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Role of Th2, Th17 and Treg Cells and relevant cytokines in pathogenesis of allergic rhinitis
Role of Th2, Th17 and Treg Cells and relevant cytokines in pathogenesis of allergic rhinitis
To explore the role of different cells and molecules in the pathogenesis of allergic rhinitis (AR) with positive Artemisia...
Severe distributive shock, neutrophilic dermatosis, and ST-elevation myocardial infarction in the setting of azathioprine hypersensitivity syndrome
Severe distributive shock, neutrophilic dermatosis, and ST-elevation myocardial infarction in the setting of azathioprine hypersensitivity syndrome
Azathioprine is a purine synthesis inhibitor used as an immunosuppressive therapy for many immune-mediated diseases. Azath...
Knockdown of miR-155 alleviates skin damage in rats with chronic spontaneous urticaria by modulating the JAK/STAT signaling pathway
Knockdown of miR-155 alleviates skin damage in rats with chronic spontaneous urticaria by modulating the JAK/STAT signaling pathway
The aim of this study was to investigate the role and mechanisms of miR-155 in chronic spontaneous urticaria (CSU). The ex...
A real-world evaluation of the effectiveness and Sufficiency of Current Emergency Department Preventative Strategies for Reducing Emergency Department revisits in a Canadian children’s hospital: a retrospective cohort study
A real-world evaluation of the effectiveness and Sufficiency of Current Emergency Department Preventative Strategies for Reducing Emergency Department revisits in a Canadian children’s hospital: a retrospective cohort study
Despite asthma guidelines’ recommended emergency department preventative strategies (EDPS), repeat asthma-related em...
Therapeutic potential of the topical recombinant human interleukin-1 receptor antagonist in guinea pigs with allergic rhinitis
Therapeutic potential of the topical recombinant human interleukin-1 receptor antagonist in guinea pigs with allergic rhinitis
Recombinant human Interleukin receptor antagonist (rhIL-Ra) can bind to the IL-1 receptor on the cell membrane and reversi...
Anaphylaxis in a Swiss university emergency department: clinical characteristics and supposed triggers
Anaphylaxis in a Swiss university emergency department: clinical characteristics and supposed triggers
Anaphylaxis is the most severe form of acute systemic and potentially life-threatening reactions triggered by mast and bas...
Comparison of cytokine expression and disease severity between plasma cell-dominant and eosinophil-dominant patients in chronic rhinosinusitis with nasal polyps
Comparison of cytokine expression and disease severity between plasma cell-dominant and eosinophil-dominant patients in chronic rhinosinusitis with nasal polyps
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous disease characterized by inflammation of the nasal an...
Sublingual immunotherapy for allergy to shrimp: the nine-year clinical experience of a Midwest Allergy-Immunology practice
Sublingual immunotherapy for allergy to shrimp: the nine-year clinical experience of a Midwest Allergy-Immunology practice
Diet restrictions and fear of adverse reactions put a significant burden on the nutrition, growth and life style of childr...
Genetic links between atopy, allergy, and alopecia areata: insights from a Mendelian randomization study
Genetic links between atopy, allergy, and alopecia areata: insights from a Mendelian randomization study
Alopecia areata (AA), a prevalent form of autoimmune hair loss, has a not well-defined relationship with atopic and allerg...
A survey of severe asthma in Canada: results from the CASCADE practice reflective program
A survey of severe asthma in Canada: results from the CASCADE practice reflective program
Since the last guidance was published by the Canadian Thoracic Society, there have been several advances in the clinical m...
Effectiveness of immunoglobulin replacement therapy in preventing infections in patients with chronic obstructive pulmonary disease: a systematic review
Effectiveness of immunoglobulin replacement therapy in preventing infections in patients with chronic obstructive pulmonary disease: a systematic review
Immunoglobulin replacement therapy is a standard treatment for patients with antibody production deficiencies, which is of...
A case of pediatric serum sickness like reaction (SSLR) after a 2-month re-exposure to amoxicillin
A case of pediatric serum sickness like reaction (SSLR) after a 2-month re-exposure to amoxicillin
Serum-sickness like reactions (SSLRs) to amoxicillin have been documented in the medical literature. Beta-lactams are impo...
Hereditary or acquired? Comprehensive genetic testing assists in stratifying angioedema patients
Hereditary or acquired? Comprehensive genetic testing assists in stratifying angioedema patients
Hereditary angioedema (HAE) poses diagnostic challenges due to its episodic, non-specific symptoms and overlapping conditi...
Evaluation of adherence to guideline-directed therapy and risk factors for exacerbation in mild asthma: a retrospective chart review
Evaluation of adherence to guideline-directed therapy and risk factors for exacerbation in mild asthma: a retrospective chart review
A significant update was made to both the Global Initiative for Asthma (GINA) in 2019 and the National Heart Lung and Bloo...
Real-world association between systemic corticosteroid exposure and complications in US patients with severe asthma
Real-world association between systemic corticosteroid exposure and complications in US patients with severe asthma
Systemic corticosteroid (SCS) use remains widespread among patients with severe asthma, despite associated complications. ...
