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In-house CHO HCPs platform: A promising approach for HCPs ELISA monitoring
In-house CHO HCPs platform: A promising approach for HCPs ELISA monitoring
A key aspect that must be supervised during the development of recombinant therapeutic products is the potential presence ...
Evaluation of the impact of tragacanth/xanthan gum interpolymer complexation with chitosan on pharmaceutical performance of gels with secnidazole as potential periodontal treatment
Evaluation of the impact of tragacanth/xanthan gum interpolymer complexation with chitosan on pharmaceutical performance of gels with secnidazole as potential periodontal treatment
Volume 192, 1 January 2024, 106657Author links open overlay panel, , , , Highlights•Polyelectrolyte complexes-based hydrog...
Development and characterization of a spray-dried inhalable ternary combination for the treatment of Pseudomonas aeruginosa biofilm infection in cystic fibrosis
Development and characterization of a spray-dried inhalable ternary combination for the treatment of Pseudomonas aeruginosa biofilm infection in cystic fibrosis
Cystic fibrosis (CF) is an inherited lung disease characterised by the accumulation of thick layers of dried mucus in the ...
In vitro biodistribution studies on clinically approved FGFR inhibitors ponatinib, nintedanib, erlotinib and the investigational inhibitor KP2692
In vitro biodistribution studies on clinically approved FGFR inhibitors ponatinib, nintedanib, erlotinib and the investigational inhibitor KP2692
Volume 192, 1 January 2024, 106651Author links open overlay panel, , Highlights•Lipophilicity, proton dissociation constan...
Overcoming drug impurity challenges in amorphous solid dispersion with rational development of biorelevant dissolution-permeation method
Overcoming drug impurity challenges in amorphous solid dispersion with rational development of biorelevant dissolution-permeation method
Hot-melt extrusion is often used to prepare amorphous solid dispersion to overcome low drug solubility and enhance bio-per...
In Vitro and In Vivo Evaluation of Dark Chocolate as Age-appropriate Oral Matrix
In Vitro and In Vivo Evaluation of Dark Chocolate as Age-appropriate Oral Matrix
Volume 192, 1 January 2024, 106646Author links open overlay panel, , , , , , , , AbstractSwallowing difficulties encounter...
A pH-sensitive silica nanoparticles for colon-specific delivery and controlled release of catechin: Optimization of loading efficiency and in vitro release kinetics
A pH-sensitive silica nanoparticles for colon-specific delivery and controlled release of catechin: Optimization of loading efficiency and in vitro release kinetics
Catechin is a naturally occurring flavonoid of the flavan-3-ol subclass with numerous biological functions; however, these...
A comprehensively validated IVRT method reliably discriminates sameness and differences between several topical clotrimazole creams
A comprehensively validated IVRT method reliably discriminates sameness and differences between several topical clotrimazole creams
In vitro release testing (IVRT) has gained increasing acceptance for use as a biowaiver for topical products intended for ...
Fibrous matrices facilitate pleurocidin killing of wound associated bacterial pathogens
Fibrous matrices facilitate pleurocidin killing of wound associated bacterial pathogens
Conventional wound infection treatments neither actively promote wound healing nor address the growing problem of antibact...
Preparation of polycaprolactone and polymethacrylate nanofibers for controlled ocular delivery of ketorolac tromethamine: Pharmacokinetic study in Rabbit's Eye
Preparation of polycaprolactone and polymethacrylate nanofibers for controlled ocular delivery of ketorolac tromethamine: Pharmacokinetic study in Rabbit's Eye
Volume 192, 1 January 2024, 106631Author links open overlay panel, , AbstractOphthalmitis is an inflammation of the eye tr...
Nanostructured lipid carriers loaded into in situ gels for breast cancer local treatment
Nanostructured lipid carriers loaded into in situ gels for breast cancer local treatment
Volume 192, 1 January 2024, 106638Author links open overlay panel, , , , AbstractIn this study, nanostructured lipid carri...
Topical delivery of seriniquinone for treatment of skin cancer and fungal infections is enabled by a liquid crystalline lamellar phase
Topical delivery of seriniquinone for treatment of skin cancer and fungal infections is enabled by a liquid crystalline lamellar phase
Volume 192, 1 January 2024, 106635Author links open overlay panel, , , , , , , , , , AbstractSeriniquinone (SQ) was initia...
Do the enantiomers of ketamine bind enantioselectively to human serum albumin?
Do the enantiomers of ketamine bind enantioselectively to human serum albumin?
KeywordsProtein bindingAlbuminElectrophoresisNuclear magnetic resonance spectroscopyUltrafiltrationEnantioselectivityAbbre...
Towards personalized drug delivery via semi-solid extrusion: Exploring poly(vinyl alcohol-co-vinyl acetate) copolymers for hydrochlorothiazide-loaded films
Towards personalized drug delivery via semi-solid extrusion: Exploring poly(vinyl alcohol-co-vinyl acetate) copolymers for hydrochlorothiazide-loaded films
Volume 192, 1 January 2024, 106645Author links open overlay panel, , , , , , Highlights•Different PVA/PVAc copolymers were...
Analysis of stabilization mechanisms in β-lactoglobulin-based amorphous solid dispersions by experimental and computational approaches
Analysis of stabilization mechanisms in β-lactoglobulin-based amorphous solid dispersions by experimental and computational approaches
Our previous work shows that β-lactoglobulin-stabilized amorphous solid dispersion (ASD) loaded with 70 % indomethacin rem...
