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A blood glucose fluctuation-responsive delivery system promotes bone regeneration and the repair function of Smpd3-reprogrammed BMSC-derived exosomes
A blood glucose fluctuation-responsive delivery system promotes bone regeneration and the repair function of Smpd3-reprogrammed BMSC-derived exosomes
Blood glucose fluctuation leads to poor bone defect repair in patients with type 2 diabetes (T2DM). Strategies to safely a...
An unexpected role of Nogo-A as regulator of tooth enamel formation
An unexpected role of Nogo-A as regulator of tooth enamel formation
Neurite outgrowth inhibitor A (Nogo-A) is a major player in neural development and regeneration and the target of clinical...
Correction: An unexpected role of Nogo-A as regulator of tooth enamel formation
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Cuproptosis-related lncRNA JPX regulates malignant cell behavior and epithelial-immune interaction in head and neck squamous cell carcinoma via miR-193b-3p/PLAU axis
Cuproptosis-related lncRNA JPX regulates malignant cell behavior and epithelial-immune interaction in head and neck squamous cell carcinoma via miR-193b-3p/PLAU axis
The development, progression, and curative efficacy of head and neck squamous cell carcinoma (HNSCC) are influenced by com...
Personalized bioceramic grafts for craniomaxillofacial bone regeneration
Personalized bioceramic grafts for craniomaxillofacial bone regeneration
The reconstruction of craniomaxillofacial bone defects remains clinically challenging. To date, autogenous grafts are cons...
Organoids in the oral and maxillofacial region: present and future
Organoids in the oral and maxillofacial region: present and future
The oral and maxillofacial region comprises a variety of organs made up of multiple soft and hard tissue, which are anatom...
An unexpected role of neurite outgrowth inhibitor A as regulator of tooth enamel formation
An unexpected role of neurite outgrowth inhibitor A as regulator of tooth enamel formation
Neurite outgrowth inhibitor A (Nogo-A) is a major player in neural development and regeneration and the target of clinical...
Periodontitis impacts on thrombotic diseases: from clinical aspect to future therapeutic approaches
Periodontitis impacts on thrombotic diseases: from clinical aspect to future therapeutic approaches
Periodontitis is a chronic inflammatory disease initiated by biofilm microorganisms and mediated by host immune imbalance....
CREB3L1 deficiency impairs odontoblastic differentiation and molar dentin deposition partially through the TMEM30B
CREB3L1 deficiency impairs odontoblastic differentiation and molar dentin deposition partially through the TMEM30B
Odontoblasts are primarily responsible for synthesizing and secreting extracellular matrix proteins, which are crucial for...
Experts consensus on management of tooth luxation and avulsion
Experts consensus on management of tooth luxation and avulsion
Traumatic dental injuries (TDIs) of teeth occur frequently in children and adolescents. TDIs that impact the periodontal t...
The circadian clock in enamel development
The circadian clock in enamel development
Circadian rhythms are self-sustaining oscillations within biological systems that play key roles in a diverse multitude of...
Expert consensus on the diagnosis and therapy of endo-periodontal lesions
Expert consensus on the diagnosis and therapy of endo-periodontal lesions
Endo-periodontal lesions (EPLs) involve both the periodontium and pulp tissue and have complicated etiologies and pathogen...
Caspase-11 mediated inflammasome activation in macrophages by systemic infection of A. actinomycetemcomitans exacerbates arthritis
Caspase-11 mediated inflammasome activation in macrophages by systemic infection of A. actinomycetemcomitans exacerbates arthritis
Clinical studies have shown that Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans) is associated with aggre...
Gingipain from Porphyromonas gingivalis causes insulin resistance by degrading insulin receptors through direct proteolytic effects
Gingipain from Porphyromonas gingivalis causes insulin resistance by degrading insulin receptors through direct proteolytic effects
Periodontitis is a critical risk factor for the occurrence and development of diabetes. Porphyromonas gingivalis may parti...
Age-related alveolar bone maladaptation in adult orthodontics: finding new ways out
Age-related alveolar bone maladaptation in adult orthodontics: finding new ways out
Compared with teenage patients, adult patients generally show a slower rate of tooth movement and more pronounced alveolar...
Stabilization of EREG via STT3B-mediated N-glycosylation is critical for PDL1 upregulation and immune evasion in head and neck squamous cell carcinoma
Stabilization of EREG via STT3B-mediated N-glycosylation is critical for PDL1 upregulation and immune evasion in head and neck squamous cell carcinoma
Dysregulated Epiregulin (EREG) can activate epidermal growth factor receptor (EGFR) and promote tumor progression in head ...
Synthetic high-density lipoprotein (sHDL): a bioinspired nanotherapeutics for managing periapical bone inflammation
Synthetic high-density lipoprotein (sHDL): a bioinspired nanotherapeutics for managing periapical bone inflammation
Apical periodontitis (AP) is a dental-driven condition caused by pathogens and their toxins infecting the inner portion of...
