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Down syndrome and DYRK1A overexpression: relationships and future therapeutic directions
1 Introduction Down syndrome (DS) is the most common human chromosomal disorder, accounting for approximately 1 in 500 l...
Wnt signaling pathway in spinal cord injury: from mechanisms to potential applications
1 Introduction Spinal Cord Injury (SCI) pertains to the impairment of spinal cord structure and function due to external...
Splice-switching antisense oligonucleotides for pediatric neurological disorders
Introduction Over the last two decades, causal variants for pediatric neurological disorders have been increasingly unco...
Control of innate immunity and lipid biosynthesis in neurodegeneration
1 Introduction Biochemical processes that protect cells from disease and infection are also processes that can become chr...
Drosophila larval motor patterning relies on regulated alternative splicing of Dscam2
1 Introduction Neuromotor patterning underlies many key aspects of animal behavior including locomotion. Understanding t...
Stress and the gut-brain axis: an inflammatory perspective
Stress and the gut-brain axis: an inflammatory perspective
1 Introduction The bidirectional communication network between the central nervous system (CNS) and the gastrointestinal ...
Post-translational modifications in prion diseases
Post-translational modifications in prion diseases
1 Introduction The structure, dynamics, and functionalities of proteins depend on or are influenced by post-translationa...
Quantitative mass spectrometry analysis of the injured proximal and distal human digital nerve ends
Quantitative mass spectrometry analysis of the injured proximal and distal human digital nerve ends
1 Introduction Peripheral nerve injuries can lead to significant functional impairments, severely affecting patients’ qu...
Context-dependent hyperactivity in syngap1a and syngap1b zebrafish models of SYNGAP1-related disorder
Context-dependent hyperactivity in syngap1a and syngap1b zebrafish models of SYNGAP1-related disorder
Background SYNGAP1-related disorder (SYNGAP1-RD), also known as SYNGAP1 syndrome, is caused by genetic variants in the S...
Disease-modifying rdHSV-CA8* non-opioid analgesic gene therapy treats chronic osteoarthritis pain by activating Kv7 voltage-gated potassium channels
Disease-modifying rdHSV-CA8* non-opioid analgesic gene therapy treats chronic osteoarthritis pain by activating Kv7 voltage-gated potassium channels
Introduction Chronic osteoarthritis (OA) pain, like most prevalent noncancer pain conditions, remains inadequately treat...
hnRNPs: roles in neurodevelopment and implication for brain disorders
hnRNPs: roles in neurodevelopment and implication for brain disorders
1 Introduction The exact number of protein-coding genes within the human genome remains a subject of intensive discussio...
Calcium-dependent activator protein for secretion 2 is involved in dopamine release in mouse midbrain neurons
1 Introduction The Ca2+-dependent activator protein for secretion (CAPS/CADPS) regulates the activity-dependent exocytos...
The roles of circular RNAs in nerve injury and repair
1 Introduction In clinical practice, injuries to the central and peripheral nervous systems are a frequent occurrence. S...
Zebrafish myo7aa affects congenital hearing by regulating Rho-GTPase signaling
Introduction Deafness and hearing impairment are major global health problems. The ear is an important hearing and balan...
NFAT3-FasL axis synchronously regulates apoptosis and necroptosis in murine cochlear outer hair cells after noise trauma
1 Introduction Noise-induced hearing loss (NIHL) is a significant cause of hearing impairment in adults due to entertain...
Copper toxicity and deficiency: the vicious cycle at the core of protein aggregation in ALS
Introduction Amyotrophic Lateral Sclerosis (ALS) is a heterogeneous neurodegenerative disease that primarily affects bot...
Editorial: Perspectives in neuroscience: mechanical forces for the modulation of axonal mechanics and nerve regeneration
Nerve injury is a pervasive clinical issue with profound social and economic implications worldwide. Despite the availab...
SFRP4 protein expression is reduced in high grade astrocytomas which is not caused by the methylation of its promoter
SFRP4 protein expression is reduced in high grade astrocytomas which is not caused by the methylation of its promoter
Introduction Gliomas comprise about 30 percent of all brain tumors and about 80 percent of all malignant brain tumors. C...
Downregulation of hsa-miR-132 and hsa-miR-129: non-coding RNA molecular signatures of Alzheimer’s disease
Downregulation of hsa-miR-132 and hsa-miR-129: non-coding RNA molecular signatures of Alzheimer’s disease
Introduction Alzheimer’s disease (AD) is the leading cause of dementia, presenting a significant socioeconomic burden wit...
Treadmill running on neuropathic pain: via modulation of neuroinflammation
Treadmill running on neuropathic pain: via modulation of neuroinflammation
1 Introduction Pain is caused by the activation of nociceptors, which are activated in three ways: mechanical, chemical,...
Pharmacological HDAC3 inhibition alters memory updating in young and old male mice
Pharmacological HDAC3 inhibition alters memory updating in young and old male mice
Introduction The ability to learn is critical for survival across species. While research has heavily explored the mecha...
Ubiquitination contributes to the regulation of GDP-mannose pyrophosphorylase B activity
Ubiquitination contributes to the regulation of GDP-mannose pyrophosphorylase B activity
Introduction GDP-mannose pyrophosphorylase B (GMPPB) catalyzes the conversion of guanosine triphosphate and mannose-1-ph...
Methods for negating the impact of zinc contamination to allow characterization of positive allosteric modulators of glycine receptors
Methods for negating the impact of zinc contamination to allow characterization of positive allosteric modulators of glycine receptors
1 Introduction Zinc is a divalent metal cation that is ubiquitous throughout nature. It is the second most abundant micr...
Retraction: Icariin reduces dopaminergic neuronal loss and microglia-mediated inflammation in vivo and in vitro
Retraction: Icariin reduces dopaminergic neuronal loss and microglia-mediated inflammation in vivo and in vitro
Retraction: Icariin Reduces Dopaminergic Neuronal Loss and Microglia-Mediated Inflammation in Vivo and in VitroPlease find...
The role of Foxo3a in neuron-mediated cognitive impairment
The role of Foxo3a in neuron-mediated cognitive impairment
1 Introduction Cognitive impairment (COI) is a brain disorder involved in impaired memory, language, reasoning, calculati...
Novel insights into STIM1's role in store-operated calcium entry and its implications for T-cell mediated inflammation in trigeminal neuralgia
Novel insights into STIM1's role in store-operated calcium entry and its implications for T-cell mediated inflammation in trigeminal neuralgia
This investigation aims to elucidate the novel role of Stromal Interaction Molecule 1 (STIM1) in modulating store-operated...
Editorial: Molecular and cellular mechanisms of sensory functions in insect models, volume II
Editorial: Molecular and cellular mechanisms of sensory functions in insect models, volume II
Sensory systems are indispensable for all organisms to receive dynamic information from their surrounding environment. A d...
Recovery kinetics of dual AAV-mediated human otoferlin expression
Recovery kinetics of dual AAV-mediated human otoferlin expression
Deafness-causing deficiencies in otoferlin (OTOF) have been addressed preclinically using dual adeno-associated virus (AAV...
Editorial: Restoring neural circuits after spinal cord injury
Editorial: Restoring neural circuits after spinal cord injury
Although there are reports of restoring neural circuits to treat spinal cord injury, the results are not ideal. Lots of wo...
Tackling neurodegeneration in vitro with omics: a path towards new targets and drugs
Tackling neurodegeneration in vitro with omics: a path towards new targets and drugs
1 Introduction Neurodegenerative diseases (NDDs) represent a growing societal and public health burden affecting million...
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