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Non-canonical Wnt signaling pathway activated NFATC3 promotes GDF15 expression in MASH: prospective analyses of UK biobank proteomic data
Non-canonical Wnt signaling pathway activated NFATC3 promotes GDF15 expression in MASH: prospective analyses of UK biobank proteomic data
Our previous research demonstrated that growth differentiation factor 15 (GDF15) exhibited superior predictive capability ...
Burden, trends, and predictions of liver cancer in China, Japan, and South Korea: analysis based on the Global Burden of Disease Study 2021
Burden, trends, and predictions of liver cancer in China, Japan, and South Korea: analysis based on the Global Burden of Disease Study 2021
Liver cancer (LC) is a major concern in the Asia-Pacific region, particularly in China, Korea, and Japan. In this study, w...
HAIC plus lenvatinib and tislelizumab for advanced hepatocellular carcinoma with Vp4 portal vein invasion
HAIC plus lenvatinib and tislelizumab for advanced hepatocellular carcinoma with Vp4 portal vein invasion
The treatment strategy for hepatocellular carcinoma (HCC) with Vp4 (main trunk) portal vein tumor thrombosis (PVTT) remain...
Development of nomograms to predict outcomes for large hepatocellular carcinoma after liver resection
Development of nomograms to predict outcomes for large hepatocellular carcinoma after liver resection
Large hepatocellular carcinoma (HCC) is difficult to resect and accompanied by poor outcome. The aim was to evaluate the s...
Antibiotic prophylaxis to prevent infection in patients with Child–Pugh A cirrhosis with upper gastrointestinal bleed: an open label randomised controlled trial
Antibiotic prophylaxis to prevent infection in patients with Child–Pugh A cirrhosis with upper gastrointestinal bleed: an open label randomised controlled trial
Although beneficial in reducing the risk of bacterial infections in patients with advanced decompensated cirrhosis after u...
Genetic predisposition of metabolic dysfunction-associated steatotic liver disease: a population-based genome-wide association study
Genetic predisposition of metabolic dysfunction-associated steatotic liver disease: a population-based genome-wide association study
Although metabolic dysfunction-associated steatotic liver disease (MASLD) has been proposed to replace the diagnosis of no...
Global, regional, and national temporal trends in incidence and mortality for liver cancer due to hepatitis B, 1990–2021: a decomposition and age-period-cohort analysis for the Global Burden of Disease Study 2021
Global, regional, and national temporal trends in incidence and mortality for liver cancer due to hepatitis B, 1990–2021: a decomposition and age-period-cohort analysis for the Global Burden of Disease Study 2021
This study comprehensively assessed the burden of liver cancer due to hepatitis B (LCHB) from 1990 to 2021, analyzing temp...
Rheumatoid factor levels indicate cryoglobulinemia severity in hepatitis B e antigen-negative hepatitis B virus carriers: a 7-year prospective cohort study
Rheumatoid factor levels indicate cryoglobulinemia severity in hepatitis B e antigen-negative hepatitis B virus carriers: a 7-year prospective cohort study
The phenotype of cryoglobulinemia in hepatitis B virus (HBV) carriers remains elusive. A 7-year prospective cohort of 648 ...
Predictive model for HBsAg clearance rate in chronic hepatitis B patients treated with pegylated interferon α-2b for 48 weeks
Predictive model for HBsAg clearance rate in chronic hepatitis B patients treated with pegylated interferon α-2b for 48 weeks
Chronic hepatitis B (CHB) is a major global health concern. This study aims to investigate the factors influencing hepatit...
Cell-free DNA methylation-based inflammation score as a marker for hepatocellular carcinoma among people living with HIV
Cell-free DNA methylation-based inflammation score as a marker for hepatocellular carcinoma among people living with HIV
People living with the human immunodeficiency virus (HIV) are at a greater risk of developing hepatocellular carcinoma (HC...
Targeted APT8(16–34) obtained by cell-SELEX and its internalization with miR-23-5p into activated hepatic stellate cells
Targeted APT8(16–34) obtained by cell-SELEX and its internalization with miR-23-5p into activated hepatic stellate cells
The activation of hepatic stellate cells play a pivotal role in the pathogenesis of hepatic fibrosis. However, the current...
MAFLD but not MASLD increases risk of all-cause mortality in regional Australia, with components of metabolic syndrome exacerbating factors: 20 year longitudinal, cohort study
MAFLD but not MASLD increases risk of all-cause mortality in regional Australia, with components of metabolic syndrome exacerbating factors: 20 year longitudinal, cohort study
Controversy remains whether the mortality risk in people with fatty liver disease (FLD) including metabolic-(dysfunction) ...
Low-risk individuals with primary biliary cholangitis and significant liver stiffness: prognosis and treatment
Low-risk individuals with primary biliary cholangitis and significant liver stiffness: prognosis and treatment
Some patients treated with ursodeoxycholic acid (UDCA) or combined fenofibrate had well-controlled biochemical parameters ...
The effect of transition timing of regorafenib on treatment outcomes in unresectable hepatocellular carcinoma: a real-world study
The effect of transition timing of regorafenib on treatment outcomes in unresectable hepatocellular carcinoma: a real-world study
Regorafenib is the recommended second-line therapy for unresectable hepatocellular carcinoma (uHCC). Our study aimed to as...
