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Status of alternative angiogenic pathways in glioblastoma resected under and after bevacizumab treatment
Status of alternative angiogenic pathways in glioblastoma resected under and after bevacizumab treatment
Glioblastoma multiforme (GBM) acquires resistance to bevacizumab (Bev) treatment. Bev affects angiogenic factors other tha...
Intratumoral heterogeneity of CDKN2A deletions in IDH-mutant astrocytoma
Intratumoral heterogeneity of CDKN2A deletions in IDH-mutant astrocytoma
Broggi G, Barresi V (2023) Assessment of CDKN2A/B homozygous deletion in gliomas: to FISH or not to FISH? J Neuropathol Ex...
Recent advances in liquid biopsy of central nervous system lymphomas: case presentations and review of the literature
Recent advances in liquid biopsy of central nervous system lymphomas: case presentations and review of the literature
Surgical biopsy is the gold standard for diagnosing central nervous system (CNS) lymphomas. However, reliable liquid biops...
Clinical and radiological features of intracranial ancient schwannomas: a single-institution, retrospective analysis
Clinical and radiological features of intracranial ancient schwannomas: a single-institution, retrospective analysis
Ancient schwannoma (AS) is a subtype of schwannoma characterized by slow progression despite degenerative changes in patho...
Oligodendroglioma, IDH-mutant and 1p/19q-codeleted-prognostic factors, standard of care and chemotherapy, and future perspectives with neoadjuvant strategy
Oligodendroglioma, IDH-mutant and 1p/19q-codeleted-prognostic factors, standard of care and chemotherapy, and future perspectives with neoadjuvant strategy
Oligodendroglioma, IDH-mutant and 1p/19q-codeleted is known for their relative chemosensitivity and indolent clinical cour...
Development of a rapid and comprehensive genomic profiling test supporting diagnosis and research for gliomas
Development of a rapid and comprehensive genomic profiling test supporting diagnosis and research for gliomas
A prompt and reliable molecular diagnosis for brain tumors has become crucial in precision medicine. While Comprehensive G...
Rise of oligodendroglioma hypermutator phenotype from a subclone harboring TP53 mutation after TMZ treatment
Rise of oligodendroglioma hypermutator phenotype from a subclone harboring TP53 mutation after TMZ treatment
Oligodendrogliomas characterized and defined by 1p/19q co-deletion are slowly growing tumors showing better prognosis than...
Pediatric diffuse glioma with EP300::BCOR fusion manifesting as low-grade epilepsy-associated neuroepithelial tumor: a case presentation
Pediatric diffuse glioma with EP300::BCOR fusion manifesting as low-grade epilepsy-associated neuroepithelial tumor: a case presentation
Wu Z, Rajan S, Chung HJ et al (2022) Molecular and clinicopathologic characteristics of gliomas with EP300::BCOR fusions. ...
Beyond the WHO 2021 classification of the tumors of the central nervous system: transitioning from the 5th edition to the next
Beyond the WHO 2021 classification of the tumors of the central nervous system: transitioning from the 5th edition to the next
After the release of the 5th edition of the WHO Classification of the Central Nervous System (WHO CNS5) in 2021 [1], vario...
FISH analysis reveals CDKN2A and IFNA14 co-deletion is heterogeneous and is a prominent feature of glioblastoma
FISH analysis reveals CDKN2A and IFNA14 co-deletion is heterogeneous and is a prominent feature of glioblastoma
Deletion of CDKN2A occurs in 50% of glioblastomas (GBM), and IFNA locus deletion in 25%. These genes reside closely on chr...
A rare case of primary central nervous system histiocytic sarcoma harboring a novel ARHGAP45::BRAF fusion: a case report and literature review
A rare case of primary central nervous system histiocytic sarcoma harboring a novel ARHGAP45::BRAF fusion: a case report and literature review
Patients with histiocytic sarcoma occurring in the central nervous system (CNS) are rare and have a very poor prognosis. T...
Primary papillary epithelial tumor of the sella: a case report of an emerging tumor type
Primary papillary epithelial tumor of the sella: a case report of an emerging tumor type
Primary papillary epithelial tumor of the sella (PPETS) is a newly described tumor entity with prototypical location in th...
Touch imprint cytology is useful for the intraoperative pathological diagnosis of PitNETs’ surgical margins
Touch imprint cytology is useful for the intraoperative pathological diagnosis of PitNETs’ surgical margins
Touch imprint cytology (TIC) and frozen section (FS) procedures are essential for intraoperative pathological diagnosis (I...
Intraventricular central neurocytoma molecularly defined as extraventricular neurocytoma: a case representing the discrepancy between clinicopathological and molecular classifications
Intraventricular central neurocytoma molecularly defined as extraventricular neurocytoma: a case representing the discrepancy between clinicopathological and molecular classifications
Central neurocytoma (CN) is classically defined by its intraventricular location, neuronal/neurocytic differentiation, and...
Integrated analysis of multiple methods reveals characteristics of the immune microenvironment in medulloblastoma
Integrated analysis of multiple methods reveals characteristics of the immune microenvironment in medulloblastoma
To explore the characteristics of the immune microenvironment (IME) of medulloblastoma (MB) by four methods: flow cytometr...
