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Somatic hypermutation mechanisms during lymphomagenesis and transformation
Somatic hypermutation mechanisms during lymphomagenesis and transformation
Activation-induced cytidine deaminase (AID) is a single-stranded DNA (ssDNA) cytidine deaminase that is predominantly expr...
Inheritance of epigenetic transcriptional memory
Inheritance of epigenetic transcriptional memory
An improved understanding of nuclear architecture has begun to reveal how genome organization affects transcription and ot...
Editorial overview: Early embryonic development models: back to the beginning
Editorial overview: Early embryonic development models: back to the beginning
Miguel Angel Esteban Miguel A Esteban is research scientist at 3DC STAR in BGI Shenzhen. Miguel obtained his BS in Medicin...
Hexasomal particles: consequence or also consequential?
Hexasomal particles: consequence or also consequential?
Volume 85, April 2024, 102163Author links open overlay panel, , It is long known that an RNA polymerase transcribing throu...
Approaches to probe and perturb long noncoding RNA functions in diseases
Approaches to probe and perturb long noncoding RNA functions in diseases
Long noncoding RNAs (lncRNAs) are a class of RNA molecules exceeding 200 nucleotides in length that lack long open-reading...
Epigenetic control and manipulation of neuronal maturation timing
Epigenetic control and manipulation of neuronal maturation timing
During brain development, the sequence of developmental steps and the underlying transcriptional regulatory logic are larg...
The influencers' era: how the environment shapes chromatin in 3D
The influencers' era: how the environment shapes chromatin in 3D
Environment–epigenome interactions are emerging as contributors to disease risk and health outcomes. In fact, organisms ou...
Therapeutic index of targeting select chromatin complexes in human cancer patients
Therapeutic index of targeting select chromatin complexes in human cancer patients
Volume 85, April 2024, 102162Author links open overlay panel, Aberrant chromatin regulation can promote the initiation and...
Cohesin regulation and roles in chromosome structure and function
Cohesin regulation and roles in chromosome structure and function
Cookies are used by this site. Cookie SettingsAll content on this site: Copyright © 2024 Elsevier B.V., its licensors, an...
A CTCF-dependent mechanism underlies the Hox timer: relation to a segmented body plan
A CTCF-dependent mechanism underlies the Hox timer: relation to a segmented body plan
During gastrulation, Hox genes are activated in a time-sequence that follows the order of the genes along their clusters. ...
Timing neurogenesis: a clock or an algorithm?
Timing neurogenesis: a clock or an algorithm?
In a fundamental sense, time represents the continuous progression of existence and events. It unfolds moment by moment an...
Degrees of freedom: temperature’s influence on developmental rate
Degrees of freedom: temperature’s influence on developmental rate
Temperature exerts a fundamental influence across scales of biology, from the biophysical nature of molecules, to the sens...
Toward a comprehensive view of gene architecture during transcription
Toward a comprehensive view of gene architecture during transcription
In multicellular organisms, the same genetic code gives rise to a large diversity of cell types. A fully stretched out ver...
Role of H3K4 monomethylation in gene regulation
Role of H3K4 monomethylation in gene regulation
Methylation of histone H3 on the lysine-4 residue (H3K4me) is found throughout the eukaryotic domain, and its initial disc...
Timing Drosophila development through steroid hormone action
Timing Drosophila development through steroid hormone action
Specifically timed pulses of the moulting hormone ecdysone are necessary for developmental progression in insects, guiding...
Emergence of the circadian clock oscillation during the developmental process in mammals
Emergence of the circadian clock oscillation during the developmental process in mammals
The circadian rhythm is an essential physiological fluctuation for the maintenance of homeostasis in various organisms inc...
What are tethering elements?
What are tethering elements?
Tethering elements (TEs) were first identified in the Hox gene Sex combs reduced (Scr), where they were proposed to foster...
On the edge: how nuclear pore complexes rule genome stability
On the edge: how nuclear pore complexes rule genome stability
Nuclear organization has emerged as a critical layer in the coordination of DNA repair activities. Distinct types of DNA l...
The stem cell zoo for comparative studies of developmental tempo
The stem cell zoo for comparative studies of developmental tempo
The rate of development is highly variable across animal species. However, the mechanisms regulating developmental tempo h...
Loops, crosstalk, and compartmentalization: it takes many layers to regulate DNA methylation
Loops, crosstalk, and compartmentalization: it takes many layers to regulate DNA methylation
In eukaryotic organisms, DNA is packaged within the nucleus via its associations with histone (H) proteins to form chromat...
Deciphering microglia phenotypes in health and disease
Deciphering microglia phenotypes in health and disease
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Exploring new roles for RNA-binding proteins in epigenetic and gene regulation
Exploring new roles for RNA-binding proteins in epigenetic and gene regulation
Cumulative studies have raised the current census of RNA-binding proteins (RBPs) encoded for by the human genome to ∼2500 ...
Polycomb repressive complex 2 accessory factors: rheostats for cell fate decision?
Polycomb repressive complex 2 accessory factors: rheostats for cell fate decision?
Epigenetic reprogramming during development is key to cell identity and the activities of the Polycomb repressive complexe...
Topical section: embryonic models (2023) for Current Opinion in Genetics & Development
Topical section: embryonic models (2023) for Current Opinion in Genetics & Development
In recent years, modeling embryo development with stem cells has opened up new avenues in developmental biology. By recons...
Human blastoid as an in vitro model of human blastocysts
Human blastoid as an in vitro model of human blastocysts
Human development is a highly coordinated process, with any abnormalities during the early embryonic stages that can often...
Modifying gastruloids to dissect mechanisms of tissue-specific induction
Modifying gastruloids to dissect mechanisms of tissue-specific induction
How functional organisms arise from a single cell is a fundamental question in biology with direct relevance to understand...