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Chromothripsis in cancer
Chromothripsis in cancer
Chromothripsis is a mutational phenomenon in which a single catastrophic event generates extensive rearrangements of one o...
Dedicated centres and multinational platforms to improve patient care and address early-onset cancers
The incidence of early-onset cancers has increased by approximately 80% over the past three decades. These patients have u...
Genetic and epigenetic bases of long-term adverse effects of childhood cancer therapy
Genetic and epigenetic bases of long-term adverse effects of childhood cancer therapy
Over the past decade, genome-scale molecular profiling of large childhood cancer survivorship cohorts has led to unprecede...
Developing multiple EGFR-mutant lung cancers
Developing multiple EGFR-mutant lung cancers
The occurrence of multiple independent tumours in patients with EGFR-mutant lung cancer was unexplained. A recent study in...
Fanconi anaemia pathway induces chromosome shattering
Fanconi anaemia pathway induces chromosome shattering
Engel et al. conducted a genetic screen in which they identified the Fanconi anaemia (FA) pathway as a driver of chromothr...
Characterization of the B cell receptor repertoire in melanoma
In this Journal Club, Chae and Chung discuss a study characterizing the differentiation and maturation of both tumour-resi...
Author Correction: The importance of 3D fibre architecture in cancer and implications for biomaterial model design
Authors and AffiliationsSchool of Veterinary Medicine & Science, Sutton Bonington Campus, University of Nottingham, Le...
Convergent inducers and effectors of T cell paralysis in the tumour microenvironment
Convergent inducers and effectors of T cell paralysis in the tumour microenvironment
Tumorigenesis embodies the formation of a heterotypic tumour microenvironment (TME) that, among its many functions, enable...
Stemness in solid malignancies: coping with immune attack
Stemness in solid malignancies: coping with immune attack
Immunotherapy has become a key new pillar of cancer treatment, and this has sparked interest in understanding mechanisms o...
Midkine crisis fuels age-related tumorigenesis
Midkine crisis fuels age-related tumorigenesis
Ageing is a well-accepted risk factor for developing cancer. Yan et al. used a preclinical rat model to study the mechanis...
The present and future of the Cancer Dependency Map
The present and future of the Cancer Dependency Map
Despite tremendous progress in the past decade, the complex and heterogeneous nature of cancer complicates efforts to iden...
High-resolution measurement of individual telomere lengths with Telo-seq
In this Tools of the Trade article, Carly Tyer describes the development of Telo-seq, a method to enrich and sequence all ...
Emerging strategies to investigate the biology of early cancer
Emerging strategies to investigate the biology of early cancer
Early detection and intervention of cancer or precancerous lesions hold great promise to improve patient survival. However...
Epigenomic heterogeneity as a source of tumour evolution
Epigenomic heterogeneity as a source of tumour evolution
In the past decade, remarkable progress in cancer medicine has been achieved by the development of treatments that target ...
New horizons in our understanding of precursor multiple myeloma and early interception
New horizons in our understanding of precursor multiple myeloma and early interception
Multiple myeloma is an incurable plasma cell malignancy that evolves over decades through the selection and malignant tran...
Immunoproteasome as a biomarker for immunotherapy
In this Journal Club, Sabarinathan discusses a study suggesting immunoproteasome expression as a potential biomarker of re...
Encoding spatial tumour dynamics with Starfysh
In this Tools of the Trade article, Siyu He describes the development of Starfysh, a computational toolbox that integrates...
Four-pronged attack on PDAC
Four-pronged attack on PDAC
Chibaya, DeMarco et al. investigated a combinatorial approach of delivering innate immune agonists and RAS pathway-targete...
Steering research on mRNA splicing in cancer towards clinical translation
Steering research on mRNA splicing in cancer towards clinical translation
Splicing factors are affected by recurrent somatic mutations and copy number variations in several types of haematologic a...
Male melanoma comes of age
Male melanoma comes of age
In a recent study published in Cell, Chhabra et al. identify age- and sex-dependent changes in skin fibroblasts that drive...
Cancer-induced systemic pre-conditioning of distant organs: building a niche for metastatic cells
Cancer-induced systemic pre-conditioning of distant organs: building a niche for metastatic cells
From their early genesis, tumour cells integrate with the surrounding normal cells to form an abnormal structure that is t...
Compressive stresses in cancer: characterization and implications for tumour progression and treatment
Compressive stresses in cancer: characterization and implications for tumour progression and treatment
Beyond their many well-established biological aberrations, solid tumours create an abnormal physical microenvironment that...
Challenging the status quo to improve the translational potential of preclinical oncology studies
The precision medicine era has precipitated inherent new challenges to the preclinical tumour biology field. Overall, cont...
Protection against tumour formation
Protection against tumour formation
Ciwinska et al. asked whether natural tissue remodelling can drive mutant cell expansion and identified three protective m...
Modelling and deciphering tumour metabolism in CRISPR screens
Modelling and deciphering tumour metabolism in CRISPR screens
Cell culture-based CRISPR screens have become instrumental in functionally annotating the human genome and identifying can...
Defining precancer: a grand challenge for the cancer community
Defining precancer: a grand challenge for the cancer community
The term ‘precancer’ typically refers to an early stage of neoplastic development that is distinguishable from...
Macrophages and T cells in metabolic disorder-associated cancers
Macrophages and T cells in metabolic disorder-associated cancers
Cancer and metabolic disorders have emerged as major global health challenges, reaching epidemic levels in recent decades....
A standing platform for cancer drug development using ctDNA-based evidence of recurrence
A standing platform for cancer drug development using ctDNA-based evidence of recurrence
The time required to conduct clinical trials limits the rate at which we can evaluate and deliver new treatment options to...
The recruitment of metastasis-associated monocytes
In this Journal Club, Kim and Jung discuss a study that demonstrates the role of CCL2 in recruiting monocytes to the metas...
VIBRANT: mapping cell phenotypes using vibrational spectroscopy
In this Tools of the Trade article, Xinwen Liu describes the development of VIBRANT, a vibrational spectroscopy method for...
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