The use of polymorphic state modifiers in solid lipid microparticles: The role of structural modifications on drug release performance
The use of polymorphic state modifiers in solid lipid microparticles: The role of structural modifications on drug release performance
Volume 192, 1 January 2024, 106650Author links open overlay panel, , , , AbstractThis study investigates the correlation b...
A randomized double-blind phase Ib clinical trial of SY-009 in patients with type 2 diabetes mellitus
A randomized double-blind phase Ib clinical trial of SY-009 in patients with type 2 diabetes mellitus
Volume 192, 1 January 2024, 106644Author links open overlay panel, , , , , , , , , AbstractIntroductionSY-009 produces a h...
A comprehensive review of advanced nasal delivery: Specially insulin and calcitonin
A comprehensive review of advanced nasal delivery: Specially insulin and calcitonin
Peptide drugs through nasal mucous membrane, such as insulin and calcitonin have been widely used in the medical field. Th...
Digestion is a critical element for absorption of cinnarizine from supersaturated lipid-based type I formulations
Digestion is a critical element for absorption of cinnarizine from supersaturated lipid-based type I formulations
Enabling formulations, such as lipid-based formulations (LBFs), are means to deliver challenging-to-formulate, poorly solu...
Salvianolic acid B-loaded polydopamine-modified hollow mesoporous organic silica nanoparticles for treatment of breast cancer metastasis via suppressing cancer-associated fibroblasts
Salvianolic acid B-loaded polydopamine-modified hollow mesoporous organic silica nanoparticles for treatment of breast cancer metastasis via suppressing cancer-associated fibroblasts
ObjectiveDrug Delivery System was constructed using dopamine-coated organic-inorganic hybrid hollow mesoporous organic sil...
Altering distribution profile of palbociclib by its prodrugs
Altering distribution profile of palbociclib by its prodrugs
Palbociclib, a cyclin-dependent kinase (CDK) 4/6 inhibitor, is currently used clinically for treating hormone receptor-pos...
The overview of development of novel bacterial topoisomerase inhibitors effective against multidrug-resistant bacteria in an academic environment: From early hits to in vivo active antibacterials
The overview of development of novel bacterial topoisomerase inhibitors effective against multidrug-resistant bacteria in an academic environment: From early hits to in vivo active antibacterials
Antimicrobial resistance caused by the excessive and inappropriate use of antibacterial drugs is a global health concern. ...
A robust analytical method for simultaneous quantification of 13 low-molecular-weight N-Nitrosamines in various pharmaceuticals based on solid phase extraction and liquid chromatography coupled to high-resolution mass spectrometry
A robust analytical method for simultaneous quantification of 13 low-molecular-weight N-Nitrosamines in various pharmaceuticals based on solid phase extraction and liquid chromatography coupled to high-resolution mass spectrometry
Volume 192, 1 January 2024, 106633Author links open overlay panel, , AbstractRecently, the potentially highly carcinogenic...
The prescription design and key properties of nasal gel for CNS drug delivery: A review
The prescription design and key properties of nasal gel for CNS drug delivery: A review
Volume 192, 1 January 2024, 106623Author links open overlay panel, , , , , , , , AbstractCentral nervous system (CNS) dise...
Stabilization effects of saccharides in protein formulations: A review of sucrose, trehalose, cyclodextrins and dextrans
Stabilization effects of saccharides in protein formulations: A review of sucrose, trehalose, cyclodextrins and dextrans
Saccharides are a popular group of stabilizers in liquid, frozen and freeze dried protein formulations. The current work r...
Proteolysis Targeting Chimeras (PROTACs) based on celastrol induce multiple protein degradation for triple-negative breast cancer treatment
Proteolysis Targeting Chimeras (PROTACs) based on celastrol induce multiple protein degradation for triple-negative breast cancer treatment
Volume 192, 1 January 2024, 106624Author links open overlay panel, , , , , , AbstractThe pursuit of single drugs targeting...
Ultrasound-guided periadventitial administration of rapamycin-fibrin glue attenuates neointimal hyperplasia in the rat carotid artery injury model
Ultrasound-guided periadventitial administration of rapamycin-fibrin glue attenuates neointimal hyperplasia in the rat carotid artery injury model
IntroductionArterial restenosis caused by intimal hyperplasia (IH) is a serious complication after vascular interventions....
Enhancing both oral bioavailability and anti-ischemic stroke efficacy of ginkgolide B by preparing nanocrystals self-stabilized Pickering nano-emulsion
Enhancing both oral bioavailability and anti-ischemic stroke efficacy of ginkgolide B by preparing nanocrystals self-stabilized Pickering nano-emulsion
Volume 192, 1 January 2024, 106620Author links open overlay panel, , , , , AbstractGinkgolide B (GB), which has been demon...
Development of a tadalafil transdermal formulation and evaluation of its ability to in vitro transdermal permeate using Strat-M® membrane
Development of a tadalafil transdermal formulation and evaluation of its ability to in vitro transdermal permeate using Strat-M® membrane
KeywordsTadalafilDipropylene glycolHDTMA-BrIn vitro transdermal permeability testStrat-M® membraneStabilityAbbreviations(B...
Bicarbonate buffer dissolution test with gentle mechanistic stress for bioequivalence prediction of enteric-coated pellet formulations
Bicarbonate buffer dissolution test with gentle mechanistic stress for bioequivalence prediction of enteric-coated pellet formulations
Volume 192, 1 January 2024, 106622Author links open overlay panel, , , AbstractThis study aimed to develop a dissolution t...
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