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Stabilization of EREG via STT3B-mediated N-glycosylation is critical for PDL1 upregulation and immune evasion in head and neck squamous cell carcinoma
Stabilization of EREG via STT3B-mediated N-glycosylation is critical for PDL1 upregulation and immune evasion in head and neck squamous cell carcinoma
Dysregulated Epiregulin (EREG) can activate epidermal growth factor receptor (EGFR) and promote tumor progression in head ...
Synthetic high-density lipoprotein (sHDL): a bioinspired nanotherapeutics for managing periapical bone inflammation
Synthetic high-density lipoprotein (sHDL): a bioinspired nanotherapeutics for managing periapical bone inflammation
Apical periodontitis (AP) is a dental-driven condition caused by pathogens and their toxins infecting the inner portion of...
Evaluation of a newly developed oral and maxillofacial surgical robotic platform (KD-SR-01) in head and neck surgery: a preclinical trial in porcine models
Evaluation of a newly developed oral and maxillofacial surgical robotic platform (KD-SR-01) in head and neck surgery: a preclinical trial in porcine models
Traditional open head and neck surgery often leaves permanent scars, significantly affecting appearance. The emergence of ...
Author Correction: FUT8-mediated aberrant N-glycosylation of SEMA7A promotes head and neck squamous cell carcinoma progression
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Exosomal miR-17-5p derived from epithelial cells is involved in aberrant epithelium-fibroblast crosstalk and induces the development of oral submucosal fibrosis
Exosomal miR-17-5p derived from epithelial cells is involved in aberrant epithelium-fibroblast crosstalk and induces the development of oral submucosal fibrosis
Oral submucous fibrosis (OSF) is a chronic and inflammatory mucosal disease caused by betel quid chewing, which belongs to...
Nociceptive adenosine A2A receptor on trigeminal nerves orchestrates CGRP release to regulate the progression of oral squamous cell carcinoma
Nociceptive adenosine A2A receptor on trigeminal nerves orchestrates CGRP release to regulate the progression of oral squamous cell carcinoma
Oral squamous cell carcinoma (OSCC) associated pain commonly predicts adverse events among patients. This clinical feature...
Expert consensus on endodontic therapy for patients with systemic conditions
The overall health condition of patients significantly affects the diagnosis, treatment, and prognosis of endodontic disea...
Integrative single-cell and bulk transcriptomes analyses reveals heterogeneity of serine-glycine-one-carbon metabolism with distinct prognoses and therapeutic vulnerabilities in HNSCC
Integrative single-cell and bulk transcriptomes analyses reveals heterogeneity of serine-glycine-one-carbon metabolism with distinct prognoses and therapeutic vulnerabilities in HNSCC
Metabolic heterogeneity plays a central role in sustaining uncontrolled cancer cell proliferation and shaping the tumor mi...
A multi-platform analysis of human gingival crevicular fluid reveals ferroptosis as a relevant regulated cell death mechanism during the clinical progression of periodontitis
A multi-platform analysis of human gingival crevicular fluid reveals ferroptosis as a relevant regulated cell death mechanism during the clinical progression of periodontitis
Ferroptosis is implicated in the pathogenesis of numerous chronic-inflammatory diseases, yet its association with progress...
METTL7A-mediated m6A modification of corin reverses bisphosphonates-impaired osteogenic differentiation of orofacial BMSCs
METTL7A-mediated m6A modification of corin reverses bisphosphonates-impaired osteogenic differentiation of orofacial BMSCs
Bisphosphonate-related osteonecrosis of jaw (BRONJ) is characterized by impaired osteogenic differentiation of orofacial b...
Multiomics profiling reveals VDR as a central regulator of mesenchymal stem cell senescence with a known association with osteoporosis after high-fat diet exposure
Multiomics profiling reveals VDR as a central regulator of mesenchymal stem cell senescence with a known association with osteoporosis after high-fat diet exposure
The consumption of a high-fat diet (HFD) has been linked to osteoporosis and an increased risk of fragility fractures. How...
Unveiling the oral-gut connection: chronic apical periodontitis accelerates atherosclerosis via gut microbiota dysbiosis and altered metabolites in apoE−/− Mice on a high-fat diet
Unveiling the oral-gut connection: chronic apical periodontitis accelerates atherosclerosis via gut microbiota dysbiosis and altered metabolites in apoE−/− Mice on a high-fat diet
The aim of this study was to explore the impact of chronic apical periodontitis (CAP) on atherosclerosis in apoE−/&#...
Human dental pulp stem cells mitigate the neuropathology and cognitive decline via AKT-GSK3β-Nrf2 pathways in Alzheimer’s disease
Human dental pulp stem cells mitigate the neuropathology and cognitive decline via AKT-GSK3β-Nrf2 pathways in Alzheimer’s disease
Oxidative stress is increasingly recognized as a major contributor to the pathophysiology of Alzheimer’s disease (AD...
m1A inhibition fuels oncolytic virus-elicited antitumor immunity via downregulating MYC/PD-L1 signaling
m1A inhibition fuels oncolytic virus-elicited antitumor immunity via downregulating MYC/PD-L1 signaling
N1-methyladenosine (m1A) RNA methylation is critical for regulating mRNA translation; however, its role in the development...
