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Timing mechanisms: insights from comparative neural differentiation systems
Timing mechanisms: insights from comparative neural differentiation systems
Temporal control is central to deploy and coordinate genetic programs during development. At present, there is limited und...
RNA editing and immune control: from mechanism to therapy
RNA editing and immune control: from mechanism to therapy
Adenosine-to-inosine (A-to-I) RNA editing is among the most prevalent RNA modifications in metazoans, catalyzed by enzymes...
Attraction and disruption: how loop extrusion and compartmentalisation shape the nuclear genome
Attraction and disruption: how loop extrusion and compartmentalisation shape the nuclear genome
Chromatin loops, which bring two distal loci of the same chromosome into close physical proximity, are the ubiquitous unit...
Mechanistic drivers of chromatin organization into compartments
Mechanistic drivers of chromatin organization into compartments
The human genome is not just a simple string of DNA, it is a complex and dynamic entity intricately folded within the cell...
Epigenetic priming in the male germline
Epigenetic priming in the male germline
The germline is the only cellular lineage capable of transmitting genetic and epigenetic information to the next generatio...
New insights into how to induce and maintain embryonic diapause in the blastocyst
New insights into how to induce and maintain embryonic diapause in the blastocyst
Embryonic diapause in mammals is a period of developmental pause of the embryo at the blastocyst stage. During diapause, t...
Chromatin and aberrant enhancer activity in KMT2A rearranged acute lymphoblastic leukemia
Chromatin and aberrant enhancer activity in KMT2A rearranged acute lymphoblastic leukemia
To make a multicellular organism, genes need to be transcribed at the right developmental stages and in the right tissues....
Therapeutic targeting of BET bromodomain and other epigenetic acetylrecognition domain–containing factors
Therapeutic targeting of BET bromodomain and other epigenetic acetylrecognition domain–containing factors
In this perspective, we discuss the emerging class of epigenetic cancer therapies targeting acetylrecognition domain–conta...
Linking mitochondria metabolism, developmental timing, and human brain evolution
Linking mitochondria metabolism, developmental timing, and human brain evolution
Changes in developmental timing are an important factor of evolution in organ shape and function. This is particularly str...
The significance of ultradian oscillations in development
The significance of ultradian oscillations in development
Embryos develop autonomously under a predetermined schedule. While the genes involved in these processes have been charact...
Temporal patterning of the vertebrate developing neural tube
Temporal patterning of the vertebrate developing neural tube
scRNAseq data has been obtained from the indicated references (forebrain, midbrain, hindbrain: [34], spinal cord: [31], re...
RNA in chromatin organization and nuclear architecture
RNA in chromatin organization and nuclear architecture
Chromatin is surrounded by various types of nuclear bodies, including the nucleolus, Cajal bodies, paraspeckles, and nucle...
Mitochondrial metabolism and the continuing search for ultimate regulators of developmental rate
Mitochondrial metabolism and the continuing search for ultimate regulators of developmental rate
A fundamental question in developmental biology is how the pace of developmental processes is controlled from a cell biolo...
Dynamic microenvironments shape nuclear organization and gene expression
Dynamic microenvironments shape nuclear organization and gene expression
Transcription is regulated at the molecular scale by highly dynamic events, including the binding of transcription factors...
Safeguarding the epigenome through the cell cycle: a multitasking game
Safeguarding the epigenome through the cell cycle: a multitasking game
Sustaining cell identity and function across cell division is germane to human development, healthspan, and cancer avoidan...
Timers, variability, and body-wide coordination: C. elegans as a model system for whole-animal developmental timing
Timers, variability, and body-wide coordination: C. elegans as a model system for whole-animal developmental timing
Successful development requires both precise timing of cellular processes, such as division and differentiation, and tight...
Somatic hypermutation mechanisms during lymphomagenesis and transformation
Somatic hypermutation mechanisms during lymphomagenesis and transformation
Activation-induced cytidine deaminase (AID) is a single-stranded DNA (ssDNA) cytidine deaminase that is predominantly expr...
Inheritance of epigenetic transcriptional memory
Inheritance of epigenetic transcriptional memory
An improved understanding of nuclear architecture has begun to reveal how genome organization affects transcription and ot...
Editorial overview: Early embryonic development models: back to the beginning
Editorial overview: Early embryonic development models: back to the beginning
Miguel Angel Esteban Miguel A Esteban is research scientist at 3DC STAR in BGI Shenzhen. Miguel obtained his BS in Medicin...
Hexasomal particles: consequence or also consequential?
Hexasomal particles: consequence or also consequential?
Volume 85, April 2024, 102163Author links open overlay panel, , It is long known that an RNA polymerase transcribing throu...
Approaches to probe and perturb long noncoding RNA functions in diseases
Approaches to probe and perturb long noncoding RNA functions in diseases
Long noncoding RNAs (lncRNAs) are a class of RNA molecules exceeding 200 nucleotides in length that lack long open-reading...
Epigenetic control and manipulation of neuronal maturation timing
Epigenetic control and manipulation of neuronal maturation timing
During brain development, the sequence of developmental steps and the underlying transcriptional regulatory logic are larg...
The influencers' era: how the environment shapes chromatin in 3D
The influencers' era: how the environment shapes chromatin in 3D
Environment–epigenome interactions are emerging as contributors to disease risk and health outcomes. In fact, organisms ou...
Therapeutic index of targeting select chromatin complexes in human cancer patients
Therapeutic index of targeting select chromatin complexes in human cancer patients
Volume 85, April 2024, 102162Author links open overlay panel, Aberrant chromatin regulation can promote the initiation and...
Cohesin regulation and roles in chromosome structure and function
Cohesin regulation and roles in chromosome structure and function
Cookies are used by this site. Cookie SettingsAll content on this site: Copyright © 2024 Elsevier B.V., its licensors, an...
A CTCF-dependent mechanism underlies the Hox timer: relation to a segmented body plan
A CTCF-dependent mechanism underlies the Hox timer: relation to a segmented body plan
During gastrulation, Hox genes are activated in a time-sequence that follows the order of the genes along their clusters. ...
Corrigendum to: “PRC2 accessory factors: rheostats for cell fate decision?” [Curr Opin Genet Dev 84 (2024) 102137]
Corrigendum to: “PRC2 accessory factors: rheostats for cell fate decision?” [Curr Opin Genet Dev 84 (2024) 102137]
Volume 85, April 2024, 102157Author links open overlay panelHina Bharti *, Sungwook Han *, Han-Wen Chang *, Danny Reinberg...
Timing neurogenesis: a clock or an algorithm?
Timing neurogenesis: a clock or an algorithm?
In a fundamental sense, time represents the continuous progression of existence and events. It unfolds moment by moment an...
Degrees of freedom: temperature’s influence on developmental rate
Degrees of freedom: temperature’s influence on developmental rate
Temperature exerts a fundamental influence across scales of biology, from the biophysical nature of molecules, to the sens...
Toward a comprehensive view of gene architecture during transcription
Toward a comprehensive view of gene architecture during transcription
In multicellular organisms, the same genetic code gives rise to a large diversity of cell types. A fully stretched out ver...
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