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Impact of modulating leptin sensitivity on the transcriptomic profile of adult-derived hypothalamic mouse neurons
1 Introduction Hypothalamic leptin resistance, a critical factor in the development of obesity and related metabolic dis...
Uncovering novel KCC2 regulatory motifs through a comprehensive transposon-based mutant library
1 Introduction Neuron-specific K-Cl cotransporter KCC2 maintains low intracellular Cl− concentration ([Cl−]i) in neurons...
Novel strategies targeting mitochondria-lysosome contact sites for the treatment of neurological diseases
1 Introduction The idea that mitochondria are merely “cellular energy factories” has now been firmly abandoned. Extensiv...
Editorial: Oxytosis/ferroptosis: unraveling the mechanisms and its multifaceted role in neurodegenerative diseases
mechanisms underlying this process are remarkably similar, if not identical, to the cell death process named ferroptosis s...
The current state of knowledge on the role of NKG2D ligands in multiple sclerosis and other autoimmune diseases
1 Introduction Multiple sclerosis (MS) is a chronic demyelinating inflammatory disease of the central nervous system (CN...
Serum metabolomic signatures of patients with rare neurogenetic diseases: an insight into potential biomarkers and treatment targets
1 Introduction Inherited muscular dystrophies (MDs) encompass a range of conditions, including Duchenne muscular dystrop...
Neurotherapeutic impact of vanillic acid and ibudilast on the cuprizone model of multiple sclerosis
1 Introduction Multiple sclerosis (MS) is a chronic, neurodegenerative autoimmune disease targeting the myelin sheath of...
Genetic and molecular mechanisms of hydrocephalus
1 Introduction Hydrocephalus is a common neurological condition and is defined as the progressive distension of the brai...
Insight into interplay between PANoptosis and autophagy: novel therapeutics in ischemic stroke
1 Introduction Stroke, a leading culprit of mortality and disability in China, causes 5.5 million deaths and 44 million ...
Urine miRNA signature as potential non-invasive diagnostic biomarker for Hirschsprung’s disease
1 Introduction Hirschsprung’s disease (HSCR) (incidence 1/5,000 births) is a congenital gastrointestinal disorder caused...
Modeling of auditory neuropathy spectrum disorders associated with the TEME43 variant reveals impaired gap junction function of iPSC-derived glia-like support cells
1 Introduction Auditory neuropathy spectrum disorder (ANSD) is a dysfunctional disorder of the auditory nerve with the n...
The role of Aha1 in cancer and neurodegeneration
1 Hsp90 co-chaperone complexes: an introduction The 90 kDa heat shock protein (Hsp90) family accounts for 1–2% of the to...
Mapping the research landscape of microRNAs in pain: a comprehensive bibliometric analysis
1 Introduction Pain is an aversive sensory and emotional experience typically caused by, or resembling, an actual or pot...
Post-transcriptional regulation of the transcriptional apparatus in neuronal development
Introduction Alternative splicing (AS) plays a major role in expanding proteomic diversity by allowing a limited number ...
Characterization of 3,3′-iminodipropionitrile (IDPN) damaged utricle transcriptome in the adult mouse utricle
Introduction Utricle is one of the important vestibular organs detecting linear acceleration through its sensory hair ce...
Activation of mechanoreceptor Piezo1 inhibits enteric neuronal growth and migration in vitro
Introduction The enteric nervous system (ENS) is a complex network of over 500 million neurons, often referred to as the ...
Analysis of the pathogenicity and pathological characteristics of NOTCH3 gene-sparing cysteine mutations in vitro and in vivo models
1 Introduction Cerebral autosomal-dominant arteriopathy with subcortical infarction and leukoencephalopathy (CADASIL) is...
Insights into the molecular underlying mechanisms and therapeutic potential of endoplasmic reticulum stress in sensorineural hearing loss
Insights into the molecular underlying mechanisms and therapeutic potential of endoplasmic reticulum stress in sensorineural hearing loss
1 Introduction Sensorineural hearing loss (SNHL) is one of the most common types of hearing loss (HL), which affects soci...
Retraction: Endothelial-monocyte activating polypeptide II suppresses the in vitro glioblastoma-induced angiogenesis by inducing autophagy
The publisher retracts the article cited above.Following publication, concerns were raised regarding the integrity of the ...
Circulating miR-134 in mesial temporal lobe epilepsy: implications in hippocampal sclerosis development and drug resistance
1 Introduction Epilepsy is a chronic neurological disease that affects more than 50 million persons worldwide, 80% of wh...
Sensory innervation in the prostate and a role for calcitonin gene-related peptide in prostatic epithelial proliferation
Introduction The prostate is a male accessory sex organ that plays a key role in reproductive function by maintaining sp...
VNS paired with training enhances recognition memory: mechanistic insights from proteomic analysis of the hippocampal synapse
1 Introduction Recognition memory is a fundamental component of cognitive health, allowing us to learn and remember new ...
A sex-specific effect of M4 muscarinic cholinergic autoreceptor deletion on locomotor stimulation by cocaine and scopolamine
1 Introduction Acetylcholine regulates numerous critical functions within the basal ganglia by activating nicotinic and m...
Chaperones vs. oxidative stress in the pathobiology of ischemic stroke
1 Introduction The global burden inflicted by ischemic stroke is dramatic: the annual number of new cases [7,630,803 in 2...
Excitatory neuron-prone prion propagation and excitatory neuronal loss in prion-infected mice
Introduction Prion diseases are fatal and intractable neurodegenerative disorders affecting both animals and humans, inc...
Calcium-sensor proteins but not bicarbonate ion activate retinal photoreceptor membrane guanylyl cyclase in photoreceptors
Introduction Vertebrate rods and cones respond to light by changing the permeability of cyclic nucleotide-gated cation c...
Development of KCC2 therapeutics to treat neurological disorders
Introduction The KCC2 transporter is the CNS neuron-specific Cl– extruder essential for the establishment and maintenance...
Mitochondrial pathways of copper neurotoxicity: focus on mitochondrial dynamics and mitophagy
1 Introduction Copper (Cu) is an essential element involved in a plethora of metabolic processes through its structural,...
Transcorneal electrical stimulation restores DNA methylation changes in retinal degeneration
Introduction Retinal degeneration is a major cause of irreversible blindness. It is projected that the incidence of reti...
Corrigendum: Mechanisms of mitophagy and oxidative stress in cerebral ischemia–reperfusion, vascular dementia, and Alzheimer's disease
• please read through all the templates before choosing• pick the most relevant text template(s) from the following page a...
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