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A single-molecule liquid biopsy for cancer diagnosis
In this article, Efrat Shema describes EPINUC, a liquid biopsy method based on epigenetic profiling of nucleosomes from ce...
Tryptophan metabolite improves PDAC response rates and survival
Tryptophan metabolite improves PDAC response rates and survival
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obta...
Nucleotide metabolism: a pan-cancer metabolic dependency
Nucleotide metabolism: a pan-cancer metabolic dependency
Metabolic alterations are a key hallmark of cancer cells, and the augmented synthesis and use of nucleotide triphosphates ...
Obesity as a promoter in BRCA mutation carriers
Obesity as a promoter in BRCA mutation carriers
In this study, Bhardwaj et al. highlight the mechanistic link between elevated body mass index and breast epithelial cell ...
Studying large genomic deletions with MACHETE
In this Tools of the Trade article, Francisco Barriga describes the development and use of MACHETE, a flexible deletion en...
Fighting rare cancers: lessons from fibrolamellar hepatocellular carcinoma
Fighting rare cancers: lessons from fibrolamellar hepatocellular carcinoma
The fight against rare cancers faces myriad challenges, including missed or wrong diagnoses, lack of information and diagn...
Switching on cancer survival mechanisms
Switching on cancer survival mechanisms
In this study, the authors investigate the mechanistic basis of alternative telomere lengthening, a process that certain c...
Nutrient priming of the pre-metastatic niche
Nutrient priming of the pre-metastatic niche
Altea-Manzano et al. find that factors secreted by primary breast tumours or high-fat diet feeding enriches the fatty acid...
Activated neutrophils: the anti-hero
Activated neutrophils: the anti-hero
In this study, Linde et al. demonstrate how therapeutic activation of neutrophils leads to tumour eradication and reduced ...
INVADEseq to study the intratumoural microbiota at host single-cell resolution
In this Tools of the Trade article, Susan Bullman describes the development and use of INVADEseq, a single-cell RNA sequen...
The advent of immune stimulating CAFs in cancer
The advent of immune stimulating CAFs in cancer
The theory that cancer-associated fibroblasts (CAFs) are immunosuppressive cells has prevailed throughout the past decade....
A timeline of tumour-associated macrophage biology
A timeline of tumour-associated macrophage biology
Tumour progression is modulated by the local microenvironment. This environment is populated by many immune cells, of whic...
Epitranscriptomics of cancer microniches
In this Tools of the Trade article, Lee describes Select-seq, a novel method for generating epitranscriptomic data from mi...
Therapeutic targeting of tumour myeloid cells
Therapeutic targeting of tumour myeloid cells
Myeloid cells are pivotal within the immunosuppressive tumour microenvironment. The accumulation of tumour-modified myeloi...
LAP1 squeezes out ahead
LAP1 squeezes out ahead
In this study, Jung-Garcia et al. use in vitro and in vivo modelling to demonstrate the role of LAP1 in promoting melanoma...
Mechanisms driving the immunoregulatory function of cancer cells
Mechanisms driving the immunoregulatory function of cancer cells
Tumours display an astonishing variation in the spatial distribution, composition and activation state of immune cells, wh...
T cells feed into cancer immune escape
T cells feed into cancer immune escape
This study shows how the selective immune pressure in early-stage tumours drives interferon-γ-dependent metabolic rep...
Acetyl-CoA metabolism in cancer
Acetyl-CoA metabolism in cancer
Few metabolites can claim a more central and versatile role in cell metabolism than acetyl coenzyme A (acetyl-CoA). Acetyl...
Leptin fuels non-genetic skin tumour progression
Leptin fuels non-genetic skin tumour progression
To understand malignant progression, Yuan et al. delineate the complex crosstalk between cancer stem cells and their micro...
RNA splicing dysregulation and the hallmarks of cancer
RNA splicing dysregulation and the hallmarks of cancer
Dysregulated RNA splicing is a molecular feature that characterizes almost all tumour types. Cancer-associated splicing al...
STAT proteins in cancer: orchestration of metabolism
STAT proteins in cancer: orchestration of metabolism
Reprogrammed metabolism is a hallmark of cancer. However, the metabolic dependency of cancer, from tumour initiation throu...
Dendritic cells rise and shine
Dendritic cells rise and shine
In a study in Nature, Wang et al. describe how circadian rhythms can impact tumour suppression through their effects on de...
Author Correction: Learning to distinguish progressive and non-progressive ductal carcinoma in situ
These authors contributed equally: Anna K. Casasent, Mathilde M. Almekinders, Charlotta Mulder.Department of Genetics, MD ...
Biology, vulnerabilities and clinical applications of circulating tumour cells
Biology, vulnerabilities and clinical applications of circulating tumour cells
In recent years, exceptional technological advances have enabled the identification and interrogation of rare circulating ...
Targeting DNA damage response pathways in cancer
Targeting DNA damage response pathways in cancer
Cells have evolved a complex network of biochemical pathways, collectively known as the DNA damage response (DDR), to prev...
When the tumour is at bay, the CD8+ T cells come out to play
When the tumour is at bay, the CD8+ T cells come out to play
Two recent studies have demonstrated how senescent cancer cells alter their cell surface proteome to induce anti-tumour im...
Improving head and neck cancer therapies by immunomodulation of the tumour microenvironment
Improving head and neck cancer therapies by immunomodulation of the tumour microenvironment
Targeted immunotherapy has improved patient survival in head and neck squamous cell carcinoma (HNSCC), but less than 20% o...
Gut microbes produce novel genotoxic metabolites
Gut microbes produce novel genotoxic metabolites
In this study, Cao et al. identified previously undiscovered metabolites produced by human gut microbes that cause DNA dam...
How to keep your neighbourhood safe
How to keep your neighbourhood safe
Schmitt et al. describe an adaptive mechanism employed by colorectal cancers to handle pro-apoptotic chemotherapeutic insu...
Epithelial and stromal co-evolution and complicity in pancreatic cancer
Epithelial and stromal co-evolution and complicity in pancreatic cancer
Pancreatic ductal adenocarcinomas are distinguished by their robust desmoplasia, or fibroinflammatory response. Dominated ...
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