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Exosomal miR-200b-3p induce macrophage polarization by regulating transcriptional repressor ZEB1 in hepatocellular carcinoma
Exosomal miR-200b-3p induce macrophage polarization by regulating transcriptional repressor ZEB1 in hepatocellular carcinoma
Accumulating evidence has elucidated that the interaction between cancer cells and M2 macrophages plays an important role ...
Etiologic fractions in patients of hepatocellular carcinoma in India with and without a background of cirrhosis: a multi-centric study
Etiologic fractions in patients of hepatocellular carcinoma in India with and without a background of cirrhosis: a multi-centric study
Hepatocellular cancer (HCC) typically arises in the background of cirrhosis. The epidemiology of HCC has changed in recent...
Downregulated VISTA enhances Th17 differentiation and aggravates inflammation in patients with acute-on-chronic liver failure
Downregulated VISTA enhances Th17 differentiation and aggravates inflammation in patients with acute-on-chronic liver failure
Persistent inflammatory response and immune activation are the core mechanisms underlying acute-on-chronic liver failure (...
Evolution of risk prediction models for post-operative mortality in patients with cirrhosis
Evolution of risk prediction models for post-operative mortality in patients with cirrhosis
The perception of high surgical risk among patients with cirrhosis has resulted in a long-standing reluctance to operate. ...
Bacterial translocation occurs early in cirrhosis and triggers a selective inflammatory response
Bacterial translocation occurs early in cirrhosis and triggers a selective inflammatory response
Experimental data suggest that bacterial translocation (BT) promotes systemic inflammation, portal hypertension, and circu...
Contribution of alcohol use to the global burden of cirrhosis and liver cancer from 1990 to 2019 and projections to 2044
Contribution of alcohol use to the global burden of cirrhosis and liver cancer from 1990 to 2019 and projections to 2044
Identifying the temporal trends of cirrhosis and liver cancer attributable to alcohol use in both the past and the future ...
Response to: “Is laparoscopic hepatectomy superior to laparotomic hepatectomy? The debate continues”
Response to: “Is laparoscopic hepatectomy superior to laparotomic hepatectomy? The debate continues”
Yang SY, Yan ML, Duan YF, Feng JK, Ye JZ, Xiang YJ, et al. Perioperative and long-term survival outcomes of laparoscopic v...
HBV, antivirals, and immunoglobulins after liver transplantation: all that glitters is not gold
HBV, antivirals, and immunoglobulins after liver transplantation: all that glitters is not gold
Conflict of interest The Edoardo G. Giannini and Quirino Lai have n...
Antioxidant, selenium and risk of nonalcoholic fatty liver disease, more than causality
Antioxidant, selenium and risk of nonalcoholic fatty liver disease, more than causality
Chen L, Fan Z, Sun X, Qiu W, Mu W, Chai K, Cao Y, Wang G, Lv G. Diet-derived antioxidants and nonalcoholic fatty liver dis...
Artificial intelligence CT radiomics to predict early recurrence of intrahepatic cholangiocarcinoma: a multicenter study
Artificial intelligence CT radiomics to predict early recurrence of intrahepatic cholangiocarcinoma: a multicenter study
In this multicenter study, we sought to develop and validate a preoperative model for predicting early recurrence (ER) ris...
Association of MAFLD with end-stage kidney disease: a prospective study of 337,783 UK Biobank participants
Association of MAFLD with end-stage kidney disease: a prospective study of 337,783 UK Biobank participants
Metabolic dysfunction-associated fatty liver (MAFLD) has been found to be associated with the prevalence of chronic kidney...
The incidence of all organ malignancies and overall survival of patient with sustained virological response of HCV-comparable to SMR (standardized mortality ratio) of Japan general population
The incidence of all organ malignancies and overall survival of patient with sustained virological response of HCV-comparable to SMR (standardized mortality ratio) of Japan general population
This study prospectively observed the incidence of all malignancies and the prognosis of all patients in a population of p...
Individualized portal pressure gradient threshold based on liver function categories in preventing rebleeding after TIPS
Individualized portal pressure gradient threshold based on liver function categories in preventing rebleeding after TIPS
The evidence in Portal pressure gradient (PPG) < 12 mmHg after transjugular intrahepatic porto...
Emergent rescue transjugular intrahepatic portosystemic shunt within 8 h improves survival in patients with refractory variceal bleed
Emergent rescue transjugular intrahepatic portosystemic shunt within 8 h improves survival in patients with refractory variceal bleed
Transjugular-intrahepatic portosystemic-shunt (TIPS) and SX-Ella stent Danis (DE stent) are available rescue ther...
Identifying the early predictors of non-response to steroids in patients with flare of autoimmune hepatitis causing acute-on-chronic liver failure
Identifying the early predictors of non-response to steroids in patients with flare of autoimmune hepatitis causing acute-on-chronic liver failure
Early identification of non-response to steroids is critical in patients with autoimmune hepatitis (AIH) causing acute-on-...
Liver decompensation: the yard stick that measures indications and adverse effects of human albumin infusion
Liver decompensation: the yard stick that measures indications and adverse effects of human albumin infusion
Bai Z, Wang L, Wang R, Zou M, Méndez-Sánchez N, Romeiro FG, et al. Use of human albumin infusion in cirrhotic patients: a ...