Evaluation of a newly developed oral and maxillofacial surgical robotic platform (KD-SR-01) in head and neck surgery: a preclinical trial in porcine models
Evaluation of a newly developed oral and maxillofacial surgical robotic platform (KD-SR-01) in head and neck surgery: a preclinical trial in porcine models
Traditional open head and neck surgery often leaves permanent scars, significantly affecting appearance. The emergence of ...
Author Correction: FUT8-mediated aberrant N-glycosylation of SEMA7A promotes head and neck squamous cell carcinoma progression
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Exosomal miR-17-5p derived from epithelial cells is involved in aberrant epithelium-fibroblast crosstalk and induces the development of oral submucosal fibrosis
Exosomal miR-17-5p derived from epithelial cells is involved in aberrant epithelium-fibroblast crosstalk and induces the development of oral submucosal fibrosis
Oral submucous fibrosis (OSF) is a chronic and inflammatory mucosal disease caused by betel quid chewing, which belongs to...
Nociceptive adenosine A2A receptor on trigeminal nerves orchestrates CGRP release to regulate the progression of oral squamous cell carcinoma
Nociceptive adenosine A2A receptor on trigeminal nerves orchestrates CGRP release to regulate the progression of oral squamous cell carcinoma
Oral squamous cell carcinoma (OSCC) associated pain commonly predicts adverse events among patients. This clinical feature...
Expert consensus on endodontic therapy for patients with systemic conditions
The overall health condition of patients significantly affects the diagnosis, treatment, and prognosis of endodontic disea...
Integrative single-cell and bulk transcriptomes analyses reveals heterogeneity of serine-glycine-one-carbon metabolism with distinct prognoses and therapeutic vulnerabilities in HNSCC
Integrative single-cell and bulk transcriptomes analyses reveals heterogeneity of serine-glycine-one-carbon metabolism with distinct prognoses and therapeutic vulnerabilities in HNSCC
Metabolic heterogeneity plays a central role in sustaining uncontrolled cancer cell proliferation and shaping the tumor mi...
A multi-platform analysis of human gingival crevicular fluid reveals ferroptosis as a relevant regulated cell death mechanism during the clinical progression of periodontitis
A multi-platform analysis of human gingival crevicular fluid reveals ferroptosis as a relevant regulated cell death mechanism during the clinical progression of periodontitis
Ferroptosis is implicated in the pathogenesis of numerous chronic-inflammatory diseases, yet its association with progress...
METTL7A-mediated m6A modification of corin reverses bisphosphonates-impaired osteogenic differentiation of orofacial BMSCs
METTL7A-mediated m6A modification of corin reverses bisphosphonates-impaired osteogenic differentiation of orofacial BMSCs
Bisphosphonate-related osteonecrosis of jaw (BRONJ) is characterized by impaired osteogenic differentiation of orofacial b...
Multiomics profiling reveals VDR as a central regulator of mesenchymal stem cell senescence with a known association with osteoporosis after high-fat diet exposure
Multiomics profiling reveals VDR as a central regulator of mesenchymal stem cell senescence with a known association with osteoporosis after high-fat diet exposure
The consumption of a high-fat diet (HFD) has been linked to osteoporosis and an increased risk of fragility fractures. How...
Unveiling the oral-gut connection: chronic apical periodontitis accelerates atherosclerosis via gut microbiota dysbiosis and altered metabolites in apoE−/− Mice on a high-fat diet
Unveiling the oral-gut connection: chronic apical periodontitis accelerates atherosclerosis via gut microbiota dysbiosis and altered metabolites in apoE−/− Mice on a high-fat diet
The aim of this study was to explore the impact of chronic apical periodontitis (CAP) on atherosclerosis in apoE−/&#...
Human dental pulp stem cells mitigate the neuropathology and cognitive decline via AKT-GSK3β-Nrf2 pathways in Alzheimer’s disease
Human dental pulp stem cells mitigate the neuropathology and cognitive decline via AKT-GSK3β-Nrf2 pathways in Alzheimer’s disease
Oxidative stress is increasingly recognized as a major contributor to the pathophysiology of Alzheimer’s disease (AD...
m1A inhibition fuels oncolytic virus-elicited antitumor immunity via downregulating MYC/PD-L1 signaling
m1A inhibition fuels oncolytic virus-elicited antitumor immunity via downregulating MYC/PD-L1 signaling
N1-methyladenosine (m1A) RNA methylation is critical for regulating mRNA translation; however, its role in the development...
A 3D In-vitro model of the human dentine interface shows long-range osteoinduction from the dentine surface
A 3D In-vitro model of the human dentine interface shows long-range osteoinduction from the dentine surface
Emerging regenerative cell therapies for alveolar bone loss have begun to explore the use of cell laden hydrogels for mini...
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