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Primary cilia support cartilage regeneration after injury
Primary cilia support cartilage regeneration after injury
In growing children, growth plate cartilage has limited self-repair ability upon fracture injury always leading to limb gr...
Micromechanical interlocking structure at the filler/resin interface for dental composites: a review
Micromechanical interlocking structure at the filler/resin interface for dental composites: a review
Dental resin composites (DRCs) are popular materials for repairing caries or dental defect, requiring excellent properties...
RANKL+ senescent cells under mechanical stress: a therapeutic target for orthodontic root resorption using senolytics
RANKL+ senescent cells under mechanical stress: a therapeutic target for orthodontic root resorption using senolytics
In dentistry, orthodontic root resorption is a long-lasting issue with no effective treatment strategy, and its mechanisms...
CD301b+ macrophage: the new booster for activating bone regeneration in periodontitis treatment
CD301b+ macrophage: the new booster for activating bone regeneration in periodontitis treatment
Periodontal bone regeneration is a major challenge in the treatment of periodontitis. Currently the main obstacle is the d...
Autologous mesenchymal stem cells offer a new paradigm for salivary gland regeneration
Autologous mesenchymal stem cells offer a new paradigm for salivary gland regeneration
Salivary gland (SG) dysfunction, due to radiotherapy, disease, or aging, is a clinical manifestation that has the potentia...
Down-regulation of DNA key protein-FEN1 inhibits OSCC growth by affecting immunosuppressive phenotypes via IFN-γ/JAK/STAT-1
Down-regulation of DNA key protein-FEN1 inhibits OSCC growth by affecting immunosuppressive phenotypes via IFN-γ/JAK/STAT-1
Oral squamous cell carcinoma (OSCC) escape from the immune system is mediated through several immunosuppressive phenotypes...
The Tip60/Ep400 chromatin remodeling complex impacts basic cellular functions in cranial neural crest-derived tissue during early orofacial development
The Tip60/Ep400 chromatin remodeling complex impacts basic cellular functions in cranial neural crest-derived tissue during early orofacial development
The cranial neural crest plays a fundamental role in orofacial development and morphogenesis. Accordingly, mutations with ...
Craniofacial therapy: advanced local therapies from nano-engineered titanium implants to treat craniofacial conditions
Craniofacial therapy: advanced local therapies from nano-engineered titanium implants to treat craniofacial conditions
Nano-engineering-based tissue regeneration and local therapeutic delivery strategies show significant potential to reduce ...
mTORC1 signaling pathway regulates tooth repair
mTORC1 signaling pathway regulates tooth repair
Tooth germ injury can lead to abnormal tooth development and even tooth loss, affecting various aspects of the stomatognat...
Wnt pathway inhibitors are upregulated in XLH dental pulp cells in response to odontogenic differentiation
Wnt pathway inhibitors are upregulated in XLH dental pulp cells in response to odontogenic differentiation
X-linked hypophosphatemia (XLH) represents the most common form of familial hypophosphatemia. Although significant advance...
Correction To: A biomimetic nanoplatform for customized photothermal therapy of HNSCC evaluated on patient-derived xenograft models
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
RGS12 represses oral squamous cell carcinoma by driving M1 polarization of tumor-associated macrophages via controlling ciliary MYCBP2/KIF2A signaling
RGS12 represses oral squamous cell carcinoma by driving M1 polarization of tumor-associated macrophages via controlling ciliary MYCBP2/KIF2A signaling
Tumor-associated macrophages (TAMs) play crucial roles in tumor progression and immune responses. However, mechanisms of d...
PPAR-γ activation promotes xenogenic bioroot regeneration by attenuating the xenograft induced-oxidative stress
PPAR-γ activation promotes xenogenic bioroot regeneration by attenuating the xenograft induced-oxidative stress
Xenogenic organ transplantation has been considered the most promising strategy in providing possible substitutes with the...
A biomimetic nanoplatform for customized photothermal therapy of HNSCC evaluated on patient-derived xenograft models
A biomimetic nanoplatform for customized photothermal therapy of HNSCC evaluated on patient-derived xenograft models
Cancer cell membrane (CCM) derived nanotechnology functionalizes nanoparticles (NPs) to recognize homologous cells, exhibi...
Study of the inflammatory activating process in the early stage of Fusobacterium nucleatum infected PDLSCs
Study of the inflammatory activating process in the early stage of Fusobacterium nucleatum infected PDLSCs
Fusobacterium nucleatum (F. nucleatum) is an early pathogenic colonizer in periodontitis, but the host response to infecti...
