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Human thermogenic adipose tissue
Adipose tissue has generally been characterized by its role in storing and dissipating energy as well as releasing endocri...
Multilevel selection on mitochondrial genomes
Mitochondria are vital organelles for life in eukaryotes, taking centre stage in the process of cellular respiration. This...
Integrative approaches to study enhancer–promoter communication
The spatiotemporal control of gene expression in complex multicellular organisms relies on noncoding regulatory sequences ...
Network models of chromatin structure
Increasing numbers of datasets and experimental assays that capture the organization of chromatin inside the nucleus warra...
When and why are mitochondria paternally inherited?
In contrast with nuclear genes that are passed on through both parents, mitochondrial genes are maternally inherited in mo...
Next-generation human adipose tissue culture methods
White adipocytes are highly specialized, lipid-storing cells. Their unique characteristics, including their large cell siz...
Circadian control of white and brown adipose tissues
White and brown adipose tissues are highly dynamic organs anticipating and responding to changes in the environment. The c...
Long interspersed nuclear element 1 and B1/Alu repeats blueprint genome compartmentalization
The genomic DNA of a human cell is approximately 2-m long when straightened but is highly folded in a nucleus that is typi...
When 3D genome changes cause disease: the impact of structural variations in congenital disease and cancer
Appreciation of spatial genome organization has improved our understanding of the genetic basis of disease. Large structur...
Recent progress in understanding the genomic architecture of sexual conflict
Genomic conflict between the sexes over shared traits is widely assumed to be resolved through the evolution of sex-biased...
Genome folding dynamics during the M-to-G1-phase transition
During mitosis, chromatin architecture undergoes dramatic reorganization 1, 2. In prophase, the nuclear envelope breaks do...
Recent developments in adipose tissue-secreted factors and their target organs
The white adipose tissue’s primary roles are to store and mobilise energy, which is very different from the brown adipose ...
Exploring the heterogeneity of white adipose tissue in mouse and man
White adipose tissue (WAT) serves to store energy in the form of triglyceride while also coordinating systemic metabolic f...
Bridging multiple dimensions: roles of transposable elements in higher-order genome regulation
Volume 80, June 2023, 102035Author links open overlay panel, , Transposable elements (TEs) such as endogenous retroviruses...
Replication timing and transcriptional control: beyond cause and effect — part IV
The faithful duplication of a cell’s genome once per cell cycle is critical to preserve cell identity, genome integrity, a...
Contributions of 3D chromatin structure to cell-type-specific gene regulation
Volume 79, April 2023, 102032Author links open overlay panel, Eukaryotic genomes are organized in 3D in a multiscale manne...
4D epigenomics: deciphering the coupling between genome folding and epigenomic regulation with biophysical modeling
Genome activity (e.g. transcription, replication) is in part regulated at the chromatin level via the controlled depositio...
Mechanisms of transgenerational epigenetic inheritance: lessons from animal model organisms
DNA is the repository of genetic information that contains the instructions to generate living organisms, and is the predo...
Nucleosomes in mammalian sperm: conveying paternal epigenetic inheritance or subject to reprogramming between generations?
The genome of mammalian sperm is largely packaged by sperm-specific proteins termed protamines. The presence of some resid...
The role of loop extrusion in enhancer-mediated gene activation
Gene expression patterns in complex multicellular organisms are regulated by enhancers, which communicate with their targe...
Recent progress and challenges in single-cell imaging of enhancer–promoter interaction
The question of how enhancers control the activity of promoters, across the thousands to millions of basepairs separating ...
Transgenerational epigenetic control of constitutive heterochromatin, transposons, and centromeres
Constitutive heterochromatin plays important roles for chromosome behavior [1] and silencing of transposable elements (TEs...
A GC-centered view of 3D genome organization
In the past two decades, our understanding of how the genome of mammalian cells is spatially organized in the three-dimens...
Evolution of 3D chromatin organization at different scales
Volume 78, February 2023, 102019Author links open overlay panelMost animal genomes fold in 3D chromatin domains called top...
Noncanonical imprinting: intergenerational epigenetic inheritance mediated by Polycomb complexes
The genomic imprinting field has evolved around DNA methylation (DNAme). DNAme is deposited during male and female gametog...
Epigenetic dynamics during germline development: insights from Drosophila and C. elegans
Gametogenesis produces the only cell type within a metazoan that contributes both genetic and epigenetic information to th...
Distinct responses to autumn and spring temperatures by the key flowering-time regulator FLOWERING LOCUS C
Plants form reproductive organs in a particular season of the year that is specific to each species, and these periods are...
Shaping inheritance: how distinct reproductive strategies influence DNA methylation memory in plants
Volume 78, February 2023, 102018Author links open overlay panelDNA methylation is a major epigenetic mark involved in the ...
Editorial overview: Congenital cardiovascular disease
Neil Hanchard, MD, DPhil, is a physician scientist with postgraduate training in pediatrics and medical genetics. Dr. Hanc...
Genetics of congenital arrhythmia syndromes: the challenge of variant interpretation
Congenital arrhythmia syndromes are rare genetic disorders that can cause a high risk of sudden cardiac death. Expert pane...
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