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Prime editing GEMMs to model cancer mutations
In this Tool of the Trade article, Nicolas Mathey-Andrews describes the generation and use of a prime editor mouse that en...
Harnessing the influenza virus to fight cancer
In this Tools of the Trade article, Dezhong Ji describes the development and use of a chimeric antigenic peptide influenza...
Computing brain metastasis impact
Computing brain metastasis impact
In a recent study, Sanchez-Aguilera, Masmudi-Martín et al. find that a molecular program explains the cognitive impai...
Tertiary lymphoid structures as hubs of antitumour immunity
In this Journal Club, Kinker & Medina discuss a study showing the role of tumour-associated tertiary lymphoid stru...
Enhanced transposable elements
Enhanced transposable elements
Karttunen et al. identify the contribution of transposable elements to gene regulatory function in colorectal and liver ca...
Synaptic activity promotes melanoma formation
Synaptic activity promotes melanoma formation
In a recent study, Tagore et al. find that the formation of synapse-like structures that serve to transfer GABA between pr...
Research does not happen in a socio-political vacuum — we should not pretend that it does
Research does not happen in a socio-political vacuum — we should not pretend that it does
On the basis of personal experiences and in light of current US socio-political realities, Eric Lau advocates for proactiv...
Identification of personalized cancer neoantigens with HANSolo
In this Tools of the Trade article, Chiara Cattaneo describes the development of HANSolo, a high-throughput genetic platfo...
Bridging live-cell imaging and next-generation cancer treatment
Bridging live-cell imaging and next-generation cancer treatment
By providing spatial, molecular and morphological data over time, live-cell imaging can provide a deeper understanding of ...
Advances in the structure, mechanism and targeting of chemoresistance-linked ABC transporters
Advances in the structure, mechanism and targeting of chemoresistance-linked ABC transporters
Cancer cells frequently display intrinsic or acquired resistance to chemically diverse anticancer drugs, limiting therapeu...
Patient-derived iPSCs to study blood cancer
In this Tools of the Trade article, Emmanuel Olivier describes an approach to reprogramming AML cancer cells into induced ...
Targeting sex steroid biosynthesis for breast and prostate cancer therapy
Targeting sex steroid biosynthesis for breast and prostate cancer therapy
Sex steroids are major promoters of the growth of breast and prostate cancers. This Review by Poutanen et al. describes th...
Maximize your research impact with storytelling
Maximize your research impact with storytelling
An often undervalued skill in science, storytelling is a powerful tool for communicating research to diverse audi...
Epigenetic lesions drive gliomagenesis
Epigenetic lesions drive gliomagenesis
Rahme et al. establish an in vivo model for low-grade glioma, and use it to demonstrate that Pdgfra insulator loss and Cdk...
METTL3 inhibition enhances anti-tumour immunity
METTL3 inhibition enhances anti-tumour immunity
In this study, Guirguis et al. show mechanistically how preventing m6A RNA modification through inhibition of METTL3 can p...
Targeting aberrant splicing
Targeting aberrant splicing
Bland et al. show that cancer types with heterozygous somatic hotspot mutations in the spliceosome component SF3B1 are vul...
AT1 cells appear centre stage
AT1 cells appear centre stage
Two independent studies published together in Nature find that AT1 cells can have a role in both the initiation and suppre...
ARPLA for spatial imaging of glycoRNAs
In this Tools of the Trade article, Yuan Ma describes the development and use of ARPLA, a spatial imaging tool that can be...
The circ du RNA
The circ du RNA
In this study, Conn et al. functionally link circular RNA and DNA interactions with chromosomal translocation in leukaemog...
Long-range gene regulation in hormone-dependent cancer
Long-range gene regulation in hormone-dependent cancer
The human genome is organized into multiple structural layers, ranging from chromosome territories to progressively smalle...
Addicted to extra chromosomes
Addicted to extra chromosomes
Girish et al. designed a method to genetically remove extra chromosomes from human aneuploid cancer cells to show that the...
Cancers make their own luck: theories of cancer origins
Cancers make their own luck: theories of cancer origins
Cancer has been a leading cause of death for decades. This dismal statistic has increased efforts to prevent the disease o...
FSP1 in cancer: not just a phase
FSP1 in cancer: not just a phase
Inducing ferroptosis in cancer cells has become a realistic method for promoting cancer cell death. In this study, Nakarmu...
Therapeutic resistance to anti-oestrogen therapy in breast cancer
Therapeutic resistance to anti-oestrogen therapy in breast cancer
The hormone receptor oestrogen receptor-α (ER) orchestrates physiological mammary gland development, breast carcinoge...
Lessons in gastric adenocarcinoma from TCGA
In this Journal Club, Felismino and Coimbra discuss the impact of TCGA’s comprehensive molecular characterization of...
Polygenic scores in cancer
Polygenic scores in cancer
Since the publication of the first genome-wide association study for cancer in 2007, thousands of common alleles that are ...
Pathogenesis of cancers derived from thyroid follicular cells
Pathogenesis of cancers derived from thyroid follicular cells
The genomic simplicity of differentiated cancers derived from thyroid follicular cells offers unique insights into how onc...
The Y chromosome as a risk factor
The Y chromosome as a risk factor
Two independent studies published in Nature have collectively addressed the long-standing question of sex bias in cancer a...
Bacteria in cancer initiation, promotion and progression
Bacteria in cancer initiation, promotion and progression
Cancer cells originate from a series of acquired genetic mutations that can drive their uncontrolled cell proliferation an...
Feeding latent brain metastasis
Feeding latent brain metastasis
In this study, Malladi and colleagues reveal the mechanism by which mitochondrial fragmentation enables latent brain metas...
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