Functional B cell deficiency promotes intrahepatic HBV replication and impairs the development of anti-HBV T cell responses
Functional B cell deficiency promotes intrahepatic HBV replication and impairs the development of anti-HBV T cell responses
The pivotal role of antibody-producing B cells in controlling hepatitis B virus (HBV) infection is well-established. Howev...
Effects of dapagliflozin on liver steatosis in patients with nonalcoholic fatty liver disease: a randomized controlled trial
Effects of dapagliflozin on liver steatosis in patients with nonalcoholic fatty liver disease: a randomized controlled trial
Nonalcoholic fatty liver disease (NAFLD) is a common liver comorbidity with considerable global consequences. This study e...
Clinical characteristics and managements of congenital hepatic hemangioma: a cohort study of 211 cases
Clinical characteristics and managements of congenital hepatic hemangioma: a cohort study of 211 cases
Hepatic hemangiomas can be classified into three morphologic patterns: focal (congenital hepatic hemangiomas [CHHs]), mult...
Semaglutide and the risk of adverse liver outcomes in patients with nonalcoholic fatty liver disease and type 2 diabetes: a multi-institutional cohort study
Semaglutide and the risk of adverse liver outcomes in patients with nonalcoholic fatty liver disease and type 2 diabetes: a multi-institutional cohort study
Semaglutide has shown potential liver benefits in patients with nonalcoholic fatty liver disease (NAFLD) and type 2 diabet...
AARC score and urine NGAL predict terlipressin non-response and mortality in patients with acute-on-chronic liver failure
AARC score and urine NGAL predict terlipressin non-response and mortality in patients with acute-on-chronic liver failure
Acute-on-chronic liver failure (ACLF) patients with hepatorenal syndrome (HRS-AKI) have limited response to vasoconstricto...
Efficacy and safety of durvalumab rechallenge in advanced hepatocellular carcinoma patients refractory to prior anti-PD-1 therapy
Efficacy and safety of durvalumab rechallenge in advanced hepatocellular carcinoma patients refractory to prior anti-PD-1 therapy
Recently, anti-programmed cell death protein-1 (anti-PD-1) and anti-PD-L1 therapies were approved for hepatocellular carci...
The dynamic patterns of metabolic-associated fatty liver disease and its severity and risk of cardiovascular disease
The dynamic patterns of metabolic-associated fatty liver disease and its severity and risk of cardiovascular disease
While metabolic-associated fatty liver disease (MAFLD) is widely recognized as a risk factor for cardiovascular disease (C...
Global, regional, and national epidemiology of hepatoblastoma in children from 1990 to 2021: a trend analysis
Global, regional, and national epidemiology of hepatoblastoma in children from 1990 to 2021: a trend analysis
Hepatoblastoma is the most common primary liver cancer in children, yet comprehensive understanding of its epidemiology is...
APASL clinical practice guidelines on systemic therapy for hepatocellular carcinoma-2024
APASL clinical practice guidelines on systemic therapy for hepatocellular carcinoma-2024
In Asia–Pacific region, hepatocellular carcinoma is a serious health threat attributing to over 600,000 deaths each ...
Comprehensive genomic profiling for advanced hepatocellular carcinoma in clinical practice
Comprehensive genomic profiling for advanced hepatocellular carcinoma in clinical practice
Although several therapeutic agents show efficacy in advanced hepatocellular carcinoma (HCC), biomarkers such as comprehen...
Non-cirrhotic portal fibrosis/idiopathic portal hypertension: APASL recommendations for diagnosis and management
Non-cirrhotic portal fibrosis/idiopathic portal hypertension: APASL recommendations for diagnosis and management
Since the Asian Pacific Association for the Study of the Liver (APASL) published guidelines on non-cirrhotic portal fibros...
Optimal threshold of portal pressure gradient for patients with ascites after covered TIPS: a multicentre cohort study
Optimal threshold of portal pressure gradient for patients with ascites after covered TIPS: a multicentre cohort study
Transjugular intrahepatic portosystemic shunt (TIPS) is recommended for treating recurrent and refractory ascites. However...
Impact of graft type on outcomes following liver transplantation for primary sclerosing cholangitis
Impact of graft type on outcomes following liver transplantation for primary sclerosing cholangitis
Limited data exists regarding impact of graft type on outcomes following liver transplantation (LT) in Primary Sclerosing ...
Metabolic (dysfunction)-associated fatty liver disease metrics and contributions to liver research
Metabolic (dysfunction)-associated fatty liver disease metrics and contributions to liver research
The international consensus to revise non-alcoholic fatty liver disease to metabolic (dysfunction)-associated fatty liver ...
Adipokine/hepatokines profiling of fatty liver in adolescents and young adults: cross-sectional and prospective analyses of the BCAMS study
Adipokine/hepatokines profiling of fatty liver in adolescents and young adults: cross-sectional and prospective analyses of the BCAMS study
The underlying connections between obesity and non-alcoholic fatty liver disease (NAFLD) are not fully understood. One pot...
Appendicular skeletal muscle mass is associated with metabolic dysfunction-associated steatotic liver disease severity in young men: a cross-sectional and longitudinal study
Appendicular skeletal muscle mass is associated with metabolic dysfunction-associated steatotic liver disease severity in young men: a cross-sectional and longitudinal study
Although appendicular skeletal muscle mass (ASM) has been linked to the severity of hepatic steatosis, investigations of i...
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