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Gut microbiome, metabolome, host immunity associated with inflammatory bowel disease and intervention of fecal microbiota transplantation
With rapidly accumulating knowledge on the impact of the microbiome on mammalian host in the past decade, gut dysbiosis, w...
Role of mitochondria in the myopathy of juvenile dermatomyositis and implications for skeletal muscle calcinosis
Legend for graphical abstract: Human-IFNα mediates mitochondrial calcification of human skeletal muscle cells (RH30 cells)...
Juvenile idiopathic arthritis-associated genetic loci exhibit spatially constrained gene regulatory effects across multiple tissues and immune cell types
KeywordsJIAJuvenile idiopathic arthritiseQTLSNPGWASData availabilityAll data used for this study is included in Supplement...
HNF4α, SP1 and c-myc are master regulators of CNS autoimmunity
Volume 138, July 2023, 103053Author links open overlay panel, , , , , , , , , , , Highlights•HNF4α supports monocyte and T...
The aryl hydrocarbon receptor in immune regulation and autoimmune pathogenesis
The aryl hydrocarbon receptor (AhR) is a member of the periodic circadian protein (PER)-AhR nuclear translocator (ARNT)-si...
LAT1 enables T cell activation under inflammatory conditions
Pharmacological modulation of T helper cell activity currently involves the use of drugs targeting immune receptors or the...
hsa-miR-424–5p and hsa-miR-513c-3p dysregulation mediated by IFN-γ is associated with salivary gland dysfunction in Sjögren's syndrome patients
The secretory capacity of salivary gland (SG) is constantly challenged by physiological requirements as well as pathologic...
Tolerogenic IL-10-engineered dendritic cell-based therapy to restore antigen-specific tolerance in T cell mediated diseases
Tolerogenic dendritic cells play a critical role in promoting antigen-specific tolerance via dampening of T cell responses...
Supraphysiological FOXP3 expression in human CAR-Tregs results in improved stability, efficacy, and safety of CAR-Treg products for clinical application
The forkhead family transcription factor (FOXP3) is an essential regulator for the development of regulatory T cells (Treg...
Increased RNA editing sites revealed as potential novel biomarkers for diagnosis in primary Sjögren's syndrome
Primary Sjögren's syndrome (pSS) is a chronic autoimmune disease characterized by the dysfunction of salivary and lacrimal...
Metabolic enzyme Suclg2 maintains tolerogenicity of regulatory dendritic cells diffDCs by suppressing Lactb succinylation
Dendritic cells (DCs) play variable roles in immune activation and tolerance, in a manner dependent on their highly hetero...
Molecular signature of neutrophil extracellular trap mediating disease module in idiopathic inflammatory myopathy
Idiopathic inflammatory myopathy (IIM) comprises a heterogeneous group of diseases, collectively referred to as myositis, ...
Cytokine receptor γc effectuates the generation of proinflammatory innate CD8 T cells by non-classical MHC-I molecules
CD8 cytotoxic T cells are generated in the thymus upon a series of developmental selection processes that render them self...
Gut microbial signatures and their functions in Behcet's uveitis and Vogt-Koyanagi-Harada disease
Uveitis is an intraocular inflammatory disease which can lead to serious visual impairment worldwide [1]. Although clinica...
Characteristics of immune response profile in patients with immediate allergic and autoimmune urticarial reactions induced by SARS-CoV-2 vaccines
The new coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic resulted in an unprecedented fas...
Effects of fecal microbiota transplant on DNA methylation in patients with systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease with multiple clinical manifestations. Immune imb...
Fecal microbiota transplantation in the treatment of systemic lupus erythematosus: What we learnt from the explorative clinical trial
Systemic lupus erythematosus (SLE) is an autoimmune disease with the characterized presence of autoantibodies with resulta...
Corrigendum to ‘Distinct gene dysregulation patterns herald precision medicine potentiality in systemic lupus erythematosus’ [J. Autoimmun. 136 (April 2023) 103025]
Available online 3 May 2023, 103052Author links open overlay panelJulius Lindblom a, Daniel Toro-Domínguez b, Elena Carner...
Fecal microbiota transplantation: Emerging applications in autoimmune diseases
Both genetic susceptibility and environmental factors are important contributors to autoimmune disease pathogenesis. As an...
Fecal microbiota transplantation for recurrent C. difficile infection in patients with inflammatory bowel disease: A systematic review and meta-analysis
Clostridioides difficile infection (CDI) is the most common healthcare-associated infectious disease, and its incidence, r...
The role of faecal microbiota transplantation in chronic noncommunicable disorders
The gut microbiome refers to the large community of microorganisms lining the mucosal of the gastrointestinal tract, which...
Fecal microbiota transplantation for recurrent Clostridioides difficile infection in patients with concurrent ulcerative colitis
Clostridioides difficile infection (CDI) is the major cause of diarrhea associated with the use of antibiotics, and the mo...
UBE2L3 regulates TLR7-induced B cell autoreactivity in Systemic Lupus Erythematosus
Both TLR7 and NF-κB hyperactivity are known to contribute to pathogenesis in Systemic Lupus Erythematosus (SLE), driving a...
The human bone marrow plasma cell compartment in rheumatoid arthritis - Clonal relationships and anti-citrulline autoantibody producing cells
KeywordsBone marrowPlasma cellsRheumatoid arthritisAntibody repertoiresAnti-Citrullinated protein autoantibodies (ACPA)Ant...
Distinct gene dysregulation patterns herald precision medicine potentiality in systemic lupus erythematosus
ObjectivesWe aimed at investigating the whole-blood transcriptome, expression quantitative trait loci (eQTLs), and levels ...
Breach of tolerance versus burden of bile acids: Resolving the conundrum in the immunopathogenesis and natural history of primary biliary cholangitis
Primary biliary cholangitis (PBC) is an autoimmune liver disease characterized by the destruction of intrahepatic bile duc...
Protein phosphatase 2A propels follicular T helper cell development in lupus
T follicular helper (Tfh) cells constitute a specialized subset of effector CD4+ T cells, which help B cells undergo class...
Single-cell analysis highlights a population of Th17-polarized CD4+ naïve T cells showing IL6/JAK3/STAT3 activation in pediatric severe aplastic anemia
Acquired aplastic anemia (AA) has been long ascribed to immune-mediated hematopoietic failure, with up to 65%–70% of cases...
ATP-binding cassette G1 membrane transporter-mediated cholesterol efflux capacity influences coronary atherosclerosis and cardiovascular risk in Rheumatoid Arthritis
Observational studies described an inverse association between high-density lipoprotein cholesterol (HDL-C) levels and car...
Pre- and perinatal exposures associated with developing pediatric-onset immune-mediated inflammatory disease: A Danish nation-wide cohort study
KeywordsJuvenile idiopathic arthritisSystemic lupus erythematosusInflammatory bowel diseaseAutoimmune hepatitisPrimary scl...
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