Diffuse paediatric-type high-grade glioma, H3-wildtype and IDH-wildtype: case series of a new entity
Diffuse paediatric-type high-grade glioma, H3-wildtype and IDH-wildtype: case series of a new entity
Diffuse paediatric-type high-grade glioma, H3-wildtype and IDH-wildtype (pHGG) is a rare and aggressive brain tumor charac...
Spontaneous malignant transformation of trigeminal schwannoma: consideration of responsible gene alterations for tumorigenesis—a case report
Spontaneous malignant transformation of trigeminal schwannoma: consideration of responsible gene alterations for tumorigenesis—a case report
Malignant peripheral nerve sheath tumors (MPNSTs) arising from the trigeminal nerves are extremely rare (only 45 cases, in...
A clinicopathological analysis of supratentorial ependymoma, ZFTA fusion-positive: utility of immunohistochemical detection of CDKN2A alterations and characteristics of the immune microenvironment
A clinicopathological analysis of supratentorial ependymoma, ZFTA fusion-positive: utility of immunohistochemical detection of CDKN2A alterations and characteristics of the immune microenvironment
EPN-ZFTA is a rare brain tumor where prognostic factors remain unclear and no effective immunotherapy or chemotherapy is c...
α-SMA positive vascular mural cells suppress cyst formation in hemangioblastoma
α-SMA positive vascular mural cells suppress cyst formation in hemangioblastoma
Approximately 60% of hemangioblastomas (HBs) have peritumoral cysts adjacent to the tumor, which can cause neurological de...
IDH wild-type lower-grade gliomas with glioblastoma molecular features: a systematic review and meta-analysis
IDH wild-type lower-grade gliomas with glioblastoma molecular features: a systematic review and meta-analysis
The WHO 2021 classification defines IDH wild type (IDHw) histologically lower-grade glioma (hLGG) as molecular glioblastom...
Lynch syndrome-associated chordoma with high tumor mutational burden and significant response to immune checkpoint inhibitors
Lynch syndrome-associated chordoma with high tumor mutational burden and significant response to immune checkpoint inhibitors
Chordoma is a rare malignant bone tumor arising from notochordal tissue. Conventional treatments, such as radical resectio...
Immunohistochemical and ultrastructural review of six cases previously diagnosed as null cell PitNETs
Immunohistochemical and ultrastructural review of six cases previously diagnosed as null cell PitNETs
Pituitary neuroendocrine tumors (PitNETs) lacking lineage affiliation are termed “null cell” PitNETs (NCTs). N...
Spatial metabolic heterogeneity of oligodendrogliomas at single-cell resolution
Spatial metabolic heterogeneity of oligodendrogliomas at single-cell resolution
Oligodendrogliomas are a type of rare and incurable gliomas whose metabolic profiles have yet to be fully examined. The pr...
An enduring debate on gliomatosis cerebri
An enduring debate on gliomatosis cerebri
Gliomatosis cerebri (GC) is a unique glial tumor that extensively invades the cerebral white matter and has been recognize...
Preface for Brain Tumor Pathology vol.40 issue 2
Preface for Brain Tumor Pathology vol.40 issue 2
I am delighted to be given the opportunity to introduce the special issue of Brain Tumor Path...
Utility of genome-wide DNA methylation profiling for pediatric-type diffuse gliomas
Utility of genome-wide DNA methylation profiling for pediatric-type diffuse gliomas
Despite the current progress of treatment, pediatric-type diffuse glioma is one of the most lethal primary malignant tumor...
Easy-to-use machine learning system for the prediction of IDH mutation and 1p/19q codeletion using MRI images of adult-type diffuse gliomas
Easy-to-use machine learning system for the prediction of IDH mutation and 1p/19q codeletion using MRI images of adult-type diffuse gliomas
Adult-type diffuse gliomas are divided into Astrocytoma, IDH-mutant, Oligodendroglioma, IDH-mutant and 1p/19q-codeleted an...
Impact of tumor markers on diagnosis, treatment and prognosis in CNS germ cell tumors: correlations with clinical practice and histopathology
Impact of tumor markers on diagnosis, treatment and prognosis in CNS germ cell tumors: correlations with clinical practice and histopathology
Tumor markers in CNS germ cell tumors (GCTs) include human chorionic gonadotropin (HCG) and alpha fetoprotein (AFP), which...
Clinical characteristics and radiological features of glioblastoma, IDH-wildtype, grade 4 with histologically lower-grade gliomas
Clinical characteristics and radiological features of glioblastoma, IDH-wildtype, grade 4 with histologically lower-grade gliomas
The 2021 World Health Organization (WHO) classification of central nervous system tumors applied molecular criteria and fu...
Clinical, histopathological and molecular risk factors for recurrence of pilocytic astrocytomas: brainstem/spinal location, nestin expression and gain of 7q and 19 are associated with early tumor recurrence
Clinical, histopathological and molecular risk factors for recurrence of pilocytic astrocytomas: brainstem/spinal location, nestin expression and gain of 7q and 19 are associated with early tumor recurrence
Pilocytic astrocytomas (PAs) are benign tumors. However, clinically aggressive PAs despite benign histology have been repo...
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