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Prevalence, characteristics and outcome of cardiac manifestations in critically-ill antiphospholipid syndrome patients
AimsAntiphospholipid syndrome (APS) is a rare autoimmune disease defined by thrombotic events occurring in patients with p...
Acute-type acquired hemophilia A after COVID-19 mRNA vaccine administration: A new disease entity?
Volume 133, December 2022, 102915Highlights•COVID-19 mRNA vaccines may cause acquired hemophilia A (AHA), even in young pa...
Regulatory B cells in patients suffering from inborn errors of immunity with severe immune dysregulation
Volume 132, October 2022, 102891Highlights•Breg profile of patients with severe symptoms of immune dysregulation due to in...
Coronavirus disease 2019, vaccination against coronavirus and immunoglobulin A-mediated diseases: systematic literature review
Volume 132, October 2022, 102899Highlights•Systematic literature review on IgA-diseases associated to SARS-CoV-2 infection...
zVAD alleviates experimental autoimmune hepatitis in mice by increasing the sensitivity of macrophage to TNFR1-dependent necroptosis
Background & aimsAutoimmune hepatitis (AIH) is characterized by hepatocyte destruction, leading to lymphocyte and macr...
Epidemiology of granulomatosis with polyangiitis and microscopic polyangiitis in adults in France
Background.Granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) are rare systemic necrotizing vasculi...
Antigen-specific immune reactions by expanded CD8+ T cell clones from HLA-B*27-positive patients with spondyloarthritis
Spondyloarthritis (SpA) is a chronic inflammatory disease that is tightly linked to HLA-B*27 but the pathophysiological ba...
Glucocorticoid use as a cause of non-cellular immune response to SARS-Cov2 Spike in patients with immune system diseases
Disease modifying therapies compromise immune response to SARS-Cov2 or its vaccine in patients with immune system diseases...
Control of naive and effector CD4 T cell receptor repertoires by rheumatoid-arthritis-risk HLA alleles
ObjectiveHuman Leukocyte Antigen (HLA) alleles regulate susceptibility to rheumatoid arthritis (RA) and immune-mediated di...
Divergent regulatory T cell responses to high-dose methylprednisolone and tocilizumab in giant cell arteritis
Volume 133, December 2022, 102909Highlights•The clinical data of the proof-of-concept-study about tocilizumab (TCZ) monoth...
Evidence for charge-based mimicry in anti dsDNA antibody generation
Mechanisms for the generation of anti-dsDNA autoantibodies are still not completely elucidated. One theory states that dsD...
SARS-CoV-2 vaccination and risk of severe COVID-19 outcomes in patients with autoimmune hepatitis
BackgroundData regarding outcome of Coronavirus disease 2019 (COVID-19) in vaccinated patients with autoimmune hepatitis (...
Forced Fox-P3 expression can improve the safety and antigen-specific function of engineered regulatory T cells
Regulatory T cells (Treg) are potent inhibitors of autoreactive T cells. The intracellular transcription factor FoxP3 cont...
Poor responses and adverse outcomes of myasthenia gravis after thymectomy: Predicting factors and immunological implications
Myasthenia gravis (MG) has been recognized as a series of heterogeneous but treatable autoimmune conditions. As one of the...
SB431542 alleviates lupus nephritis by regulating B cells and inhibiting the TLR9/TGFβ1/PDGFB signaling
Volume 132, October 2022, 102894Highlights•The effective treatment of lupus nephritis is still difficult.•SB431542 improve...
Neuropsychiatric lupus erythematosus: Focusing on autoantibodies
Available online 25 August 2022, 102892Highlights•The pathogenesis of lupus-specific autoantibodies distinguish NPLE from ...
Systemic lupus erythematosus-complicating immune thrombocytopenia: From pathogenesis to treatment
Available online 25 August 2022, 102887Highlights•Severe thrombocytopenia is a poor prognostic factor for SLE and is assoc...
Dual B-cell targeting therapy ameliorates autoimmune cholangitis
ObjectiveThe ability to regulate B cell development has long been recognized to have therapeutic potential in a variety of...
Autoimmune and autoinflammatory conditions after COVID-19 vaccination. New case reports and updated literature review
Autoimmunity linked to COVID-19 immunization has been recorded throughout the pandemic. Herein we present six new patients...
IgA-diseases associated to SARS-CoV-2 infection or vaccination: A systematic literature review
Coronavirus disease 2019 (COVID-19) and vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) h...
Lupus nephritis: new progress in diagnosis and treatment
Systemic lupus erythematosus (SLE) is a chronic multifactorial autoimmune disease that affects many organs, including the ...
COVID-19 mRNA vaccine BNT162b2 induces autoantibodies against type I interferons in a healthy woman
Coronavirus disease (COVID-19) caused by SARS-CoV-2 virus is associated with a wide range of clinical manifestations, incl...
Sex-specific analysis in Behçet's disease reveals higher genetic risk in male patients
Volume 132, October 2022, 102882Highlights•Male patients with Behçet's disease have a higher disease genetic risk.•Genetic...
Phosphatase control of cytokine-mediated overproduction of galactose-deficient IgA1, the main autoantigen in IgA nephropathy
IgA nephropathy (IgAN) is an autoimmune disease characterized by the deposition of galactose-deficient IgA1 (Gd-IgA1)-cont...
Renal and vascular outcomes in patients with isolated antiphospholipid syndrome nephropathy
BackgroundAntiphospholipid syndrome (APS) nephropathy (APSN) is a rare pattern with specific features resulting from micro...