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Associations between CD70 methylation of T cell DNA and age in adults with systemic lupus erythematosus and population controls: The Michigan Lupus Epidemiology & Surveillance (MILES) Program
Associations between CD70 methylation of T cell DNA and age in adults with systemic lupus erythematosus and population controls: The Michigan Lupus Epidemiology & Surveillance (MILES) Program
Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease for which specific etiologic agents remain largely u...
High-resolution HLA genotyping in inclusion body myositis refines 8.1 ancestral haplotype association to DRB1*03:01:01 and highlights pathogenic role of arginine-74 of DRβ1 chain
High-resolution HLA genotyping in inclusion body myositis refines 8.1 ancestral haplotype association to DRB1*03:01:01 and highlights pathogenic role of arginine-74 of DRβ1 chain
ObjectivesInclusion body myositis (IBM) is a progressive inflammatory-degenerative muscle disease of older individuals, wi...
Neointimal myofibroblasts contribute to maintaining Th1/Tc1 and Th17/Tc17 inflammation in giant cell arteritis
Neointimal myofibroblasts contribute to maintaining Th1/Tc1 and Th17/Tc17 inflammation in giant cell arteritis
Vascular smooth muscle cells (VSMCs) have been shown to play a role in the pathogenesis of giant cell arteritis (GCA) thro...
AIM/CD5L ameliorates autoimmune arthritis by promoting removal of inflammatory DAMPs at the lesions
AIM/CD5L ameliorates autoimmune arthritis by promoting removal of inflammatory DAMPs at the lesions
Volume 142, January 2024, 103149Author links open overlay panel, , , , , , , , , , , Highlights•Autoimmune arthritis is re...
2023 International Consensus Guidance for the use of Tripterygium Wilfordii Hook F in the treatment of active rheumatoid arthritis
2023 International Consensus Guidance for the use of Tripterygium Wilfordii Hook F in the treatment of active rheumatoid arthritis
BackgroundRheumatoid arthritis (RA) is a chronic autoimmune disorder that affects the joints and produces pain, swelling, ...
Lung transplantation in pulmonary sarcoidosis
Lung transplantation in pulmonary sarcoidosis
Sarcoidosis is a multisystem inflammatory disease characterized by noncaseating granulomas of unknown etiology [1,2]. Up t...
Targeting NF-κB signaling in B cells as a potential new treatment modality for ANCA-associated vasculitis
Targeting NF-κB signaling in B cells as a potential new treatment modality for ANCA-associated vasculitis
B lineage cells are critically involved in ANCA-associated vasculitis (AAV), evidenced by alterations in circulating B cel...
Novel biomarker discovery through comprehensive proteomic analysis of lupus mouse serum
Novel biomarker discovery through comprehensive proteomic analysis of lupus mouse serum
Systemic lupus erythematosus (SLE; lupus) primarily affects women of reproductive age [1]. Unpredictable flares of inflamm...
Integrative single-cell analysis reveals distinct adaptive immune signatures in the cutaneous lesions of pemphigus
Integrative single-cell analysis reveals distinct adaptive immune signatures in the cutaneous lesions of pemphigus
Pemphigus is an organ-specific autoimmune bullous disease characterized by the presence of IgG autoantibodies (autoAbs) ta...
Single-cell transcriptomic profiling reveals a pathogenic role of cytotoxic CD4+ T cells in giant cell arteritis
Single-cell transcriptomic profiling reveals a pathogenic role of cytotoxic CD4+ T cells in giant cell arteritis
Giant cell arteritis (GCA) is a systemic vasculitis mediated by an aberrant immunological response against the blood vesse...
Novel and unique rheumatoid factors cross-react with viral epitopes in COVID-19
Novel and unique rheumatoid factors cross-react with viral epitopes in COVID-19
Rheumatoid factors (RFs) are antibodies of any isotype that bind the Fc region of IgG. Initially discovered in 1939 [1], R...
K2P2.1 is a regulator of inflammatory cell responses in idiopathic inflammatory myopathies
K2P2.1 is a regulator of inflammatory cell responses in idiopathic inflammatory myopathies
K2P2.1 (TREK1), a two-pore domain potassium channel, has emerged as regulator of leukocyte transmigration into the central...
Pathogenicity of functionally activated PD-1+CD8+ cells and counterattacks by muscular PD-L1 through IFNγ in myositis
Pathogenicity of functionally activated PD-1+CD8+ cells and counterattacks by muscular PD-L1 through IFNγ in myositis
Polymyositis (PM) and dermatomyositis (DM), subsets of idiopathic inflammatory myopathies (IIMs), are chronic autoimmune d...
