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Race influences the tumour microbiome
Luo et al. uncover strong associations between the tumour microbiome and race, a finding that further emphasises the need ...
Structural study could aid design of antifolates
Wright et al. reveal how methotrexate binds to the human reduced folate carrier and outline key features that will aid the...
Rethinking cancer targeting strategies in the era of smart cell therapeutics
Rethinking cancer targeting strategies in the era of smart cell therapeutics
In the past several decades, the development of cancer therapeutics has largely focused on precision targeting of single c...
Platelets limit liver tumours
Platelets limit liver tumours
Ma et al. demonstrate that platelets suppress liver tumour growth in the context of non-alcoholic fatty liver disease thro...
In vivo labelling system to study cell neighbourhoods
In this Tools of the Trade article, Luigi Ombrato describes the development of Cherry-niche, a cell labelling system, whic...
Operation mind control
Operation mind control
Xu, Yan et al. show that the hypothalamic–pituitary unit produces α-melanocyte-stimulating hormone in tumour-be...
Tumour avatars to model patients’ responses to immunotherapy
In this Tools of the Trade article, Daniela S. Thommen describes the development and use of a patient-derived tumour fragm...
Tracking genome evolution following p53 inactivation
Tracking genome evolution following p53 inactivation
Using a reporter system in a mouse model of pancreatic cancer, Baslan et al. detail the progression of genomic disruption ...
Immunobiology of high-grade serous ovarian cancer: lessons for clinical translation
Immunobiology of high-grade serous ovarian cancer: lessons for clinical translation
Treatment of high-grade serous ovarian cancer (HGSOC) remains challenging. Although HGSOC can potentially be responsive to...
Gliomas lean on pyrimidines
Gliomas lean on pyrimidines
In two studies published concurrently, Pal et al. and Shi et al. reveal that certain gliomas rely on the de novo synthesis...
Impersonating neurons
Impersonating neurons
Venkataramani et al. used longitudinal intravital two-photon imaging to track migrating glioblastoma cells in vivo, and id...
Resolving the spatial heterogeneity of cancer in 3D
In this Tools of the Trade article, Anne C. Rios describes the development of multispectral large-scale single-cell resolu...
How medical anthropology can contribute to cancer research
Medical anthropology is a social science that uses qualitative methods to better understand how people in different parts ...
Big data in basic and translational cancer research
Big data in basic and translational cancer research
Historically, the primary focus of cancer research has been molecular and clinical studies of a few essential pathways and...
Leaving cancer in the cold
Leaving cancer in the cold
Seki et al. show that exposure to cold suppresses tumour growth in mice through increasing glucose uptake and thermogenesi...
Local CAR manufacturing
Local CAR manufacturing
Chen et al. have developed a preclinical platform that enables the reprogramming of locoregional macrophages and microglia...
Strength lies in difference
Strength lies in difference
Cancer cells are characterized by transcriptional heterogeneity, which contributes to tumour progression, metastasis and t...
Oncofetal reprogramming in tumour development and progression
Oncofetal reprogramming in tumour development and progression
Embryonic development is characterized by rapidly dividing cells, cellular plasticity and a highly vascular microenvironme...
Mastering the use of cellular barcoding to explore cancer heterogeneity
Mastering the use of cellular barcoding to explore cancer heterogeneity
Tumours are often composed of a multitude of malignant clones that are genomically unique, and only a few of them may have...
Key role for microbiota in gut–bone crosstalk
Key role for microbiota in gut–bone crosstalk
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Cancer nanomedicine
The field of cancer nanomedicine seeks to overcome the inherent shortcomings of conventional cancer diagnostics and therap...
Hidden epithelial subtypes refine colorectal cancer classification
Hidden epithelial subtypes refine colorectal cancer classification
Using single-cell transcriptomic data, Joanito et al. reveal that colorectal cancers can be defined by the presence of one...
Natural killer cells in antitumour adoptive cell immunotherapy
Natural killer cells in antitumour adoptive cell immunotherapy
Natural killer (NK) cells comprise a unique population of innate lymphoid cells endowed with intrinsic abilities to identi...
Aristolochic acid-associated cancers: a public health risk in need of global action
Aristolochic acid-associated cancers: a public health risk in need of global action
Aristolochic acids (AAs) are a group of naturally occurring compounds present in many plant species of the Aristolochiacea...
AR blockers augment melanoma treatment
AR blockers augment melanoma treatment
Finding sex differences in the response of patients with melanoma to BRAF/MEK-targeted therapy, Vellano et al. show that t...
To sleep, perchance to spread
To sleep, perchance to spread
Diamantopoulou et al. have found that in both mouse models and patients with breast cancer, the timing of spontaneous circ...
Targeting telomeres: advances in telomere maintenance mechanism-specific cancer therapies
Targeting telomeres: advances in telomere maintenance mechanism-specific cancer therapies
Cancer cells establish replicative immortality by activating a telomere-maintenance mechanism (TMM), be it telomerase or t...
Z-nucleic acids give immunotherapy a boost
Z-nucleic acids give immunotherapy a boost
Zhang et al. demonstrate that the adenosine deaminase ADAR1 prevents responsiveness to immune checkpoint blockade (ICB) th...
Structural variations in cancer and the 3D genome
Structural variations in cancer and the 3D genome
Structural variations (SVs) affect more of the cancer genome than any other type of somatic genetic alteration but difficu...
The link between vitamin D and prostate cancer
In this Journal Club, Kanaan and Copeland discuss a study showing that a high 1,25(OH)2D:25(OH)D molar ratio, indicative o...