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Defining a ‘cells to society’ research framework for appendiceal tumours
Defining a ‘cells to society’ research framework for appendiceal tumours
Tumours of the appendix — a vestigial digestive organ attached to the colon — are rare. Although we estimate t...
Using mathematical modelling and AI to improve delivery and efficacy of therapies in cancer
Using mathematical modelling and AI to improve delivery and efficacy of therapies in cancer
Mathematical modelling has proven to be a valuable tool in predicting the delivery and efficacy of molecular, antibody-bas...
Dendritic cell maturation in cancer
Dendritic cell maturation in cancer
Dendritic cells (DCs) are specialized antigen-presenting cells that are present at low abundance in the circulation and ti...
Small speckles, big impact
Small speckles, big impact
In this study, Alexander et al. find that HIF2α regulates speckle–DNA associations to fine-tune the expression ...
Maximizing the dual benefit of pet dogs in cancer trials
Maximizing the dual benefit of pet dogs in cancer trials
Pet dogs with cancer have catalysed the translation of preclinical discoveries to first-in-human trials, highlighting the ...
Allies in the epidermis
Allies in the epidermis
Immunosuppression disrupts normal skin homeostasis, raising the risk of cancer development. Now, Son et al. find that comm...
Tumour hypoxia in driving genomic instability and tumour evolution
Tumour hypoxia in driving genomic instability and tumour evolution
Intratumour hypoxia is a feature of all heterogenous solid tumours. Increased levels or subregions of tumour hypoxia are a...
Cross-priming in cancer immunology and immunotherapy
Cross-priming in cancer immunology and immunotherapy
Cytotoxic T cell immune responses against cancer crucially depend on the ability of a subtype of professional antigen-pres...
Metabolic interplays between the tumour and the host shape the tumour macroenvironment
Metabolic interplays between the tumour and the host shape the tumour macroenvironment
Metabolic reprogramming of cancer cells and the tumour microenvironment are pivotal characteristics of cancers, and studyi...
Rusting away with age
Rusting away with age
In a recent study published in Nature, Zhuang et al. outline how ageing affects stemness and tumorigenic potential of tumo...
Decoding the functional impact of the cancer genome through protein–protein interactions
Decoding the functional impact of the cancer genome through protein–protein interactions
Acquisition of genomic mutations enables cancer cells to gain fitness advantages under selective pressure and, ultimately,...
Fructose takes a detour to feed cancer
Fructose takes a detour to feed cancer
The mechanisms by which dietary fructose promotes tumour progression have remained poorly understood. A recent study publi...
Conventional chemotherapy: millions of cures, unresolved therapeutic index
Conventional chemotherapy: millions of cures, unresolved therapeutic index
In recent decades, millions of patients with cancer have been cured by chemotherapy alone. By ‘cure’, we mean ...
PDX models for functional precision oncology and discovery science
PDX models for functional precision oncology and discovery science
Precision oncology relies on detailed molecular analysis of how diverse tumours respond to various therapies, with the aim...
Lactate gives a sour taste
Lactate gives a sour taste
Wang et al. demonstrate that lactate derived from glioblastoma stem cells, microglia and macrophages drives histone lactyl...
Re-envisioning genetic predisposition to childhood and adolescent cancers
Re-envisioning genetic predisposition to childhood and adolescent cancers
Although cancer is rare in children and adolescents, it remains a leading cause of death within this age range, and geneti...
Nanotubes power up T cells
Nanotubes power up T cells
Intercellular mitochondrial transfer via tunnelling nanotubes can influence cellular bioenergetics and function in tumours...
Identifying memory genes in cancer drug tolerance
In this Journal Club, Chakrabarti discusses a method to dissect the molecular architecture of inheritable gene expression ...
Androgen receptor signalling in non-prostatic malignancies: challenges and opportunities
Androgen receptor signalling in non-prostatic malignancies: challenges and opportunities
The androgen receptor (AR) signalling pathway has been intensively studied in the context of prostate cancer, where androg...
Chromothripsis in cancer
Chromothripsis in cancer
Chromothripsis is a mutational phenomenon in which a single catastrophic event generates extensive rearrangements of one o...
Dedicated centres and multinational platforms to improve patient care and address early-onset cancers
The incidence of early-onset cancers has increased by approximately 80% over the past three decades. These patients have u...
Genetic and epigenetic bases of long-term adverse effects of childhood cancer therapy
Genetic and epigenetic bases of long-term adverse effects of childhood cancer therapy
Over the past decade, genome-scale molecular profiling of large childhood cancer survivorship cohorts has led to unprecede...
Developing multiple EGFR-mutant lung cancers
Developing multiple EGFR-mutant lung cancers
The occurrence of multiple independent tumours in patients with EGFR-mutant lung cancer was unexplained. A recent study in...
Fanconi anaemia pathway induces chromosome shattering
Fanconi anaemia pathway induces chromosome shattering
Engel et al. conducted a genetic screen in which they identified the Fanconi anaemia (FA) pathway as a driver of chromothr...
Characterization of the B cell receptor repertoire in melanoma
In this Journal Club, Chae and Chung discuss a study characterizing the differentiation and maturation of both tumour-resi...
Author Correction: The importance of 3D fibre architecture in cancer and implications for biomaterial model design
Authors and AffiliationsSchool of Veterinary Medicine & Science, Sutton Bonington Campus, University of Nottingham, Le...
Convergent inducers and effectors of T cell paralysis in the tumour microenvironment
Convergent inducers and effectors of T cell paralysis in the tumour microenvironment
Tumorigenesis embodies the formation of a heterotypic tumour microenvironment (TME) that, among its many functions, enable...
Stemness in solid malignancies: coping with immune attack
Stemness in solid malignancies: coping with immune attack
Immunotherapy has become a key new pillar of cancer treatment, and this has sparked interest in understanding mechanisms o...
Midkine crisis fuels age-related tumorigenesis
Midkine crisis fuels age-related tumorigenesis
Ageing is a well-accepted risk factor for developing cancer. Yan et al. used a preclinical rat model to study the mechanis...
The present and future of the Cancer Dependency Map
The present and future of the Cancer Dependency Map
Despite tremendous progress in the past decade, the complex and heterogeneous nature of cancer complicates efforts to iden...
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