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A reverse translational approach reveals the protective roles of Mangifera indica in inflammatory bowel disease
A reverse translational approach reveals the protective roles of Mangifera indica in inflammatory bowel disease
Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), are chronic debilitating con...
Quantitative and structural changes of blood platelet cytoskeleton proteins in multiple sclerosis (MS)
Quantitative and structural changes of blood platelet cytoskeleton proteins in multiple sclerosis (MS)
KeywordsMultiple sclerosisBlood plateletsMegakaryocytesCytoskeleton proteinsβ1-tubulinβ-actinPlatelet overactivationPost-t...
Anti-DNA antibody-targeted D-peptide nanoparticles ameliorate lupus nephritis in MRL/lpr mice
Anti-DNA antibody-targeted D-peptide nanoparticles ameliorate lupus nephritis in MRL/lpr mice
Volume 145, May 2024, 103205Author links open overlay panel, , , , , , , , , , Highlights•Poor stability and non-kidney ta...
Targeting macrophages with phosphatidylserine-rich liposomes as a potential antigen-specific immunotherapy for type 1 diabetes
Targeting macrophages with phosphatidylserine-rich liposomes as a potential antigen-specific immunotherapy for type 1 diabetes
Type 1 diabetes (T1D) results from a breakdown in immunological tolerance, with pivotal involvement of antigen-presenting ...
Application of laboratory models for sarcoidosis research
Application of laboratory models for sarcoidosis research
Available online 4 March 2024, 103184Author links open overlay panel, Highlights•Recently developed laboratory models prov...
Ectopic CD4+ T cells in choroid plexus mediate neuropsychiatric lupus symptoms in mice via interferon-γ induced microglia activation
Ectopic CD4+ T cells in choroid plexus mediate neuropsychiatric lupus symptoms in mice via interferon-γ induced microglia activation
Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by the involvement of multiple organs [1]...
CADHERIN-11 regulation of myeloid phagocytes and autoimmune inflammation in murine lupus
CADHERIN-11 regulation of myeloid phagocytes and autoimmune inflammation in murine lupus
Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by autoantibody production, inflammation,...
Identifying the genetic association between systemic lupus erythematosus and the risk of autoimmune liver diseases
Identifying the genetic association between systemic lupus erythematosus and the risk of autoimmune liver diseases
Autoimmune liver diseases (AILDs) are uncommon, chronic hepatic disorders characterized by abnormal immune attack on hepat...
miR-146a and miR-146b regulate the expression of ICAM-1 in giant cell arteritis
miR-146a and miR-146b regulate the expression of ICAM-1 in giant cell arteritis
Giant cell arteritis (GCA) is a chronic inflammatory disease that affects large and medium-sized arteries. It is the most ...
Autoimmune diseases and female-specific cancer risk: A systematic review and meta-analysis
Autoimmune diseases and female-specific cancer risk: A systematic review and meta-analysis
Volume 144, April 2024, 103187Author links open overlay panel, , Highlights•Patients with rheumatoid arthritis show a redu...
Impact of muscle biopsy on the clinical decision-making process in patients with suspected idiopathic inflammatory myopathy
Impact of muscle biopsy on the clinical decision-making process in patients with suspected idiopathic inflammatory myopathy
BackgroundThe significance of muscle biopsy as a diagnostic tool in idiopathic inflammatory myopathies (IIM) remains elusi...
Modulation of PKM2 inhibits follicular helper T cell differentiation and ameliorates inflammation in lupus-prone mice
Modulation of PKM2 inhibits follicular helper T cell differentiation and ameliorates inflammation in lupus-prone mice
The growth, survival, and performance of immune effector functions of immune cells are closely linked to metabolism, and i...
P2RX7 gene variants associate with altered inflammasome assembly and reduced pyroptosis in chronic nonbacterial osteomyelitis (CNO)
P2RX7 gene variants associate with altered inflammasome assembly and reduced pyroptosis in chronic nonbacterial osteomyelitis (CNO)
Chronic nonbacterial osteomyelitis (CNO), an autoinflammatory bone disease primarily affecting children, can cause pain, h...
