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Advances in aqueous humor proteomics for biomarker discovery and disease mechanisms exploration: a spotlight on primary open angle glaucoma
Advances in aqueous humor proteomics for biomarker discovery and disease mechanisms exploration: a spotlight on primary open angle glaucoma
Altered protein levels in the aqueous humor (AH) may be a valuable source of novel biomarkers in neurodegenerative retinal...
Studying m6A in the brain: a perspective on current methods, challenges, and future directions
Studying m6A in the brain: a perspective on current methods, challenges, and future directions
A major mechanism of post-transcriptional RNA regulation in cells is the addition of chemical modifications to RNA nucleos...
Rotenone-induced PINK1/Parkin-mediated mitophagy: establishing a silkworm model for Parkinson’s disease potential
Rotenone-induced PINK1/Parkin-mediated mitophagy: establishing a silkworm model for Parkinson’s disease potential
Parkinson’s disease (PD), ranking as the second most prevalent neurodegenerative disorder globally, presents a pressing ne...
Editorial: Molecular and network mechanisms underlying stress resilience
Editorial: Molecular and network mechanisms underlying stress resilience
A wide range of biological mechanisms induced by stress contribute to the onset and development of disorders like anxiety ...
Circular RNA expression profiles and functional predication after restraint stress in the amygdala of rats
Circular RNA expression profiles and functional predication after restraint stress in the amygdala of rats
Prolonged or repeated exposure to stress elevates the risk of various psychological diseases, many of which are characteri...
Targeted protein degradation in CNS disorders: a promising route to novel therapeutics?
Targeted protein degradation in CNS disorders: a promising route to novel therapeutics?
Targeted protein degradation (TPD) is a rapidly expanding field, with various PROTACs (proteolysis-targeting chimeras) in ...
The endocannabinoid system is involved in the anxiety-like behavior induced by dual-frequency 2.65/0.8 GHz electromagnetic radiation in mice
The endocannabinoid system is involved in the anxiety-like behavior induced by dual-frequency 2.65/0.8 GHz electromagnetic radiation in mice
As wireless communication devices gain popularity, concerns about the potential risks of environmental exposure to complex...
Risk factors and a predictive model for the occurrence of adverse outcomes in patients with new-onset refractory status epilepsy
Risk factors and a predictive model for the occurrence of adverse outcomes in patients with new-onset refractory status epilepsy
ObjectivesTo determine risk factors for the occurrence of adverse outcomes in patients with new-onset refractory status ep...
PLC-γ-Ca2+ pathway regulates axonal TrkB endocytosis and is required for long-distance propagation of BDNF signaling
PLC-γ-Ca2+ pathway regulates axonal TrkB endocytosis and is required for long-distance propagation of BDNF signaling
Brain-derived neurotrophic factor (BDNF) and its tropomyosin receptor kinase B (TrkB) are important signaling proteins tha...
Extracellular vesicles mediate inflammasome signaling in the brain and heart of Alzheimer’s disease mice
Extracellular vesicles mediate inflammasome signaling in the brain and heart of Alzheimer’s disease mice
IntroductionAlzheimer’s disease (AD) is an inflammatory neurodegenerative disease characterized by memory loss and cogniti...
A novel pathogenic SLC12A5 missense variant in epilepsy of infancy with migrating focal seizures causes impaired KCC2 chloride extrusion
A novel pathogenic SLC12A5 missense variant in epilepsy of infancy with migrating focal seizures causes impaired KCC2 chloride extrusion
The potassium-chloride co-transporter 2, KCC2, is a neuron-specific ion transporter that plays a multifunctional role in n...
Expression characteristics and potential function of non-coding RNA in mouse cortical cells
Expression characteristics and potential function of non-coding RNA in mouse cortical cells
Non-coding RNAs (ncRNAs) play essential regulatory functions in various physiological and pathological processes in the br...
Current understanding of the molecular mechanisms of chemotherapy-induced peripheral neuropathy
Current understanding of the molecular mechanisms of chemotherapy-induced peripheral neuropathy
Chemotherapy-induced peripheral neuropathy (CIPN) is the most common off-target adverse effects caused by various chemothe...
Allelic heterogeneity and abnormal vesicle recycling in PLAA-related neurodevelopmental disorders
Allelic heterogeneity and abnormal vesicle recycling in PLAA-related neurodevelopmental disorders
The human PLAA gene encodes Phospholipase-A2-Activating-Protein (PLAA) involved in trafficking of membrane proteins. Throu...
Morphogenetic theory of mental and cognitive disorders: the role of neurotrophic and guidance molecules
Morphogenetic theory of mental and cognitive disorders: the role of neurotrophic and guidance molecules
Mental illness and cognitive disorders represent a serious problem for the modern society. Many studies indicate that ment...
