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Itch: from the skin to the brain – peripheral and central neural sensitization in chronic itch
Itch: from the skin to the brain – peripheral and central neural sensitization in chronic itch
Similar to chronic pain, chronic itch is frequently linked to neural sensitization, a phenomenon wherein the nervous syste...
Insights on therapeutic potential of clemastine in neurological disorders
Insights on therapeutic potential of clemastine in neurological disorders
Clemastine, a Food and Drug Administration (FDA)-approved compound, is recognized as a first-generation, widely available ...
Unraveling the functional consequences of a novel germline missense mutation (R38C) in the yeast model of succinate dehydrogenase subunit B: insights into neurodegenerative disorders
Unraveling the functional consequences of a novel germline missense mutation (R38C) in the yeast model of succinate dehydrogenase subunit B: insights into neurodegenerative disorders
This study explores the implications of a novel germline missense mutation (R38C) in the succinate dehydrogenase (SDH) sub...
Editorial: Inflammatory pain: mechanisms, assessment, and intervention
Editorial: Inflammatory pain: mechanisms, assessment, and intervention
Inflammatory pain refers to the increased sensitivity of perception and emotional response to noxious stimuli, that arises...
Syntaxin-1 is necessary for UNC5A-C/Netrin-1-dependent macropinocytosis and chemorepulsion
Syntaxin-1 is necessary for UNC5A-C/Netrin-1-dependent macropinocytosis and chemorepulsion
IntroductionBrain connectivity requires correct axonal guidance to drive axons to their appropriate targets. This process ...
Human BBB-on-a-chip reveals barrier disruption, endothelial inflammation, and T cell migration under neuroinflammatory conditions
Human BBB-on-a-chip reveals barrier disruption, endothelial inflammation, and T cell migration under neuroinflammatory conditions
The blood-brain barrier (BBB) is a highly selective barrier that ensures a homeostatic environment for the central nervous...
Age-dependent changes on fractalkine forms and their contribution to neurodegenerative diseases
Age-dependent changes on fractalkine forms and their contribution to neurodegenerative diseases
The chemokine fractalkine (FKN, CX3CL1), a member of the CX3C subfamily, contributes to neuron–glia interaction and the re...
PGC-1α regulates critical period onset/closure, mediating cortical plasticity
PGC-1α regulates critical period onset/closure, mediating cortical plasticity
Peroxisome proliferator-activated receptor PPARγ coactivator-α (PGC-1α) is concentrated in inhibitory interneurons and pla...
Brain cell-specific origin of circulating microRNA biomarkers in experimental temporal lobe epilepsy
Brain cell-specific origin of circulating microRNA biomarkers in experimental temporal lobe epilepsy
The diagnosis of epilepsy is complex and challenging and would benefit from the availability of molecular biomarkers, idea...
Enhanced TrkA signaling impairs basal forebrain-dependent behavior
Enhanced TrkA signaling impairs basal forebrain-dependent behavior
Basal forebrain cholinergic neurons (BFCNs) modulate cognitive functions such as attention, learning and memory. The NGF/T...
The retrograde IFT dynein is required for normal function of diverse mechanosensory cilia in Drosophila
The retrograde IFT dynein is required for normal function of diverse mechanosensory cilia in Drosophila
IntroductionCilia biogenesis relies on intraflagellar transport (IFT), a conserved transport mechanism which functions bi-...
Dynamic alterations in the amplitude of low-frequency fluctuation in patients with cerebral small vessel disease
Dynamic alterations in the amplitude of low-frequency fluctuation in patients with cerebral small vessel disease
Background and purposePrevious studies have focused on the changes of dynamic and static functional connections in cerebra...
Neurodevelopmental disorders and microcephaly: how apoptosis, the cell cycle, tau and amyloid-β precursor protein APPly
Neurodevelopmental disorders and microcephaly: how apoptosis, the cell cycle, tau and amyloid-β precursor protein APPly
Recent studies promote new interest in the intersectionality between autism spectrum disorder (ASD) and Alzheimer’s Diseas...
A role for pathogenic autoantibodies in small fiber neuropathy?
A role for pathogenic autoantibodies in small fiber neuropathy?
The immune system has a role in neuropathic pain which includes autoimmune mechanisms (e.g., autoantibodies). Clinical stu...
Analyzing alternative splicing in Alzheimer’s disease postmortem brain: a cell-level perspective
Analyzing alternative splicing in Alzheimer’s disease postmortem brain: a cell-level perspective
Alzheimer’s disease (AD) is a neurodegenerative disease with no effective cure that attacks the brain’s cells resulting in...
