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Editorial overview: Congenital cardiovascular disease
Neil Hanchard, MD, DPhil, is a physician scientist with postgraduate training in pediatrics and medical genetics. Dr. Hanc...
Genetics of congenital arrhythmia syndromes: the challenge of variant interpretation
Congenital arrhythmia syndromes are rare genetic disorders that can cause a high risk of sudden cardiac death. Expert pane...
Centromere drive: chromatin conflict in meiosis
Centromeres are essential loci in eukaryotes that are necessary for the faithful segregation of chromosomes in mitosis and...
Editorial overview: How to generate and maintain organs–organoids, regeneration, and beyond
Ophir D. Klein: Prof. Klein serves as the inaugural executive director of Cedars-Sinai Guerin Children’s and the David and...
Plasticity of muscle stem cells in homeostasis and aging
We are living longer, but our healthspan has not increased. The goal of regenerative medicine is to increase quality of li...
Editorial overview: evolutionary genetics: how a tiny model system enables big discoveries
Dr Christian Landry holds the Canada Research Chair in Cellular Systems and Synthetic Biology at Université Laval. His lab...
In vitro models of pre- and post-gastrulation embryonic development
Volume 77, December 2022, 101985The successful derivation and culture of pluripotent stem cells (PSCs) is tightly connecte...
Mechanisms of regulatory evolution in yeast
Volume 77, December 2022, 101998Highlights•Cis- and trans-acting mutations contribute differently to gene expression evolu...
Copy-number variation in congenital heart disease
Volume 77, December 2022, 101986Genomic copy-number variants (CNVs) contribute to as many congenital heart disease (CHD) c...
Epistasis and evolutionary dependencies in human cancers
Volume 77, December 2022, 101989Cancer evolution is driven by the concerted action of multiple molecular alterations, whic...
Metal ion availability and homeostasis as drivers of metabolic evolution and enzyme function
Volume 77, December 2022, 101987Metal ions are potent catalysts and have been available for cellular biochemistry at all s...
Recent insights into mammalian natural and synthetic ex utero embryogenesis
Volume 77, December 2022, 101988Research on early postimplantation mammalian development has been limited by the small siz...
Reconstitution of reproductive organ system that produces functional oocytes
Volume 77, December 2022, 101982Reproductive organs have unique developmental and functional properties that enable them t...
Correlation between protein abundance and sequence conservation: what do recent experiments say?
Volume 77, December 2022, 101984Cells evolve in a space of parameter values set by physical and chemical forces. These con...
Prospects for precision genetic medicine in congenital heart disease
Volume 77, December 2022, 101983Precision medicine, defined as tailoring medical care individually based upon relevant fac...
High-throughput approaches to functional characterization of genetic variation in yeast
Volume 76, October 2022, 101979Expansion of sequencing efforts to include thousands of genomes is providing a fundamental ...
Corneal regeneration: insights in epithelial stem cell heterogeneity and dynamics
Volume 77, December 2022, 101981The discovery of slow-cycling cells at the corneal periphery three decades ago established...
Evolution of yeast hybrids by aborted meiosis
Volume 77, December 2022, 101980Sterile hybrids are broadly considered evolutionary dead-ends because of their faulty sexu...
Intestinal epithelial organoids: regeneration and maintenance of the intestinal epithelium
Volume 76, October 2022, 101977Vital functions of the intestines: digestion, absorption, and surface barrier are performed...
How gene duplication diversifies the landscape of protein oligomeric state and function
Volume 76, October 2022, 101966Oligomeric proteins are central to cellular life and the duplication and divergence of thei...
Editorial overview: The genome in space–time
Jeanne Lawrence is the Leo P. and Theresa M. LaChance Chair in Medical Research and Professor of Neurology and Pediatrics ...
Stem-cell-based human and mouse embryo models
Volume 76, October 2022, 101970Synthetic embryology aims to develop embryo-like structures from stem cells to provide new ...
Adipocyte plasticity in tissue regeneration, repair, and disease
Volume 76, October 2022, 101968Mammalian tissue repair forms a scar that fills the injured area with a fibrotic lesion, li...
Experimental evolution of drug resistance in human fungal pathogens
Volume 76, October 2022, 101965Highlights•Experimental evolution studies are useful to study drug resistance acquisition ....
Exploring conditional gene essentiality through systems genetics approaches in yeast
Volume 76, October 2022, 101963An essential gene encodes for a cellular function that is required for viability. Although ...
Evolution of short linear motifs and disordered proteins Topic: yeast as model system to study evolution
Volume 76, October 2022, 101964Evolutionary preservation of protein structure had a major influence on the field of molecu...
Statistical models of the genetic etiology of congenital heart disease
Volume 76, October 2022, 101967Congenital heart disease (CHD) is a collection of anatomically and clinically heterogeneous...
Extending the spectrum in aortopathy: stenosis to aneurysm
Volume 76, October 2022, 101962Highlights•Aortic caliber is a quantitative trait on a continuous spectrum from stenosis to...