Perinatal exposure to atazanavir-based antiretroviral regimens in a mouse model leads to differential long-term motor and cognitive deficits dependent on the NRTI backbone
Perinatal exposure to atazanavir-based antiretroviral regimens in a mouse model leads to differential long-term motor and cognitive deficits dependent on the NRTI backbone
BackgroundCombination antiretroviral therapy (ART) use in pregnancy has been pivotal in improving maternal health and redu...
Nano-pulling stimulates axon regeneration in dorsal root ganglia by inducing stabilization of axonal microtubules and activation of local translation
Nano-pulling stimulates axon regeneration in dorsal root ganglia by inducing stabilization of axonal microtubules and activation of local translation
IntroductionAxonal plasticity is strongly related to neuronal development as well as regeneration. It was recently demonst...
Corrigendum: Endothelial β-catenin deficiency causes blood-brain barrier breakdown via enhancing the paracellular and transcellular permeability
Corrigendum: Endothelial β-catenin deficiency causes blood-brain barrier breakdown via enhancing the paracellular and transcellular permeability
In the published article, there was an error in Supplementary Table 1. We just found that in the Supplementary Table 1, we...
Cannabinoid type-1 receptor signaling in dopaminergic Engrailed-1 expressing neurons modulates motivation and depressive-like behavior
Cannabinoid type-1 receptor signaling in dopaminergic Engrailed-1 expressing neurons modulates motivation and depressive-like behavior
The endocannabinoid system comprises highly versatile signaling functions within the nervous system. It is reported to mod...
Heterogenous effect of early adulthood stress on cognitive aging and synaptic function in the dentate gyrus
Heterogenous effect of early adulthood stress on cognitive aging and synaptic function in the dentate gyrus
Cognitive aging widely varies among individuals due to different stress experiences throughout the lifespan and vulnerabil...
GluN2B-containing NMDA receptor attenuated neuronal apoptosis in the mouse model of HIBD through inhibiting endoplasmic reticulum stress-activated PERK/eIF2α signaling pathway
GluN2B-containing NMDA receptor attenuated neuronal apoptosis in the mouse model of HIBD through inhibiting endoplasmic reticulum stress-activated PERK/eIF2α signaling pathway
IntroductionNeonatal hypoxic-ischemic brain damage (HIBD) refers to brain damage in newborns caused by hypoxia and reduced...
Insights from the neural guidance factor Netrin-1 into neurodegeneration and other diseases
Insights from the neural guidance factor Netrin-1 into neurodegeneration and other diseases
Netrin-1 was initially discovered as a neuronal growth cue for axonal guidance, and its functions have later been identifi...
Mutations in the postsynaptic density signaling hub TNIK disrupt PSD signaling in human models of neurodevelopmental disorders
Mutations in the postsynaptic density signaling hub TNIK disrupt PSD signaling in human models of neurodevelopmental disorders
A large number of synaptic proteins have been recurrently associated with complex brain disorders. One of these proteins, ...
Liver kinase B-1 modulates the activity of dopamine neurons in the ventral tegmental area and regulates social memory formation
Liver kinase B-1 modulates the activity of dopamine neurons in the ventral tegmental area and regulates social memory formation
Social memory is the ability to discriminate between familiar and unknown conspecifics. It is an important component of so...
KANPHOS: Kinase-associated neural phospho-signaling database for data-driven research
KANPHOS: Kinase-associated neural phospho-signaling database for data-driven research
Protein phosphorylation, a key regulator of cellular processes, plays a central role in brain function and is implicated i...
Editorial: Molecular mechanisms of sensorineural hearing loss and hearing protection
Editorial: Molecular mechanisms of sensorineural hearing loss and hearing protection
More than 1.5 billion people experience declining hearing ability during their lifetime. With an ageing population and inc...
Morphogenetic theory of mental and cognitive disorders: the role of neurotrophiс and guidance molecules
Morphogenetic theory of mental and cognitive disorders: the role of neurotrophiс and guidance molecules
Mental illness and cognitive disorders represent a serious problem for the modern society. Many studies indicate that ment...
The impact of canonical Wnt transcriptional repressors TLE3 and TLE4 on postsynaptic transcription at the neuromuscular junction
The impact of canonical Wnt transcriptional repressors TLE3 and TLE4 on postsynaptic transcription at the neuromuscular junction
Here, we investigated the role of the canonical Wnt signaling pathway transcriptional regulators at the neuromuscular junc...
Cuproptosis in stroke: focusing on pathogenesis and treatment
Cuproptosis in stroke: focusing on pathogenesis and treatment
Annually, more than 15 million people worldwide suffer from stroke, a condition linked to high mortality and disability ra...
Generation of contractile forces by three-dimensional bundled axonal tracts in micro-tissue engineered neural networks
Generation of contractile forces by three-dimensional bundled axonal tracts in micro-tissue engineered neural networks
Axonal extension and retraction are ongoing processes that occur throughout all developmental stages of an organism. The a...
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