APPlications of amyloid-β precursor protein metabolites in macrocephaly and autism spectrum disorder
APPlications of amyloid-β precursor protein metabolites in macrocephaly and autism spectrum disorder
Metabolites of the Amyloid-β precursor protein (APP) proteolysis may underlie brain overgrowth in Autism Spectrum Disorder...
Possible mechanisms of treatment for spinal cord injury repair with tanshinone IIA
Possible mechanisms of treatment for spinal cord injury repair with tanshinone IIA
Tanshinone IIA serves as a coenzyme for certain biochemical reactions, exhibiting various pharmacological effects in the t...
Human blood-labyrinth barrier model to study the effects of cytokines and inflammation
Human blood-labyrinth barrier model to study the effects of cytokines and inflammation
Hearing loss is one of the 10 leading causes of disability worldwide. No drug therapies are currently available to protect...
A juvenile mouse model of anti-N-methyl-D-aspartate receptor encephalitis by active immunization
A juvenile mouse model of anti-N-methyl-D-aspartate receptor encephalitis by active immunization
IntroductionAnti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a common autoimmune encephalitis, and it is associa...
The miRNA transcriptome of cerebrospinal fluid in preterm infants reveals the signaling pathways that promote reactive gliosis following cerebral hemorrhage
The miRNA transcriptome of cerebrospinal fluid in preterm infants reveals the signaling pathways that promote reactive gliosis following cerebral hemorrhage
IntroductionGerminal Matrix-Intraventricular Haemorrhage (GM-IVH) is one of the most common neurological complications in ...
Scratching increases epidermal neuronal branching and alters psychophysical testing responses in atopic dermatitis and brachioradial pruritus
Scratching increases epidermal neuronal branching and alters psychophysical testing responses in atopic dermatitis and brachioradial pruritus
BackgroundChronic scratching imposes a major stress on the skin and can lead to itch intensity worsening, and consequently...
Closest horizons of Hsp70 engagement to manage neurodegeneration
Closest horizons of Hsp70 engagement to manage neurodegeneration
Our review seeks to elucidate the current state-of-the-art in studies of 70-kilodalton-weighed heat shock proteins (Hsp70)...
The role of glycogen synthase kinase 3 beta in neurodegenerative diseases
The role of glycogen synthase kinase 3 beta in neurodegenerative diseases
Neurodegenerative diseases (NDDs) pose an increasingly prevalent threat to the well-being and survival of elderly individu...
A tactile twist: decoding the phenomena of mechanical itch and alloknesis
A tactile twist: decoding the phenomena of mechanical itch and alloknesis
Itch is a sensation in the skin which provokes the desire to scratch. In the past few decades there has been a significant...
Neurodegeneration and its potential markers in the diagnosing of secondary progressive multiple sclerosis. A review
Neurodegeneration and its potential markers in the diagnosing of secondary progressive multiple sclerosis. A review
Approximately 70% of relapsing-remitting multiple sclerosis (RRMS) patients will develop secondary progressive multiple sc...
Editorial: Mitochondrial dysfunction as a target in neurodegenerative diseases
Editorial: Mitochondrial dysfunction as a target in neurodegenerative diseases
promoting neurodegeneration by promoting the activation of the NLRP3 inflammasome (8,9), suggesting that mitochondrial dys...
Involvement of brain-derived neurotrophic factor signaling in the pathogenesis of stress-related brain diseases
Involvement of brain-derived neurotrophic factor signaling in the pathogenesis of stress-related brain diseases
Neurotrophins including brain-derived neurotrophic factor, BDNF, have critical roles in neuronal differentiation, cell sur...
Bacterial extracellular vesicles – brain invaders? A systematic review
Bacterial extracellular vesicles – brain invaders? A systematic review
IntroductionKnowledge on the human gut microbiota in health and disease continues to rapidly expand. In recent years, chan...
Peripheral mechanisms of peripheral neuropathic pain
Peripheral mechanisms of peripheral neuropathic pain
Peripheral neuropathic pain (PNP), neuropathic pain that arises from a damage or disease affecting the peripheral nervous ...
Conflicting theories on addiction aetiology and the strengths and limitations of substance use disorder disease modelling
Conflicting theories on addiction aetiology and the strengths and limitations of substance use disorder disease modelling
A lack of cross-disciplinary unanimity prevails within addiction research. Theories conceptualizing addiction through the ...
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