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Circ-Vps41 positively modulates Syp and its overexpression improves memory ability in aging mice
Circ-Vps41 positively modulates Syp and its overexpression improves memory ability in aging mice
IntroductionAge is an established risk factor for neurodegenerative disorders. Aging-related cognitive decline is a common...
The effect and mechanism of exercise for post-stroke pain
The effect and mechanism of exercise for post-stroke pain
One of the common negative effects of a stroke that seriously lowers patients’ quality of life is post-stroke pain (PSP). ...
Miro1 R272Q disrupts mitochondrial calcium handling and neurotransmitter uptake in dopaminergic neurons
Miro1 R272Q disrupts mitochondrial calcium handling and neurotransmitter uptake in dopaminergic neurons
The Rho GTPase Miro1, located at the mitochondrial outer membrane is known to properly distribute mitochondria to synapses...
Evolutionary perspective of Big tau structure: 4a exon variants of MAPT
Evolutionary perspective of Big tau structure: 4a exon variants of MAPT
The MAPT gene encoding the microtubule-associated protein tau can generate multiple isoforms by alternative splicing givin...
Dynamic functional and structural remodeling during retinal regeneration in zebrafish
Dynamic functional and structural remodeling during retinal regeneration in zebrafish
IntroductionZebrafish regenerate their retinas following damage, resulting in restoration of visual function. Here we eval...
Association between grip strength and cognitive impairment in older American adults
Association between grip strength and cognitive impairment in older American adults
Background and aimsExponential population aging has led to an increased prevalence of cognitive impairment worldwide. Hand...
A steroid receptor coactivator small molecule “stimulator” attenuates post-stroke ischemic brain injury
A steroid receptor coactivator small molecule “stimulator” attenuates post-stroke ischemic brain injury
Introduction: Pathologic remodeling of the brain following ischemic stroke results in neuronal loss, increased inflammatio...
A developmental delay linked missense mutation in Kalirin-7 disrupts protein function and neuronal morphology
A developmental delay linked missense mutation in Kalirin-7 disrupts protein function and neuronal morphology
The Rac1 guanine exchange factor Kalirin-7 is a key regulator of dendritic spine morphology, LTP and dendritic arborizatio...
Transcription factors regulating the specification of brainstem respiratory neurons
Transcription factors regulating the specification of brainstem respiratory neurons
Breathing (or respiration) is an unconscious and complex motor behavior which neuronal drive emerges from the brainstem. I...
Valproic acid exposure decreases neurogenic potential of outer radial glia in human brain organoids
Valproic acid exposure decreases neurogenic potential of outer radial glia in human brain organoids
Valproic acid (VPA) exposure during pregnancy leads to a higher risk of autism spectrum disorder (ASD) susceptibility in o...
Transcription factor ZNF22 regulates blood-tumor barrier permeability by interacting with HDAC3 protein
Transcription factor ZNF22 regulates blood-tumor barrier permeability by interacting with HDAC3 protein
ObjectiveThe primary goals of this study were to investigate the potential roles of ZNF22 and HDAC3 as a histone deacetyla...
Cochlear resident macrophage mediates development of ribbon synapses via CX3CR1/CX3CL1 axis
Cochlear resident macrophage mediates development of ribbon synapses via CX3CR1/CX3CL1 axis
Cochlear ribbon synapses formed between spiral ganglion neurons and inner hair cells in postnatal mice must undergo signif...
Altered expression of glycobiology-related genes in Parkinson’s disease brain
Altered expression of glycobiology-related genes in Parkinson’s disease brain
The precise mechanisms initiating and perpetuating the cellular degeneration in Parkinson’s disease (PD) remain unclear. T...
The AMPylase FIC-1 modulates TGF-β signaling in Caenorhabditis elegans
The AMPylase FIC-1 modulates TGF-β signaling in Caenorhabditis elegans
Post-translational protein modifications are essential for the spatio-temporal regulation of protein function. In this stu...
Advances in brain-heart syndrome: Attention to cardiac complications after ischemic stroke
Advances in brain-heart syndrome: Attention to cardiac complications after ischemic stroke
Neurocardiology is an emerging field that studies the interaction between the brain and the heart, namely the effects of h...
Extracellular vesicles in neurodegenerative diseases: A systematic review
Extracellular vesicles in neurodegenerative diseases: A systematic review
IntroductionExtracellular vesicles (EVs) are known to have a significant role in the central nervous system (CNS) and neur...
White matter abnormalities in the Hdc knockout mouse, a model of tic and OCD pathophysiology
White matter abnormalities in the Hdc knockout mouse, a model of tic and OCD pathophysiology
IntroductionAn inactivating mutation in the histidine decarboxylase gene (Hdc) has been identified as a rare but high-pene...
Inhibition of glycogen synthase kinase 3 by lithium, a mechanism in search of specificity
Inhibition of glycogen synthase kinase 3 by lithium, a mechanism in search of specificity
Inhibition of Glycogen synthase kinase 3 (GSK3) is a popular explanation for the effects of lithium ions on mood regulatio...
Galectin-9/Tim-3 pathway mediates dopaminergic neurodegeneration in MPTP-induced mouse model of Parkinson’s disease
Galectin-9/Tim-3 pathway mediates dopaminergic neurodegeneration in MPTP-induced mouse model of Parkinson’s disease
Galectin-9 (Gal-9) is a crucial immunoregulatory mediator in the central nervous system. Microglial activation and neuroin...
Anesthesia and developing brain: What have we learned from recent studies
Anesthesia and developing brain: What have we learned from recent studies
Anesthesia is unavoidable in surgical procedures. However, whether the general anesthetics are neurotoxic to immature brai...
Non-coding RNA and n6-methyladenosine modification play crucial roles in neuropathic pain
Non-coding RNA and n6-methyladenosine modification play crucial roles in neuropathic pain
After peripheral nerve injury, pain signals are transmitted from primary sensory neurons in the dorsal root ganglion (DRG)...