SCI时时刷

search
+
Sialic Acid-Targeted Cyclodextrin-Based Nanoparticles Deliver CSF-1R siRNA and Reprogram Tumour-Associated Macrophages for Immunotherapy of Prostate Cancer
Prostate cancer remains a serious condition threatening the health of men. Due to the complicated nature of the tumour mic...
2′,4′-Dihydroxy-6′‑methoxy-3′,5′-dimethylchalcone and its amino acid-conjugated derivatives induce G0/G1 cell cycle arrest and apoptosis via BAX/BCL2 ratio upregulation and in silico insight in SiHa cell lines
We modified the chemical structure of 2′,4′-dihydroxy-6′‑methoxy-3′,5′-dimethylchalcone (DMC, 1), a phytochemical found in...
Nanosuspensions technology as a master key for nature products drug delivery and In vivo fate
Available online 18 March 2023, 106425Author links open overlay panel, , , AbstractThe drug nanosuspensions is a universal...
2′,4′-Dihydroxy-6′-methoxy-3′,5′-dimethylchalcone and its amino acid–conjugated derivatives induce G0/G1 cell cycle arrest and apoptosis via BAX/BCL2 ratio upregulation and in silico insight in SiHa cell lines
We modified the chemical structure of 2′,4′-dihydroxy-6′-methoxy-3′,5′-dimethylchalcone (DMC, 1), a phytochemical found in...
Retraction notice to “Transdermal delivery of flurbiprofen from polyoxypropylene-polyoxyethylene block copolymer stabilized reduced graphene oxide to manage pain in spondylitis: In vitro and in vivo studies” [European Journal of Pharmaceutical Sciences 165 (2021) 105929]
We use cookies to help provide and enhance our service and tailor content and ads. By continuing you agree to the use of c...
Population pharmacokinetic analysis reveals no impact of aprepitant on the pharmacokinetics of ifosfamide, 2-dechloroifosfamide, and 3-dechloroifosfamide
PurposeSeveral case reports and retrospective series have clearly pointed to the role of aprepitant, an antiemetic drug, i...
Design, synthesis, and biological screening of a series of pyrazolo [1,5-a]quina-zoline derivatives as SIRT6 activators
Available online 12 March 2023, 106424Author links open overlay panel, , , , , ABSTRACTSIRT6 has emerged as a novel therap...
Investigation of the degradation and in-situ amorphization of the enantiomeric drug escitalopram oxalate during Fused Deposition Modeling (FDM) 3D printing
Volume 185, 1 June 2023, 106423Author links open overlay panel, , Highlights•In-situ amorphization of ESC-OX from bPMMA ex...
A profile of SGLT-2 inhibitors in hyponatremia: The evidence to date
Hyponatremia is the most common electrolyte disorder in clinical practice, which may lead to life-threatening complication...
Pharmacokinetics and pharmacodynamics of imatinib for optimal drug repurposing from cancer to COVID-19
Volume 184, 1 May 2023, 106418Author links open overlay panel, , , , , , , , , , , , , Highlights•This is the first study ...
Albumin-binding DARPins as scaffold improve the hypoglycemic and anti-obesity effects of exendin-4 in vivo
Volume 185, 1 June 2023, 106422Author links open overlay panel, , , , Highlights•Albumin-binding DARPins can be used as a ...
Evaluation of the 18F-labeled analog of the therapeutic all-D-enantiomeric peptide RD2 for amyloid β imaging
Volume 184, 1 May 2023, 106421Author links open overlay panel, , , , , , , , , , , , AbstractPositron emission tomography ...
Implementation of Quality by Design (QbD) for development of bilayer tablets
Bilayer tablets offer various drug release profiles for individual drugs incorporated in each layer of a bilayer tablet, w...
Individual dose recommendations for drug interaction between tacrolimus and voriconazole in adult liver transplant recipients: A semiphysiologically based population pharmacokinetic modeling approach
The magnitude of drug-drug interaction between tacrolimus and voriconazole is highly variable, and individually tailoring ...
