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[Comment] Combination CFTR modulator therapy in children and adults with cystic fibrosis
For most of the 83 years since its pathological description, treatment of cystic fibrosis has focused on amelioratin...
[Correspondence] Inhaled budesonide for early treatment of COVID-19 – Authors' reply
We share the enthusiasm of Rafael San-Juan and colleagues, Markus Zeitlinger and Marco Idzko, and Jae Chol Choi and Won-Yo...
[Correspondence] Inhaled budesonide for early treatment of COVID-19
We read with interest the Article by Sanjay Ramakrishnan and colleagues1Ramakrishnan S Nicolau Jr, DV Langford B et al.Inh...
[Articles] Changes in in-hospital mortality in the first wave of COVID-19: a multicentre prospective observational cohort study using the WHO Clinical Characterisation Protocol UK
Methods Study design and patientsWe did a multicentre prospective observational cohort study at 247 acute general hospital...
[Articles] Cytokine adsorption in patients with severe COVID-19 pneumonia requiring extracorporeal membrane oxygenation (CYCOV): a single centre, open-label, randomised, controlled trial
SummaryBackgroundWe sought to clarify the benefit of cytokine adsorption in patients with COVID-19 supported with venoveno...
[Comment] Cytokine adsorption during ECMO for COVID-19-related ARDS
A syndrome of dysregulated systemic immune overactivation has been described in patients with COVID-19. Initially a cytoki...
[Spotlight] Passive tobacco smoke in children and young people during the COVID-19 pandemic
Second-hand smoke (SHS) exposure is harmful to children and young people. They inhale double the amount of dust compared w...
[News] Ensuring fair distribution of COVID-19 vaccines: is an intellectual waiver the answer?
On May 5, 2021, the US Government announced that it was in favour of waiving intellectual property protections for the COV...
[Personal View] COVID-19-associated Aspergillus tracheobronchitis: the interplay between viral tropism, host defence, and fungal invasion
SummaryInvasive pulmonary aspergillosis is emerging as a secondary infection in patients with COVID-19, which can present ...
[News] 2021 American Thoracic Society International Conference
Dupilumab, a fully human monoclonal antibody, added to existing inhaled corticosteroid therapy significantly reduced...
[News] Repurposing drugs for treatment of COVID-19
Although the COVID-19 vaccine programme continues to be rolled out globally, there is still a need to identify effective t...
[Corrections] Correction to Lancet Respir Med 2021; published online May 14. https://doi.org/10.1016/S2213-2600(21)00177-6
Supady A, Weber E, Rieder M et al. Cytokine adsorption in patients with severe COVID-19 pneumonia requiring extracorporeal...
[Country in Focus] Bhutan: small nation, big ideas affecting respiratory health
Bhutan surprised the world in April, 2021. The tiny kingdom on the eastern slopes of the Himalayas started its COVID-19 va...
[Comment] SARS-CoV-2 antigen testing: weighing the false positives against the costs of failing to control transmission
Lateral flow device (LFD) rapid tests for SARS-CoV-2 antigens are used for asymptomatic testing (including for people who ...
[Editorial] Digital health: balancing innovation and cybersecurity
Digital health is an area of medicine that has seen huge acceleration and investment globally over the past decade—even mo...
[Corrections] Correction to Lancet Respir Med 2021; 9: 373–86
Day TA, Penn-Nicholson A, Luabeya AKK, et al. Safety and immunogenicity of the adjunct therapeutic vaccine ID93 + GLA-SE i...
[Articles] Switching to riociguat versus maintenance therapy with phosphodiesterase-5 inhibitors in patients with pulmonary arterial hypertension (REPLACE): a multicentre, open-label, randomised controlled trial
Background Riociguat and phosphodiesterase-5 inhibitors (PDE5i), approved for the treatment of pulmo...
[Articles] Efficacy and safety of pembrolizumab in patients with advanced mesothelioma in the open-label, single-arm, phase 2 KEYNOTE-158 study
Background Malignant pleural mesothelioma (MPM) has few treatment options. Pembrolizumab showed prel...
[Corrections] Correction to Lancet Respir Med 2021; published online April 9. https://doi. org/10.1016/S2213-2600(21)00160-0
Ramakrishnan S, Nicolau DV Jr, Langford B, et al. Inhaled budesonide in the treatment of early COVID-19 (STOIC): a phase 2...
[Corrections] Correction to Lancet Respir Med 2021; published online April 9. https://doi. org/10.1016/S2213-2600(21)00171-5
In most individuals, infection with SARS-CoV-2 is either asymptomatic or produces mild illness (COVID-19) that resolves sp...
[Comment] Non-invasive respiratory support strategies in COVID-19
In hospitalised patients with COVID-19, an increase in oxygen requirements prompts the clinician to decide how and when to...
[Series] Interleukin-6: obstacles to targeting a complex cytokine in critical illness
1.Hirano T Yasukawa K Harada H et al.Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to...
[Comment] Saliva as a gold-standard sample for SARS-CoV-2 detection
As COVID-19 continues to strain public health systems and vaccination programmes race against new variants that might be m...
[Corrections] Correction to Lancet Respir Med 2021; published online Feb 26. https://doi.org/10.1016/S2213-2600(20)30448-3
Wallis RS, Ginindza S, Beattie T, et al. Adjunctive host-directed therapies for pulmonary tuberculosis: a prospective, ope...
[Comment] Evidence-based European guidelines for the diagnosis of asthma in children aged 5–16 years
Asthma is the most common non-communicable disease in children, but there is no single test available to confirm the...
[Corrections] Correction to Lancet Respir Med 2021; published online April 19. https://doi.org/10.1016/S2213-2600(21)00096-5
Beyond associations with similar factors to those reported on ECMO for non-COVID-19 ARDS, 90-day survival among ECMO-assis...
[Series] Interleukin-6 receptor blockade in patients with COVID-19: placing clinical trials into context
CORIMUNO-19,20Hermine O Mariette X Tharaux PL Resche-Rigon M Porcher R Ravaud P Effect of tocilizumab vs usual care in adu...
[Correspondence] Has the time come to end use of the blue inhaler?
Asthma attacks can lead to death, and new approaches to prevent asthma deaths, particularly in children and adolescents, a...
[Correspondence] Early humoral response among lung transplant recipients vaccinated with BNT162b2 vaccine
Lung transplant recipients are given immunosuppressive therapy that might impair their ability to generate an adequate imm...
[Series] The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity
1.Andersen KG Rambaut A Lipkin WI Holmes EC Garry RF The proximal origin of SARS-CoV-2.Nat Med. 26: 450-4522.COVID-19 coro...
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