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Spatial metabolomics in tissue injury and regeneration
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Recent insights into N6-methyladenosine during viral infection
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Exploring pseudouridylation: dysregulation in disease and therapeutic potential
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Interplay between N6-adenosine RNA methylation and mRNA splicing
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Clinical Perspectives in Epitranscriptomics
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NAT10 and cytidine acetylation in mRNA: intersecting paths in development and disease
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Quantitative mapping of the mammalian epitranscriptome
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Chromatin insulator mechanisms ensure accurate gene expression by controlling overall 3D genome organization
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The metabolic baton: conducting the dance of N6-methyladenosine writing and erasing
The metabolic baton: conducting the dance of N6-methyladenosine writing and erasing
RNA post-transcriptional modifications represent a crucial layer of noncoding information embedded in RNA transcripts. The...
Crosstalk between histone/DNA modifications and RNA N6-methyladenosine modification
Crosstalk between histone/DNA modifications and RNA N6-methyladenosine modification
N6-methyladenosine (m6A) is the most prevalent internal RNA modification in eukaryotic messenger RNAs (mRNAs), regulating ...
Exploring the role of ribosomal RNA modifications in cancer
Exploring the role of ribosomal RNA modifications in cancer
Recent advances have highlighted the significant roles of post-transcriptional modifications in rRNA in various cancers. E...
Insights into multilevel spatial regulation within the root stem cell niche
Insights into multilevel spatial regulation within the root stem cell niche
Developmental biology focuses on studying how cells, tissues, and entire organs grow and develop. At the foundational leve...
Timing and Tempo in Development
Timing and Tempo in Development
James Briscoe is a group leader at the Francis Crick Institute, London. His laboratory’s research interests include the mo...
Phase separation and inheritance of repressive chromatin domains
Phase separation and inheritance of repressive chromatin domains
Polycomb-associated chromatin and pericentromeric heterochromatin form genomic domains important for the epigenetic regula...
Hijacked enhancer–promoter and silencer–promoter loops in cancer
Hijacked enhancer–promoter and silencer–promoter loops in cancer
The three-dimensional (3D) spatial organization of the human genome plays a crucial role in maintaining normal cellular fu...
Spatial orchestration of the genome: topological reorganisation during X-chromosome inactivation
Spatial orchestration of the genome: topological reorganisation during X-chromosome inactivation
Genomes are organised through hierarchical structures, ranging from local kilobase-scale cis-regulatory contacts to large ...
m6A regulates heterochromatin in mammalian embryonic stem cells
m6A regulates heterochromatin in mammalian embryonic stem cells
m6A is the most abundant and well-studied RNA modification in mRNAs. The majority of m6A sites on mRNAs are catalyzed by M...
Timing mechanisms: insights from comparative neural differentiation systems
Timing mechanisms: insights from comparative neural differentiation systems
Temporal control is central to deploy and coordinate genetic programs during development. At present, there is limited und...
RNA editing and immune control: from mechanism to therapy
RNA editing and immune control: from mechanism to therapy
Adenosine-to-inosine (A-to-I) RNA editing is among the most prevalent RNA modifications in metazoans, catalyzed by enzymes...
Attraction and disruption: how loop extrusion and compartmentalisation shape the nuclear genome
Attraction and disruption: how loop extrusion and compartmentalisation shape the nuclear genome
Chromatin loops, which bring two distal loci of the same chromosome into close physical proximity, are the ubiquitous unit...
Mechanistic drivers of chromatin organization into compartments
Mechanistic drivers of chromatin organization into compartments
The human genome is not just a simple string of DNA, it is a complex and dynamic entity intricately folded within the cell...
Epigenetic priming in the male germline
Epigenetic priming in the male germline
The germline is the only cellular lineage capable of transmitting genetic and epigenetic information to the next generatio...
New insights into how to induce and maintain embryonic diapause in the blastocyst
New insights into how to induce and maintain embryonic diapause in the blastocyst
Embryonic diapause in mammals is a period of developmental pause of the embryo at the blastocyst stage. During diapause, t...
Chromatin and aberrant enhancer activity in KMT2A rearranged acute lymphoblastic leukemia
Chromatin and aberrant enhancer activity in KMT2A rearranged acute lymphoblastic leukemia
To make a multicellular organism, genes need to be transcribed at the right developmental stages and in the right tissues....
Therapeutic targeting of BET bromodomain and other epigenetic acetylrecognition domain–containing factors
Therapeutic targeting of BET bromodomain and other epigenetic acetylrecognition domain–containing factors
In this perspective, we discuss the emerging class of epigenetic cancer therapies targeting acetylrecognition domain–conta...
Linking mitochondria metabolism, developmental timing, and human brain evolution
Linking mitochondria metabolism, developmental timing, and human brain evolution
Changes in developmental timing are an important factor of evolution in organ shape and function. This is particularly str...
The significance of ultradian oscillations in development
The significance of ultradian oscillations in development
Embryos develop autonomously under a predetermined schedule. While the genes involved in these processes have been charact...
Temporal patterning of the vertebrate developing neural tube
Temporal patterning of the vertebrate developing neural tube
scRNAseq data has been obtained from the indicated references (forebrain, midbrain, hindbrain: [34], spinal cord: [31], re...
RNA in chromatin organization and nuclear architecture
RNA in chromatin organization and nuclear architecture
Chromatin is surrounded by various types of nuclear bodies, including the nucleolus, Cajal bodies, paraspeckles, and nucle...
Mitochondrial metabolism and the continuing search for ultimate regulators of developmental rate
Mitochondrial metabolism and the continuing search for ultimate regulators of developmental rate
A fundamental question in developmental biology is how the pace of developmental processes is controlled from a cell biolo...
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