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METTL7A-mediated m6A modification of corin reverses bisphosphonates-impaired osteogenic differentiation of orofacial BMSCs
METTL7A-mediated m6A modification of corin reverses bisphosphonates-impaired osteogenic differentiation of orofacial BMSCs
Bisphosphonate-related osteonecrosis of jaw (BRONJ) is characterized by impaired osteogenic differentiation of orofacial b...
m1A inhibition fuels oncolytic virus-elicited antitumor immunity via downregulating MYC/PD-L1 signaling
m1A inhibition fuels oncolytic virus-elicited antitumor immunity via downregulating MYC/PD-L1 signaling
N1-methyladenosine (m1A) RNA methylation is critical for regulating mRNA translation; however, its role in the development...
A 3D In-vitro model of the human dentine interface shows long-range osteoinduction from the dentine surface
A 3D In-vitro model of the human dentine interface shows long-range osteoinduction from the dentine surface
Emerging regenerative cell therapies for alveolar bone loss have begun to explore the use of cell laden hydrogels for mini...
Fully automatic AI segmentation of oral surgery-related tissues based on cone beam computed tomography images
Fully automatic AI segmentation of oral surgery-related tissues based on cone beam computed tomography images
Accurate segmentation of oral surgery-related tissues from cone beam computed tomography (CBCT) images can significantly a...
Transcriptomic and cellular decoding of scaffolds-induced suture mesenchyme regeneration
Transcriptomic and cellular decoding of scaffolds-induced suture mesenchyme regeneration
Precise orchestration of cell fate determination underlies the success of scaffold-based skeletal regeneration. Despite ex...
Expert consensus on pediatric orthodontic therapies of malocclusions in children
Expert consensus on pediatric orthodontic therapies of malocclusions in children
Malocclusion, identified by the World Health Organization (WHO) as one of three major oral diseases, profoundly impacts th...
Tailored apoptotic vesicles promote bone regeneration by releasing the osteoinductive brake
Tailored apoptotic vesicles promote bone regeneration by releasing the osteoinductive brake
Accumulating evidence has demonstrated that apoptotic vesicles (apoVs) derived from mesenchymal stem cells (MSCs; MSC-apoV...
The evolution of robotics: research and application progress of dental implant robotic systems
The evolution of robotics: research and application progress of dental implant robotic systems
The use of robots to augment human capabilities and assist in work has long been an aspiration. Robotics has been developi...
FUT8-mediated aberrant N-glycosylation of SEMA7A promotes head and neck squamous cell carcinoma progression
FUT8-mediated aberrant N-glycosylation of SEMA7A promotes head and neck squamous cell carcinoma progression
SEMA7A belongs to the Semaphorin family and is involved in the oncogenesis and tumor progression. Aberrant glycosylation h...
Periodontitis exacerbates pulmonary hypertension by promoting IFNγ+ T cell infiltration in mice
Periodontitis exacerbates pulmonary hypertension by promoting IFNγ+ T cell infiltration in mice
Uncovering the risk factors of pulmonary hypertension and its mechanisms is crucial for the prevention and treatment of th...
A Wnt10a-Notch signaling axis controls Hertwig’s epithelial root sheath cell behaviors during root furcation patterning
A Wnt10a-Notch signaling axis controls Hertwig’s epithelial root sheath cell behaviors during root furcation patterning
Human with bi-allelic WNT10A mutations and epithelial Wnt10a knockout mice present enlarged pulp chamber and apical displa...
Promising dawn in tumor microenvironment therapy: engineering oral bacteria
Promising dawn in tumor microenvironment therapy: engineering oral bacteria
Despite decades of research, cancer continues to be a major global health concern. The human mouth appears to be a multipl...
Expert consensus on difficulty assessment of endodontic therapy
Endodontic diseases are a kind of chronic infectious oral disease. Common endodontic treatment concepts are based on the r...
Expert consensus on irrigation and intracanal medication in root canal therapy
Chemical cleaning and disinfection are crucial steps for eliminating infection in root canal treatment. However, irrigant ...
Tim4 deficiency reduces CD301b+ macrophage and aggravates periodontitis bone loss
Tim4 deficiency reduces CD301b+ macrophage and aggravates periodontitis bone loss
Periodontitis is a common chronic inflammatory disease that causes the periodontal bone destruction and may ultimately res...
The neutrophil–osteogenic cell axis promotes bone destruction in periodontitis
The neutrophil–osteogenic cell axis promotes bone destruction in periodontitis
The immune-stromal cell interactions play a key role in health and diseases. In periodontitis, the most prevalent infectio...
Stromal thrombospondin 1 suppresses angiogenesis in oral submucous fibrosis
Stromal thrombospondin 1 suppresses angiogenesis in oral submucous fibrosis
A decline in mucosal vascularity is a histological hallmark of oral submucous fibrosis (OSF), a premalignant disease that ...
PRX1-positive mesenchymal stem cells drive molar morphogenesis
PRX1-positive mesenchymal stem cells drive molar morphogenesis
Mammalian teeth, developing inseparable from epithelial-mesenchymal interaction, come in many shapes and the key factors g...
A novel saliva-based miRNA profile to diagnose and predict oral cancer
A novel saliva-based miRNA profile to diagnose and predict oral cancer
Oral cancer (OC) is the most common form of head and neck cancer. Despite the high incidence and unfavourable patient outc...
Genomic alterations in oral multiple primary cancers
Genomic alterations in oral multiple primary cancers
Oral squamous cell carcinoma (OSCC) is the predominant type of oral cancer, while some patients may develop oral multiple ...