Circ_0070934 promotes MGAT3 expression and inhibits epithelial-mesenchymal transition in bronchial epithelial cells by sponging miR-199a-5p
Circ_0070934 promotes MGAT3 expression and inhibits epithelial-mesenchymal transition in bronchial epithelial cells by sponging miR-199a-5p
Circular RNA (circRNA) has the potential to serve as a crucial regulator in the progression of bronchial asthma. The objec...
The role of molecular diagnosis in anaphylactic patients with dual or triple-sensitization to Hymenoptera venoms
The role of molecular diagnosis in anaphylactic patients with dual or triple-sensitization to Hymenoptera venoms
The poly-sensitization to Hymenoptera venom makes it difficult to select genuine allergens for immunotherapy and increases...
Infantile atopic dermatitis – increasing severity predicts negative impacts on maternal and infant sleep: a mixed methods study
Infantile atopic dermatitis – increasing severity predicts negative impacts on maternal and infant sleep: a mixed methods study
While the impacts of atopic dermatitis (AD) on maternal and child sleep outcomes have been previously explored, less is kn...
Introduction of a penicillin allergy de-labelling program with direct oral challenge and its effects on utilization of beta-lactam antimicrobials: a multicenter retrospective parallel cohort study
Introduction of a penicillin allergy de-labelling program with direct oral challenge and its effects on utilization of beta-lactam antimicrobials: a multicenter retrospective parallel cohort study
Self-reported penicillin allergy labels are common and often inaccurate after assessment. These labels can lead to reduced...
Eosinophilic gastritis and gluten-sensitive enteropathy manifested as hypoproteinemia and treated with omalizumab: a case report
Eosinophilic gastritis and gluten-sensitive enteropathy manifested as hypoproteinemia and treated with omalizumab: a case report
Eosinophilic gastritis (EoG) has rarely been reported in conjunction with gluten-sensitive enteropathy (GSE). When this do...
The chronic rhinosinusitis with nasal polyp patient journey in the United States and Europe
The chronic rhinosinusitis with nasal polyp patient journey in the United States and Europe
In this letter to the editor, we present questionnaire-based data assessing the patient journey of adults with moderate...
Two-stage association study of mitochondrial DNA variants in allergic rhinitis
Two-stage association study of mitochondrial DNA variants in allergic rhinitis
Correlations between mitochondrial DNA (mtDNA) and allergic rhinitis (AR) have not been reported before. This study aimed ...
Immune endotyping and gene expression profile of patients with chronic rhinosinusitis with nasal polyps in the aspirin-exacerbated respiratory disease (AERD) and the non-AERD subgroups
Immune endotyping and gene expression profile of patients with chronic rhinosinusitis with nasal polyps in the aspirin-exacerbated respiratory disease (AERD) and the non-AERD subgroups
Chronic Rhinosinusitis (CRS) is a paranasal sinus inflammatory disease and is divided into two subgroups defined as CRS wi...
Acuity of asthma exacerbations in Alberta, Canada is increasing: a population-based study
Acuity of asthma exacerbations in Alberta, Canada is increasing: a population-based study
Asthma is a common respiratory illness affecting 2.8 million Canadians, including 9.7% of Albertans. Prior studie...
Prevalence of asthma in people with type 1 diabetes mellitus: a scoping review
Prevalence of asthma in people with type 1 diabetes mellitus: a scoping review
According to the Th1/Th2 paradigm, the expansion of Th1-type clones in individuals with type 1 diabetes results in reduced...
Real-world outcomes of mepolizumab for the treatment of severe eosinophilic asthma in Canada: an observational study
Real-world outcomes of mepolizumab for the treatment of severe eosinophilic asthma in Canada: an observational study
Mepolizumab, the first widely available anti-interleukin 5 biologic, targets eosinophilic inflammation and has been shown ...
Association of single nucleotide polymorphisms in the F2RL1 gene with clinical and inflammatory characteristics of patients with asthma
Association of single nucleotide polymorphisms in the F2RL1 gene with clinical and inflammatory characteristics of patients with asthma
Proteinase-activated receptor 2 (PAR-2) is a G-protein coupled receptor associated with many inflammatory diseases, includ...
The prevalence of obstructive sleep apnea in Japanese asthma patients
The prevalence of obstructive sleep apnea in Japanese asthma patients
Obstructive sleep apnea (OSA) occurs more commonly in asthma patients than in the general population because these conditi...
Delayed presentation of food protein-induced enterocolitis syndrome (FPIES) to okra in a toddler
Delayed presentation of food protein-induced enterocolitis syndrome (FPIES) to okra in a toddler
Food protein-induced enterocolitis syndrome (FPIES) is a non-immunoglobulin E (IgE) -mediated food allergy predominantly o...
Resource utilization and cost assessment of a proactive penicillin allergy de-labeling program for low-risk inpatients
Resource utilization and cost assessment of a proactive penicillin allergy de-labeling program for low-risk inpatients
Resource utilization and costs can impede proactive assessment and de-labeling of penicillin allergy among inpatients. Our...
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