controlled trial
The anti-inflammatory and antimicrobial benefits of prebiotics may present an affordable and cost-effective strategy for n...
High-concentrated platelet-rich plasma (PRP) versus placebo in osteoarthritis in the thumb base: study protocol for an assessor-blinded randomized controlled trial
High-concentrated platelet-rich plasma (PRP) versus placebo in osteoarthritis in the thumb base: study protocol for an assessor-blinded randomized controlled trial
Osteoarthritis in the thumb base (trapeziometacarpal joint, CMC-1 joint) is prevalent, particularly among middle-aged and ...
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