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Helping C. difficile to thrive
Helping C. difficile to thrive
This study reports that Enterococcus species can remodel the metabolic environment in the gut and reprogramme the metaboli...
SARS-CoV-2 viral load and shedding kinetics
SARS-CoV-2 viral load and shedding kinetics
SARS-CoV-2 viral load and detection of infectious virus in the respiratory tract are the two key parameters for estimating...
Zooming into the structure of the microbiome
Zooming into the structure of the microbiome
This month’s Genome Watch highlights how genome sequencing can be used to understand the strain-level diversity, evo...
Trichoderma: a multipurpose, plant-beneficial microorganism for eco-sustainable agriculture
Trichoderma: a multipurpose, plant-beneficial microorganism for eco-sustainable agriculture
Trichoderma is a cosmopolitan and opportunistic ascomycete fungal genus including species that are of interest to agricult...
Breaking the bond
This study reports that the Chlamydia trachomatis effector TepP modulates epithelial tight junctions to promote infection.
Uneven division
This study characterized the role of periplasmic PgfA in mycobacterial growth and division.
Viral spillback
This study reports the identification of a highly divergent lineage of SARS-CoV-2 in white-tailed deer and provides eviden...
Molecular mechanisms of antibiotic resistance revisited
Molecular mechanisms of antibiotic resistance revisited
Antibiotic resistance is a global health emergency, with resistance detected to all antibiotics currently in clinical use ...
A driver of monkeypox virus evolution?
A new study identified two distinct lineages of monkeypox virus (MPXV) in the United States with evidence of genome editin...
Gut bacteria shape social behaviour
A recent study used a zebrafish model to show that the microbiota promotes social behaviour by stimulating microglial prun...
Ending the COVID-19 pandemic
In this study, a multinational and multidisciplinary panel of experts provides actionable recommendations for policy maker...
The dynamic lung microbiome in health and disease
The dynamic lung microbiome in health and disease
New methods and technologies within the field of lung biology are beginning to shed new light into the microbial world of ...
Shaping bacterial gene expression by physiological and proteome allocation constraints
Shaping bacterial gene expression by physiological and proteome allocation constraints
Networks of molecular regulators are often the primary objects of focus in the study of gene regulation, with the machiner...
Gut bacteria degrade nicotine
Gut bacteria degrade nicotine
A recent study reports that nicotine accumulates in the gut during smoking and promotes the progression of non-alcoholic f...
Soil viral diversity, ecology and climate change
Soil viral diversity, ecology and climate change
Soil viruses are highly abundant and have important roles in the regulation of host dynamics and soil ecology. Climate cha...
SARS-CoV-2 variants offer a second chance to fix vaccine inequities
Global COVID-19 vaccine equity remains aspirational for much of the world. But the emergence of rapidly evolving SARS-CoV-...
Preventing programmed destruction
Preventing programmed destruction
This study identifies the Mycobacterium tuberculosis effector protein PtpB and shows that it counteracts gasdermin D-media...
SARS-CoV-2 variant evasion of monoclonal antibodies based on in vitro studies
SARS-CoV-2 variant evasion of monoclonal antibodies based on in vitro studies
Monoclonal antibodies (mAbs) offer a treatment option for individuals with severe COVID-19 and are especially important in...
The effects of the COVID-19 pandemic on community respiratory virus activity
The effects of the COVID-19 pandemic on community respiratory virus activity
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused substantial global morbidity and deat...
Bile acids and the gut microbiota: metabolic interactions and impacts on disease
Bile acids and the gut microbiota: metabolic interactions and impacts on disease
Despite decades of bile acid research, diverse biological roles for bile acids have been discovered recently due to develo...
Architecture of the dynamic fungal cell wall
Architecture of the dynamic fungal cell wall
The fungal cell wall is essential for growth and survival, and is a key target for antifungal drugs and the immune system....
Unravelling the genome of giants
This study provides insights into how to determine how mimiviruses package and protect their genomes.
Spotlight on the cancer mycobiome
Two new studies report comprehensive analyses of the fungal communities associated with cancer.
Schistosomes go single cell
Schistosomes go single cell
This Genome Watch article highlights how single-cell sequencing has transformed the approaches to understand schistosome d...
Gut bugs disrupt cancer drugs
Gut bugs disrupt cancer drugs
A recent study finds that an enzyme expressed by gut bacteria can inactivate anti-cancer fluoropyrimidine drugs, reducing ...
Histone mimicry by SARS-CoV-2
This study found that the SARS-CoV-2 protein ORF8 disrupts host epigenetic regulation through histone mimicry.
The bodily distribution of monkeypox virus
A recent study investigated viral loads in clinical samples with the aim of understanding the distribution of monkeypox vi...
Phages to the rescue
Phage–antibiotic combination therapy was successful in treating extensively-resistant Pseudomonas aeruginosa infecti...
RNA-targeting CRISPR–Cas systems
RNA-targeting CRISPR–Cas systems
CRISPR–Cas is a widespread adaptive immune system in bacteria and archaea that protects against viral infection by t...
Spreading out of the lung
Spreading out of the lung
A recent study characterizes an inducible morphotype of Cryptococcus neoformans that is critical for extrapulmonary organ ...