MSCs-derived apoptotic extracellular vesicles promote muscle regeneration by inducing Pannexin 1 channel-dependent creatine release by myoblasts
MSCs-derived apoptotic extracellular vesicles promote muscle regeneration by inducing Pannexin 1 channel-dependent creatine release by myoblasts
Severe muscle injury is hard to heal and always results in a poor prognosis. Recent studies found that extracellular vesic...
Porphyromonas gingivalis bacteremia increases the permeability of the blood-brain barrier via the Mfsd2a/Caveolin-1 mediated transcytosis pathway
Porphyromonas gingivalis bacteremia increases the permeability of the blood-brain barrier via the Mfsd2a/Caveolin-1 mediated transcytosis pathway
Bacteremia induced by periodontal infection is an important factor for periodontitis to threaten general health. P. gingiv...
Specific RNA m6A modification sites in bone marrow mesenchymal stem cells from the jawbone marrow of type 2 diabetes patients with dental implant failure
Specific RNA m6A modification sites in bone marrow mesenchymal stem cells from the jawbone marrow of type 2 diabetes patients with dental implant failure
The failure rate of dental implantation in patients with well-controlled type 2 diabetes mellitus (T2DM) is higher than th...
Systemic antibiotics increase microbiota pathogenicity and oral bone loss
Systemic antibiotics increase microbiota pathogenicity and oral bone loss
Periodontitis is the most widespread oral disease and is closely related to the oral microbiota. The oral microbiota is ad...
Tooth number abnormality: from bench to bedside
Tooth number abnormality: from bench to bedside
Tooth number abnormality is one of the most common dental developmental diseases, which includes both tooth agenesis and s...
Promising applications of human-derived saliva biomarker testing in clinical diagnostics
Promising applications of human-derived saliva biomarker testing in clinical diagnostics
Saliva testing is a vital method for clinical applications, for its noninvasive features, richness in substances, and the ...
Mutation-associated transcripts reconstruct the prognostic features of oral tongue squamous cell carcinoma
Mutation-associated transcripts reconstruct the prognostic features of oral tongue squamous cell carcinoma
Tongue squamous cell carcinoma is highly malignant and has a poor prognosis. In this study, we aimed to combine whole-geno...
Expert consensus on regenerative endodontic procedures
Expert consensus on regenerative endodontic procedures
Regenerative endodontic procedures (REPs) is a biologic-based treatment modality for immature permanent teeth diagnosed wi...
Low intensity near-infrared light promotes bone regeneration via circadian clock protein cryptochrome 1
Low intensity near-infrared light promotes bone regeneration via circadian clock protein cryptochrome 1
Bone regeneration remains a great clinical challenge. Low intensity near-infrared (NIR) light showed strong potential to p...
Metformin can mitigate skeletal dysplasia caused by Pck2 deficiency
Metformin can mitigate skeletal dysplasia caused by Pck2 deficiency
As an important enzyme for gluconeogenesis, mitochondrial phosphoenolpyruvate carboxykinase (PCK2) has further complex fun...
The role of dendritic cells in the immunomodulation to implanted biomaterials
The role of dendritic cells in the immunomodulation to implanted biomaterials
Considering the substantial role played by dendritic cells (DCs) in the immune system to bridge innate and adaptive immuni...
Advances in regenerative medicine applications of tetrahedral framework nucleic acid-based nanomaterials: an expert consensus recommendation
Advances in regenerative medicine applications of tetrahedral framework nucleic acid-based nanomaterials: an expert consensus recommendation
With the emergence of DNA nanotechnology in the 1980s, self-assembled DNA nanostructures have attracted considerable atten...
Disrupted tenogenesis in masseter as a potential cause of micrognathia
Disrupted tenogenesis in masseter as a potential cause of micrognathia
Micrognathia is a severe craniofacial deformity affecting appearance and survival. Previous studies revealed that multiple...
Getting the job: it’s not just who you know, but how you know them
Getting the job: it’s not just who you know, but how you know them
People are more likely to land high-paying jobs through friends of friends than through their close friends or family, stu...
Stem cell microencapsulation maintains stemness in inflammatory microenvironment
Stem cell microencapsulation maintains stemness in inflammatory microenvironment
Maintaining the stemness of the transplanted stem cell spheroids in an inflammatory microenvironment is challenging but im...
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