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The rhythm of the night
The rhythm of the night
Patient progression and response to immunotherapy are directly influenced by the presence and quality of tumour-infiltrati...
Why do patients with cancer die?
Why do patients with cancer die?
Cancer is a major cause of global mortality, both in affluent countries and increasingly in developing nations. Many patie...
The road less travelled
In our Roadmap articles, we ask authors to provide a sense of direction to a field, to encourage new lines of thinking and...
The importance of 3D fibre architecture in cancer and implications for biomaterial model design
The importance of 3D fibre architecture in cancer and implications for biomaterial model design
The need for improved prediction of clinical response is driving the development of cancer models with enhanced physiologi...
Exploiting temporal aspects of cancer immunotherapy
Exploiting temporal aspects of cancer immunotherapy
Many mechanisms underlying an effective immunotherapy-induced antitumour response are transient and critically time depend...
The path to leptomeningeal metastasis
The path to leptomeningeal metastasis
The leptomeninges, the cerebrospinal-fluid-filled tissues surrounding the central nervous system, play host to various pat...
Charting spatially resolved cell states with CytoSPACE
In this Tools of the Trade article, Erin Brown describes the development of CytoSPACE, a computational tool that aligns si...
Eliminating false positives
To establish microbiome-based screening for colorectal cancer, a study published in Nature Medicine tackled two key challe...
Defining clinically useful biomarkers of immune checkpoint inhibitors in solid tumours
Defining clinically useful biomarkers of immune checkpoint inhibitors in solid tumours
Although more than a decade has passed since the approval of immune checkpoint inhibitors (ICIs) for the treatment of mela...
Bone voyage: immune crosstalk sets sail
Bone voyage: immune crosstalk sets sail
Monteran et al. identified key interactions between granulocytes and T cells that promote an immunosuppressive bone microe...
No mutation, tumour initiation
No mutation, tumour initiation
Parreno et al. provide evidence for epigenetically initiated cancers in Drosophila and show that cancer develops after tra...
Liquid biopsies for Hodgkin lymphoma
In this Journal Club, Lim and Jeon discuss a recent study demonstrating the utility of noninvasive genomic profiling for s...
Author Correction: Developmental origins shape the paediatric cancer genome
Authors and AffiliationsDepartment of Computational Biology, St. Jude Children’s Research Hospital, Memphis, TN, USAXiaolo...
Finding the truth in science
Finding the truth in science
In a ‘publish or perish’ culture, some scientists may resort to questionable research practices or even fraud....
A guide to artificial intelligence for cancer researchers
A guide to artificial intelligence for cancer researchers
Artificial intelligence (AI) has been commoditized. It has evolved from a specialty resource to a readily accessible tool ...
Cancer therapy with antibodies
Cancer therapy with antibodies
The greatest challenge in cancer therapy is to eradicate cancer cells with minimal damage to normal cells. Targeted therap...
Taking a detour
Kong et al. have now shown that Knudson’s two-hit hypothesis can be circumvented through the actions of the...
Right ON target: a new RAS-GTP inhibitor
Right ON target: a new RAS-GTP inhibitor
Two studies published concurrently in Nature report the development and preclinical activity of RMC-7977, a multi-selectiv...
AACR 2024
The annual American Association for Cancer Research (AACR) meeting provides a platform for scientists, clinicians and othe...
A MEGA RNA-editing tool
In this Tools of the Trade article, Victor Tieu describes the development of MEGA, a platform that exploits the RNA-target...
Histological transformation to small-cell carcinoma
In this Journal Club, Oh and Kim discuss a study demonstrating the mechanisms underlying histological transformation of lu...
Connie J. Eaves (1944–2024)
Connie J. Eaves (1944–2024)
Connie Eaves, a formidable figure and a global authority on haematopoietic, mammary and cancer stem c...
Developmental origins shape the paediatric cancer genome
Developmental origins shape the paediatric cancer genome
In the past two decades, technological advances have brought unprecedented insights into the paediatric cancer genome reve...
Too much of a good thing
Too much of a good thing
Dias et al. have shown that intentional further activation of oncogenic signalling rather than its inhibition represents a...
Using the tumour microenvironment to improve therapy efficacy
Targeted anticancer agents and chemotherapies exploit vulnerabilities intrinsic to cancer cells. However, evidence suggest...
Investigating immune cells across time in vivo
In this Tools of the Trade article, Daniel Kirschenbaum describes the development of Zman-seq and its utility for capturin...
Guardrails for the use of generalist AI in cancer care
Guardrails for the use of generalist AI in cancer care
Artificial narrow intelligence models, trained for specific intended purposes, have gained approval and recommendation for...
Combinatorial strategies to target RAS-driven cancers
Combinatorial strategies to target RAS-driven cancers
Although RAS was formerly considered undruggable, various agents that inhibit RAS or specific RAS oncoproteins have now be...
Programming immune escape
Programming immune escape
In a recent study published in Nature, Goto et al. explore mechanisms of immune evasion in early colorectal cancers and ad...
NET-working under stress
NET-working under stress
In this recent study, He et al. establish that chronic stress promotes metastasis through stress-induced formation of neut...