Risk factors for hypogammaglobulinemia and association with relapse and severe infections in ANCA-associated vasculitis: A cohort study
Risk factors for hypogammaglobulinemia and association with relapse and severe infections in ANCA-associated vasculitis: A cohort study
Antineutrophil cytoplasm antibodies (ANCA)-associated vasculitides (AAV) are systemic inflammatory diseases characterized ...
Isolation and characterisation of PR3-specific B cells and their immunoglobulin sequences
Isolation and characterisation of PR3-specific B cells and their immunoglobulin sequences
BackgroundPR3 autoantibodies are essential to the diagnosis and monitoring of granulomatosus with polyangiitis, but to dat...
Genetic predisposition to sarcoidosis
Genetic predisposition to sarcoidosis
Sarcoidosis is a complex systemic disease characterized by the formation of granulomas in various organs. Predominantly af...
Pulmonary sarcoidosis: A comprehensive review: Past to present
Pulmonary sarcoidosis: A comprehensive review: Past to present
Sarcoidosis is a sterile non-necrotizing granulomatous disease without known causes that can involve multiple organs with ...
Circulating T cells in sarcoidosis have an aberrantly activated phenotype that correlates with disease outcome
Circulating T cells in sarcoidosis have an aberrantly activated phenotype that correlates with disease outcome
Available online 18 October 2023, 103120Author links open overlay panel, , , , , , , , , Highlights•Disease course in sarc...
Rapamycin nanoparticles increase the therapeutic window of engineered interleukin-2 and drive expansion of antigen-specific regulatory T cells for protection against autoimmune disease
Rapamycin nanoparticles increase the therapeutic window of engineered interleukin-2 and drive expansion of antigen-specific regulatory T cells for protection against autoimmune disease
KeywordsAntigen-specific immune toleranceRegulatory T cellsInterleukin-2Autoimmune diseaseType 1 diabetesPrimary biliary c...
Cognition following chimeric antigen receptor T-cell therapy: A systematic review
Cognition following chimeric antigen receptor T-cell therapy: A systematic review
BackgroundThis systematic review aimed to characterise the cognitive outcomes of patients who received chimeric antigen re...
Autoreactive T cells targeting type II pneumocyte antigens in COVID-19 convalescent patients
Autoreactive T cells targeting type II pneumocyte antigens in COVID-19 convalescent patients
Conceptualization and methodology: CL, MK, JA, LF; supervision: JA, LF; investigation and data collection: BB, CL, MK, FB,...
Autoimmune pancreatitis type 2 (idiopathic duct-centric pancreatitis): A comprehensive review
Autoimmune pancreatitis type 2 (idiopathic duct-centric pancreatitis): A comprehensive review
Autoimmune pancreatitis (AIP) is an atypical chronic pancreatic fibro-inflammatory condition presenting with autoimmune/in...
Sarcoidosis and its relation to other immune-mediated diseases: Epidemiological insights
Sarcoidosis and its relation to other immune-mediated diseases: Epidemiological insights
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Comparison of circulating and excreted metals and of autoimmunity between two Great Plains Tribal communities
Comparison of circulating and excreted metals and of autoimmunity between two Great Plains Tribal communities
More than one hundred years of hard rock mining left a complex environmental legacy of more than 160,000 abandoned mines i...
Quality of life in sarcoidosis
Quality of life in sarcoidosis
Having sarcoidosis often has a major impact on quality of life of patients and their families. Improving quality of life i...
In cis “benign” SOCS1 variants linked to enhanced interferon signaling and autoimmunity
In cis “benign” SOCS1 variants linked to enhanced interferon signaling and autoimmunity
Autoimmune diseases are caused by a breach of tolerance to self-antigens. Systemic lupus erythematosus (SLE) is a prototyp...
Environmental exposures as risk factors for idiopathic inflammatory myopathies
Environmental exposures as risk factors for idiopathic inflammatory myopathies
Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of rare autoimmune diseases, with increasing incidence ...
Prioritization of infectious epitopes for translational investigation in type 1 diabetes etiology
Prioritization of infectious epitopes for translational investigation in type 1 diabetes etiology
A growing body of evidence supports an important role for infectious agents in the onset of type 1 diabetes etiology [1,2]...
The gut ecosystem and immune tolerance
The gut ecosystem and immune tolerance
Available online 23 September 2023, 103114Author links open overlay panel, , , , , , , , , , , , Highlights•Interaction be...
Corrigendum to “Antibodies in cerebral cavernous malformations react with cytoskeleton autoantigens in the lesional milieu” [J. Autoimmun. 113 (2020) 102469]
Corrigendum to “Antibodies in cerebral cavernous malformations react with cytoskeleton autoantigens in the lesional milieu” [J. Autoimmun. 113 (2020) 102469]
Available online 23 September 2023, 103116Author links open overlay panelDongdong Zhang a b, Andrew J. Kinloch c 1, Abhina...
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