A 3D In-vitro model of the human dentine interface shows long-range osteoinduction from the dentine surface
A 3D In-vitro model of the human dentine interface shows long-range osteoinduction from the dentine surface
Emerging regenerative cell therapies for alveolar bone loss have begun to explore the use of cell laden hydrogels for mini...
Sinensetin protects against periodontitis through binding to Bach1 enhancing its ubiquitination degradation and improving oxidative stress
Sinensetin protects against periodontitis through binding to Bach1 enhancing its ubiquitination degradation and improving oxidative stress
Periodontitis is a chronic inflammatory and immune reactive disease induced by the subgingival biofilm. The therapeutic ef...
Fully automatic AI segmentation of oral surgery-related tissues based on cone beam computed tomography images
Fully automatic AI segmentation of oral surgery-related tissues based on cone beam computed tomography images
Accurate segmentation of oral surgery-related tissues from cone beam computed tomography (CBCT) images can significantly a...
Phenformin activates ER stress to promote autophagic cell death via NIBAN1 and DDIT4 in oral squamous cell carcinoma independent of AMPK
Phenformin activates ER stress to promote autophagic cell death via NIBAN1 and DDIT4 in oral squamous cell carcinoma independent of AMPK
The efficient clinical treatment of oral squamous cell carcinoma (OSCC) is still a challenge that demands the development ...
Transcriptomic and cellular decoding of scaffolds-induced suture mesenchyme regeneration
Transcriptomic and cellular decoding of scaffolds-induced suture mesenchyme regeneration
Precise orchestration of cell fate determination underlies the success of scaffold-based skeletal regeneration. Despite ex...
Expert consensus on pediatric orthodontic therapies of malocclusions in children
Expert consensus on pediatric orthodontic therapies of malocclusions in children
Malocclusion, identified by the World Health Organization (WHO) as one of three major oral diseases, profoundly impacts th...
Single cell analysis unveils B cell-dominated immune subtypes in HNSCC for enhanced prognostic and therapeutic stratification
Single cell analysis unveils B cell-dominated immune subtypes in HNSCC for enhanced prognostic and therapeutic stratification
Head and neck squamous cell carcinoma (HNSCC) is characterized by high recurrence or distant metastases rate and the progn...
Tetrahedral framework nucleic acids/hyaluronic acid-methacrylic anhydride hybrid hydrogel with antimicrobial and anti-inflammatory properties for infected wound healing
Tetrahedral framework nucleic acids/hyaluronic acid-methacrylic anhydride hybrid hydrogel with antimicrobial and anti-inflammatory properties for infected wound healing
Bacterial resistance and excessive inflammation are common issues that hinder wound healing. Antimicrobial peptides (AMPs)...
Tailored apoptotic vesicles promote bone regeneration by releasing the osteoinductive brake
Tailored apoptotic vesicles promote bone regeneration by releasing the osteoinductive brake
Accumulating evidence has demonstrated that apoptotic vesicles (apoVs) derived from mesenchymal stem cells (MSCs; MSC-apoV...
The evolution of robotics: research and application progress of dental implant robotic systems
The evolution of robotics: research and application progress of dental implant robotic systems
The use of robots to augment human capabilities and assist in work has long been an aspiration. Robotics has been developi...
FUT8-mediated aberrant N-glycosylation of SEMA7A promotes head and neck squamous cell carcinoma progression
FUT8-mediated aberrant N-glycosylation of SEMA7A promotes head and neck squamous cell carcinoma progression
SEMA7A belongs to the Semaphorin family and is involved in the oncogenesis and tumor progression. Aberrant glycosylation h...
Periodontitis exacerbates pulmonary hypertension by promoting IFNγ+ T cell infiltration in mice
Periodontitis exacerbates pulmonary hypertension by promoting IFNγ+ T cell infiltration in mice
Uncovering the risk factors of pulmonary hypertension and its mechanisms is crucial for the prevention and treatment of th...
A Wnt10a-Notch signaling axis controls Hertwig’s epithelial root sheath cell behaviors during root furcation patterning
A Wnt10a-Notch signaling axis controls Hertwig’s epithelial root sheath cell behaviors during root furcation patterning
Human with bi-allelic WNT10A mutations and epithelial Wnt10a knockout mice present enlarged pulp chamber and apical displa...
Promising dawn in tumor microenvironment therapy: engineering oral bacteria
Promising dawn in tumor microenvironment therapy: engineering oral bacteria
Despite decades of research, cancer continues to be a major global health concern. The human mouth appears to be a multipl...
Expert consensus on difficulty assessment of endodontic therapy
Endodontic diseases are a kind of chronic infectious oral disease. Common endodontic treatment concepts are based on the r...
Expert consensus on irrigation and intracanal medication in root canal therapy
Chemical cleaning and disinfection are crucial steps for eliminating infection in root canal treatment. However, irrigant ...
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