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Discovering functional motifs in long noncoding RNAs
Discovering functional motifs in long noncoding RNAs
Abstract Long noncoding RNAs (lncRNAs) are products of pervasive transcription that closely resemble messenger RNAs on the...
Uncovering the impacts of alternative splicing on the proteome with current omics techniques
Uncovering the impacts of alternative splicing on the proteome with current omics techniques
Abstract The high-throughput sequencing of cellular RNAs has underscored a broad effect of isoform diversification through...
Telomerase ribonucleoprotein and genome integrity—An emerging connection in protozoan parasites
Telomerase ribonucleoprotein and genome integrity—An emerging connection in protozoan parasites
Abstract Telomerase has an established role in telomere maintenance in eukaryotes. However, recent studies have begun to i...
RNA nucleotide methylation: 2021 update
RNA nucleotide methylation: 2021 update
Abstract Among RNA modifications, transfer of methylgroups from the typical cofactor S-adenosyl-l-methionine by methyltran...
microRNA‐based diagnostic and therapeutic applications in cancer medicine
microRNA‐based diagnostic and therapeutic applications in cancer medicine
Abstract It has been almost two decades since the first link between microRNAs and cancer was established. In the ensuing ...
Detecting the epitranscriptome
Detecting the epitranscriptome
Abstract RNA modifications and their corresponding epitranscriptomic writer and eraser enzymes regulate gene expression. A...
The control of polycomb repressive complexes by long noncoding RNAs
The control of polycomb repressive complexes by long noncoding RNAs
Abstract The polycomb repressive complexes 1 and 2 (PRCs; PRC1 and PRC2) are conserved histone-modifying enzymes that ofte...
Ribosome dynamics and mRNA turnover, a complex relationship under constant cellular scrutiny
Ribosome dynamics and mRNA turnover, a complex relationship under constant cellular scrutiny
Abstract Eukaryotic gene expression is closely regulated by translation and turnover of mRNAs. Recent advances highlight t...
The many facets of miR‐223 in cancer: Oncosuppressor, oncogenic driver, therapeutic target, and biomarker of response
The many facets of miR‐223 in cancer: Oncosuppressor, oncogenic driver, therapeutic target, and biomarker of response
Abstract Given their intrinsic pleiotropism, microRNAs (miR) play complex biological roles, in both normal and pathologica...
Long noncoding RNAs in bacterial infection
Long noncoding RNAs in bacterial infection
Abstract Infectious and inflammatory diseases remain major causes of mortality and morbidity worldwide. To combat bacteria...
Long noncoding RNA‐dependent methylation of nonhistone proteins
Long noncoding RNA‐dependent methylation of nonhistone proteins
Abstract In the last decade, an intriguing new paradigm of regulation has emerged in which some transcripts longer than 20...
Choosing the right exit: How functional plasticity of the nuclear pore drives selective and efficient mRNA export
Choosing the right exit: How functional plasticity of the nuclear pore drives selective and efficient mRNA export
Abstract The nuclear pore complex (NPC) serves as a central gate for mRNAs to transit from the nucleus to the cytoplasm. T...
The “guiding” principles of noncoding RNA function
The “guiding” principles of noncoding RNA function
Abstract The human genome is pervasively transcribed and yet only a small fraction of these RNAs (less than 2%) are known ...
Antisense oligonucleotide: A promising therapeutic option to beat COVID‐19
Antisense oligonucleotide: A promising therapeutic option to beat COVID‐19
Abstract The COVID-19 crisis and the development of the first approved mRNA vaccine have highlighted the power of RNA-base...
Non‐coding RNAs and their cross‐talks impacting reproductive health of women
Non‐coding RNAs and their cross‐talks impacting reproductive health of women
Abstract Non-coding RNAs (ncRNAs) work as crucial posttranscriptional modulators of gene expression regulating a wide arra...
RNA modifications as emerging therapeutic targets
RNA modifications as emerging therapeutic targets
Abstract The field of epitranscriptome, posttranscriptional modifications to RNAs, is still growing up and has presented s...
Regulation and different functions of the animal microRNA‐induced silencing complex
Regulation and different functions of the animal microRNA‐induced silencing complex
Abstract Among the different types of small RNAs, microRNAs (miRNAs) are key players in controlling gene expression at the...
A mechanistic view of long noncoding RNAs in cancer
A mechanistic view of long noncoding RNAs in cancer
Abstract Long noncoding RNAs (lncRNAs) have emerged as important modulators of a wide range of biological processes in nor...
The importance of RNA modifications: From cells to muscle physiology
The importance of RNA modifications: From cells to muscle physiology
Abstract Naturally occurring post-transcriptional chemical modifications serve critical roles in impacting RNA structure a...
Non‐coding RNAs in malaria infection
Non‐coding RNAs in malaria infection
Abstract Malaria is one of the most severe infectious diseases affecting humans and it is caused by protozoan pathogens of...
Riboregulation in bacteria: From general principles to novel mechanisms of the trp attenuator and its sRNA and peptide products
Riboregulation in bacteria: From general principles to novel mechanisms of the trp attenuator and its sRNA and peptide products
Abstract Gene expression strategies ensuring bacterial survival and competitiveness rely on cis- and trans-acting RNA-regu...
Applications of the versatile CRISPR‐Cas13 RNA targeting system
Applications of the versatile CRISPR‐Cas13 RNA targeting system
Abstract CRISPR-Cas are adaptable natural prokaryotic defense systems that act against invading viruses and plasmids. Amon...
Alternative polyadenylation: An enigma of transcript length variation in health and disease
Alternative polyadenylation: An enigma of transcript length variation in health and disease
Abstract Alternative polyadenylation (APA) is a molecular mechanism during a pre-mRNA processing that involves usage of mo...
Micro‐RNAs: A safety net to protect hematopoietic stem cell self‐renewal
Micro‐RNAs: A safety net to protect hematopoietic stem cell self‐renewal
Abstract The hematopoietic system is sustained over time by a small pool of hematopoietic stem cells (HSCs). They reside a...
Mitochondrial RNA, a new trigger of the innate immune system
Mitochondrial RNA, a new trigger of the innate immune system
Abstract Mitochondria play a pivotal role in numerous cellular processes. One of them is regulation of the innate immune p...
A (dis)integrated stress response: Genetic diseases of eIF2α regulators
A (dis)integrated stress response: Genetic diseases of eIF2α regulators
Abstract The integrated stress response (ISR) is a conserved mechanism by which eukaryotic cells remodel gene expression t...
Conserved motifs in the flavivirus NS3 RNA helicase enzyme
Conserved motifs in the flavivirus NS3 RNA helicase enzyme
Abstract Flaviviruses are a major health concern because over half of the world population is at risk of infection and the...
Cover Image, Volume 12, Issue 5
Cover Image, Volume 12, Issue 5
The cover image is based on the Advanced Review On the function and relevance of alternative 3′-UTRs in gene expres...
Circular RNA translation, a path to hidden proteome
Circular RNA translation, a path to hidden proteome
Abstract Functional proteins in the cell are translated from the messenger RNA (mRNA) molecules, constituting less than 5%...
Time to infer miRNA sponge modules
Time to infer miRNA sponge modules
Abstract Inferring competing endogenous RNA (ceRNA) or microRNA (miRNA) sponge modules is a challenging and meaningful tas...
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