SCI时时刷

search
+
Guardrails for the use of generalist AI in cancer care
Guardrails for the use of generalist AI in cancer care
Artificial narrow intelligence models, trained for specific intended purposes, have gained approval and recommendation for...
Combinatorial strategies to target RAS-driven cancers
Combinatorial strategies to target RAS-driven cancers
Although RAS was formerly considered undruggable, various agents that inhibit RAS or specific RAS oncoproteins have now be...
Programming immune escape
Programming immune escape
In a recent study published in Nature, Goto et al. explore mechanisms of immune evasion in early colorectal cancers and ad...
NET-working under stress
NET-working under stress
In this recent study, He et al. establish that chronic stress promotes metastasis through stress-induced formation of neut...
Lymphatic vessels in the age of cancer immunotherapy
Lymphatic vessels in the age of cancer immunotherapy
Lymphatic transport maintains homeostatic health and is necessary for immune surveillance, and yet lymphatic growth is oft...
Revealing genomic secrets of archival FFPE samples
In this Tools of the Trade article, Kaile Wang describes the development and use of Arc-well, a high-throughput single-cel...
Global post-mortem tissue donation programmes to accelerate cancer research
Global post-mortem tissue donation programmes to accelerate cancer research
Metastatic cancer represents the main cause of death in patients with cancer. However, basic and translational research is...
Hallmarks of sex bias in immuno-oncology: mechanisms and therapeutic implications
Hallmarks of sex bias in immuno-oncology: mechanisms and therapeutic implications
Sex differences are present across multiple non-reproductive organ cancers, with male individuals generally experiencing h...
Routes to second cancers
Routes to second cancers
Sánchez-Guixé et al. investigated the possible routes to second malignancies in survivors of paediatric cancer b...
Trastuzumab: dreams, desperation and hope
Trastuzumab: dreams, desperation and hope
The story of trastuzumab begins with Axel Ullrich’s dedication to the concept that receptor tyrosine kinases must be...
New pathogen on the block
New pathogen on the block
Fu et al. provide data indicating a pathogenic role for Streptococcus anginosus in gastric cancer.
Immunogenic cell death in cancer: targeting necroptosis to induce antitumour immunity
Immunogenic cell death in cancer: targeting necroptosis to induce antitumour immunity
Most metastatic cancers remain incurable due to the emergence of apoptosis-resistant clones, fuelled by intratumour hetero...
Catastrophic conformity
Catastrophic conformity
Recently published in Nature, Fan et al. demonstrate that accumulation of advanced glycation end-products in the extracell...
B-ring sterols to the rescue
B-ring sterols to the rescue
Two independent studies published in Nature implicate distal cholesterol biosynthesis in the regulation of ferroptosis and...
Protein lipidation in cancer: mechanisms, dysregulation and emerging drug targets
Protein lipidation in cancer: mechanisms, dysregulation and emerging drug targets
Protein lipidation describes a diverse class of post-translational modifications (PTMs) that is regulated by over 40 enzym...
Extrachromosomal DNA in cancer
Extrachromosomal DNA in cancer
Extrachromosomal DNA (ecDNA) has recently been recognized as a major contributor to cancer pathogenesis that is i...
Black voices in cancer research and oncology
Over the past few years, there has been an increasing realization that we need a more equal, diverse and inclusive culture...
Beyond genetics: driving cancer with the tumour microenvironment behind the wheel
Beyond genetics: driving cancer with the tumour microenvironment behind the wheel
Cancer has long been viewed as a genetic disease of cumulative mutations. This notion is fuelled by studies showing that a...
Fungi in cancer
Both the gut and the tumour microbiome are now established as crucial regulators of cancer phenotypes and have been implic...
Discovering new drivers of cancer aneuploidy
In this Tools of the Trade, Juliann Shih describes the development of BISCUT, which detects genomic loci that are subject ...
Cancer burden in low-income and middle-income countries
As cancer detection rates and therapy successes increase in high-income countries, it is predicted that over the next deca...
Nanoreceptors take down mutant p53
Nanoreceptors take down mutant p53
Mutant gain-of-function p53 is commonly found in human cancers. Huang, Cao, Qian et al. developed and validated the use of...
Inferring cancer metabolism from gene-expression data
In this Tools of the Trade article, Vakul Mohanty describes the development and use of METAFlux, a computational framework...
Multiplex protein imaging in tumour biology
Multiplex protein imaging in tumour biology
Tissue imaging has become much more colourful in the past decade. Advances in both experimental and analytical methods now...
Finding the needle in the haystack
Finding the needle in the haystack
Goddard et al. report that disseminated tumour cells evade T cell immunity due to their relative scarcity, which decreases...
Cholesterol-fuelled glioblastoma
Cholesterol-fuelled glioblastoma
Zhao et al. identified lymphatic endothelial-like cells in glioblastoma and demonstrated their role in promoting tumour gr...
Translating p53-based therapies for cancer into the clinic
Translating p53-based therapies for cancer into the clinic
Inactivation of the most important tumour suppressor gene TP53 occurs in most, if not all, human cancers. Loss of function...
Differentiating high-grade neuroendocrine neoplasms
In this Journal Club, Taboada and Riechelmann discuss the importance of a study outlining a novel neuroendocrine neoplasm ...
Linking cell mechanical memory and cancer metastasis
Linking cell mechanical memory and cancer metastasis
Metastasis causes most cancer-related deaths; however, the efficacy of anti-metastatic drugs is limited by incomplete unde...
Patient-derived organoids unveil sarcoma vulnerabilities
In this Journal Club, Góss dos Santos discusses a study that successfully generated sarcoma-derived organoid...
阅读更多
format_indent_increase