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Remyelination in multiple sclerosis from the miRNA perspective
Remyelination in multiple sclerosis from the miRNA perspective
Remyelination relies on the repair of damaged myelin sheaths, involving microglia cells, oligodendrocyte precursor cells (...
A distinct Golgi-targeting mechanism of dGM130 in Drosophila neurons
A distinct Golgi-targeting mechanism of dGM130 in Drosophila neurons
GM130 is a matrix protein that is conserved in metazoans and involved in the architecture of the Golgi apparatus. In neuro...
Gut microbiota-derived metabolite trimethylamine-N-oxide and stroke outcome: a systematic review
Gut microbiota-derived metabolite trimethylamine-N-oxide and stroke outcome: a systematic review
IntroductionThe relationship between baseline trimethylamine N-oxide (TMAO) levels and stroke outcomes remains unclear. Th...
The modulation effects of repeated transcutaneous auricular vagus nerve stimulation on the functional connectivity of key brainstem regions along the vagus nerve pathway in migraine patients
The modulation effects of repeated transcutaneous auricular vagus nerve stimulation on the functional connectivity of key brainstem regions along the vagus nerve pathway in migraine patients
BackgroundPrevious studies have shown a significant response to acute transcutaneous vagus nerve stimulation (taVNS) in re...
Cardiolipin externalization mediates prion protein (PrP) peptide 106–126-associated mitophagy and mitochondrial dysfunction
Cardiolipin externalization mediates prion protein (PrP) peptide 106–126-associated mitophagy and mitochondrial dysfunction
Proper mitochondrial performance is imperative for the maintenance of normal neuronal function to prevent the development ...
The recurrent pathogenic Pro890Leu substitution in CLTC causes a generalized defect in synaptic transmission in Caenorhabditis elegans
The recurrent pathogenic Pro890Leu substitution in CLTC causes a generalized defect in synaptic transmission in Caenorhabditis elegans
De novo CLTC mutations underlie a spectrum of early-onset neurodevelopmental phenotypes having developmental delay/intelle...
Identification of miRNAs regulating MAPT expression and their analysis in plasma of patients with dementia
Identification of miRNAs regulating MAPT expression and their analysis in plasma of patients with dementia
BackgroundDementia is one of the most common diseases in elderly people and hundreds of thousand new cases per year of Alz...
An updated catalog of CTCF variants associated with neurodevelopmental disorder phenotypes
An updated catalog of CTCF variants associated with neurodevelopmental disorder phenotypes
IntroductionCTCF-related disorder (CRD) is a neurodevelopmental disorder (NDD) caused by monoallelic pathogenic variants i...
GluN2B-containing NMDARs in the mammalian brain: pharmacology, physiology, and pathology
GluN2B-containing NMDARs in the mammalian brain: pharmacology, physiology, and pathology
Glutamate N-methyl-D-aspartate receptor (NMDAR) is critical for promoting physiological synaptic plasticity and neuronal v...
Differences in the neural basis and transcriptomic patterns in acute and persistent pain-related anxiety-like behaviors
Differences in the neural basis and transcriptomic patterns in acute and persistent pain-related anxiety-like behaviors
BackgroundBoth acute and persistent pain is associated with anxiety in clinical observations, but whether the underlying n...
Dysfunction of inhibitory interneurons contributes to synaptic plasticity via GABABR-pNR2B signaling in a chronic migraine rat model
Dysfunction of inhibitory interneurons contributes to synaptic plasticity via GABABR-pNR2B signaling in a chronic migraine rat model
BackgroundAccording to our previous study, the loss of inhibitory interneuron function contributes to central sensitizatio...
Comparative analysis of transcriptional changes in zebrafish cep290 and bbs2 mutants by RNA-seq reveals upregulation of inflammatory and stress-related pathways
Comparative analysis of transcriptional changes in zebrafish cep290 and bbs2 mutants by RNA-seq reveals upregulation of inflammatory and stress-related pathways
Acute injury to the adult zebrafish retina triggers the release of pro-inflammatory cytokines and growth factors that stim...
Gene expression changes in cerebellum induced by dietary restriction
Gene expression changes in cerebellum induced by dietary restriction
BackgroundDietary restriction (DR) is a well-established universal anti-aging intervention, and is neuroprotective in mult...
The impact of environmental factors during maternal separation on the behaviors of adolescent C57BL/6 mice
The impact of environmental factors during maternal separation on the behaviors of adolescent C57BL/6 mice
Neonatal maternal separation is a widely used method to construct an early-life stress model in rodents. In this method, p...
Olink proteomics profiling platform reveals non-invasive inflammatory related protein biomarkers in autism spectrum disorder
Olink proteomics profiling platform reveals non-invasive inflammatory related protein biomarkers in autism spectrum disorder
BackgroundOwing to the lack of valid biomarkers, the diagnosis of autism spectrum disorder (ASD) diagnosis relies solely o...
