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Experimental models for elderly patients with membranous nephropathy: Application and advancements
Experimental models for elderly patients with membranous nephropathy: Application and advancements
Membranous nephropathy (MN) occurs predominantly in middle-aged and elderly individuals and ranks among the most prevalent...
Sex differences in frailty among older adults
Sex differences in frailty among older adults
By definition, aging is a natural, gradual and continuous process. On the other hand, frailty reflects the increase in vul...
Effects of free versus restricted arm movements on postural control in normal and modified sensory conditions in young and older adults
Effects of free versus restricted arm movements on postural control in normal and modified sensory conditions in young and older adults
Volume 184, December 2023, 112338Author links open overlay panel, , , , Highlights•We explored how arm movements influence...
The combined deleterious effects of multiple sclerosis and ageing on neuromuscular function
The combined deleterious effects of multiple sclerosis and ageing on neuromuscular function
BackgroundThe prevalence of older (>60 years) people with multiple sclerosis (pwMS) is increasing. This introduces nume...
Dietary supplementation with nacre reduces cortical bone loss in aged female mice
Dietary supplementation with nacre reduces cortical bone loss in aged female mice
Aging is associated with detrimental bone loss leading to fragility fractures in both men and women. Notably, a majority o...
Introduction to special issue on ‘physiological and evolutionary mechanisms of aging’
Introduction to special issue on ‘physiological and evolutionary mechanisms of aging’
We use cookies to help provide and enhance our service and tailor content and ads. By continuing you agree to the use of c...
Heme oxygenase-1: A potential therapeutic target for improving skeletal muscle atrophy
Heme oxygenase-1: A potential therapeutic target for improving skeletal muscle atrophy
Skeletal muscle atrophy is a common muscle disease that is directly caused by an imbalance in protein synthesis and degrad...
Old age as a risk factor for liver diseases: Modern therapeutic approaches
Old age as a risk factor for liver diseases: Modern therapeutic approaches
Recent scientific interest has been directed towards age-related diseases, driven by the significant increase in global li...
Does a pickle a day keep Alzheimer's away? Fermented food in Alzheimer's disease: A review
Does a pickle a day keep Alzheimer's away? Fermented food in Alzheimer's disease: A review
Fermented food is commonly viewed as healthy, mostly due to its probiotic and digestion-enhancing properties and recently ...
Association between maximal oxygen consumption and physical performance tests among older adults with cognitive frailty
Association between maximal oxygen consumption and physical performance tests among older adults with cognitive frailty
IntroductionCardiorespiratory fitness has an inverse relationship with cognitive impairment and frailty in older adults. D...
MiR-20b-5p involves in vascular aging induced by hyperhomocysteinemia
MiR-20b-5p involves in vascular aging induced by hyperhomocysteinemia
Hyperhomocysteinemia (HHcy) is an independent risk factor of atherosclerosis (AS). Some reports have shown that homocystei...
Metformin attenuates inflammation and boosts autophagy in the liver and intestine of chronologically aged rats
Metformin attenuates inflammation and boosts autophagy in the liver and intestine of chronologically aged rats
BackgroundOur previous studies found that autophagy levels in liver and intestinal segments of naturally aging rats were d...
Corrigendum to “Daily behavioral and sleep patterns are associated with aging-induced male-specific disorders in individuals with reduced renal function” [Exp. Gerontol. 16 (2022) 1–7 (111717)]
Corrigendum to “Daily behavioral and sleep patterns are associated with aging-induced male-specific disorders in individuals with reduced renal function” [Exp. Gerontol. 16 (2022) 1–7 (111717)]
Available online 28 October 2023, 112315Author links open overlay panelMasaki Yoshioka a h, Keisei Kosaki b, Shunta Noma c...
Microbiota-derived tryptophan metabolism: Impacts on health, aging, and disease
Microbiota-derived tryptophan metabolism: Impacts on health, aging, and disease
The intricate interplay between gut microbiota and the host is pivotal in maintaining homeostasis and health. Dietary tryp...
An experimental study for quantitative assessment of fatty infiltration and blood flow perfusion in quadriceps muscle of rats using IDEAL-IQ and BOLD-MRI for early diagnosis of sarcopenia
An experimental study for quantitative assessment of fatty infiltration and blood flow perfusion in quadriceps muscle of rats using IDEAL-IQ and BOLD-MRI for early diagnosis of sarcopenia
BackgroundSevere sarcopenia may result in severe disability. Early diagnosis is currently the key to enhancing the treatme...
Memory-related hippocampal brain-derived neurotrophic factor activation pathways from repetitive transcranial magnetic stimulation in the 3xTg-AD mouse line
Memory-related hippocampal brain-derived neurotrophic factor activation pathways from repetitive transcranial magnetic stimulation in the 3xTg-AD mouse line
Alzheimer's disease is associated with a loss of plasticity and cognitive functioning. Previous research has shown that re...
