SCI时时刷

search
+
Conventional chemotherapy: millions of cures, unresolved therapeutic index
Conventional chemotherapy: millions of cures, unresolved therapeutic index
In recent decades, millions of patients with cancer have been cured by chemotherapy alone. By ‘cure’, we mean ...
PDX models for functional precision oncology and discovery science
PDX models for functional precision oncology and discovery science
Precision oncology relies on detailed molecular analysis of how diverse tumours respond to various therapies, with the aim...
Lactate gives a sour taste
Lactate gives a sour taste
Wang et al. demonstrate that lactate derived from glioblastoma stem cells, microglia and macrophages drives histone lactyl...
Re-envisioning genetic predisposition to childhood and adolescent cancers
Re-envisioning genetic predisposition to childhood and adolescent cancers
Although cancer is rare in children and adolescents, it remains a leading cause of death within this age range, and geneti...
Nanotubes power up T cells
Nanotubes power up T cells
Intercellular mitochondrial transfer via tunnelling nanotubes can influence cellular bioenergetics and function in tumours...
Identifying memory genes in cancer drug tolerance
In this Journal Club, Chakrabarti discusses a method to dissect the molecular architecture of inheritable gene expression ...
Androgen receptor signalling in non-prostatic malignancies: challenges and opportunities
Androgen receptor signalling in non-prostatic malignancies: challenges and opportunities
The androgen receptor (AR) signalling pathway has been intensively studied in the context of prostate cancer, where androg...
Chromothripsis in cancer
Chromothripsis in cancer
Chromothripsis is a mutational phenomenon in which a single catastrophic event generates extensive rearrangements of one o...
Dedicated centres and multinational platforms to improve patient care and address early-onset cancers
The incidence of early-onset cancers has increased by approximately 80% over the past three decades. These patients have u...
Genetic and epigenetic bases of long-term adverse effects of childhood cancer therapy
Genetic and epigenetic bases of long-term adverse effects of childhood cancer therapy
Over the past decade, genome-scale molecular profiling of large childhood cancer survivorship cohorts has led to unprecede...
Developing multiple EGFR-mutant lung cancers
Developing multiple EGFR-mutant lung cancers
The occurrence of multiple independent tumours in patients with EGFR-mutant lung cancer was unexplained. A recent study in...
Fanconi anaemia pathway induces chromosome shattering
Fanconi anaemia pathway induces chromosome shattering
Engel et al. conducted a genetic screen in which they identified the Fanconi anaemia (FA) pathway as a driver of chromothr...
Characterization of the B cell receptor repertoire in melanoma
In this Journal Club, Chae and Chung discuss a study characterizing the differentiation and maturation of both tumour-resi...
Author Correction: The importance of 3D fibre architecture in cancer and implications for biomaterial model design
Authors and AffiliationsSchool of Veterinary Medicine & Science, Sutton Bonington Campus, University of Nottingham, Le...
Convergent inducers and effectors of T cell paralysis in the tumour microenvironment
Convergent inducers and effectors of T cell paralysis in the tumour microenvironment
Tumorigenesis embodies the formation of a heterotypic tumour microenvironment (TME) that, among its many functions, enable...
Stemness in solid malignancies: coping with immune attack
Stemness in solid malignancies: coping with immune attack
Immunotherapy has become a key new pillar of cancer treatment, and this has sparked interest in understanding mechanisms o...
Midkine crisis fuels age-related tumorigenesis
Midkine crisis fuels age-related tumorigenesis
Ageing is a well-accepted risk factor for developing cancer. Yan et al. used a preclinical rat model to study the mechanis...
The present and future of the Cancer Dependency Map
The present and future of the Cancer Dependency Map
Despite tremendous progress in the past decade, the complex and heterogeneous nature of cancer complicates efforts to iden...
High-resolution measurement of individual telomere lengths with Telo-seq
In this Tools of the Trade article, Carly Tyer describes the development of Telo-seq, a method to enrich and sequence all ...
Emerging strategies to investigate the biology of early cancer
Emerging strategies to investigate the biology of early cancer
Early detection and intervention of cancer or precancerous lesions hold great promise to improve patient survival. However...
Epigenomic heterogeneity as a source of tumour evolution
Epigenomic heterogeneity as a source of tumour evolution
In the past decade, remarkable progress in cancer medicine has been achieved by the development of treatments that target ...
New horizons in our understanding of precursor multiple myeloma and early interception
New horizons in our understanding of precursor multiple myeloma and early interception
Multiple myeloma is an incurable plasma cell malignancy that evolves over decades through the selection and malignant tran...
Immunoproteasome as a biomarker for immunotherapy
In this Journal Club, Sabarinathan discusses a study suggesting immunoproteasome expression as a potential biomarker of re...
Encoding spatial tumour dynamics with Starfysh
In this Tools of the Trade article, Siyu He describes the development of Starfysh, a computational toolbox that integrates...
Four-pronged attack on PDAC
Four-pronged attack on PDAC
Chibaya, DeMarco et al. investigated a combinatorial approach of delivering innate immune agonists and RAS pathway-targete...
Steering research on mRNA splicing in cancer towards clinical translation
Steering research on mRNA splicing in cancer towards clinical translation
Splicing factors are affected by recurrent somatic mutations and copy number variations in several types of haematologic a...
Male melanoma comes of age
Male melanoma comes of age
In a recent study published in Cell, Chhabra et al. identify age- and sex-dependent changes in skin fibroblasts that drive...
Cancer-induced systemic pre-conditioning of distant organs: building a niche for metastatic cells
Cancer-induced systemic pre-conditioning of distant organs: building a niche for metastatic cells
From their early genesis, tumour cells integrate with the surrounding normal cells to form an abnormal structure that is t...
Compressive stresses in cancer: characterization and implications for tumour progression and treatment
Compressive stresses in cancer: characterization and implications for tumour progression and treatment
Beyond their many well-established biological aberrations, solid tumours create an abnormal physical microenvironment that...
Challenging the status quo to improve the translational potential of preclinical oncology studies
The precision medicine era has precipitated inherent new challenges to the preclinical tumour biology field. Overall, cont...
阅读更多
format_indent_increase