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Fibroblast Growth Factor 19 Secretion and Function in Perinatal Development
Fibroblast Growth Factor 19 Secretion and Function in Perinatal Development
Limited work has focused on Fibroblast Growth Factor-19 (FGF19) secretion and function in the perinatal period. FGF19 is a...
Key Hepatoprotective Roles of Mitochondria in Liver Regeneration
Key Hepatoprotective Roles of Mitochondria in Liver Regeneration
Treatment of advanced liver disease using surgical modalities is possible due to the liver's innate ability to regenerate ...
Who's talking to who: microbiome-enteric nervous system interactions in early life
Who's talking to who: microbiome-enteric nervous system interactions in early life
The enteric nervous system (ENS) is the intrinsic nervous system of the intestine and regulates important gut functions, i...
Effect of an obesogenic high-fat and high-sucrose diet on hepatic gene expression signatures in male Collaborative Cross mice
Effect of an obesogenic high-fat and high-sucrose diet on hepatic gene expression signatures in male Collaborative Cross mice
Nonalcoholic fatty liver disease (NAFLD), the most prevalent chronic liver disease, is characterized by substantial variat...
Short-chain fatty acids ameliorate necrotizing enterocolitis-like intestinal injury through enhancing Notch1-mediated single immunoglobulin interleukin-1-related receptor, toll-interacting protein, and A20 induction
Short-chain fatty acids ameliorate necrotizing enterocolitis-like intestinal injury through enhancing Notch1-mediated single immunoglobulin interleukin-1-related receptor, toll-interacting protein, and A20 induction
Short-chain fatty acids (SCFAs), such as propionate and butyrate, metabolites produced by symbiotic gut bacteria are known...
Loss of apical sodium bile acid transporter alters bile acid circulation and reduces biliary damage in cholangitis
Loss of apical sodium bile acid transporter alters bile acid circulation and reduces biliary damage in cholangitis
We evaluated knockdown of the apical sodium bile acid transporter (ASBT) using Vivo-Morpholino in Mdr2KO mice. ASBT inhibi...
Maternal hepatocytes heterogeneously and dynamically exhibit developmental phenotypes partially via yes-associated protein 1 during pregnancy
Maternal hepatocytes heterogeneously and dynamically exhibit developmental phenotypes partially via yes-associated protein 1 during pregnancy
We found that maternal hepatocytes exhibit developmental phenotypes in a temporal and spatial manner, similarly to fetal h...
Novel insights into physiological mechanisms underlying fecal continence
Novel insights into physiological mechanisms underlying fecal continence
The machinery maintaining fecal continence prevents involuntary loss of stool and is based on the synchronized interplay o...
Enterocyte-specific deletion of metal transporter Zip14 (Slc39a14) alters intestinal homeostasis through epigenetic mechanisms
Enterocyte-specific deletion of metal transporter Zip14 (Slc39a14) alters intestinal homeostasis through epigenetic mechanisms
Zinc, an essential micronutrient, has anti-inflammatory properties employing mechanisms that are unclear. Zip14 (Slc39a14)...
Tissue and cell specific properties of enterochromaffin cells affect the fate of tumorigenesis toward non-endocrine adenocarcinoma of the small intestine
Tissue and cell specific properties of enterochromaffin cells affect the fate of tumorigenesis toward non-endocrine adenocarcinoma of the small intestine
Small intestinal neuroendocrine tumor SI-NETs are serotonin-secreting well-differentiated neuroendocrine tumors of putativ...
Metabolomics analysis of urine from patients with alcohol-associated liver disease reveals dysregulated caffeine metabolism
Metabolomics analysis of urine from patients with alcohol-associated liver disease reveals dysregulated caffeine metabolism
Excess alcohol intake causes millions of deaths annually worldwide. Asymptomatic early-stage alcohol-associated liver dise...
Proteolipid protein 1 is involved in the regulation of intestinal motility and barrier function in the mouse
Proteolipid protein 1 is involved in the regulation of intestinal motility and barrier function in the mouse
Proteolipid protein 1 (Plp1) is highly expressed in enteric glia, labeling cells throughout the mucosa, muscularis and the...
A Biomechanical Response of the Esophagus Participates in Swallowing
A Biomechanical Response of the Esophagus Participates in Swallowing
Evidence suggests that a biomechanical process participates in esophageal function, but no such function has yet been iden...
Localized bioelectrical conduction block from radiofrequency gastric ablation persists after healing: safety and feasibility in a recovery model
Localized bioelectrical conduction block from radiofrequency gastric ablation persists after healing: safety and feasibility in a recovery model
Ablation has recently emerged as a tool for modulating gastric electrical activation and may hold interventional potential...
Spatial transcriptomics add a new dimension to our understanding of the gut
Spatial transcriptomics add a new dimension to our understanding of the gut
The profound complexity of the intestinal mucosa demands a spatial approach to the study of gut transcriptomics. Although ...
Nutritional, pharmacological, and environmental programming of NAFLD in early life
Nutritional, pharmacological, and environmental programming of NAFLD in early life
Non-alcoholic fatty liver disease (NAFLD) is the main liver disease worldwide, and its prevalence in children and adolesce...