Cullin-3 intervenes in muscle atrophy in the elderly by mediating the degradation of nAchRs ubiquitination
Cullin-3 intervenes in muscle atrophy in the elderly by mediating the degradation of nAchRs ubiquitination
Volume 183, November 2023, 112318Author links open overlay panel, , , , Highlights•To investigate the expression, role and...
Obesity exacerbates postoperative cognitive dysfunction by activating the PARP1/NAD+/SIRT1 axis through oxidative stress
Obesity exacerbates postoperative cognitive dysfunction by activating the PARP1/NAD+/SIRT1 axis through oxidative stress
The purposes of this study were to explore the impact of obesity on postoperative cognitive dysfunction (POCD) and to inve...
Age-dependent down-regulation of orexin receptors in trigeminal nucleus caudalis correlated with attenuation of orexinergic analgesia in rats
Age-dependent down-regulation of orexin receptors in trigeminal nucleus caudalis correlated with attenuation of orexinergic analgesia in rats
Aging is related to a variety of physiological organ changes, including central and peripheral nervous systems. It has bee...
Smaller grey matter volume in the central olfactory system in mild cognitive impairment
Smaller grey matter volume in the central olfactory system in mild cognitive impairment
One of the major challenges in the diagnosis of Alzheimer's disease (AD) is to increase the specificity of the early diagn...
Polypharmacy, physical activity, and sedentary time in older adults: A scoping review
Polypharmacy, physical activity, and sedentary time in older adults: A scoping review
ObjectiveTo map out the studies that have investigated the associations of polypharmacy and/or potentially inappropriate m...
Metabolic syndrome accelerates epigenetic ageing in older adults: Findings from The Irish Longitudinal Study on Ageing (TILDA)
Metabolic syndrome accelerates epigenetic ageing in older adults: Findings from The Irish Longitudinal Study on Ageing (TILDA)
Metabolic syndrome (MetS) is a risk factor for the development of diabetes, cardiovascular disease, and all-cause mortalit...
Effect of exercise on inflammatory markers in postmenopausal women with overweight and obesity: A systematic review and meta-analysis
Effect of exercise on inflammatory markers in postmenopausal women with overweight and obesity: A systematic review and meta-analysis
ImportancePostmenopausal women affected by overweight and obesity are susceptible to a variety of diseases due to inflamma...
A bibliometric analysis of inflammation in sarcopenia from 2007 to 2022
A bibliometric analysis of inflammation in sarcopenia from 2007 to 2022
ObjectiveIn recent years, the impact of inflammation regulation on the progression of sarcopenia has garnered significant ...
Ameliorative effects of pine nut peptide-zinc chelate (Korean pine) on a mouse model of Alzheimer's disease
Ameliorative effects of pine nut peptide-zinc chelate (Korean pine) on a mouse model of Alzheimer's disease
In this study, 50 SD adult male mice were used to create an Alzheimer's disease model. The mice's learning and memory abil...
Saponins of Panax japonicus ameliorates cardiac aging phenotype in aging rats by enhancing basal autophagy through AMPK/mTOR/ULK1 pathway
Saponins of Panax japonicus ameliorates cardiac aging phenotype in aging rats by enhancing basal autophagy through AMPK/mTOR/ULK1 pathway
AbbreviationsSPJSaponins from Panax japonicsAMPKAMP-activated protein kinaseULK1Unc-51 like autophagy activating kinase 1T...
Treadmill exercise prevents the hyperexcitability of pyramidal neurons in medial entorhinal cortex in the 3xTg-AD mouse model of Alzheimer's disease
Treadmill exercise prevents the hyperexcitability of pyramidal neurons in medial entorhinal cortex in the 3xTg-AD mouse model of Alzheimer's disease
Neuronal hyperactivity is a key abnormality in early stage Alzheimer's disease (AD). Medial entorhinal cortex (mEC) plays ...
The multi-tissue benefits of exercise on aging human physiology
The multi-tissue benefits of exercise on aging human physiology
We use cookies to help provide and enhance our service and tailor content and ads. By continuing you agree to the use of c...
Interaction of Klotho and sirtuins
Interaction of Klotho and sirtuins
Volume 182, 15 October 2023, 112306Author links open overlay panel, , Highlights•Sirtuin and klotho are involved in the oc...
Are assessment measures for components of the International Classification of Functioning, Disability and Health reproducible for use on pre-frail and frail older adults? A systematic review
Are assessment measures for components of the International Classification of Functioning, Disability and Health reproducible for use on pre-frail and frail older adults? A systematic review
AbbreviationsCOSMINCOnsensus-based Standards for the selection of health Measurement INstrumentsFRAILFatigue, Resistance, ...
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