Programmable RNA editing with endogenous ADAR enzymes – a feasible option for the treatment of inherited retinal disease?
Programmable RNA editing with endogenous ADAR enzymes – a feasible option for the treatment of inherited retinal disease?
RNA editing holds great promise for the therapeutic correction of pathogenic, single nucleotide variants (SNV) in the huma...
Layer-specific changes of KCC2 and NKCC1 in the mouse dentate gyrus after entorhinal denervation
Layer-specific changes of KCC2 and NKCC1 in the mouse dentate gyrus after entorhinal denervation
The cation-chloride cotransporters KCC2 and NKCC1 regulate the intracellular Cl− concentration and cell volume of neurons ...
Combined treatment with Sigma1R and A2AR agonists fails to inhibit cocaine self-administration despite causing strong antagonistic accumbal A2AR-D2R complex interactions: the potential role of astrocytes
Combined treatment with Sigma1R and A2AR agonists fails to inhibit cocaine self-administration despite causing strong antagonistic accumbal A2AR-D2R complex interactions: the potential role of astrocytes
Previous studies have indicated that acute treatment with the monoamine stabilizer OSU-6162 (5 mg/kg), which has a high af...
Behavioral and neuro-functional consequences of eliminating the KCNQ3 GABA binding site in mice
Behavioral and neuro-functional consequences of eliminating the KCNQ3 GABA binding site in mice
Voltage-gated potassium (Kv) channels formed by α subunits KCNQ2-5 are important in regulating neuronal excitability. We p...
From molecule to oblivion: dedicated brain circuitry underlies anesthetic loss of consciousness permitting pain-free surgery
From molecule to oblivion: dedicated brain circuitry underlies anesthetic loss of consciousness permitting pain-free surgery
The canonical view of how general anesthetics induce loss-of-consciousness (LOC) permitting pain-free surgery posits that ...
Alpha synuclein post translational modifications: potential targets for Parkinson’s disease therapy?
Alpha synuclein post translational modifications: potential targets for Parkinson’s disease therapy?
Parkinson’s disease (PD) is the most common neurodegenerative disorder with motor symptoms. The neuropathological alterati...
Excess cerebellar granule neurons induced by the absence of p75NTR during development elicit social behavior deficits in mice
Excess cerebellar granule neurons induced by the absence of p75NTR during development elicit social behavior deficits in mice
IntroductionRecently, the cerebellum has been implicated with non-motor functions, including cognitive and emotional behav...
Cesium activates the neurotransmitter receptor for glycine
Cesium activates the neurotransmitter receptor for glycine
The monovalent cations sodium and potassium are crucial for the proper functioning of excitable cells, but, in addition, o...
A single intranasal dose of human mesenchymal stem cell-derived extracellular vesicles after traumatic brain injury eases neurogenesis decline, synapse loss, and BDNF-ERK-CREB signaling
A single intranasal dose of human mesenchymal stem cell-derived extracellular vesicles after traumatic brain injury eases neurogenesis decline, synapse loss, and BDNF-ERK-CREB signaling
An optimal intranasal (IN) dose of human mesenchymal stem cell-derived extracellular vesicles (hMSC-EVs), 90 min post-trau...
Altered GABAergic, glutamatergic and endocannabinoid signaling is accompanied by neuroinflammatory response in a zebrafish model of social withdrawal behavior
Altered GABAergic, glutamatergic and endocannabinoid signaling is accompanied by neuroinflammatory response in a zebrafish model of social withdrawal behavior
IntroductionDeficits in social communication are in the core of clinical symptoms characterizing many neuropsychiatric dis...
iASPP regulates neurite development by interacting with Spectrin proteins
iASPP regulates neurite development by interacting with Spectrin proteins
IntroductionSince its discovery in 1999, a substantial body of research has shown that iASPP is highly expressed in variou...
Pipsqueak family genes dan/danr antagonize nuclear Pros to prevent neural stem cell aging in Drosophila larval brains
Pipsqueak family genes dan/danr antagonize nuclear Pros to prevent neural stem cell aging in Drosophila larval brains
Neural stem cell aging is a fundamental question in neurogenesis. Premature nuclear Pros is considered as an indicator of ...
Extracellular vesicles highlight many cases of photoreceptor degeneration
Extracellular vesicles highlight many cases of photoreceptor degeneration
The release of extracellular vesicles is observed across numerous cell types and serves a range of biological functions in...
Bibliometric and visual analysis of microglia-related neuropathic pain from 2000 to 2021
Bibliometric and visual analysis of microglia-related neuropathic pain from 2000 to 2021
BackgroundMicroglia has gradually gained researchers’ attention in the past few decades and has shown its promising prospe...
Therapeutic effects of phlorotannins in the treatment of neurodegenerative disorders
Therapeutic effects of phlorotannins in the treatment of neurodegenerative disorders
Phlorotannins are natural polyphenolic compounds produced by brown marine algae and are currently found in nutritional sup...
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