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Circulating cytokines and vascular dementia: A bi-directional Mendelian randomization study
Circulating cytokines and vascular dementia: A bi-directional Mendelian randomization study
Inflammatory responses are associated with the development of vascular dementia (VaD). Circulating cytokines modulate the ...
Eldecalcitol protected osteocytes against ferroptosis of D-gal-induced senescent MLO-Y4 cells and ovariectomized mice
Eldecalcitol protected osteocytes against ferroptosis of D-gal-induced senescent MLO-Y4 cells and ovariectomized mice
Volume 189, May 2024, 112408Author links open overlay panel, , , , , , Highlights•Ferroptosis appeared during the developm...
Pulmonary function and trajectories of cognitive decline in aging population
Pulmonary function and trajectories of cognitive decline in aging population
Volume 189, May 2024, 112386Author links open overlay panel, , , , Highlights•Longitudinal analysis of peak expiratory flo...
Remazolam affects the phenotype and function of astrocytes to improve traumatic brain injury by regulating the Cx43
Remazolam affects the phenotype and function of astrocytes to improve traumatic brain injury by regulating the Cx43
PurposeTo explore the mechanism by which Remazolam affects the phenotype and function of astrocytes to improve traumatic b...
Visuospatial cognition predicts performance on an obstructed vision obstacle walking task in older adults
Visuospatial cognition predicts performance on an obstructed vision obstacle walking task in older adults
Walking performance and cognitive function demonstrate strong associations in older adults, with both declining with advan...
Endoplasmic reticulum stress-induced necroptosis promotes cochlear inflammation: Implications for age-related hearing loss
Endoplasmic reticulum stress-induced necroptosis promotes cochlear inflammation: Implications for age-related hearing loss
Age-related hearing loss (ARHL) is the most common sensory disorder associated with human aging. Chronic inflammation is s...
The mediating role of lower body muscle strength and IGF-1 level in the relationship between age and cognition. A MIDUS substudy
The mediating role of lower body muscle strength and IGF-1 level in the relationship between age and cognition. A MIDUS substudy
ObjectiveAging is a natural process associated with a decline in cognition. However, the mediating effect of physical func...
Effect of outer membrane vesicles of Lactobacillus pentosus on Tau phosphorylation and CDK5-Calpain pathway in mice
Effect of outer membrane vesicles of Lactobacillus pentosus on Tau phosphorylation and CDK5-Calpain pathway in mice
Alzheimer's disease (AD) stands as a neurodegenerative disorder causing cognitive decline, posing a significant health con...
Parental age at death is associated with age at first birth in offspring
Parental age at death is associated with age at first birth in offspring
PurposePeople age at different rates and the available evidence suggests that the rate of aging is partly inherited from p...
CircHIVEP2 alleviates Parkinson's nerve damage and inflammatory response by targeting miR-485-3p
CircHIVEP2 alleviates Parkinson's nerve damage and inflammatory response by targeting miR-485-3p
ObjectiveDysregulation of covalently closed circular RNAs (circRNAs) has been associated with neurological disorders, the ...
Combined effects of sleep and objectively-measured daily physical activity on arterial stiffness in middle-aged and older adults
Combined effects of sleep and objectively-measured daily physical activity on arterial stiffness in middle-aged and older adults
KeywordsAgingSleep disorderPulse wave velocityModerate-to-vigorous-intensity physical activityDaily step countData availab...
p53 accelerates endothelial cell senescence in diabetic retinopathy by enhancing FoxO3a ubiquitylation and degradation via UBE2L6
p53 accelerates endothelial cell senescence in diabetic retinopathy by enhancing FoxO3a ubiquitylation and degradation via UBE2L6
Diabetic retinopathy (DR) is the most common ocular fundus disease in diabetic patients. Chronic hyperglycemia not only pr...
Kaempferol: Paving the path for advanced treatments in aging-related diseases
Kaempferol: Paving the path for advanced treatments in aging-related diseases
Aging-related diseases (ARDs) are a major global health concern, and the development of effective therapies is urgently ne...
Relationship between glycated hemoglobin levels at admission and chronic post-stroke fatigue in patients with acute ischemic stroke
Relationship between glycated hemoglobin levels at admission and chronic post-stroke fatigue in patients with acute ischemic stroke
BackgroundChronic Post-Stroke Fatigue (PSF) is a common and persistent complications among ischemic stroke survivors. The ...
Path analysis to identify factors influencing osteoporosis: A cross-sectional study
Path analysis to identify factors influencing osteoporosis: A cross-sectional study
AbbreviationsGFRglomerular filtration rateDXAdual-energy X-ray absorptiometryRMSEAroot mean square error of approximationK...
The role of mitochondrial quality control mechanisms in chondrocyte senescence
The role of mitochondrial quality control mechanisms in chondrocyte senescence
Chondrocytes are the exclusive cellular constituents of articular cartilage, and their functional status governs the healt...
Visualizing the bibliometrics of the inflammatory mechanisms in intervertebral disc degeneration
Visualizing the bibliometrics of the inflammatory mechanisms in intervertebral disc degeneration
ObjectiveIntervertebral disc degeneration (IVDD) constitutes a crucial pathological foundation for spinal degenerative dis...
Laboratory-assessed gait cycle entropy for classifying walking limitations among community-dwelling older adults
Laboratory-assessed gait cycle entropy for classifying walking limitations among community-dwelling older adults
Volume 188, April 2024, 112381Author links open overlay panel, , , , , Highlights•Older people with walking issues show hi...
Sarcopenic patients “get even”: The impact of COVID-19 vaccination on mortality
Sarcopenic patients “get even”: The impact of COVID-19 vaccination on mortality
BackgroundCoronavirus Disease-2019 (COVID-19), driven by the SARS-CoV-2 virus, has disproportionately affected the elderly...
Pilates versus Zumba training effects on postural control under conflicting sensory conditions in postmenopausal women
Pilates versus Zumba training effects on postural control under conflicting sensory conditions in postmenopausal women
The current study aimed to compare the effects of Pilates versus Zumba training on postural performance in middle-aged pos...
Does excess body weight accelerate immune aging?
Does excess body weight accelerate immune aging?
BackgroundOverweight and obesity in older adults increase the risk of a range of comorbidities by sustaining chronic infla...
Alterations in the diversity, composition and function of the gut microbiota in Uyghur individuals with sarcopenia
Alterations in the diversity, composition and function of the gut microbiota in Uyghur individuals with sarcopenia
BackgroundResearch on the gut microbiota has emerged as a new direction for understanding pathophysiologic changes in dise...
Pathological α-synuclein detected by real-time quaking-induced conversion in synucleinopathies
Pathological α-synuclein detected by real-time quaking-induced conversion in synucleinopathies
synucleinopathies are diseases characterized by the aggregation of α-synuclein (α-syn), which forms fibrils through misfol...