Repeated immunization with ATRA-containing liposomal adjuvant transdifferentiates Th17 cells to a Tr1-like phenotype
Repeated immunization with ATRA-containing liposomal adjuvant transdifferentiates Th17 cells to a Tr1-like phenotype
In many autoimmune diseases, autoantigen-specific Th17 cells play a pivotal role in disease pathogenesis. Th17 cells can t...
Risk factors for damage accrual in primary antiphospholipid syndrome: A retrospective single-center cohort study
Risk factors for damage accrual in primary antiphospholipid syndrome: A retrospective single-center cohort study
Antiphospholipid syndrome (APS) is a rare immune-mediated acquired thrombophilia mainly affecting young adults. It is char...
The enigma of sclera-specific autoimmunity in scleritis
The enigma of sclera-specific autoimmunity in scleritis
Scleritis is a severe and painful ophthalmic disorder, in which a pathogenic role for collagen-directed autoimmunity was r...
LIGHT signaling through LTβR and HVEM in keratinocytes promotes psoriasis and atopic dermatitis-like skin inflammation
LIGHT signaling through LTβR and HVEM in keratinocytes promotes psoriasis and atopic dermatitis-like skin inflammation
Skin inflammatory diseases like psoriasis (PS) and atopic dermatitis (AD) exhibit some features in common, including a thi...
T cell-mediated skin-brain axis: Bridging the gap between psoriasis and psychiatric comorbidities
T cell-mediated skin-brain axis: Bridging the gap between psoriasis and psychiatric comorbidities
Psoriasis represents a chronic inflammatory skin disorder and etiologically results from immune system dysregulation. Acro...
Age-related bone diseases: Role of inflammaging
Age-related bone diseases: Role of inflammaging
Bone aging is characterized by an imbalance in the physiological and pathological processes of osteogenesis, osteoclastoge...
The universal effects of low-dose interleukin-2 across 13 autoimmune diseases in a basket clinical trial
The universal effects of low-dose interleukin-2 across 13 autoimmune diseases in a basket clinical trial
Volume 144, April 2024, 103172Author links open overlay panel, , , , , , , , , , , , , , , , , , , …AbstractBackgroundA Tr...
Phenotypes in antiphospholipid syndrome: A hierarchical cluster analysis based on two independent databases
Phenotypes in antiphospholipid syndrome: A hierarchical cluster analysis based on two independent databases
Volume 144, April 2024, 103173Author links open overlay panel, , , , , , , AbstractBackgroundAntiphospholipid syndrome (AP...
CXCL12-CXCR4 mediates CD57+ CD8+ T cell responses in the progression of type 1 diabetes
CXCL12-CXCR4 mediates CD57+ CD8+ T cell responses in the progression of type 1 diabetes
Type 1 diabetes (T1D) is an autoimmune disease that prompted by autoreactive T cells, leading to the destruction of pancre...
IL-23 induces CLEC5A+ IL-17A+ neutrophils and elicit skin inflammation associated with psoriatic arthritis
IL-23 induces CLEC5A+ IL-17A+ neutrophils and elicit skin inflammation associated with psoriatic arthritis
IL-23 is a pleiotropic cytokine which is involved in many autoimmune diseases including psoriasis and psoriatic arthritis ...
Immunosuppression induces regression of fibrosis in primary biliary cholangitis with moderate-to-severe interface hepatitis
Immunosuppression induces regression of fibrosis in primary biliary cholangitis with moderate-to-severe interface hepatitis
MethodsWe conducted a multicenter study involving PBC patients with moderate-to-severe interface hepatitis who underwent p...
Older age of celiac disease diagnosis and risk of autoimmune disease: A nationwide matched case-control study
Older age of celiac disease diagnosis and risk of autoimmune disease: A nationwide matched case-control study
Volume 143, February 2024, 103170Author links open overlay panel, , , , , , , Highlights•The diagnosis of celiac disease p...