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A survey of severe asthma in Canada: results from the CASCADE practice reflective program
A survey of severe asthma in Canada: results from the CASCADE practice reflective program
Since the last guidance was published by the Canadian Thoracic Society, there have been several advances in the clinical m...
Effectiveness of immunoglobulin replacement therapy in preventing infections in patients with chronic obstructive pulmonary disease: a systematic review
Effectiveness of immunoglobulin replacement therapy in preventing infections in patients with chronic obstructive pulmonary disease: a systematic review
Immunoglobulin replacement therapy is a standard treatment for patients with antibody production deficiencies, which is of...
A case of pediatric serum sickness like reaction (SSLR) after a 2-month re-exposure to amoxicillin
A case of pediatric serum sickness like reaction (SSLR) after a 2-month re-exposure to amoxicillin
Serum-sickness like reactions (SSLRs) to amoxicillin have been documented in the medical literature. Beta-lactams are impo...
Hereditary or acquired? Comprehensive genetic testing assists in stratifying angioedema patients
Hereditary or acquired? Comprehensive genetic testing assists in stratifying angioedema patients
Hereditary angioedema (HAE) poses diagnostic challenges due to its episodic, non-specific symptoms and overlapping conditi...
Evaluation of adherence to guideline-directed therapy and risk factors for exacerbation in mild asthma: a retrospective chart review
Evaluation of adherence to guideline-directed therapy and risk factors for exacerbation in mild asthma: a retrospective chart review
A significant update was made to both the Global Initiative for Asthma (GINA) in 2019 and the National Heart Lung and Bloo...
Real-world association between systemic corticosteroid exposure and complications in US patients with severe asthma
Real-world association between systemic corticosteroid exposure and complications in US patients with severe asthma
Systemic corticosteroid (SCS) use remains widespread among patients with severe asthma, despite associated complications. ...
Circ_0070934 promotes MGAT3 expression and inhibits epithelial-mesenchymal transition in bronchial epithelial cells by sponging miR-199a-5p
Circ_0070934 promotes MGAT3 expression and inhibits epithelial-mesenchymal transition in bronchial epithelial cells by sponging miR-199a-5p
Circular RNA (circRNA) has the potential to serve as a crucial regulator in the progression of bronchial asthma. The objec...
The role of molecular diagnosis in anaphylactic patients with dual or triple-sensitization to Hymenoptera venoms
The role of molecular diagnosis in anaphylactic patients with dual or triple-sensitization to Hymenoptera venoms
The poly-sensitization to Hymenoptera venom makes it difficult to select genuine allergens for immunotherapy and increases...
Infantile atopic dermatitis – increasing severity predicts negative impacts on maternal and infant sleep: a mixed methods study
Infantile atopic dermatitis – increasing severity predicts negative impacts on maternal and infant sleep: a mixed methods study
While the impacts of atopic dermatitis (AD) on maternal and child sleep outcomes have been previously explored, less is kn...
Introduction of a penicillin allergy de-labelling program with direct oral challenge and its effects on utilization of beta-lactam antimicrobials: a multicenter retrospective parallel cohort study
Introduction of a penicillin allergy de-labelling program with direct oral challenge and its effects on utilization of beta-lactam antimicrobials: a multicenter retrospective parallel cohort study
Self-reported penicillin allergy labels are common and often inaccurate after assessment. These labels can lead to reduced...
Eosinophilic gastritis and gluten-sensitive enteropathy manifested as hypoproteinemia and treated with omalizumab: a case report
Eosinophilic gastritis and gluten-sensitive enteropathy manifested as hypoproteinemia and treated with omalizumab: a case report
Eosinophilic gastritis (EoG) has rarely been reported in conjunction with gluten-sensitive enteropathy (GSE). When this do...
The chronic rhinosinusitis with nasal polyp patient journey in the United States and Europe
The chronic rhinosinusitis with nasal polyp patient journey in the United States and Europe
In this letter to the editor, we present questionnaire-based data assessing the patient journey of adults with moderate...
Two-stage association study of mitochondrial DNA variants in allergic rhinitis
Two-stage association study of mitochondrial DNA variants in allergic rhinitis
Correlations between mitochondrial DNA (mtDNA) and allergic rhinitis (AR) have not been reported before. This study aimed ...
Immune endotyping and gene expression profile of patients with chronic rhinosinusitis with nasal polyps in the aspirin-exacerbated respiratory disease (AERD) and the non-AERD subgroups
Immune endotyping and gene expression profile of patients with chronic rhinosinusitis with nasal polyps in the aspirin-exacerbated respiratory disease (AERD) and the non-AERD subgroups
Chronic Rhinosinusitis (CRS) is a paranasal sinus inflammatory disease and is divided into two subgroups defined as CRS wi...