Hepatocyte- or macrophage-specific SREBP-1a deficiency in mice exacerbates methionine- and choline-deficient diet-induced nonalcoholic fatty liver disease
Hepatocyte- or macrophage-specific SREBP-1a deficiency in mice exacerbates methionine- and choline-deficient diet-induced nonalcoholic fatty liver disease
Hepatocyte- and macrophage-specific SREBP-1a knockout mice were generated for the first time. This study reveals that SREB...
Characterization of hepatic inflammatory changes in a C57BL/6J mouse model of alpha1-antitrypsin deficiency
Characterization of hepatic inflammatory changes in a C57BL/6J mouse model of alpha1-antitrypsin deficiency
We have characterized a mouse model of human alpha-1 antitrypsin deficiency with a strong manifestation of liver disease t...
Manganese efflux transporter SLC30A10 missense polymorphism T95I associated with liver injury retains manganese efflux activity
Manganese efflux transporter SLC30A10 missense polymorphism T95I associated with liver injury retains manganese efflux activity
The activity of the manganese (Mn) efflux transporter SLC30A10 in the liver and intestines is critical for Mn excretion an...
Gastrointestinal organoids in the study of viral infections
Gastrointestinal organoids in the study of viral infections
Viruses are among the most prevalent enteric pathogens. While virologists historically relied on cell lines and animal mod...
Inflammatory bowel disease therapeutic strategies by modulation of the microbiota: how and when to introduce pre-, pro-, syn-, or postbiotics?
Inflammatory bowel disease therapeutic strategies by modulation of the microbiota: how and when to introduce pre-, pro-, syn-, or postbiotics?
Inflammatory bowel diseases (IBD), a heterogeneous group of inflammatory conditions that encompass both ulcerative colitis...
Cross talk between the gut microbiome and host immune response in ulcerative colitis: nonpharmacological strategies to improve homeostasis
Cross talk between the gut microbiome and host immune response in ulcerative colitis: nonpharmacological strategies to improve homeostasis
Ulcerative colitis (UC) is a chronic disease that is characterized by diffuse inflammation of the colonic and rectal mucos...
Esophageal wall compliance/stiffness during peristalsis in patients with functional dysphagia and high-amplitude esophageal contractions
Esophageal wall compliance/stiffness during peristalsis in patients with functional dysphagia and high-amplitude esophageal contractions
We studied healthy asymptomatic subject, patients with functional dysphagia (FD), and patients with high-amplitude esophag...
Loss of Apical Sodium Bile Acid Transporter Disrupts Bile Acid Circulation and Reduces Biliary Damage in Cholangitis
Loss of Apical Sodium Bile Acid Transporter Disrupts Bile Acid Circulation and Reduces Biliary Damage in Cholangitis
Background: Primary Sclerosing Cholangitis (PSC) is characterized by increased ductular reaction (DR), liver fibrosis, hep...
Short Chain Fatty Acids Ameliorate Necrotizing enterocolitis-like Intestinal Injury through Enhancing Notch1-mediated SIGIRR, TOLLIP and A20 induction
Short Chain Fatty Acids Ameliorate Necrotizing enterocolitis-like Intestinal Injury through Enhancing Notch1-mediated SIGIRR, TOLLIP and A20 induction
Single Immunoglobulin Interleukin-1 Related Receptor (SIGIRR), toll interacting protein (TOLLIP) and A20 are major inhibit...
Dysbiosis and reduced small intestinal function are required to induce intestinal insufficiency in mice
Dysbiosis and reduced small intestinal function are required to induce intestinal insufficiency in mice
Extensive bowel resection can lead to short bowel syndrome and intestinal failure. Resection-induced dysbiosis may be rela...
β-PIX cooperates with GIT1 to regulate endothelial nitric oxide synthase in sinusoidal endothelial cells
β-PIX cooperates with GIT1 to regulate endothelial nitric oxide synthase in sinusoidal endothelial cells
β-PIX is a multidomain protein known to be a GIT1 binding partner. We report here that in the normal liver, the distributi...
Examining enteric nervous system function in rat and mouse: an interspecies comparison of colonic motility
Examining enteric nervous system function in rat and mouse: an interspecies comparison of colonic motility
Mice and rats are widely used in gastrointestinal research but have fundamental differences that make them important as di...
Toll-like receptor 4 signaling pathway mediates both liver and kidney injuries in mice with hepatorenal syndrome
Toll-like receptor 4 signaling pathway mediates both liver and kidney injuries in mice with hepatorenal syndrome
Our study established BDL, UUO, and BDL + UUO models, providing a novel idea for analyzing liver and kidney diseases. It i...
Coffee modulates insulin-hepatocyte nuclear factor-4α-Cyp7b1 pathway and reduces oxysterol-driven liver toxicity in a nonalcoholic fatty liver disease mouse model
Coffee modulates insulin-hepatocyte nuclear factor-4α-Cyp7b1 pathway and reduces oxysterol-driven liver toxicity in a nonalcoholic fatty liver disease mouse model
This study demonstrated dietary coffee prevented the accumulation of hepatic oxysterols by maintaining Cyp7b1/Sult2b1 expr...
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