Real-world efficacy and prognostic factors of lenvatinib plus PD-1 inhibitors in 378 unresectable hepatocellular carcinoma patients
Real-world efficacy and prognostic factors of lenvatinib plus PD-1 inhibitors in 378 unresectable hepatocellular carcinoma patients
Combining lenvatinib with a programmed cell death protein-1 (PD-1) inhibitor has been explored for the treatment of un-res...
Differential DNA methylation of steatosis and non-alcoholic fatty liver disease in adolescence
Differential DNA methylation of steatosis and non-alcoholic fatty liver disease in adolescence
Epigenetic modifications are associated with hepatic fat accumulation and non-alcoholic fatty liver disease (NAFLD). Howev...
Synergistic antitumor effect of histone deacetylase class IIa inhibitor with lenvatinib in hepatocellular carcinoma
Synergistic antitumor effect of histone deacetylase class IIa inhibitor with lenvatinib in hepatocellular carcinoma
Histone deacetylase (HDAC) class I and IIa are highly expressed in hepatocellular carcinoma (HCC) and associated with decr...
DENND3 p.L708V activating variant is involved in the pathogenesis of hereditary hemochromatosis via the RAB12/TFR2 signaling pathway
DENND3 p.L708V activating variant is involved in the pathogenesis of hereditary hemochromatosis via the RAB12/TFR2 signaling pathway
Pathogenic variants in HFE and non-HFE genes have been identified in hereditary hemochromatosis (HH) in different patient ...
Sofosbuvir/velpatasvir/voxilaprevir for patients with chronic hepatitis C virus infection previously treated with NS5A direct-acting antivirals: a real-world multicenter cohort in Taiwan
Sofosbuvir/velpatasvir/voxilaprevir for patients with chronic hepatitis C virus infection previously treated with NS5A direct-acting antivirals: a real-world multicenter cohort in Taiwan
Real-world data are scarce about the effectiveness and safety of sofosbuvir/velpatasvir/voxilaprevir (SOF/VEL/VOX) for ret...
Reflections on prediction of microvascular invasion in hepatocellular carcinoma by pathology images
Reflections on prediction of microvascular invasion in hepatocellular carcinoma by pathology images
Conflict of interest The authors declare that the study was conduct...
A preoperative scoring system to predict lymph node metastasis in intrahepatic cholangiocarcinoma
A preoperative scoring system to predict lymph node metastasis in intrahepatic cholangiocarcinoma
The abnormality of imaging finding of lymph node (LN) has demonstrated unsatisfactory diagnostic accuracy for pathologic l...
Biomarkers of hepatocellular synthesis in patients with decompensated cirrhosis
Biomarkers of hepatocellular synthesis in patients with decompensated cirrhosis
Since hepatocytes produce majority of serum proteins, patients with cirrhosis display substantial alterations in the serum...
Adjuvant anti-PD-1 antibody for hepatocellular carcinoma with high recurrence risks after hepatectomy
Adjuvant anti-PD-1 antibody for hepatocellular carcinoma with high recurrence risks after hepatectomy
The clinical role of postoperative adjuvant therapy in hepatocellular carcinoma (HCC) is still unclear. The purpose of our...
Correction to: HMGCL‑induced β‑hydroxybutyrate production attenuates hepatocellular carcinoma via DPP4‑mediated ferroptosis susceptibility
Correction to: HMGCL‑induced β‑hydroxybutyrate production attenuates hepatocellular carcinoma via DPP4‑mediated ferroptosis susceptibility
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which ...
Genetic landscape and immune mechanism of monocytes associated with the progression of acute-on-chronic liver failure
Genetic landscape and immune mechanism of monocytes associated with the progression of acute-on-chronic liver failure
Acute-on-chronic liver failure (ACLF) has a high prevalence and short-term mortality. Monocytes play an important role in ...
Comparative efficacy of PD-1 inhibitors plus lenvatinib and regorafenib after lenvatinib failure for advanced hepatocellular carcinoma: a real-world study
Comparative efficacy of PD-1 inhibitors plus lenvatinib and regorafenib after lenvatinib failure for advanced hepatocellular carcinoma: a real-world study
Cheng AL, Qin S, Ikeda M, Galle PR, Ducreux M, Kim TY, et al. Updated efficacy and safety data from IMbrave150: Atezolizum...
Identification and development of a novel risk model based on cuproptosis-associated RNA methylation regulators for predicting prognosis and characterizing immune status in hepatocellular carcinoma
Identification and development of a novel risk model based on cuproptosis-associated RNA methylation regulators for predicting prognosis and characterizing immune status in hepatocellular carcinoma
Cuproptosis, a novel cell death caused by excess copper, is quite obscure in hepatocellular carcinoma (HCC) and needs more...
Pure laparoscopic versus open left lateral hepatectomy in pediatric living donor liver transplantation: a review and meta-analysis
Pure laparoscopic versus open left lateral hepatectomy in pediatric living donor liver transplantation: a review and meta-analysis
The meta-analysis was conducted to evaluate the safety and feasibility of pure laparoscopic left lateral hepatectomy in co...
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