Acuity of asthma exacerbations in Alberta, Canada is increasing: a population-based study
Acuity of asthma exacerbations in Alberta, Canada is increasing: a population-based study
Asthma is a common respiratory illness affecting 2.8 million Canadians, including 9.7% of Albertans. Prior studie...
Prevalence of asthma in people with type 1 diabetes mellitus: a scoping review
Prevalence of asthma in people with type 1 diabetes mellitus: a scoping review
According to the Th1/Th2 paradigm, the expansion of Th1-type clones in individuals with type 1 diabetes results in reduced...
Real-world outcomes of mepolizumab for the treatment of severe eosinophilic asthma in Canada: an observational study
Real-world outcomes of mepolizumab for the treatment of severe eosinophilic asthma in Canada: an observational study
Mepolizumab, the first widely available anti-interleukin 5 biologic, targets eosinophilic inflammation and has been shown ...
Association of single nucleotide polymorphisms in the F2RL1 gene with clinical and inflammatory characteristics of patients with asthma
Association of single nucleotide polymorphisms in the F2RL1 gene with clinical and inflammatory characteristics of patients with asthma
Proteinase-activated receptor 2 (PAR-2) is a G-protein coupled receptor associated with many inflammatory diseases, includ...
The prevalence of obstructive sleep apnea in Japanese asthma patients
The prevalence of obstructive sleep apnea in Japanese asthma patients
Obstructive sleep apnea (OSA) occurs more commonly in asthma patients than in the general population because these conditi...
Delayed presentation of food protein-induced enterocolitis syndrome (FPIES) to okra in a toddler
Delayed presentation of food protein-induced enterocolitis syndrome (FPIES) to okra in a toddler
Food protein-induced enterocolitis syndrome (FPIES) is a non-immunoglobulin E (IgE) -mediated food allergy predominantly o...
Resource utilization and cost assessment of a proactive penicillin allergy de-labeling program for low-risk inpatients
Resource utilization and cost assessment of a proactive penicillin allergy de-labeling program for low-risk inpatients
Resource utilization and costs can impede proactive assessment and de-labeling of penicillin allergy among inpatients. Our...
Inborn errors of immunity in adulthood
Inborn errors of immunity in adulthood
Inborn errors of immunity (IEIs) are a group of conditions whereby parts of the immune system are missing or dysfunctional...
Different expression levels of interleukin-36 in asthma phenotypes
Different expression levels of interleukin-36 in asthma phenotypes
Interleukin (IL)-36 family is closely associated with inflammation and consists of IL-36α, IL-36β, IL-36γ, ...
Accelerometer-derived sleep metrics in mild and difficult-to-treat asthma
Accelerometer-derived sleep metrics in mild and difficult-to-treat asthma
Poor sleep health is associated with increased asthma morbidity and mortality. Accelerometers have been validated to asses...
Update on the association between Helicobacter pylori infection and asthma in terms of microbiota and immunity
Update on the association between Helicobacter pylori infection and asthma in terms of microbiota and immunity
H. pylori is a gram-negative bacterium that is usually acquired in childhood and can persistently colonize the gastric muc...
Pollen food allergy syndrome secondary to molds and raw mushroom cross-reactivity: a case report
Pollen food allergy syndrome secondary to molds and raw mushroom cross-reactivity: a case report
Pollen food allergy syndrome (PFAS) is an immunoglobulin E (IgE) mediated reaction that causes oropharyngeal pruritus or a...
IL-1β and iNOS can drive the asthmatic comorbidities and decrease of lung function in perennial allergic rhinitis children
IL-1β and iNOS can drive the asthmatic comorbidities and decrease of lung function in perennial allergic rhinitis children
Allergic asthma and rhinitis (AR) are closely linked, with a significant proportion of AR patients developing asthma. Iden...
13th C1-inhibitor deficiency and angioedema workshop—2023
13th C1-inhibitor deficiency and angioedema workshop—2023
Anna Valerieva 1, Maria T. Staevska1, Vesna Grivcheva-Panovska2, Mi...
Associations between HT, BMI, and allergic rhinitis in perimenopausal women
Associations between HT, BMI, and allergic rhinitis in perimenopausal women
Increasing evidence suggests that hormone therapy (HT) and obesity exert an influence on allergic rhinitis (AR). It is imp...
Patient outcomes associated with subcutaneous C1INH prophylaxis for hereditary angioedema: a retrospective analysis
Patient outcomes associated with subcutaneous C1INH prophylaxis for hereditary angioedema: a retrospective analysis
Real-world data on subcutaneous C1INH (C1INH[SC]) usage and patient-level impacts on hereditary angioedema (HAE)-related o...
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