Preparation of an HI-6-loaded brain-targeted liposomes based on the nasal delivery route and the evaluation of its reactivation of central toxic acetylcholinesterase
PurposeOrganophosphorus compounds (OPs) is a serious threat to human health and life safety, but because of the existence ...
In-situ investigation of solid phase evolution during lyophilization of mannitol-based antibody formulations using an XRPD climate chamber
Lyophilization process optimizationMannitol-based antibody formulationsX-ray powder diffraction (XRPD) climate chamberDiff...
Discovery of ANO1 Inhibitors based on Machine learning and molecule docking simulation approaches
Calcium-activated chloride channels (CaCCs) are chloride channels that are regulated according to intracellular calcium io...
Polymeric nano-micelle of carbon monoxide donor SMA/CORM2 ameliorates acetaminophen-induced liver injury via suppressing HMGB1/TLR4 signaling pathway
Acetaminophen (APAP) overdose-induced hepatotoxicity is the most common cause of acute liver failure. Excessive generation...
Dissolving microneedle patches-mediated percutaneous delivery of tetramethylpyrazine for rheumatoid arthritis treatment
Recently, transdermal treatment of rheumatoid arthritis (RA) has received increasing attention due to the advantages of im...
Mechanistic insights into the effect of drug content on adhesive properties of transdermal patch containing lidocaine
This study aims to shed light on the relationship between drug content and adhesive properties in drug-in-adhesive transde...
Insight into the mechanism behind oral bioavailability-enhancement by nanosuspensions through combined dissolution/permeation studies
KeywordsDual asymmetric centrifugationDissolution/permeationNanosuspensionNanomillingPoorly soluble drugsSupersaturationAb...
Effect of budesonide on pulmonary activity of multidrug resistance-associated protein 1 assessed with PET imaging in rats
Multidrug resistance-associated protein 1 (MRP1/ABCC1) is a highly abundant efflux transporter in the lungs, which protect...
Pyrazole and pyrazoline derivatives as antimalarial agents: A key review
Volume 183, 1 April 2023, 106365Author links open overlay panel, , , Review highlights•The development of drug resistance ...
Influence of P-glycoprotein on pulmonary disposition of the model substrate [11C]metoclopramide assessed by PET imaging in rats
In the lungs, the membrane transporter P-glycoprotein (P-gp) is expressed in the apical (i.e. lumen-facing) membrane of ai...
In vitro evaluation of the potential use of snake-derived peptides in the treatment of respiratory infections using inhalation therapy: A proof of concept study
Volume 183, 1 April 2023, 106398Author links open overlay panel, , , , , AbstractInhalation therapy using nebulisers is an...
Design, synthesis and cytotoxic evaluation of a selective serotonin reuptake inhibitor (SSRI) by virtual screening
Volume 183, 1 April 2023, 106403Author links open overlay panel, , Highlights•A potencial SSRI (18a) was designed rational...
Preparation of hyaluronic acid-loaded Harmine polymeric micelles and in vitro effect anti-breast cancer
Volume 183, 1 April 2023, 106388Author links open overlay panel, , , , AbstractAimsTo prepare hyaluronic acid-loaded Harmi...
Selenomethionine as alternative label to the fluorophore TAMRA when exploiting cell-penetrating peptides as blood-brain barrier shuttles to better mimic the physicochemical properties of the non-labelled peptides
The cell-penetrating peptides (CPPs) Tat and penetratin are frequently explored as shuttles for drug delivery across the b...
Development of a population pharmacokinetic model and optimal dosing regimen of leflunomide in Korean population
PurposeLeflunomide is an immunosuppressive drug indicated for the treatment of rheumatoid arthritis (RA). While the pharma...
The impact of possible improper use on the performance in vitro of NEXThaler in comparison with Ellipta inhaler
The correct use of dry powder inhalers by the patients is essential to ensure effective treatment and management of the di...
阅读更多
format_indent_increase