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Ubiquitination contributes to the regulation of GDP-mannose pyrophosphorylase B activity
Ubiquitination contributes to the regulation of GDP-mannose pyrophosphorylase B activity
Introduction GDP-mannose pyrophosphorylase B (GMPPB) catalyzes the conversion of guanosine triphosphate and mannose-1-ph...
Retraction: Icariin reduces dopaminergic neuronal loss and microglia-mediated inflammation in vivo and in vitro
Retraction: Icariin reduces dopaminergic neuronal loss and microglia-mediated inflammation in vivo and in vitro
Retraction: Icariin Reduces Dopaminergic Neuronal Loss and Microglia-Mediated Inflammation in Vivo and in VitroPlease find...
The role of Foxo3a in neuron-mediated cognitive impairment
The role of Foxo3a in neuron-mediated cognitive impairment
1 Introduction Cognitive impairment (COI) is a brain disorder involved in impaired memory, language, reasoning, calculati...
Editorial: Molecular and cellular mechanisms of sensory functions in insect models, volume II
Editorial: Molecular and cellular mechanisms of sensory functions in insect models, volume II
Sensory systems are indispensable for all organisms to receive dynamic information from their surrounding environment. A d...
Recovery kinetics of dual AAV-mediated human otoferlin expression
Recovery kinetics of dual AAV-mediated human otoferlin expression
Deafness-causing deficiencies in otoferlin (OTOF) have been addressed preclinically using dual adeno-associated virus (AAV...
Editorial: Restoring neural circuits after spinal cord injury
Editorial: Restoring neural circuits after spinal cord injury
Although there are reports of restoring neural circuits to treat spinal cord injury, the results are not ideal. Lots of wo...
Tackling neurodegeneration in vitro with omics: a path towards new targets and drugs
Tackling neurodegeneration in vitro with omics: a path towards new targets and drugs
1 Introduction Neurodegenerative diseases (NDDs) represent a growing societal and public health burden affecting million...
Fluorescence lifetime imaging of AMPA receptor endocytosis in living neurons: effects of Aβ and PP1
Fluorescence lifetime imaging of AMPA receptor endocytosis in living neurons: effects of Aβ and PP1
Introduction Trafficking of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptors, which are re...
Potential of ferroptosis and ferritinophagy in migraine pathogenesis
Potential of ferroptosis and ferritinophagy in migraine pathogenesis
1 Introduction Aberrant iron metabolism is reported in many conditions, including neurological disorders, in particular ...
Flight to insight: maximizing the potential of Drosophila models of C9orf72-FTD
Flight to insight: maximizing the potential of Drosophila models of C9orf72-FTD
Introduction Frontotemporal dementia (FTD) comprises a spectrum of rare neurodegenerative disorders resulting from neuro...
Deletion of a core APC/C component reveals APC/C function in regulating neuronal USP1 levels and morphology
Deletion of a core APC/C component reveals APC/C function in regulating neuronal USP1 levels and morphology
IntroductionThe Anaphase Promoting Complex (APC/C), an E3 ubiquitin ligase, plays a key role in cell cycle control, but it...
Mechanisms of inflammation after ischemic stroke in brain-peripheral crosstalk
Mechanisms of inflammation after ischemic stroke in brain-peripheral crosstalk
1 Introduction Stroke is the second leading cause of death and the third leading cause of adult disability worldwide (Sa...
Exercise-induced neuroplasticity: a new perspective on rehabilitation for chronic low back pain
Exercise-induced neuroplasticity: a new perspective on rehabilitation for chronic low back pain
1 Introduction Chronic low back pain (CLBP) can have a certain degree of impact on the patient’s physical structure and ...
Can repetitive mechanical motion cause structural damage to axons?
Can repetitive mechanical motion cause structural damage to axons?
1 Introduction Biological structures have evolved to generate, transmit, and withstand mechanical forces in a highly sop...
Editorial: Targeting ion channels for drug discovery: emerging challenges for high throughput screening technologies
Editorial: Targeting ion channels for drug discovery: emerging challenges for high throughput screening technologies
France.Cellular functions are regulated by complex signaling networks that determine gene expression and cellular behavior...
MicroRNA biomarkers as next-generation diagnostic tools for neurodegenerative diseases: a comprehensive review
MicroRNA biomarkers as next-generation diagnostic tools for neurodegenerative diseases: a comprehensive review
Neurodegenerative diseases (NDs) are characterized by abnormalities within neurons of the brain or spinal cord that gradua...
Microglia and infiltrating macrophages in ictogenesis and epileptogenesis
Microglia and infiltrating macrophages in ictogenesis and epileptogenesis
Phagocytes maintain homeostasis in a healthy brain. Upon injury, they are essential for repairing damaged tissue, recruiti...
CDGSH iron-sulfur domain 2 as a therapeutic target for stroke: an opinion article
CDGSH iron-sulfur domain 2 as a therapeutic target for stroke: an opinion article
Dramatic changes in global climate and metabolic dysfunction in the population, attributed to dietary modifications, have ...
Ketamine modulates disrupted in schizophrenia-1/glycogen synthase kinase-3β interaction
Ketamine modulates disrupted in schizophrenia-1/glycogen synthase kinase-3β interaction
IntroductionDisrupted in schizophrenia-1 (DISC1) is a scaffolding protein whose mutated form has been linked to schizophre...
Expression of guanylate cyclase C in human prefrontal cortex depends on sex and feeding status
Expression of guanylate cyclase C in human prefrontal cortex depends on sex and feeding status
IntroductionGuanylate cyclase C (GC-C) has been detected in the rodent brain in neurons of the cerebral cortex, amygdala, ...
Adolescent binge ethanol impacts H3K9me3-occupancy at synaptic genes and the regulation of oligodendrocyte development
Adolescent binge ethanol impacts H3K9me3-occupancy at synaptic genes and the regulation of oligodendrocyte development
IntroductionBinge drinking in adolescence can disrupt myelination and cause brain structural changes that persist into adu...
Post-stroke cognitive impairment: exploring molecular mechanisms and omics biomarkers for early identification and intervention
Post-stroke cognitive impairment: exploring molecular mechanisms and omics biomarkers for early identification and intervention
Post-stroke cognitive impairment (PSCI) is a major stroke consequence that has a severe impact on patients’ quality of lif...
Identification of crucial inflammaging related risk factors in multiple sclerosis
Identification of crucial inflammaging related risk factors in multiple sclerosis
BackgroundMultiple sclerosis (MS) is an immune-mediated disease characterized by inflammatory demyelinating lesions in the...